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Global Markets for Media, Sera and Reagents in Biotechnology

Global Markets for Media, Sera and Reagents in Biotechnology

The global market for cell culture products will grow from nearly $3.2 billion in 2014 to nearly $4.1 billion by 2019 at a compound annual growth rate (CAGR) of 5.1% between 2014 and 2019.

This report provides:

An overview of the global markets and technologies for media, sera and reagents used in biotechnology.

Analyses of global market trends, with data from 2013, estimates for 2014, and projections of compound annual growth rates (CAGRs) through 2019.

Information on different types of cell cultures and products from cell culture technology as well as the advantages and disadvantages for the use of various types of media are also covered.

Detailed analysis of the cell culture industry's structure.

Discussion covering the applications of cell culture technology with an emphasis on usage in the research, production and contract segments.

Comprehensive profiles of major players in the media, sera, and reagents industry.


The study entails the current cell culture products market. The scope of this study encompasses the biotechnology, pharmaceutical and medical markets. The report analyzes the market trends in three major cell culture products, that is, media, sera and reagents and their applications in production, research, contract and others sectors. In addition to the current and future markets, it includes regulatory aspects, new development in cell culture techniques, and patent analysis and growth and restriction factors for the market during the forecast period. Technological issues include the latest trends and developments. The emerging market for media, sera and reagents in biotechnology includes countries like India, China, Japan, Korea, Taiwan, Canada, Africa, Australia, New Zealand, etc.

