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Global Markets for Protein Labeling

Global Markets for Protein Labeling

The global protein-labeling market reached $2.2 billion in 2016. The market should reach $4.2 billion by 2021, growing at a compound annual growth rate (CAGR) of 14.1% from 2016 to 2021.

Report Includes
An overview of the global protein labeling market.
Analyses of global market trends, with data from 2015, 2016 and projections of compound annual growth rates (CAGRs) through 2021.
Coverage of most commonly used labels including biotin, reporter enzymes, fluorophores and radioactive isotopes.
A look at the current trends in the market as well as factors influencing demand.
Coverage of protein labeling products: kits, reagents and services.
Coverage of protein labeling applications: cell-based assays, fluorescence microscopy, mass spectrometry, immunological techniques, protein microarray.
Coverage of protein labeling methods: in vitro labeling, in vivo labeling and bio-orthogonal labeling.
Profiles of major players in the industry.


Report Scope
This research report presents an in-depth analysis of the global protein-modeling market by application, product categories, labeling methods and regional markets. It includes key labeling methods involved in vitro and in vivo labeling methods. It discusses the role of supply chain members from manufacturers to researchers. The report has an in-depth analysis of key companies operating in the global protein-labeling market. In-depth patent analysis will focus on providing extensive technological trends across years and regions, including the U.S., Europe and Japan.

The protein-labeling market is segmented into three labeling methods: in vitro labeling, in vivo labeling and biorthogonal labeling methods. In vitro labeling methods are further segmented into nanoparticle, site-specific, dye-based, cotranslational and enzymatic labeling. The in vivo labeling method market is segmented into radioactive and photoreactive labeling. The protein-labeling market is further segmented on the basis of products offered for in-depth analysis of technology markets during the analysis period. The market study is detailed for technology based on procedures, as well as its further implication on the research and development area. These two segmentations are also discussed in detail for the given period. The market is segmented by region into North America, Europe, the Asia-Pacific region and ROW. Companies profiled in this report include General Electric Company, Kaneka Corp. LI-COR Biosciences, Merck and Company Inc., New England Biolabs Inc., Perkinelmer Inc., Promega Corp., F. Hoffman-La-Roche AG, Seracare Lifesciences and Thermo Fisher Scientific Inc.

CHAPTER 1 INTRODUCTION
STUDY GOALS AND OBJECTIVES
STUDY BACKGROUND
SCOPE OF THE REPORT
INTENDED AUDIENCE
SOURCE OF INFORMATION AND METHODOLOGY
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 EXECUTIVE SUMMARY
SUMMARY TABLE GLOBAL PROTEIN-LABELING MARKET, BY REGION, THROUGH 2021 ($ MILLIONS)
SUMMARY FIGURE GLOBAL PROTEIN-LABELING MARKET, BY REGION, 2015-2021 ($ MILLIONS)
CHAPTER 3 MARKET OVERVIEW
MARKET DEFINITION
FIGURE 1 KEY PROTEIN LABELS USED FOR PROTEIN LABELING
ENZYME CONJUGATES
