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In Vitro Toxicity Testing: Technologies and Global Markets

In Vitro Toxicity Testing: Technologies and Global Markets

Report Scope:

The scope of the report encompasses the major types of traditional toxicity testing that have been used, and the in vitro techniques that are being developed by industry, government agencies and nonprofits. It analyzes current market status, examines drivers on future markets and presents forecasts of growth over the next five years.

Technology developments, including the latest trends, are discussed. Other influential factors such as validation and testing strategies for pharmaceuticals, cosmetics, and chemicals also have been included.

Regulatory drivers play a large role in toxicology, determining the specific parameters of tests that have been explicitly required. They also heavily influence the testing that is performed by companies in earlier stages of research. The report examines the regulatory role and the different federal and international agencies that play an active role in in vitro toxicology research, development and adoption.

Report Includes:

- 52 data table and 18 additional tables
- An overview of the global markets and technologies for the in vitro toxicity testing techniques within the pharmaceutical industry
- Analyses of global market trends with data from 2017, 2018, and projections of compound annual growth rates (CAGRs) through 2023
- Information on latest trends, technological developments and government regulations that influence the growth of the market
- A breakdown of influential factors, such as validation of the alternative measures for toxicity and toxicity testing strategies for chemicals, pesticides, and food additives
- Evaluation covering equipment, assays, cells, reagents, and services used in toxicity testing
- Profiles of major players in the toxicology market, including Abbott Laboratories, Inc., Agilent Technologies, Inc., Evotec AG, GE Healthcare Life Sciences and Thermo Fisher Scientific, Inc.