CHAPTER 1 INTRODUCTION
STUDY OBJECTIVES
REASONS FOR DOING THIS STUDY
CONTRIBUTIONS OF THE STUDY
SCOPE OF THE STUDY
METHODOLOGY
INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
SUMMARY TABLE GLOBAL MARKET FOR MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, BY REGION, THROUGH 2019 ($ MILLIONS)
SUMMARY FIGURE GLOBAL MARKET FOR MEDIA, SERA AND REAGENTS USED IN CELL CULTURE, BY REGION, 2012-2019 ($ MILLIONS)
CHAPTER 3 OVERVIEW
TERMINOLOGY
CELL CULTURE
CULTURE MEDIA
CELL LINE
PROKARYOTES
EUKARYOTES
SUBCULTURE
OSMOLALITY
ZWITTERION
ANEUPLOIDY
HETEROPLOIDY
MONOLAYER SLOUGHING
SERUM
HOMEOSTASIS
PROTEOLYSIS
PHOSPHORYLATION
MUTAGENESIS
CARCINOGENESIS
TUMOROGENICITY
HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT
TABLE 1 HISTORICAL EVENTS IN CELL CULTURE DEVELOPMENT
TYPES OF CELL CULTURE
PRIMARY CELL CULTURE
TABLE 2 ADHERENT VERSUS SUSPENSION CULTURE
TABLE 3 ADVANTAGES AND DISADVANTAGES OF PRIMARY CELL
CULTURE
SECONDARY CELL CULTURES
CELL LINE, CELL STRAIN AND TRANSFORMED CELL LINES
MORPHOLOGY OF CELLS IN CULTURE
QUALITY CONTROL CONSIDERATIONS IN CELL CULTURE
QUALITY OF REAGENTS AND MATERIALS USED
PLACE OF ORIGIN AND INTEGRITY OF CELL LINES
MICROBIAL CONTAMINATION
ENVIRONMENTAL MONITORING
FACTORS AFFECTING CELL CULTURE
TEMPERATURE
PH
OSMOLALITY
CARBON DIOXIDE (CO2)
HUMIDITY
CONCENTRATION OF THE NUTRIENTS
PROBLEMS ARISING DURING CELL CULTURE
BASIC REQUIREMENTS OF CELL CULTURE
CELL CULTURE MEDIA
Basal Media
Reduced-Serum Media
Serum-Free Media
TABLE 4 ADVANTAGES AND DISADVANTAGES OF SERUM-FREE MEDIA
BASIC CONSTITUENTS OF CULTURE MEDIA
Buffering Systems
Phenol Red
Inorganic Salt
TABLE 5 THE ROLES OF DIFFERENT INORGANIC NUTRIENTS
Amino Acids
Carbohydrates
Proteins and Peptides
Fatty Acids and Lipids
Vitamins
Trace Elements
Media Supplements
Antibiotics
Serum
TABLE 6 ADVANTAGES AND DISADVANTAGES OF SERUM
TYPES OF CELL CULTURE MEDIA FOR ANIMAL CELL CULTURE
Natural Media
Artificial Media
Serum-free Media
Protein-free Media
Chemically Defined Media
TABLE 7 TYPES OF MEDIA USED FOR ANIMAL CELL CULTURE
SERUM
Risks Associated with the Use of Serum
Sources of Serum
CELL CULTURE REAGENTS
Biological Growth Modifiers
Cell Dissociation Reagents
Other Reagents
Antibiotics
TABLE 8 COMMONLY USED ANTIBIOTICS
Amino Acids
Other Growth Supplements
Zinc
Transferrin
Hydrolysates
APPLICATIONS OF CELL CULTURE
MODEL SYSTEM
CANCER RESEARCH
VIROLOGY
TOXICITY TESTING
VACCINE PRODUCTION
TABLE 9 CULTURE MEDIA USED IN VARIOUS VACCINES
THERAPEUTIC PROTEIN
TABLE 10 THERAPEUTIC PROTEINS MADE BY CELL CULTURE
REPLACEMENT TISSUE OR ORGAN
GENETIC COUNSELING
PRENATAL DIAGNOSTICS
GENETIC ENGINEERING
GENE THERAPY
DRUG SCREENING AND DEVELOPMENT
CHAPTER 4 REGULATORY ASPECTS
BIOLOGICAL LICENSE APPLICATION
TABLE 11 APPROVALS OF BIOLOGICAL LICENSE APPLICATION, 2010-NOVEMBER 2014
BIOLOGICS ADMINISTRATIVE ACTIONS
TABLE 12 BIOLOGICAL ADMINISTRATIVE ACTIONS AGAINST HCT/P MANUFACTURERS, 2010-NOVEMBER 2014
RECALLS
TABLE 13 RECALLS, 2010-NOVEMBER 2014
OTHER REGULATORY ISSUES
CHAPTER 5 NEW DEVELOPMENTS
TABLE 14 NEW DEVELOPMENTS IN CELL CULTURE INDUSTRY, JANUARY 2010-OCTOBER 2014
NEW DEVELOPMENTS IN CELL CULTURE APPLICATION
TABLE 15 NEW DEVELOPMENTS IN APPLICATION OF CELL CULTURE
CHAPTER 6 MARKET ANALYSIS
TABLE 16 GLOBAL MARKET FOR CELL CULTURE, THROUGH 2019 ($ ILLIONS)
FIGURE 1 GLOBAL MARKET FOR CELL CULTURE, 2012-2019 ($ MILLIONS)