FLUORESCENT PROBES
MARKET EVOLUTION AND INNOVATION
QUALITY ASSURANCE AND CONTROL
QUALITY CONTROL
Quality Control Applications
Quality Control Logs
SPACE
PERSONNEL SAFETY
GOOD LABORATORY PRACTICES
FIGURE 2 COMPONENTS INVOLVED IN AN EFFECTIVE GOOD LABORATORY
PRACTICE INVESTIGATION
TABLE 1 COMPARATIVE ANALYSIS OF U.S. FOOD AND DRUG
ADMINISTRATION, ENVIRONMENTAL PROTECTION AGENCY AND ORGANIZATION FOR ECONOMIC COOPERATION AND DEVELOPMENT REGULATIONS BY PARAMETER
STANDARD OPERATING PROTOCOL
GOOD LABORATORY PRACTICE ELEMENTS
Protocol
Reports
Archives
Key Good Laboratory Practice Points
FIGURE 3 KEY GOOD LABORATORY PRACTICE ELEMENTS
Facilities and Equipment
Characterization
Test Item Control Before Formulation
Physical Separation
Equipment Suitability and Calibration
Maintenance
Good Laboratory Practice Standards for Laboratory Equipment
ROLE OF GOOD LABORATORY PRACTICES IN IN VITRO STUDIES
TECHNOLOGY TRENDS
SLENDR TECHNIQUE
NEW BIOTIN LABELS
ITRAQ
DEVELOPMENT OF LABELING TOOLS
MUTANT B-LACTAMASE TAG TECHNOLOGY
MARKET DYNAMICS
DRIVERS
Increasing Investment in Research and Development Endeavors
Increase in Genome Sequencing Demand
Increasing Healthcare Expenditure
Increase in Proteomics Research
RESTRAINTS
Protein-Labeling Product Application
Lack of Skilled Professionals
OPPORTUNITIES
Effective Protein-Labeling Technology Pricing
Technological Advances in Protein Labeling
CHAPTER 4 PROTEIN-LABELING MARKET BY APPLICATION
TABLE 2 GLOBAL PROTEIN-LABELING MARKET, BY APPLICATION, THROUGH 2021 ($ MILLIONS)
CELL-BASED ASSAYS
HISTORY OF CELL-BASED ASSAYS
FIGURE 4 CELL-BASED ASSAY TYPES
CELL-BASED ASSAY APPLICATIONS
TABLE 3 GLOBAL PROTEIN-LABELING MARKET FOR CELL-BASED ASSAYS, BY REGION, THROUGH 2021 ($ MILLIONS)
ADVANCES IN CELL-BASED ASSAYS
FLUORESCENCE MICROSCOPY
FLUORESCENCE MICROSCOPY HISTORY
FLUORESCENT MICROSCOPY TECHNIQUES
FLUORESCENCE MICROSCOPY PROCEDURE
FIGURE 5 FLUORESCENCE MICROSCOPY PROTOCOL
Fluorescent Microscope Functioning
Fluorescent Microscopy Applications
RECENT ADVANCES IN FLUORESCENT MICROSCOPY
TABLE 4 GLOBAL PROTEIN-LABELING MARKET FOR FLUORESCENCE MICROSCOPY, BY REGION, THROUGH 2021 ($ MILLIONS)
MASS SPECTROMETRY
MASS SPECTROMETRY HISTORY
FUNCTIONS OF A MASS SPECTROMETER
Mass Spectrometers
TABLE 5 GLOBAL PROTEIN-LABELING MARKET FOR MASS SPECTROSCOPY, BY REGION, THROUGH 2021 ($ MILLIONS)
MASS SPECTROMETRY APPLICATIONS
METHODS USED FOR MASS SPECTROMETRY
Matrix-Assisted Laser Desorption
Protocol for Data Acquisition Through Matrix-Assisted Laser Desorption
Time of Flight
MASS SPECTROMETRY ADVANCES
FIGURE 6 PROTEOMICS STUDY APPROACHES
IMMUNOLOGICAL TECHNIQUES
TABLE 6 GLOBAL PROTEIN-LABELING MARKET FOR IMMUNOLOGICAL TECHNIQUE APPLICATIONS, BY REGION, THROUGH 2021 ($ MILLIONS)
CLINICAL IMMUNOLOGY APPLICATIONS
Immunoassay
Radioimmunoassay
Immunoprecipitation
Immunoelectrophoresis
Immunofluorescence
Immunohistochemistry
Immunocytochemistry
ELISA Types
FIGURE 7 ELISA TYPES
FIGURE 8 DIRECT ELISA PROTOCOL
FIGURE 9 INDIRECT ELISA PROTOCOL
FIGURE 10 COMPETITIVE ELISA PROTOCOL
FIGURE 11 SANDWICH ELISA PROTOCOL
Immunomonitoring
Immunomonitoring Application
Diabetes Mellitus
Infectious Diseases
ADVANCES IN IMMUNOLOGICAL TECHNIQUES
PROTEIN MICROARRAY
TABLE 7 GLOBAL PROTEIN-LABELING MARKET FOR PROTEIN MICROARRAYS, BY REGION, THROUGH 2021 ($ MILLIONS)
