Market Research Logo

3D Cell Cultures: Technologies and Global Markets

3D Cell Cultures: Technologies and Global Markets

REPORT HIGHLIGHTS

The three dimensional cell culture market was $438 million in 2013. This market is expected to grow to $586.1 million and about $2.2 billion in 2019, a compound annual growth rate(CAGR) of 30.1%.

This report provides:

An overview of the global markets and technologies for 3D cell cultures.

Analyses of global market trends, with data from 2013, estimates for 2014, and projections of compound annual growth rates (CAGRs) through 2019.

Information on 3D technologies with a focus on representative platforms including cube, spherical droplet, stacked plate, magnetic bead, and other platforms.

Value chain analysis at the following levels: key innovation or founding intellectual property, prototyping, beta testing, and research collaborations or reltationship building.

Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities.

Relevant patent analysis including recent activity and a list of key patents.

Comprehensive profiles of major players in the industry.


SCOPE OF REPORT

The scope of the report encompasses the major types of 3D cell culture that have been used, as well as the major applications being developed by industry, academic researchers and their commercialization offices, and government agencies. It analyzes current market status, examines future market drivers and presents forecasts of growth over the next five years. Technology developments, including the latest trends, are discussed. Other influential factors such as screening strategies for pharmaceuticals have also been included.