MEDIA
MARKET OVERVIEW
MARKET REVENUE
TABLE 17 GLOBAL MARKET FOR MEDIA USED IN CELL CULTURE, BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 2 GLOBAL MARKET FOR MEDIA USED IN CELL CULTURE, BY REGION, 2012-2019 ($ MILLIONS)
MARKET SHARES
TABLE 18 REGIONAL MARKET SHARES OF MEDIA USED IN BIOTECHNOLOGY BY REGION, 2013 (%)
FIGURE 3 REGIONAL MARKET SHARES OF MEDIA USED IN BIOTECHNOLOGY BY REGION, 2013 (%)
SERUM-REQUIRING AND SERUM-FREE MEDIA
Serum-Free Media Market Revenue
TABLE 19 GLOBAL MARKET FOR SERUM-FREE MEDIA USED IN CELL CULTURE, THROUGH 2019 ($ MILLIONS)
FIGURE 4 GLOBAL MARKET FOR SERUM-FREE MEDIA USED IN CELL CULTURE, 2012-2019 ($ MILLIONS)
Serum-Requiring Media Market Revenue
TABLE 20 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 5 GLOBAL MARKET FOR SERUM-REQUIRING MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
POWDERED AND LIQUID MEDIA
Powdered Media Market Revenue
TABLE 21 GLOBAL MARKET FOR POWDERED MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 6 GLOBAL MARKET FOR POWDERED MEDIA USED IN CELL CULTURE, 2012-2019 ($ MILLIONS)
Liquid Media Market Revenue
TABLE 22 GLOBAL MARKET FOR LIQUID MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 7 GLOBAL MARKET FOR LIQUID MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
CLASSICAL AND SPECIALTY MEDIA
Classical Media Market Revenue
TABLE 23 GLOBAL MARKET FOR CLASSICAL MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 8 GLOBAL MARKET FOR CLASSICAL MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
Specialty Media Market Revenue
TABLE 24 GLOBAL MARKET FOR SPECIALTY MEDIA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 9 GLOBAL MARKET FOR SPECIALTY MEDIA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
SERA
MARKET OVERVIEW
MARKET REVENUE
TABLE 25 GLOBAL MARKET FOR SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 10 GLOBAL MARKET FOR SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
MARKET SHARES
TABLE 26 GLOBAL SERA MARKET SHARES BY REGION, 2013 (%)
FIGURE 11 GLOBAL SERA MARKET SHARES BY REGION, 2013 (%)
BOVINE SERA OR FETAL BOVINE SERA
Market Overview
Market Revenue
TABLE 27 GLOBAL MARKET FOR BOVINE SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 12 GLOBAL MARKET FOR BOVINE SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
OTHER SERA
Market Overview
Market Revenue
TABLE 28 GLOBAL MARKET FOR OTHER SERA USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 13 GLOBAL MARKET FOR OTHER SERA USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
REAGENTS
MARKET OVERVIEW
MARKET REVENUE
TABLE 29 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 14 GLOBAL MARKET FOR CELL CULTURE REAGENTS BY REGION, 2012-2019 ($ MILLIONS)
MARKET SHARES
TABLE 30 GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2013 (%)
FIGURE 15 GLOBAL CELL CULTURE REAGENT MARKET SHARES BY REGION, 2013 (%)
BIOLOGICAL RESPONSE MODIFIERS
Market Revenue
TABLE 31 GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 16 GLOBAL MARKET FOR BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
GROWTH FACTORS MARKET REVENUE
TABLE 32 GLOBAL MARKET FOR GROWTH FACTORS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 17 GLOBAL MARKET FOR GROWTH FACTORS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
CYTOKINES MARKET REVENUE