PROTEIN MICROARRAY TYPES
PROTEIN ARRAY CLINICAL APPLICATIONS
FIGURE 12 METHODS FOR PROTEIN ARRAY DETECTION
ELISA
PROTEIN MICROARRAY ADVANTAGES
CHAPTER 5 MARKET ANALYSIS BY PRODUCT
TABLE 8 GLOBAL PROTEIN-LABELING MARKET, BY PRODUCT, THROUGH 2021 ($ MILLIONS)
FIGURE 13 PROTEIN-LABELING PRODUCTS
KITS
TABLE 9 GLOBAL PROTEIN-LABELING MARKET FOR KITS, BY REGION, THROUGH 2021 ($ MILLIONS)
TABLE 10 AMERSHAM CYDYE ANTIBODY LABELING KIT COMPONENTS
TABLE 11 AMERSHAM CYDYE MONOCLONAL ANTIBODY LABELING KIT
COMPONENTS
TABLE 12 ZENON ANTIBODY LABELING KIT COMPONENTS
TABLE 13 APEX ANTIBODY LABELING KIT COMPENENTS
TABLE 14 MICROSCALE PROTEIN-LABELING KIT
TABLE 15 SITECLICK ANTIBODY LABELING KIT
TABLE 16 MOLECULAR PROBES' DSB-X BIOTIN PROTEIN-LABELING KIT
TABLE 17 ROCHE BIOTIN PROTEIN-LABELING KIT
TABLE 18 SNAP CELL STARTER KIT
TABLE 19 CLIP CELL STARTER KIT
REAGENTS
TABLE 20 GLOBAL PROTEIN-LABELING MARKET FOR REAGENTS, BY TYPE, THROUGH 2021 ($ MILLIONS)
TABLE 21 GLOBAL PROTEIN-LABELING MARKET FOR REAGENTS, BY REGION, THROUGH 2021 ($ MILLIONS)
ENZYMES
TABLE 22 GLOBAL PROTEIN-LABELING MARKET FOR ENZYMES, BY REGION, THROUGH 2021 ($ MILLIONS)
HORSERADISH PEROXIDASE
TABLE 23 THERMO FISHER SCIENTIFIC HORSERADISH PEROXIDASE
TABLE 24 BIO-RAD HORSERADISH PEROXIDASE
ALKALINE PHOSPHATASE
TABLE 25 THERMO FISHER SCIENTIFIC PIERCE ALKALINE PHOSPHATASE
TABLE 26 NEW ENGLAND BIOLABS ALKALINE PHOSPHATES CALF
INTESTINAL
MONOCLONAL ANTIBODIES
TABLE 27 GLOBAL PROTEIN-LABELING MARKET FOR MONOCLONAL ANTIBODIES, BY REGION, THROUGH 2021 ($ MILLIONS)
CHIMERIC MONOCLONAL ANTIBODIES
TABLE 28 CHIMERIC MONOCLONAL ANTIBODIES
HUMAN MONOCLONAL ANTIBODIES
TABLE 29 HUMAN MONOCLONAL ANTIBODIES
PROBES/TAGS
TABLE 30 GLOBAL PROTEIN-LABELING MARKET FOR PROBES/TAGS, BY REGION, THROUGH 2021 ($ MILLIONS)
PROTEINS
TABLE 31 GLOBAL PROTEIN-LABELING MARKET FOR PROTEINS, BY REGION, THROUGH 2021 ($ MILLIONS)
BLOCKING BUFFERS
IODINATION REAGENTS
ELUTION BUFFERS
SERVICES
TABLE 33 GLOBAL PROTEIN-LABELING MARKET FOR SERVICES, BY REGION, THROUGH 2021 ($ MILLIONS)
CHAPTER 6 PROTEIN LABELING MARKET ANALYSIS BY LABELING
METHOD
TABLE 34 GLOBAL PROTEIN-LABELING MARKET, BY LABELING METHOD, THROUGH 2021 ($ MILLIONS)
FIGURE 14 PROTEIN-LABELING METHODS
LABELING METHOD TYPES
IN VITRO LABELING
TABLE 35 GLOBAL PROTEIN-LABELING MARKET FOR IN VITRO LABELING METHODS, BY REGION, THROUGH 2021 ($ MILLIONS)
TABLE 36 GLOBAL PROTEIN-LABELING MARKET FOR IN VITRO LABELING METHODS BY TYPE, THROUGH 2021 ($ MILLIONS)
Nanoparticle Labeling
Nanoparticle Applications: A Biological Perspective
TABLE 37 GLOBAL PROTEIN-LABELING MARKET FOR NANOPARTICLE LABELING METHODS, BY REGION, THROUGH 2021 ($ MILLIONS)
Nanoparticles Use in Protein Labeling
Luminescent Particles as Nanoparticles for Protein Labeling
FIGURE 15 KEY NANOPARTICLE FORMS USED IN BIOCONJUGATION
Site-Specific Labeling
TABLE 38 GLOBAL PROTEIN-LABELING MARKET FOR SITE-SPECIFIC LABELING, BY REGION, THROUGH 2021 ($ MILLIONS)
Site-Specific Protein Labeling Using an Integration of Unnatural Amino
Acids
Site-Specific Protein-Labeling Using Protein Targeting Sequences
Site-Specif Protein Labeling Using Peptide Targeting Sequences
TABLE 39 SITE-SPECIFIC TAGS FOR PROTEIN-LABELING
Dye-Based Labeling
Reactive Fluorescent Dyes
