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Metabolomics: Technologies and Global Markets

Metabolomics: Technologies and Global Markets

The global metabolomic market totaled $5.9 billion in 2014 and should total $6.8 billion in 2015 and $12.5 billion by 2020, registering a compound annual growth rate (CAGR) of 13.0%.

This report provides:
An overview of the commercial potential of the metabolomics research field, the systematic study of the unique chemical fingerprints that cellular processes leaves behind
Analyses of global market trends, with data from 2014, estimates for 2015 and projections of compound annual growth rates (CAGRs) through 2020
Definitions of metabolome, metabolites, and metabolomics vs. metabonomics
Discussion of the conceptual approach in metabolomics: target analysis, metabolite profiling, metabolomics, metabolic fingerprinting
Examination of the main structure of the metabolomics market: segments, key application areas, and market participants
Separation techniques for metabolomics: gas chromatography, capillary electrophoresis, and high-performance liquid chromatography (HPLC)
Patent analysis
Company profiles of major players in the field


SCOPE OF REPORT

The scope of the report encompasses the major metabolomic technology types that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

CHAPTER 1 INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
SUMMARY TABLE GLOBAL METABOLOMIC MARKET BY APPLICATION, THROUGH 2020 ($ MILLIONS)
SUMMARY FIGURE GLOBAL METABOLOMIC MARKET BY APPLICATION, 2014-2020 ($ MILLIONS)
CHAPTER 3 OVERVIEW OF METABOLOMICS
METABOLITES
METABOLOMICS
METABOLOMIC HISTORY
TABLE 1 HUMAN METABOLOME PROJECT AND DATABASE, 2006-2013
METABOLISM BASICS
CATABOLIC AND ANABOLIC PATHWAYS
TABLE 2 CELLULAR RESPIRATION STAGES
ADENOSINE TRIPHOSPHATE
ENZYME ROLE
TABLE 3 FACTORS IMPACTING ENZYME ACTIVITY
FEEDBACK INHIBITION
LOCATED IN MITOCHONDRIA
OXIDATION AND REDUCTION REACTIONS
DEHYDROGENASES
ELECTRON TRANSPORT CHAIN
OXIDATIVE AND SUBSTRATE-LEVEL PHOSPHORYLATION
GLYCOLYSIS
KREBS CYCLE
ACETYL COA
NADH AND FADH2 DONATE ELECTRONS
ELECTRON TRANSPORTERS: FLAVOPROTEIN AND CYTOCHROMES
TRICARBOXYLIC ACID CYCLE
ADENOSINE TRIPHOSPHATE SYNTHESIS
FERMENTATION
FOOD TO ENERGY
LIPID PROCESSING
FATTY ACID BETA-OXIDATION IN THE HEART
KETOSIS
BENEFITS
METABOLOMES
LARGE BOWEL MICROFLORA
URINE METABOLOME
FOOD METABOLOME
LIPIDOMICS
FLUXOMICS
APPLICATIONS
CHALLENGES
ANALYTICAL TECHNOLOGIES
PERFORMANCE DRIVERS
LIMITS OF DETECTION