Chapter 1 Introduction
Study Goals and Objectives
Reasons for Doing This Study
Intended Audience
Scope of Report
Information Sources
Methodology
Geographic Breakdown
Analyst's Credentials
BCC Custom Research
Related BCC Research Reports
Chapter 2 Summary and Highlights
Chapter 3 Market and Technology Background
Introduction
Regulatory Framework and Programs
European Union
India
Regulatory Programs
Key Market Growth Factors
Replacement of In Vivo Models, by In Vitro Models
In Vitro Toxicity in the Drug Discovery Process
CROs Gaining Popularity
Application of High-Throughput Screening in Toxicology
Opportunities
Extensive Funding, by Research Institutes on Toxicology
Paradigm Shift in Toxicity Testing in the 21st Century
Limitations and Challenges
Expensive Equipment Used in Toxicology
Chapter 4 Market Breakdown by Toxicity Endpoints and Tests
ADME
In Vitro Metabolism Offerings
Metabolism Reaction Phenotyping for Genetic Polymorphisms
Skin Irritation, Corrosion and Sensitization
Genotoxicity Testing
In Vitro Micronucleus Test (MNT)
Cytotoxicity Testing
Use of Cytotoxicity Assays for Acute Toxicity Testing
Example of Commercially Available Cytotoxicity Assay Kit
Ocular Toxicity
Organ Toxicity
Phototoxicity Testing
Dermal Toxicity
Carcinogenicity
The AMES Test
Neurotoxicity
Development and Reproductive Toxicity (DART)
Other Toxicity Endpoints and Tests
Chapter 5 Market Breakdown by End-User Industry
Pharmaceutical and Biotechnology Companies
Healthcare (Diagnosis)
Food and Beverage Industry
Chemical Industry
Challenges for Chemical Companies: Depth and Breadth
Personal Care Products (Cosmetics)
Contract Research Organizations
Research Institutes
Center for Alternatives to Animal Testing (CAAT)
European Union Reference Laboratory for Alternatives to Animal Testing (EURL)
The Hamner Institutes for Health Sciences
Chapter 6 Market Breakdown by Tool/Technology
Transcriptomics
Tools Used in Transcriptomics
Proteomics
Proteomics Tools
Metabolomics
Collaboration for Establishing Metabolomics Lab
Metabolomics Tools
Cellomics or Cytomics
Chapter 7 Market Breakdown by Component
Assays
Companies Strategies for the Development of New, and Expansion of Existing Products:
Assay Kits for High-Content Screening
Cell-Based Assays: Overview and Newer Developments
Components of Cell-Based Assay Systems
Equipment
Reagents and Kits
New Reagents in the Market
Software and Analytics
Trace Finder Software, by Thermo Fisher Scientific, Inc.
Services
ADME Screening
Chapter 8 Market Breakdown by Region
North America
United States
Recent Developments in the Region
Canada
Europe
United Kingdom
Germany
France
Spain
Italy
Rest of Europe
Asia-Pacific
China
Japan
India
Rest of Asia-Pacific
Rest of the World
Middle East
Africa
Latin America
Chapter 9 Patent Review/ New Developments
Biomarkers for In Vitro Toxicology
Uses of In Vitro Biomarkers
In Vitro Biomarkers: Future Prospects
Types of Biomarkers
Competitive Landscape
Key Companies
Key Market Player Strategies
Patent Analysis
Chapter 10 Company Profiles
ABBOTT LABORATORIES, INC.
Business Overview
ACEA BIOSCIENCES, INC.
Business Overview
AGILENT TECHNOLOGIES, INC.
Business Overview
ALBANY MOLECULAR RESEARCH, INC.
Business Overview
APTUIT, INC.
Business Overview
BIOGNOSYS AG
Business Overview
BIORELIANCE
Business Overview
BIOVIA
CELLULAR DYNAMICS INTERNATIONAL, INC.
Business Overview
CHANTEST
Business Overview
CHARLES RIVER LABORATORIES
Business Overview
COVANCE, INC.
Business Overview
CYPROTEX PLC
Business Overview
DRIK LLC
Business Overview
ENZO LIFE SCIENCES, INC.
Business Overview
ESSEN BIOSCIENCE, INC.
Business Overview
EUROFINS SCIENTIFIC SE
Business Overview
Products Offered
EVOTEC AG
Business Overview
GE HEALTHCARE LIFE SCIENCES
Business Overview
GENEDATA
Business Overview
GENTRONIX LTD.
Business Overview
HUREL CORP.
Business Overview
IMQUEST BIOSCIENCES, INC.
Business Overview
IMSTAR SA
Business Overview
INSPHERO AG
Business Overview
KIYATEC, INC.
Business Overview
LONZA GROUP LTD.
Business Overview
Products Offered
METABOLON, INC.
Business Overview
MOLECULAR DEVICES LLC
Business Overview
PERKINELMER, INC.
Business Overview
PROMEGA CORP.
Business Overview
Products Offered
QIAGEN NV
Business Overview
Products Offered
SGS-SA
Business Overview
STEMINA BIOMARKER DISCOVERY, INC.
Business Overview
SYNVIVO, INC.
Business Overview
THERMO FISHER SCIENTIFIC, INC.
Business Overview
VALA SCIENCES, INC.
Business Overview
VISTAGEN THERAPEUTICS, INC.
Business Overview
XENOMETRIX AG
Business Overview
List of Tables
Summary Table : Global Market for In Vitro Toxicity Testing, by Region, Through 2023
Table 1 : Research Institutes/Organizations that Offer In Vitro Testing and Other Services
Table 2 : Instruments Used in In Vitro Toxicology Testing, 2017
Table 3 : Global Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint and Test, Through 2023
Table 4 : ADME In Vitro Toxicity Products
Table 5 : Global Market for ADME Testing Technologies, by Region, Through 2023
Table 6 : Global Market for Skin Irritation, Corrosion and Sensitization Testing Technologies, by Region, Through 2023
Table 7 : Genotoxicity Testing Products
Table 8 : Global Market for Genotoxicity Testing Technologies, by Region, Through 2023
Table 9 : Global Market for Cytotoxicity Testing Technologies, by Region, Through 2023
Table 10 : Global Market for Ocular Toxicity Testing Technologies, by Region, Through 2023
Table 11 : Global Market for Organ Toxicity Testing Technologies, by Region, Through 2023
Table 12 : Validated Non-animal Methods
Table 13 : Global Market for Phototoxicity Testing Technologies, by Region, Through 2023
Table 14 : Global Market for Dermal Toxicity Testing Technologies, by Region, Through 2023
Table 15 : OECD TGs for In Vitro Genotoxicity and Mutagenicity Testing