Amine-Reactive Dyes
FIGURE 16 REACTIVE FLUORESCENT AGENTS
Thiol-Reactive Dyes
Amine-Containing Dyes
TABLE 40 GLOBAL PROTEIN-LABELING MARKET FOR DYE-BASED LABELING, BY REGION, THROUGH 2021 ($ MILLIONS)
Cadaverines
Carbonyl-Reactive Hydrazides
Avidin/Streptavidin-Biotin
Phalloidins
Co-Translational Labeling
TABLE 41 GLOBAL PROTEIN-LABELING MARKET FOR CO-TRANSLATIONAL LABELING, BY REGION, THROUGH 2021 ($ MILLIONS)
Enzymatic Labeling
TABLE 42 GLOBAL PROTEIN-LABELING MARKET FOR ENZYMATIC LABELING METHOD, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 17 ENZYMES USED FOR PROTEIN LABELING
Formylglycine Generating Enzyme
Phosphopantetheinyl Transferase
Transglutaminase
Biotin Ligase
IN VIVO LABELING
TABLE 43 GLOBAL PROTEIN-LABELING MARKET FOR IN VIVO LABELING, BY TYPE, THROUGH 2021 ($ MILLIONS)
TABLE 44 GLOBAL PROTEIN-LABELING MARKET FOR IN VIVO LABELING, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 18 STEPS INVOLVED IN VIVO PROTEIN-LABELING
Radioactive Labeling
TABLE 45 GLOBAL PROTEIN-LABELING MARKET FOR RADIOACTIVE LABELING METHOD, BY REGION, THROUGH 2021 ($ MILLIONS)
TABLE 46 RADIOACTIVE ELEMENTS
General Steps in Radioactive Labeling of Proteins
FIGURE 19 RADIOACTIVE LABELING OF PROTEINS
Photoreactive Labeling
TABLE 47 GLOBAL PROTEIN-LABELING MARKET FOR PHOTOREACTIVE LABELING METHOD, BY REGION, THROUGH 2021 ($ MILLIONS)
FIGURE 20 GENERAL PROTOCOL FOR PHOTOLABELING OF PROTEINS
BIOORTHOGONAL LABELING
TABLE 48 GLOBAL PROTEIN-LABELING MARKET FOR BIORTHOGONAL LABELING METHOD, BY REGION, THROUGH 2021 ($ MILLIONS)
CHAPTER 7 COMPETITIVE LANDSCAPE
FIGURE 21 KEY COMPETITIVE STRATEGIES, 2014-2016 (%)
MERGERS AND ACQUISITIONS
FIGURE 22 MERGER AND ACQUISTION STRATEGIES BY COMPANY, 2014-2016
TABLE 49 KEY ACQUISTIONS, 2012-2016
PRODUCT LAUNCHES
FIGURE 23 PRODUCT LAUNCH STRATEGIES, BY COMPANY, 2014-2016
TABLE 50 KEY PRODUCT LAUNCHES, 2014-2016
PARTNERSHIPS AND COLLABORATIONS
FIGURE 24 PARTNERSHIP AND COLLABORATION STRATEGIES, BY COMPANY, 2014-2016 (%)
TABLE 51 KEY ANNOUNCED AGREEMENTS, 2014-2016
OTHER STRATEGIES
FIGURE 25 PARTNERSHIP AND COLLABORATION STRATEGIES, BY COMPANY, 2014-2016 (%)
TABLE 52 PARTNERSHIP AND COLLABORATION STRATEGIES, BY COMPANY, 2014-2016 (%)
CHAPTER 8 PROTEIN-LABELING MARKET ANALYSIS BY REGION
FIGURE 26 GLOBAL MARKET FOR PROTEIN-LABELING, BY REGION, 2015 (%)
FIGURE 27 PATENTS GRANTED FOR PROTEIN-LABELING RESEARCH, BY REGION, 2015 (%)
FIGURE 28 TOP 2,500 COMPANIES RESEARCH AND DEVELOPMENT INVESTMENT, BY REGION, 2014 (%)
NORTH AMERICA
TABLE 53 NORTH AMERICAN PROTEIN-LABELING MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
EUROPE
FIGURE 29 TOP 2,500 EUROPEAN COMPANIES RESEARCH AND DEVELOPMENT INVESTMENT, BY COUNTRY, 2014 (%)
TABLE 54 EUROPEAN PROTEIN-LABELING MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
ASIA-PACIFIC
TABLE 55 ASIA-PACIFIC PROTEIN-LABELING MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
REST OF THE WORLD
TABLE 56 REST OF THE WORLD PROTEIN-LABELING MARKET, BY PRODUCT TYPE, THROUGH 2021 ($ MILLIONS)
CHAPTER 9 PATENT ANALYSIS
FIGURE 30 PATENTS REGISTERED AND APPROVED IN NORTH AMERICA, EUROPE, ASIA-PACIFIC AND THE REST OF THE WORLD, 2013-2016 (%)
PATENT ANALYSIS BY MARKET PARTICIPANTS
FIGURE 31 PATENT ANALYSIS, BY MARKET APPLICANT, 2013-2016 (%)