TARGETED VERSUS UNTARGETED APPROACHES
TARGETED ANALYSIS
METABOLITE PROFILING
METABOLIC FINGERPRINTING
UNTARGETED APPROACHES
MARKET SUB-SEGMENTS
TABLE 4 PUBLICATIONS USING KEYWORD METABOLOMICS IN THE SEARCH, 2002-2014 (TOTAL PER YEAR)
FIGURE 1 PUBLICATIONS USING KEYWORD METABOLOMICS IN THE SEARCH, 2002-2014 (TOTAL PER YEAR)
CHAPTER 4 METABOLOMIC ANALYTICAL PROCESSES AND INSTRUMENTS
METABOLOMIC PROCESS STEPS
TABLE 5 TYPICAL ANALYTICAL METRABOLOMIC PROCESS STEPS
METABOLOMIC ANALYSIS PROCEDURES
SAMPLE PREPARATION
EXTRACTION
DERIVATIZATION
SEPARATION AND DETECTION
DATA ANALYSIS
EQUIPMENT USED IN SAMPLE PREPARATION AND EXTRACTION
SEPARATION AND DETECTION PRODUCTS
SEPARATION
CHROMATOGRAPHY
High-Performance Liquid Chromatography
Gas Chromatography
CAPILLARY ELECTROPHORESIS
SEPARATION EQUIPMENT MARKET
SUPPLIERS
TABLE 6 MAIN SEPARATION INSTRUMENT SUPPLIERS
DETECTION
MASS SPECTROMETRY
TABLE 7 MAIN MASS SPECTROSCOPY SUPPLIERS FOR LIFE SCIENCES
Direct Injection
Mass Spectrometry Imaging
Mass Spectrometry Types
Ion Trap
Quadrupole
Time-of-Flight Mass Spectrometers
TABLE 8 LEADING MASS SPECTROSCOPY SYSTEMS
NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
NUCLEAR MAGNETIC RESONANCE VERSUS MASS SPECTROSCOPY
HYPHENATED APPROACHES
GAS CHROMATOGRAPHY-MASS SPECTROMETRY
SINGLE QUADRUPOLE INSTRUMENTS
TIME OF FLIGHT INSTRUMENTS
LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY
CAPILLARY ELECTROPHORESIS-MASS SPECTROSCOPY
TABLE 9 COMMON HYPHENATED PLATFORMS IN METABOLOMIC RESEARCH
EMERGING DETECTION TECHNOLOGIES
MATRIX-ASSISTED LASER DESORPTION/IONIZATION
FOURIER TRANSFORM MASS SPECTROSCOPY
FOLDED FLIGHT PATH
COMPREHENSIVE TWO-DIMENSIONAL GAS CHROMATOGRAPHY
TIME-OF-FLIGHT MASS SPECTROSCOPY
MULTIPLE REACTION MONITORING
Targeted Untargeted Approach
Capillary Electrophoresis Mass Spectroscopy with Sheathless Interfaces
PROTEOMIC USE
Proteomics
METALLOMICS OVERVIEW
Tools Used in Metallomics
ANALYTICAL EQUIPMENT MARKET
TABLE 10 GLOBAL MASS SPECTROMETRY MARKET, THROUGH 2017 ($ BILLIONS)
ANALYTICAL EQUIPMENT USED IN THE METABOLOMIC MARKET
TABLE 11 GLOBAL ANALYTICAL EQUIPMENT USED IN THE METABOLOMIC MARKET, THROUGH 2020 ($ MILLIONS)
CHAPTER 5 ASSAY COMPONENTS AND KITS FOR METABOLOMICS
TARGETED METABOLOMICS
CHAPTER SCOPE
ASSAYS OVERVIEW
BACKGROUND ON ASSAYS AND ASSAY KITS
BIOCHEMICAL ASSAYS
CELL-BASED ASSAYS
CELL-BASED ASSAY TYPES
ASSAY READOUT: OVERVIEW OF DETECTION
CELL TYPES USED IN CELL-BASED ASSAYS
Immortalized Cell Lines and Primary Cells for Screening
Stem Cells at Scale
Cellular Dynamics Inc.