CHAPTER 1 INTRODUCTION
STUDY GOALS AND OBJECTIVES
REASONS FOR DOING THE STUDY
SCOPE OF REPORT
INTENDED AUDIENCE
METHODOLOGY AND INFORMATION SOURCES
ANALYST'S CREDENTIALS
RELATED BCC RESEARCH REPORTS
BCC RESEARCH WEBSITE
DISCLAIMER
CHAPTER 2 SUMMARY
SUMMARY TABLE THREE-DIMENSIONAL CELL CULTURE MARKET, THROUGH 2019 ($ MILLIONS/%)
SUMMARY FIGURE THREE-DIMENSIONAL CELL CULTURE MARKET, 2013-2019 ($ MILLIONS)
CHAPTER 3 TISSUE AND CELL CULTURE
OVERVIEW
TISSUE
TABLE 1 TISSUE TYPES
CELLS
CELL TYPES
TABLE 2 CELL TYPES
TISSUE CULTURE AND CELL CULTURE DEFINITIONS
OBTAINING CELL CULTURES
ISOLATING CELLS FROM TISSUES
MAINTAINING CELLS IN CULTURE
PLATING DENSITY AND SUB-CULTURING
CRYOGENIC STORAGE
OBTAINING CELLS FROM OTHER SOURCES: ISSUE OF CROSS-CONTAMINATION
CELL TYPES BASED ON MORPHOLOGY
CELL TYPES BASED ON HYBRIDOMAS
CELL CULTURE: BASIC REQUIREMENTS
AVOIDING CONTAMINATION
IMPORTANT INDICATORS OF CELL CULTURE HEALTH
MAINTAINING OPTIMAL CELL CULTURE CONDITIONS
BASIC CELL CULTURE SYSTEMS
ADHERENT CELLS REQUIRING ATTACHMENT SUBSTRATE
SUSPENSION CELL CULTURES
HISTORY AND EARLY APPLICATIONS
INVENTION OF TISSUE CULTURE
DEVELOPMENT OF SUSTAINED CELL LINES
FIRST CELL CULTURE FLASK AND RIGOROUS TECHNIQUES
LINDBERGH: THE CELL CULTURE EQUIPMENT PIONEER
Perfusion Chamber
Cell Culture Flask
Centrifugal Filter for Serum Isolation
ESTABLISHING CONTINUOUS CELL LINES
KEY EQUIPMENT DEVELOPMENTS
VACCINE DEVELOPMENT AS CATALYST
Background and Drawbacks of Live Animal Approaches
Efforts to Develop Polio Vaccine in Cell Culture
CELL STRAINS AND CELL LINES
VACCINES DEVELOPED USING HUMAN CELL STRAINS
CONTINUED CATALYST
CHAPTER 4 TISSUE AND CELL CULTURE SYSTEMS LANDSCAPE
TABLE 3 CELL CULTURE APPLICATIONS
LARGE-SCALE MANUFACTURE OF BIOPHARMACEUTICALS AND VACCINES
SUSPENSION PROTEINS AND MONOCLONAL ANTIBODIES
ADHERENT- CELL-BASED THERAPIES AND VACCINES
SMALL-SCALE ADHERENT TO MAKE SOMATIC CELLS, STEM CELLS AND TISSUES
FIGURE 1 TECHNOLOGY MATURITY
TECHNOLOGY OVERVIEW BY CELL CULTURE TYPE
SUSPENSION APPROACHES
Stirred Tank
TABLE 4 LEADING BIOREACTOR SUPPLIERS, 2014
INNOVATION AND CHALLENGES
Perfusion
Microcarriers
Magnetic Applications
SINGLE-USE TECHNOLOGY
MINI- AND MICRO-BIOREACTORS: CLONE SELECTION AND DEVELOPMENT
Commercial Example: TAP/Sartorious Stedim
ADHERENT APPROACHES
TRADITIONAL ROLLER BOTTLES
OTHER SYSTEMS
Commercial Example: Icellis by ATMI now part of Pall Corp.
NEW UNDERSTANDING OF CELL ATTACHMENT AND DETACHMENT
THREE-DIMENSIONAL BIOREACTORS
REVENUE ESTIMATE
TABLE 5 THREE-DIMENSIONAL BIOREACTOR AND MICROCARRIERS MARKET, THROUGH 2019 ($ MILLIONS)
CHAPTER 5 RESEARCH LANDSCAPE AND CONSUMABLES USED IN THREE-DIMENSIONAL CELL CULTURE
MICROPLATES
STANDARDS SETTING
CONTINUOUS INNOVATION
MICROPLATE READERS
LIQUID-HANDLING EQUIPMENT
CELLOMICS OVERVIEW
FLUORESCENCE AS DRIVER OF SCREENING
HIGH CONTENT SCREENING
IMAGING ADVANCES
FLOW CYTOMETRY
FUTURE VISION FOR HIGH-CONTENT SCREENING
TABLE 6 HIGH-CONTENT SCREENING SUPPLIERS AND KEY ATTRIBUTES, JANUARY 2014
LABEL-FREE PLATFORMS
TABLE 7 LABEL-FREE TECHNOLOGIES AND SUPPLIERS, JANUARY 2014