PATENT ANALYSIS BY YEAR
FIGURE 32 PATENT ANALYSIS, BY YEAR, 2013-2016 (%)
CHAPTER 10 COMPANY PROFILES
ACTIVE MOTIF INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 57 ACTIVE MOTIF RECENT DEVELOPMENTS
AGILENT TECHNOLOGIES INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 58 AGILENT TECHNOLOGIES RECENT DEVELOPMENTS
TABLE 59 AGILENT TECHNOLOGIES FINANCIALS, 2013-2015 ($ MILLIONS)
BIO-RAD LABORATORIES
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 60 BIO-RAD RECENT DEVELOPMENTS
TABLE 61 BIO-RAD FINANCIALS 2013-2015 ($ MILLIONS)
BIOTIUM INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
CANDOR BIOSCIENCE GMBH
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 62 CANDOR RECENT DEVELOPMENTS
CAPRION BIOSCIENCES
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 63 CAPRION RECENT DEVELOPMENTS
F. HOFFMANN-LA ROCHE AG
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 64 F. HOFFMANN-LA ROCHE AG RECENT DEVELOPMENTS
TABLE 65 F. HOFFMANN-LA ROCHE AG FINANCIALS, 2013-2015 ($ MILLIONS)
GENERAL ELECTRIC COMPANY
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 66 GENERAL ELECTRIC COMPANY RECENT DEVELOPMENTS
TABLE 67 GENERAL ELECTRIC COMPANY FINANCIALS, 2013-2015 ($ MILLIONS)
INNOVA BIOSCIENCES LTD.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 68 INNOVA BIOSCIENCES RECENT DEVELOPMENTS
KANEKA CORP.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 69 KANEKA RECENT DEVELOPMENTS
TABLE 70 KANEKA FINANCIALS, 2013-2015 ($ MILLIONS)
LI-COR BIOSCIENCES
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 71 LI-COR RECENT DEVELOPMENTS
LUMINEX CORP.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 72 LUMINEX, RECENT DEVELOPMENTS
TABLE 73 LUMINEX FINANCIALS 2013-2015 ($ MILLIONS)
MERCK & COMPANY INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 74 MERCK RECENT DEVELOPMENTS
TABLE 75 MERCK FINANCIALS, 2013-2015 ($ MILLIONS)
NANOTEMPER TECHNOLOGIES GMBH
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 76 NANOTEMPER RECENT DEVELOPMENTS
NEW ENGLAND BIOLABS INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 77 NEW ENGLAND BIOLABS INC. RECENT DEVELOPMENTS
PERKINELMER INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 78 PERKINELMER RECENT DEVELOPMENTS
TABLE 79 PERKINELMER FINANCIALS, 2013-2015 ($ MILLIONS)
PROMEGA COPRPORATION
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 80 PROMEGA RECENT DEVELOPMENTS
TABLE 81 PROMEGA FINANCIALS, 2013-2015 ($ MILLIONS)
SERACARE LIFE SCIENCES
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 82 SERACARE LIFE SCIENCES RECENT DEVELOPMENTS
TAKARA BIO USA INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 83 TAKARA BIO RECENT DEVELOPMENTS
TABLE 84 TAKARA BIO FINANCIALS, 2013-2015 ($ MILLIONS)
THERMO FISHER SCIENTIFIC INC.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 85 THERMO FISHER RECENT DEVELOPMENTS
TABLE 86 THERMO FISHER FINANCIALS, 2013-2015 ($ MILLIONS)
QIAGEN N.V.
PROTEIN-LABELING PRODUCT PORTFOLIO
TABLE 87 QIAGEN RECENT DEVELOPMENTS
TABLE 88 QIAGEN FINANCIALS, 2013-2015 ($ MILLIONS)
CHAPTER 11 PATENTS BY REGION
TABLE 89 NORTH AMERICAN PATENTS
TABLE 90 EUROPEAN PATENTS
TABLE 91 ASIA-PACIFIC REGION PATENTS
TABLE 92 REST OF THE WORLD PATENTS

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