ASSAY COMMERCIAL CONSIDERATIONS
MICROPLATE PLATFORM
STANDARDS SETTING
CONTINUOUS INNOVATION
MICROPLATE READERS
ASSAY DETECTION OVERVIEW
FLUORESCENCE AS A DRIVER
HIGH-CONTENT SCREENING
Imaging Advances
Future Vision for High-Content Screening
TABLE 12 HIGH-CONTENT SCREENING SUPPLIERS AND KEY
ATTRIBUTES
LABEL-FREE PLATFORMS
TABLE 13 LABEL-FREE TECHNOLOGIES AND SUPPLIERS
ELECTROPHYSIOLOGY
COMMERCIAL LANDSCAPE OF CELL-BASED ASSAYS
MAJOR ASSAYS TYPES USED IN METABOLOMICS RESEARCH
OTHER TYPES
TABLE 14 OTHER ASSAY TYPES USED IN METABOLOMIC RESEARCH
MAIN CELL METABOLISM ASSAY APPLICATIONS
TABLE 15 MAIN CELL METABOLISM ASSAY APPLICATIONS
ASSAYS USED IN METABOLISM
ADENOSINE TRIPHOSPHATE
ENZYME ROLE
Phosphofructokinase
2-Phosphoglycerate
OXIDATION AND REDUCTION REACTIONS
DEHYDROGENASES
ELECTRON TRANSPORT CHAIN
OXIDATIVE AND SUBSTRATE-LEVEL PHOSPHORYLATION
GLYCOLYSIS
KREBS CYCLE
METABOLITE ASSAYS
ACETYL COA
NICOTINAMIDE ADENINE DINUCLEOTIDE AND NADH FADH2
Nicotinamide Adenine Dinucleotide Assays
OXIDATIVE STRESS ASSAYS
TABLE 16 ASSAYS COMMONLY USED IN METABOLOMICS
DRUG DISCOVERY USES
DRUG DISCOVERY DRIVERS
MITOCHONDRIA OPPORTUNITY
MITOCHONDRIAL FUNCTION AND CELL METABOLISM
MITOCHONDRIAL TOXICITY
TABLE 17 MAJOR CATEGORIES OF ASSAYS USED IN METABOLOMICS FOR DRUG DISCOVERY
TOOLS AND TECHNOLOGIES
TRADITIONAL METHODS
OTHER TECHNOLOGIES
NEW ANALYSIS TOOLS
BIOMARKER ASSAYS
FLUORESCENT DYES
BIOSENSING TECHNOLOGY
ADOPTION TRENDS
CANCER
OXYGEN CONSUMPTION ASSAY
SEAHORSE METABOLIC ANALYZERS
ASSAYS IN RELATED APPLICATIONS
TABLE 18 OTHER ASSAYS COMMONLY USED ALONGSIDE METABOLOMIC
ASSAYS
CYTOTOXICITY: A MAJOR CATEGORY
CYTOTOXIC AND/OR CYTOSTATIC IMPACTS
SCREENING STRATEGIES
PERMEABILITY ASSAYS FOR CELL VIABILITY AND SURVIVAL
LACTATE DEHYDROGENASE ENZYME RELEASE ASSAYS
DYE UPTAKE
NEUTRAL RED UPTAKE FOR CELL SURVIVAL ASSAYS
ADVANTAGES AND DISADVANTAGES
METABOLIC ASSAYS FOR CELL VIABILITY AND SURVIVAL
MTT ASSAY
ADENOSINE TRIPHOSPHATE ASSAY
DISADVANTAGES OF METABOLIC ASSAYS
FLUOROMETRIC APPROACHES
ALTERED CELL ADHESION
ASSAYS FOR CELL DEATH
APOPTOSIS VERSUS NECROSIS
CASPASE ACTIVATION
MEMBRANE RESIDUES
CYTOCHROME C RELEASE FROM MITOCHONDRIA
ASSAYS FOR CYTOSTATIC OR LONG-TERM IMPACT
CLONOGENIC CELL SURVIVAL ASSAY
MULTIPLEX ASSAYS
COMPOSITE SCREENING STRATEGIES
HIGH THROUGHPUT
CORRELATION WITH GENE-EXPRESSION DATA
TOXICOLOGY AND ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION ASSAYS
ACUTE TOXICITY
CYTOTOXICITY ASSAY KIT
CHRONIC AND REPEATED DOSE TOXICITY
SUB-CHRONIC STUDIES
ACCUMULATION AND FREQUENCY OF EXPOSURE
DOSAGE LEVELS
DURATION
REVERSIBILITY
ANALYSIS
DEVELOPMENT OF REPEATED DOSE TOXICITY TESTING IN VITRO
CARCINOGENICITY AND GENOTOXICITY