ELECTROPHYSIOLOGY
TABLE 8 AUTOMATED PATCH CLAMPING COMPANIES AND
TECHNOLOGIES, JANUARY 2014
ASSAYS AND ASSAY KITS
CELL-BASED ASSAYS: OVERVIEW AND NEWER DEVELOPMENTS
CELLS USED IN CELL-BASED ASSAYS
Immortalized Cell Lines and Primary Cells
Stem Cells at Scale
TWO-DIMENSIONAL CULTURES VERSUS THREE- DIMENSIONAL CULTURES
REVENUE SUMMARY
TABLE 9 LEADING TISSUE PRODUCT SUPPLIERS, JANUARY 2014
TABLE 10 LEADING CELL LINE SUPPLIERS, JANUARY 2014
TABLE 11 LEADING PRIMARY CELL SUPPLIERS, JANUARY 2014
TABLE 12 LEADING STEM CELL SUPPLIERS, JANUARY 2014
REVENUE ESTIMATE
TABLE 13 CELLS AND REAGENTS USED IN THREE-DIMENSIONAL CELL CULTURE MARKET, THROUGH 2019 ($ MILLIONS)
TABLE 14 CELLS USED IN THREE-DIMENSIONAL CELL CULTURE MARKET BY TYPE, THROUGH 2019 ($ MILLIONS)
TABLE 15 REAGENTS, MEDIA AND SERA USED IN THREE-DIMENSIONAL CELL CULTURE MARKET, 2013-2019 ($ MILLIONS)
CHAPTER 6 THREE-DIMENSIONAL TECHNOLOGIES AND BASIC PRODUCTS
MICROTITER PLATES PROVIDE PLATFORM
SUPPORTIVE STANDARDS
MICROPLATE WELL INSERTS
THREE-DIMENSIONAL CELL CULTURE TECHNOLOGIES
THREE-DIMENSIONAL ADOPTION STATUS
IMPORTANCE OF TWO-DIMENSIONAL VERSUS THREE- DIMENSIONAL SYSTEMS
PARACRINE VERSUS AUTOCRINE SIGNALING
BASIC CELL CULTURE VARIABLES
CELL ADHESION
CELL MIGRATION
CELL INVASION
BASIC ASSAY TYPES
THREE-DIMENSIONAL TECHNOLOGY AND PRODUCTS
THREE-DIMENSIONAL MATRICES TO REPLICATE THE EXTRACELLULAR
MATRIX
FOUNDATIONAL TOOLS: GELS AND BASEMENT MEMBRANES
Gels
Basement Membranes
SCAFFOLDS
Natural Materials
Collagen
Laminin
Other
Artificial Materials
Polystyrene Bridges Two-Dimensional to Three-Dimensional
INNOVATION EXAMPLES
Collagen Innovation
Real Architecture for Three-Dimensional Tissues from TAP Biosystems
Innovation via Biomimetics
3D Biotek
Innovation via Finer Pores
Alvetex
SCAFFOLD-FREE FORMATS
Spheroids
APPLICATIONS OVERVIEW
Liquid-Overlay Technique
Centrifugation
Hanging-Drop Approach
InSphero
3D Biomatrix
Low-Adhesion Plates
Thermo Scientific Nunclon Sphera Surface
Ultra-Low-Adhesion Plates
Corning Transwell Low-Adhesion
Micropatterning
CYTOO
Hepregen
Magnetic Applications
Nano3D Biosciences
ANALYTICAL METHODS
IMAGING
LIQUID HANDLING
HIGH-THROUGHPUT SCREENING CAPABILITY
CONTINUED SPHEROID ADOPTION
ORGANOTYPIC MODELS
MatTek
Life Technologies
DIRECTIONAL CULTURE
MICROFLUIDICS
GLASS/SILICON-BASED PLATFORMS
POLYMER-BASED PLATFORMS
Typical Configuration
Studying Differentiation
Scaffolding
Gel-Free Three-Dimensional Cell Culture
Stem Cells
Cancer
Adoption and Evolution
Hurel
CHIP TECHNOLOGY
Basic Configurations
Providing Motion
Inflammation
Imaging
Unmet Need
Body on a Chip
Wyss Institute
Solidus Biosciences
BIOPRINTING
Overall Three-Dimensional Printing
Biomedical Three-Dimensional Printing
Technology Derivations
Bioink
Valve-Based Droplet Ejection
Laser Printing
Acoustic Ejectors
De-Cellularized Extracellular Matrix as Scaffold
Viability and Functionality
Scaffold-Free Self-Assembly
Subassemblies
Vasculature
Software
APPLICATIONS
Liver Testing
Stem Cells
FUTURE CHALLENGES
REVENUE SUMMARY