Table 16 : Global Market for Carcinogenicity Testing Technologies, by Region, Through 2023
Table 17 : General Endpoints Used for In Vitro Neurotoxicity Testing
Table 18 : Global Market for Neurotoxicity Testing Technologies, by Region, Through 2023
Table 19 : Global Market for DART Testing Technologies, by Region, Through 2023
Table 20 : Global Market for Other Toxicity Endpoints and Tests Technologies, by Region, Through 2023
Table 21 : Global Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 22 : Global Market for Pharmaceutical and Biotechnology End-User Industry, by Region, Through 2023
Table 23 : Global Market for Healthcare End-User Industry, by Region, Through 2023
Table 24 : Global Market for Food and Beverage End-User Industry, by Region, Through 2023
Table 25 : Global Market for Chemical End-User Industry, by Region, Through 2023
Table 26 : Chemical Companies that Provide Vitro Toxicology Services
Table 27 : Global Market for Personal Care Products End-User Industry, by Region, Through 2023
Table 28 : CROs Providing In Vitro Toxicology Services
Table 29 : Global Market for CROs End-User Industries, by Region, Through 2023
Table 30 : Global Market for Research Institutes End-User Industries, by Region, Through 2023
Table 31 : Research Institutes Providing In Vitro Toxicology Tests
Table 32 : Global Market for In Vitro Toxicology Testing Technologies, by Tool/Technology, Through 2023
Table 33 : Global Market for Transcriptomics, by Region, Through 2023
Table 34 : Global Market for Proteomics, by Region, Through 2023
Table 35 : Global Market for Metabolomics, by Region, Through 2023
Table 36 : Common Analytical Platforms Used in Metabolomics
Table 37 : Global Market for Cellomics, by Region, Through 2023
Table 38 : Global Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 39 : Global Market for Assays, by Region, Through 2023
Table 40 : Global Market for Equipment, by Region, Through 2023
Table 41 : Global Market for Reagents and Kits, by Region, Through 2023
Table 42 : Specifications of HCS LIVE⁄DEAD Green Kit
Table 43 : Global Market for Software and Analytics, by Region, Through 2023
Table 44 : Global Market for Services, by Region, Through 2023
Table 45 : North American Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 46 : North American Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 47 : North American Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 48 : North American Market for In Vitro Toxicity Testing Technologies, by Tools/Technology, Through 2023
Table 49 : North American Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 50 : In Vitro Services Offered by Nucro-Technics
Table 51 : Tracking System for Alternative Test Methods, Review (TSAR), 2018
Table 52 : European Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 53 : European Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 54 : European Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 55 : European Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 56 : European Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 57 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Country, Through 2023
Table 58 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 59 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 60 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 61 : Asia-Pacific Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 62 : Top 20 R&D Pharmaceutical Companies in China
Table 63 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by Toxicity Endpoint/Test, Through 2023
Table 64 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by End-User Industry, Through 2023
Table 65 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by Tool/Technology, Through 2023
Table 66 : Rest of the World Market for In Vitro Toxicity Testing Technologies, by Component, Through 2023
Table 67 : Number of Patents, by Category in Different Countries, January 2016 to July 2018
Table 68 : Patents, by Key Players, January 2016 to July 2018
Table 69 : List of Patents Analyzed, January 2016 to July 2018
List of Figures
Summary Figure : Global Market for In Vitro Toxicity Testing, by Region, 2017-2023
Figure 1 : Timeline of Animal Testing Ban in India
Figure 2 : Regulations timeline for Cosmetic Testing on Animals
Figure 3 : Comparison Between In Vivo and In Vitro Toxicity
Figure 4 : Discovery Toxicology
Figure 5 : Merck KGaA Toxicology Services
Figure 6 : Global Per Capita Healthcare Expenditure, by Country, 2016
Figure 7 : In Vitro Toolbox for Acute Inhalation Toxicity
Figure 8 : Features of ToxiScreen
Figure 9 : Drug Discovery Process
Figure 10 : Use of Metabolomics Toxicology
Figure 11 : Types of Toxicity Studies
Figure 12 : Features of Thiol Tracker Violet
Figure 13 : Features of TraceFinder Software
Figure 14 : Healthcare Expenditures for R&D, by State and Performer, FY 2016
Figure 15 : Total Health Expenditures, by Source of Finance, 2016
Figure 16 : Healthcare Expenditure as a Share of GDP, by Region/Country, 2015
Figure 17 : E.U. Innovation Funding, by Horizon 2020, by Projects, 2014-2022
Figure 18 : Biotech Funding in the U.K., 2017
Figure 19 : Active Market Players in the U.K.
Figure 20 : Germany Health Spending, 2013-2016
Figure 21 : Research and Development Funding in Health Research and Health Industry, 2016-2017
Figure 22 : Chinese Pharmaceutical Sales, 2015 and 2020
Figure 23 : List of Programs and Description
Figure 24 : Japan’s Pharmaceutical R&D Expenditure, 1995-2015
Figure 25 : Indian’s Pharmaceutical Exports, 2014-2018
Figure 26 : Thermo Fisher Scientific, Inc.: Revenue Share, by Segment, 2017
Figure 27 : Thermo Fisher Scientific, Inc.: Share of Revenue Generation, by Region, 2017

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