IN VITRO METHODS: BACKGROUND AND RECENT DEVELOPMENTS
REGULATORY VERSUS DRUG DEVELOPMENT APPLICATIONS
AMES TEST
IN VITRO MICRONUCLEUS TEST
EFFORTS TO REDUCE FALSE POSITIVES
RECENT INNOVATIONS FOR SCREENING
METABOLITE ASSESSMENT
FUTURE CHALLENGE: NON-GENOTOXIC CARCINOGENS
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY
FOLLOWING THE REPRODUCTIVE CYCLE
EMBRYOTOXICITY
MALE REPRODUCTIVE TOXICITY
FEMALE REPRODUCTIVE TOXICITY
DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY TESTING TYPES
ZEBRAFISH MODEL FOR DEVELOPMENTAL TOXICITY SCREENING
COMBINATIONS OF ZEBRAFISH AND STEM CELLS
BIOMEDICAL FRONTIERS: MALE TESTIS
ENDOCRINE DISRUPTOR SCREENING
ENVIRONMENTAL TOXICOLOGY IMPACTS IN VITRO METHODS
U.S. ENVIRONMENTAL PROTECTION AGENCY’S ENDOCRINE DISRUPTOR
SCREENING PROGRAM
TABLE 19 IN VITRO AND IN VIVO ASSAY TESTS IN THE TIER 1 SCREENING BATTERY, 2013
HIGH-PRODUCTION VOLUME CHEMICALS
TOXCAST AND TOX 21 INITIATIVES
FUTURE CHALLENGE: THYROID DISRUPTION
BG1 ASSAY
LIVER TOXICITY APPLICATIONS
IMPORTANCE OF TWO-DIMENSIONAL VERSUS THREE-DIMENSIONAL SYSTEMS
IMMUNE MEDIATED DRUG-INDUCED LIVER INJURY
KIDNEY TOXICITY
FUTURE CHALLENGE: STEM CELL-DERIVED KIDNEY CELLS
ABSORPTION, DISTRIBUTION, METABOLISM AND EXCRETION AND TOXICOKINETICS
IN VITRO DEVELOPMENTS
UNMET NEED FOR METABOLIC TRANSFORMATION
IN VITRO METABOLISM OFFERINGS
METABOLISM BY CYP450 ENZYMES: REACTION PHENOTYPING STUDIES
CYPROTEX
MICROFLUIDICS AND ORGANS-ON-A-CHIP
SUMMARY
COMMERCIAL CONSIDERATIONS
CELL-BASED ASSAY MARKET
GENOME SEQUENCING MARKET
MARKET
TABLE 20 GLOBAL RESEARCH ASSAYS USED IN METABOLOMICS MARKET, THROUGH 2020 ($ MILLIONS)
CHAPTER 6 BIOINFORMATICS IN METABOLOMICS
OVERVIEW
BIOINFORMATIC PROCESSES
TABLE 21 BIOINFORMATIC PROCESSES FOR METABOLOMICS
DATA COMPOSITION ANALYSIS AND PROCESSING
DATA COMPOSITION ANALYSIS
XCMS
Others
TABLE 22 METABOLOMIC OPEN-ACCESS DATA-PROCESSING TOOLS
DATA REDUCTION AND INTEGRATION
STATISTICAL APPROACHES AND CHALLENGES
GENOMICS INFLUENCE
METABOLOMIC METHODS
PRINCIPAL COMPONENT ANALYSIS
Upgrading Principal Component Analysis
FUNCTIONAL CLASSIFIERS BASED ON PATHWAYS AND NETWORKS
PATHWAY MAPS
KNOWLEDGE-BASED APPROACHES
DATA MODELING
RECONSTRUCTION
VERIFICATION
NETWORK SIMULATION
DATA VISUALIZATION
DATABASE CURATION AND MANAGEMENT
METABOLOMICS PUBLIC RESOURCES
TABLE 23 METABOLOMIC PUBLIC RESOURCES
SELECT DESCRIPTIONS
DAVID WISHART RESEARCH GROUP
METLIN
KYOTO ENCYCLOPEDIA OF GENES AND GENOMES
OTHERS
TABLE 24 OTHER METABOLOMIC BIOINFORMATIC RESOURCES
COMMERCIAL MARKET STRUCTURE
VENDORS AND EQUIPMENT MANUFACTURERS
BIOINFORMATICS COMPANIES AND SYSTEMS BIOLOGY PLAYERS WITH A SPECIFIC FOCUS ON METABOLOMICS RESEARCH
Thomson Reuters' Metadrug
GENEDATA SCREENER AND EXPRESSIONIST
QIAGEN