TABLE 16 LEADING REAGENT, MEDIA AND MICROPLATE SUPPLIERS, JANUARY 2014
REVENUE ESTIMATE
TABLE 17 THREE-DIMENSIONAL TECHNOLOGY PRODUCT MARKET, THROUGH 2019 ($ MILLIONS)
TABLE 18 THREE-DIMENSIONAL STANDALONE TECHNOLOGY PRODUCT MARKET, THROUGH 2019 ($ MILLIONS)
CHAPTER 7 ASSAY KITS AND CONTRACT RESEARCH ORGANIZATION
SERVICES
BASIC CELL CULTURE VARIABLES
CELL ADHESION
CELL MIGRATION
Migration Assays
CELL INVASION
Cell Invasion Assays
VIABILITY AND CYTOTOXICITY
CELL SIGNALING AND COMMUNICATION
ENHANCED FUNCTIONALITY AND CONFIRMING ASSAYS
Extracellular Matrix Mimetics Arrays
Cell Proliferation Assays
Angiogenesis Assay
Vascular Permeability Assays
Cell Signaling
CYTOTOXICITY: A MAJOR CATEGORY
Cytotoxic and/or Cytostatic Impacts
Screening Strategies
PERMEABILITY ASSAYS FOR CELL VIABILITY AND SURVIVAL
Lactate Dehydrogenase Enzyme Release Assays
Uptake of Dyes Such as Trypan Blue and Alamar Blue Assays
Uptake of Neutral Red Uptake for Cell Survival Assays
Advantages and Disadvantages
METABOLIC ASSAYS FOR CELL VIABILITY AND SURVIVAL
MTT Assay
Adenosine Triphosphate Assay
Disadvantages of Metabolic Assays
Fluorometric Approaches
Altered Cell Adhesion
CELL DEATH ASSAYS
Apoptosis versus Necrosis
Caspase Activation
Membrane Residues
Cytochrome C Release from Mitochondria
CYTOSTATIC OR LONG-TERM IMPACT ASSAYS
Clonogenic Cell Survival Assay
MULTIPLEX ASSAYS
COMPOSITE SCREENING STRATEGIES
HIGH THROUGHPUT
CORRELATION WITH GENE-EXPRESSION DATA
THREE-DIMENSIONAL CYTOTOXICITY APPLICATIONS
Need for Three-Dimensional Validation
Promega
3D Biomatrix
REVENUE SUMMARY
TABLE 19 TYPICAL ASSAY ENDPOINTS AND TESTS
LEADING SUPPLIERS
TABLE 20 LEADING PRECLINICAL CONTRACT RESEARCH ORGANIZATIONS, JANUARY 2014
TABLE 21 ASSAYS KIT AND CONTRACT RESEARCH ORGANIZATIONS SERVICE MARKET, 2013-2019 ($ MILLIONS)
CHAPTER 8 THREE-DIMENSIONAL MODELS FOR CANCER
CANCER AT CELLULAR LEVEL OVERVIEW
APPROACHES TO DATE
CURRENT IN VIVO PRACTICES
EX VIVO TISSUE SLICES
TWO-DIMENSIONAL LEARNINGS AND DRAWBACKS
Two-Dimensional Co-Culture Learnings
InSphero
Genetic Mechanisms
THREE-DIMENSIONAL REQUIREMENTS
CELL NUMBER AND VIABILITY
MIGRATION AND INVASION
UNMET NEEDS: ANGIOGENESIS AND IMMUNE SYSTEM EVASION
THREE-DIMENSIONAL BENEFITS TO CANCER RESEARCH
GREATER DISTINCTION IN CELL MORPHOLOGY AND PROLIFERATION
GREATER GENE EXPRESSION AND CELL BEHAVIOR
BETTER MODELS OF CELL MIGRATION AND INVASION
CELL HETEROGENEITY
BREAST CANCER AS A DRIVER OF THREE-DIMENSIONAL CULTURES
STRUCTURE, POLARITY AND APOPTOSIS
MELANOMA AS A DRIVER OF THREE-DIMENSIONAL CULTURES
MOVING TO SPHEROID CONFIGURATIONS
Benefits of Spheroids
THREE-DIMENSIONAL SYSTEMS IN CANCER RESEARCH
MULTICELLULAR TUMOR SPHEROIDS
Testing Chemotherapy
MULTILAYERED CELL CULTURES
Cell-Excreted Extracellular Matrix as a Three-Dimensional Matrix
THREE-DIMENSIONAL ENGINEERED SCAFFOLDS
NATURAL MATERIALS
SYNTHETIC MATERIALS
LEARNINGS FROM DRUG SENSITIVITY AND RESISTANCE
ALTERED SIGNALING AND SENSITIVITY
DRUG RESISTANCE
CELLULAR SIGNALING
CELLULAR SIGNALING MEDIATED BY INTEGRINS
DRUG SCREENING
APPROACHES AND ENDPOINTS