TABLE 33 GLOBAL MARKET FOR CYTOKINES USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 18 GLOBAL MARKET FOR CYTOKINES USED IN CELL CULTURE BY REGION, 2012- 2019 ($ MILLIONS)
OTHER BIOLOGICAL RESPONSE MODIFIERS MARKET REVENUE
TABLE 34 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 19 GLOBAL MARKET FOR OTHER BIOLOGICAL RESPONSE MODIFIERS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
CELL DISSOCIATION REAGENTS
Market Revenue
TABLE 35 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 20 GLOBAL MARKET FOR CELL DISSOCIATION REAGENTS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
OTHER REAGENTS
Market Revenue
TABLE 36 GLOBAL MARKET FOR OTHER REAGENTS USED IN CELL CULTURE BY REGION, THROUGH 2019 ($ MILLIONS)
FIGURE 21 GLOBAL MARKET FOR OTHER REAGENTS USED IN CELL CULTURE BY REGION, 2012-2019 ($ MILLIONS)
CHAPTER 7 LEADING MANUFACTURERS IN THE INDUSTRY AND THEIR
PRODUCTS
MEDIA MANUFACTURERS/SUPPLIERS
TABLE 37 LEADING MANUFACTURERS OF MEDIA
SERA MANUFACTURERS/SUPPLIERS
TABLE 38 LEADING MANUFACTURERS OF SERA
REAGENTS MANUFACTURERS/SUPPLIERS
BIOLOGICAL RESPONSE MODIFIERS
TABLE 39 LEADING MANUFACTURERS OF BIOLOGIC RESPONSE
MODIFIERS
CELL DISSOCIATION REAGENTS
TABLE 40 LEADING MANUFACTURERS OF CELL DISSOCIATION
REAGENTS
ANTIBIOTICS AND ANTIMYCOTICS
TABLE 41 LEADING MANUFACTURERS OF ANTIBIOTICS AND ANTIMYCOTICS USED IN CELL CULTURE
OTHER REAGENTS
TABLE 42 LEADING MANUFACTURERS OF OTHER REAGENTS
INDUSTRY STRUCTURE IN 2013 WITH MARKET SHARES
MEDIA
Serum-Free Media
TABLE 43 MARKET SHARES OF SERUM-FREE MEDIA, 2013 (%)
FIGURE 22 MARKET SHARES OF SERUM-FREE MEDIA, 2013 (%)
Serum-Requiring/Containing Media
TABLE 44 MARKET SHARES OF SERUM-CONTAINING MEDIA, 2013 (%)
FIGURE 23 MARKET SHARES OF SERUM-CONTAINING MEDIA, 2013 (%)
Powdered Media
TABLE 45 MARKET SHARES OF POWDERED MEDIA, 2013 (%)
FIGURE 24 MARKET SHARES OF POWDERED MEDIA, 2013 (%)
Liquid Media
TABLE 46 MARKET SHARES OF LIQUID MEDIA, 2013 (%)
FIGURE 25 MARKET SHARES OF LIQUID MEDIA, 2013 (%)
Classical Media
TABLE 47 MARKET SHARES OF CLASSICAL MEDIA, 2013 (%)
FIGURE 26 MARKET SHARES OF CLASSICAL MEDIA, 2013 (%)
Specialty Media
TABLE 48 MARKET SHARES OF SPECIALTY MEDIA, 2013 (%)
FIGURE 27 MARKET SHARES OF SPECIALTY MEDIA, 2013 (%)
SERA
Bovine Sera
TABLE 49 MARKET SHARES OF BOVINE SERA, 2013 (%)
FIGURE 28 MARKET SHARES OF BOVINE SERA, 2013 (%)
Other Sera
TABLE 50 MARKET SHARES OF OTHER SERA, 2013 (%)
FIGURE 29 MARKET SHARES OF OTHER SERA, 2013 (%)
REAGENTS
Biological Response Modifiers
TABLE 51 MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS, 2013 (%)
FIGURE 30 MARKET SHARES OF BIOLOGICAL RESPONSE MODIFIERS, 2013 (%)
Cell Dissociation Reagents
TABLE 52 U.S. MARKET SHARES OF CELL DISSOCIATION REAGENTS, 2013 (%)
FIGURE 31 U.S. MARKET SHARES OF CELL DISSOCIATION REAGENTS, 2013 (%)
Other Reagents
TABLE 53 MARKET SHARES OF OTHER REAGENTS, 2013 (%)
FIGURE 32 MARKET SHARES OF OTHER REAGENTS, 2013 (%)
CHAPTER 8 MARKET BY END USERS
TABLE 54 MEDIA, SERA AND REAGENT MARKET BY SEGMENT, THROUGH 2019
($ MILLIONS)
FIGURE 33 MEDIA, SERA AND REAGENT MARKET BY END SEGMENT, THROUGH 2019 ($ MILLIONS)
MARKET SHARE
TABLE 55 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES, BY SEGMENT, 2013 (%)
FIGURE 34 GLOBAL MEDIA, SERA AND REAGENT MARKET SHARES, BY SEGMENT, 2013 (%)
RESEARCH SEGMENT
MARKET REVENUE