INGENUITY PATHWAY ANALYSIS
BMSYSTEMS
COMPANIES THAT DEVELOP THEIR OWN SOFTWARE
METABOLON
CHENOMX
LIMITATIONS
UNMET NEEDS
DATA STANDARDIZATION
MARKET
TABLE 25 GLOBAL BIOINFORMATIC TOOLS USED IN THE METABOLOMIC MARKET, THROUGH 2020 ($ MILLIONS)
CHAPTER 7 CLINICAL BIOMARKERS
OVERVIEW
TABLE 26 MAJOR CLINICAL METABOLOMIC APPLICATIONS
BIOMARKER CHALLENGES
PROGRESS FROM PROTEOMICS
METABOLOMIC ADVANTAGE
APPLICATION ADOPTION
GENOMICS LEADERSHIP
METABOLOMICS' KEY ROLE
MAJOR CLINICAL APPLICATIONS
INBORN ERRORS OF METABOLISM
BACKGROUND
Amino Acid Disorders
Fatty Acid Oxidation Disorders
Organic Acid Disorders
ONSET AND SEVERITY
EXAMPLES OF INBORN ERRORS OF METABOLISM
INCIDENCE AND TESTING
PHARMACOGENOMICS
PHARMACOGENOMICS ADOPTION
CURRENT SUCCESSES IN PHARMACOGENOMICS
Warfarin
Simvastatin
Cancer Drugs
Cisplatin Chemotherapy
Anthracyclines
LIVER ENZYME CYP2C19
CLOPIDIGREL
CODEINE
HUMAN LEUKOCYTE ANTIGEN B
CARBAMAZEPINE
AZATHIOPRINE
MENTAL HEALTH
ANTIDEPRESSANTS
SEROTONIN
CATECHOL METHYL TRANSFERASE
PHARMACOKINETIC AND PHARMACODYNAMIC GENES
COMMERCIAL EXAMPLE
CHALLENGES AND FUTURE DIRECTIONS
VALIDATION
CANCER
CANCER HALLMARKS
CANCER METABOLISM OVERVIEW
CANCER GLUCOSE METABOLISM
CANCER GLUTAMINE METABOLISM
CANCER SERINE AND GLYCINE METABOLISM
ONE-CARBON METABOLISM
CANCER AND THE FOLATE CYCLE
Folic Acid
METHIONE CYCLE
CANCER AND GLUTATHIONE CYCLE
LIPID METABOLISM
CANCER DRUG APPLICATIONS
Folate Agonist Drugs
Nucleotide Metabolism
Targeting Metabolic Enzymes in Cancer
Enzyme Starvation
Mitochondrial Folate Metabolism
In Vitro Models
Path Forward
CARDIOVASCULAR AND METABOLIC DISEASE
APPLICATIONS
PLANNED MYOCARDIAL ISCHEMIA AND INFARCTION
EXERCISE STRESS TESTING
ALCOHOL SEPTAL ABLATION
NITRIC OXIDE METABOLIC PATHWAY
ANTHRACYCLINE-INDUCED CARDIOTOXICITY
ATRIAL FIBRILLATION
DETECTING HEART FAILURE VERSUS B-TYPE NATRIURETIC PEPTIDE
PULMONARY HYPERTENSION
Pulmonary Hypertension as Mitochondria Dysfunction
Pulmonary Hypertension and Insulin Resistance
ATHEROSCLEROSIS RISK
Lipid Profiles
Cholesterol
Particles
CHOLESTEROL TESTING CLINICAL USES AND MARKET
STATINS
POSSIBLE ADVERSE DRUG REACTIONS
SERUM MARKERS
STATIN DOSE MARKER
COADMINISTRATION
METABOLIZATION DIFFERENCES
GENETIC VARIABILITY
LIPID PROFILE
BEYOND STATINS TO MULTIMARKER APPROACH
Jupiter Trial
Jupiter Expands Statin Use
Jupiter Also Raises Diabetes Risk
Guidelines
SYSTEMIC AND VASCULAR INFLAMMATION
High-Sensitivity C-Reactive Protein
Myeloperoxidase
Lipoprotein-Associated Phospholipase-A2
ADVANCED LIPID TESTING
Apolipoprotein B and A1 (ApoA1)
Small-Dense LDL
Lipoprotein (a)
HDL2b
Particle Type
COMPANIES OFFERING ADVANCED LIPID TESTING
LIPOSCALE TEST
PRIMARY CARE PHYSICIANS
CLEVELAND HEARTLAB
NON-FASTING TRIGLYCERIDES