TABLE 22 COMMON THREE-DIMENSIONAL ASSAYS
SPHEROIDS APPLICATIONS
TABLE 23 THREE-DIMENSIONAL TUMOR MODELS DEVELOPED FOR DRUG DISCOVERY, JUNE 2014
CYTOO
METASTASIS VIA THREE-DIMENSIONAL CELL MIGRATION MODEL
METASTASIS VIA LUNG-ON-CHIP
FUTURE HORIZONS
CO-CULTURE
VASCULARIZATION
CANCER-ASSOCIATED FIBROBLASTS
CANCER STEM CELLS
COMBINATION THERAPIES
BIOLOGICS DEVELOPMENT
TUMOR RECURRENCE
PATIENT-DERIVED CELLS
STANDARDS CHALLENGE
WE'VE COME A LONG WAY
TABLE 24 THREE-DIMENSIONAL CULTURE USED IN CANCER APPLICATIONS MARKET, THROUGH 2019 ($ MILLIONS)
CHAPTER 9 LANDSCAPE FOR TOXICOLOGY AND DRUG SAFETY TESTING
TOXICOLOGY BACKGROUND
TESTING FOR ADVERSE EFFECTS ON THE SKIN
SKIN IRRITATION
SKIN CORROSION
PHOTOTOXICITY
SKIN SENSITIZATION
EYE IRRITATION
Organotypic Assays
Cytotoxicity and Cell Function-Based Assays
ACUTE SYSTEMIC TOXICITY
ACUTE TOXICITY TESTING
CYTOTOXICITY ASSAYS FOR ACUTE TOXICITY TESTING
Commercially Available Cytotoxicity Assay Kit
CHRONIC AND REPEATED DOSE TOXICITY
CHRONIC AND REPEATED DOSE TOXICITY STUDY GOALS
Effects of Accumulation and Frequency of Exposure
Dosage Levels
Duration
Reversibility
Analysis
DEVELOPMENT OF REPEATED DOSE TOXICITY TESTING IN VITRO
CARCINOGENICITY AND GENOTOXICITY
OVERVIEW
IN VITRO METHODS: BACKGROUND AND RECENT DEVELOPMENTS
REGULATORY VERSUS DRUG DEVELOPMENT APPLICATIONS
Ames Test
In Vitro Micronucleus Test
EFFORTS TO REDUCE FALSE POSITIVES
RECENT INNOVATIONS FOR SCREENING
FUTURE CHALLENGE: NON-GENOTOXIC CARCINOGENS
REPRODUCTIVE AND DEVELOPMENTAL TOXICITY
BACKGROUND
FOLLOWING THE REPRODUCTIVE CYCLE
Embryotoxicity
Male Reproductive Toxicity
Female Reproductive Toxicity
DEVELOPMENT AND REPRODUCTIVE TOX TESTING TYPES
ZEBRAFISH MODEL FOR DEVELOPMENTAL TOXICITY SCREENING
COMBINATIONS OF ZEBRAFISH AND STEM CELLS
BIOMEDICAL FRONTIERS: MALE TESTIS
ENDOCRINE DISRUPTOR SCREENING
BACKGROUND
ENVIRONMENTAL TOXICOLOGY IMPACTS IN VITRO METHODS
U.S. Environmental Protection Agency’s Endocrine Disruptor
Screening Program
TABLE 25 IN VITRO AND IN VIVO ASSAYS IN THE TIER 1 SCREENING BATTERY, JANUARY 2014
HIGH-PRODUCTION VOLUME CHEMICALS
TOXCAST AND TOX 21 INITIATIVES
FUTURE CHALLENGE: THYROID DISRUPTION
BG1 ASSAY
Challenge For Chemical Companies: Depth and Breadth
Resource with Full Depth and Breadth
TOXICOKINETICS AND ADME
IN VITRO DEVELOPMENTS
METABOLISM
In Vitro Metabolism Offerings
Metabolism Reaction Phenotyping for Genetic Polymorphisms
Metabolite Profiling
Mitochondrial Toxicity
ORGANOTYPIC MODELS
THREE-DIMENSIONAL MODELS FOR SKIN
THREE-DIMENSIONAL CORNEAL SYSTEM
ABSORPTION BARRIER MODELS
GASTROINTESTINAL
LUNG
BLOOD-BRAIN BARRIER
Real Architecture for Three-Dimensional Tissue Barriers and Extracellular Matrix
OTHER APPLICATIONS IN LIVER TOXICITY
KIDNEY TOXICITY APPLICATIONS
FUTURE CHALLENGE: STEM-CELL DERIVED KIDNEY CELLS
PANCREATIC TOXICOLOGY APPLICATIONS
CARDIOVASCULAR SAFETY TESTING OF NEW DRUG CANDIDATES
COMMERCIAL AVENUE
COLLABORATION WITH REGULATORS
IN SILICO: MODEL-BASED DRUG DEVELOPMENT
MICROELECTRODE ARRAYS BASED ON IMPEDANCE