TABLE 56 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2019 ($MILLIONS)
FIGURE 35 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN RESEARCH SEGMENT, THROUGH 2019 ($ MILLIONS)
PRODUCTION SEGMENT
TABLE 57 PROTEIN DRUGS MADE BY CELL CULTURE
MARKET REVENUE
TABLE 58 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, THROUGH 2019 ($ MILLIONS)
FIGURE 36 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN PRODUCTION SEGMENT, 2012-2019 ($ MILLIONS)
CONTRACT SEGMENT
MARKET REVENUE
TABLE 59 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, THROUGH 2019 ($ MILLIONS)
FIGURE 37 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN CONTRACT SEGMENT, 2012-2019 ($ MILLIONS)
OTHERS SEGMENT
MARKET REVENUE
TABLE 60 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENT, THROUGH 2019 ($MILLIONS)
FIGURE 38 GLOBAL SALES OF MEDIA, SERA AND REAGENTS IN OTHER SEGMENT, 2012-2019 ($ MILLIONS)
CHAPTER 9 PATENT ANALYSIS
PATENTS BY YEAR
TABLE 61 NO. OF PATENTS BY YEAR, 2011-OCTOBER 2014
FIGURE 39 NO. OF PATENTS BY YEAR, 2011-OCTOBER 2014
PATENTS BY TYPE
TABLE 62 PATENTS BY TYPE, 2011-OCTOBER 2014
FIGURE 40 PATENTS BY TYPE, 2011-OCTOBER 2014
TABLE 63 PRODUCT-RELATED PATENT BREAKDOWN, 2011-OCTOBER 2014 (NO./%)
FIGURE 41 PRODUCT-RELATED PATENT BREAKDOWN, 2011-OCTOBER 2014 (%)
PATENTS BY COMPANY
TABLE 64 PATENTS BY COMPANY, 2011-OCTOBER 2014
PATENTS BY COUNTRY
TABLE 65 U.S. PATENTS BY COUNTRY AWARDED, 2010-OCTOBER 2014
FIGURE 42 U.S. PATENTS BY COUNTRY AWARDED, 2010-OCTOBER 2014
TABLE 66 TRENDS OF PATENTS ISSUED BY COUNTRY, 2010-OCTOBER 2014 (NO./%)
FIGURE 43 TRENDS OF PATENTS ISSUED BY COUNTRY, 2010-OCTOBER 2014 (NUMBER OF PATENTS)
PATENTS BY ASSIGNEE
TABLE 67 PATENTS BY ASSIGNEE, 2011-OCTOBER 2014 (NO. OF PATENTS)
FIGURE 44 PATENTS BY ASSIGNEE, 2011-OCTOBER 2014 (NO. OF PATENTS)
CHAPTER 10 CURRENT SITUATION
TRENDS AND ISSUES IN CELL CULTURE MARKET
GLOBAL ECONOMY
INCREASED RESEARCH AND DEVELOPMENT BUDGET
TABLE 68 R &D BUDGETS OF TOP 10 COMPANIES IN 2013 ($ MILLIONS)
GROWING DEMAND AND RICH PIPELINE OF BIOTHERAPEUTICS
LIFESTYLE CHANGES
INCREASED EMPHASIS ON CELL-CULTURE-BASED VACCINES
BIOMEDICAL RESEARCH
STEM CELL RESEARCH
GOVERNMENT POLICIES ON RESEARCH
INNOVATIONS
ETHICAL AND ANIMAL WELFARE ISSUES
REGULATORY ISSUES
MERGERS, ACQUISITIONS AND ALLIANCES
CONTRACT MANUFACTURING
CHAPTER 11 COMPANY PROFILES
ADVANCED BIOTECHNOLOGIES INC.
AFFYMETRIX
AKORN BIOTECHNOLOGY LLC
AMRESCO LLC
ATLANTA BIOLOGICALS INC.
ATHENA ENVIRONMENTAL SCIENCES INC.
BD BIOSCIENCES
BIO RECLAMATION INC.
BOVOGEN BIOLOGICALS
CELL APPLICATIONS INC.
CELL CULTURE TECHNOLOGIES
CIASSON LABORATORIES
CLONETECH LABORATORIES INC.
CORNING INC.
EMD MILLIPORE
EQUITECH BIO INC.
GEMINI BIO PRODUCTS
GE HEALTHCARE LIFE SCIENCES
GENEX INDIA BIOSCIENCE PVT. LTD.
HIMEDIA LABORATORIES
IRVINE SCIENTIFIC
J R SCIENTIFIC INC.
KRISHGEN BIOSYSTEMS
LABMATE (ASIA) PVT. LTD.
LONZA GROUP LTD
MEDIATECH INC.
MEDOX BIOTECH INDIA PVT. LTD.
MP BIOMEDICALS
PEPROTECH INC.
PROMOCELL GMBH
QUALITY BIOLOGICAL INC.
R AND D SYSTEMS
REPROCELL INC.
ROCHE DIAGNOSTICS CORP.
SARTORIUS AG
SERA LABORATORIES INTERNATIONAL LTD.
SIGMA ALRICH
STEM CELLS INC.
STEMCELL TECHNOLOGIES INC.
THERMOFISHER SCIENTIFIC INC.
TICO EUROPE
VALLEY BIOMEDICAL
ZELLE BIOTECHNOLOGY PVT. LTD.
ZENBIO INC.
CHAPTER 12 APPENDIX I-ABBREVIATIONS
ABBREVIATIONS

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