METABOLOMIC APPLICATIONS
LIPIDOMICS
CHOLINE METABOLISM
ACYLCARNITINES
Trimethylamine N-oxide
MICROFLORA-DERIVED CHOLINE METABOLITES
LINK WITH GUT MICROFLORA
DIABETES AND PRE-DIABETES
Insulin Resistance
Link with Obesity not Conclusive
TOOLS TO DETECT INSULIN RESISTANCE
COMPANIES OFFERING INSULIN-RESISTANCE TESTING
OTHER INSULIN-RESISTANCE TESTING
Branched-Chain Amino Acids: Insulin Resistance via Exercise Stress
Testing
Branched-Chain Amino Acids and Gastric Bypass
LIVER DISEASES
METHYLATION DEFICIENCY
FOLATE DEFICIENCY
CLINICAL LIVER DISEASE
Diagnosis
Treatment
Research
Progress on Non-Alcoholic Fatty Liver Disease
OWL
European Association for the Study of the Liver
APPLICATIONS IN LIVER RESEARCH
Liver Metabolism Overview
Liver Function and Structure
Hepatocytes or Parenchymal Cells
Specialized Liver Endothelial Cells
Non-Parenchymal Stellate and Kupffer Cells
Morphogen Signaling
In Vitro Applications
Drug-Induced Liver Injury
Kiyatec
Liver Inflammation Models
Hepregen
Liver Regeneration
Achieving Hepatocyte Expansion Still Elusive
Cell Types
HepaRG
TABLE 27 ORGANIZATIONS OFFERING IMMORTALIZED CELL LINES, 2013
Human and Other Primary Hepatocytes
TABLE 28 COMPANIES OFFERING PRIMARY CELLS, 2013
Stem Cell-Derived Hepatocytes
RAFT for iPS Hepatocytes Longevity
Hepatotoxicity Screening Library
Stem Cell Companies
TABLE 29 COMPANIES OFFERING STEM CELLS FOR LIVER SAFETY
TESTING AND RESEARCH, 2013
TOXICITY STUDIES AND NON-PARENCHYMAL CELLS AS DRIVERS OF IN VITRO DEVELOPMENT
TYPICAL END POINTS
KEY REQUIREMENTS
Cell-Cell Contacts Key for Differentiation and Functionality
Oxygen Supply
Co-Culture
Developments
Challenges
Benefits of Three-Dimensional Spheroids
High-Content Imaging and Analysis
Microfluidics
Dielectrophoretic Forces
HepaChip
Learnings from Microfluidics
Self-Organizing Systems
COMMERCIAL CONSIDERATIONS
LABORATORY-DEVELOPED TESTS
TABLE 30 LABORATORY-DEVELOPED TEST PROVIDERS, 2015
CLEVELAND HEARTLAB
MARKET
TABLE 31 GLOBAL CLINICAL BIOMARKERS USED IN METABOLOMICS MARKET, THROUGH 2020 ($ MILLIONS)
CHAPTER 8 COMPANY PROFILES
ABCAM
AGILENT TECHNOLOGIES INC.
ATHEROTECH DIAGNOSTICS LAB
BG MEDICINE INC.
BIOVISION INC.
CALITHERA BIOSCIENCES INC.
CHENOMX
CITOXLAB
CLEVELAND HEARTLAB INC.
CLINMET INC.
COURTAGEN LIFE SCIENCES INC.
CYPROTEX PLC
EMD MILLIPORE
EXALENZ BIOSCIENCE LTD,
GENOMIND INC.
LECO CORP.
LUMINEX CORP.
METABOLOMIC DIAGNOSTICS
METABOLOMIC TECHNOLOGIES INC.
METABOLOMX
METABOLON INC.
METANOMICS GMBH
ONE WAY LIVER GENOMICS, S.L
PHENOMENOME DISCOVERIES INC.
PROMEGA CORP.
QIAGEN GMBH
SEAHORSE BIOSCIENCE
SIGMA-ALDRICH
STEMINA BIOMARKER DISCOVERY INC.
THERMO FISHER SCIENTIFIC
XENOTECH

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