SURROGATE FOR AORTIC RING ASSAY VIA BIOPRINTED MAGNETICS
VASODILATOR ACTIVITY
THREE-DIMENSIONAL ENGINEERED HEART TISSUES
REVENUE ESTIMATE
TABLE 26 THREE-DIMENSIONAL CULTURES USED IN PREDICTIVE TOX APPLICATIONS MARKET, THROUGH 2019 ($ MILLIONS)
CHAPTER 10 THREE-DIMENSIONAL CULTURES AND THE LIVER
UNIQUENESS AND COMPLEXITY OF LIVER
LIVER AS A KEY DRIVER FOR THREE-DIMENSIONAL INNOVATION
IN VITRO LIVER APPLICATIONS
LIVER TOXICITY TESTING
PRIMARY HEPATOCYTE USE
LEARNINGS FROM MONOLAYER CULTURES
LEARNINGS FROM CO-CULTURES CONTRIBUTION TO THE DEVELOPMENT
OF CYTOTOXICITY AND THREE-DIMENSIONAL ASSAYS
IN VIVO LIVER FUNCTION AND STRUCTURE
HEPATOCYTES OR PARENCHYMAL CELLS
SPECIALIZED LIVER ENDOTHELIAL CELLS
ENDOTHELIAL CELLS SURROUND HEPATOCYTE CORE
NON-PARENCHYMAL STELLATE AND KUPFFER CELLS
LIVER METABOLISM
SUB-CELLULAR LIVER ENZYME FRACTIONS
EXTRACELLULAR MATRIX AS A DRIVER OF DIFFERENTIATION`
TOXICITY STUDIES AND NON-PARENCHYMAL CELLS’ DRIVE IN VITRO
DEVELOPMENT
CHALLENGES
LIVER IN VITRO MODELS
ISOLATED PERFUSED RAT LIVER
PRECISION-CUT LIVER SLICES
HUMAN HEPATOCYTE ISOLATION
ISOLATED HEPATOCYTE SHIPPING
CO-CULTURES OF HEPATOCYTES AND MACROPHAGES
TWO-CHAMBER SYSTEMS
MICROPATTERNING
THREE-DIMENSIONAL LIVER MODELS
TWO-DIMENSIONAL SANDWICH
SANDWICH-CULTURE MODEL
HYDROGEL THREE-DIMENSIONAL SCAFFOLDS
SYNTHETIC SCAFFOLDS
Alvetex
SELF-ASSEMBLED HEPATOSPHERES
HEPATOSPHERES-DERIVED FROM CELL LINES VERSUS PRIMARY CELLS
HepG2
HepaRG
Human and Other Primary Hepatocytes
DETECTED HEPATOSPHERE STRUCTURES AND FUNCTIONALITY
EXTRACELLULAR MATRIX
CELL-CELL CONTACTS: LEARNINGS FROM IN VITRO TOX
OXYGEN SUPPLY
CO-CULTURE WITH NON-PARENCHYMAL CELLS IN THREE-DIMENSIONAL
SPHEROIDS
REFINEMENTS TO CO-CULTURE
IDEAL CRITERIA
DRUG RESISTANCE
TRANSPORTER STUDIES
ACHIEVING HETEROTYPIC CELL-CELL CONTACTS
SUMMARY LEARNINGS
UNMET NEEDS AND FUTURE DRIVERS OF INNOVATION
REGENERATION
ACHIEVEMENT OF HEPATOCYTE EXPANSION STILL ELUSIVE
INFLAMMATION MODELS
Hepregen
IMMUNE-MEDIATED DRUG-INDUCED LIVER INJURY
Kiyatec
HIGH-CONTENT IMAGING AND ANALYSIS
STEM CELL-DERIVED HEPATOCYTE POTENTIAL
Real Architecture for Three-Dimensional Tissues for Induced Pluripotent
Stem Cell Hepatocyte Longevity
MORPHOGEN SIGNALING
MICROFLUIDICS APPLICATIONS
DIELECTROPHORETIC FORCES
HepaChip
LEARNINGS FROM MICROFLUIDICS
SELF-ORGANIZING SYSTEMS
CHAPTER 11 THREE-DIMENSIONAL CULTURE ROLE IN STEM CELLS
EARLY LEARNINGS
EMBRYOGENESIS
GROWTH, STRUCTURE AND MORPHOLOGY
DIFFERENTIATION
DIFFERENTIATION VERSUS PROLIFERATION
EXTRACELLULAR MATRIX
SOLUBLE FACTORS
MECHANICAL FORCES
MICRORNAS
THREE-DIMENSIONAL STEM CELL CULTURE SYSTEMS
PLATE OR CULTURE DISH
SPINNER FLASK AND ROTATING WALL VESSEL
PERFUSION BIOREACTOR AND MICROCARRIER SYSTEMS
SHORTCOMINGS
CONTROLLING EMBRYOID BODY FORMATION
FORCED AGGREGATION CULTURES
HANGING-DROP APPROACH
APPLICATIONS
STEM CELL MICROENVIRONMENTS
STEM CELL MARKERS FOR HIGH-THROUGHPUT SCREENING
TERATOMAS AND THE TERATOMA ASSAY
REVENUE ESTIMATE
TABLE 27 THREE-DIMENSIONAL CULTURES USED IN STEM CELL RESEARCH APPLICATIONS MARKET, THROUGH 2019 ($ MILLIONS)
CHAPTER 12 THREE-DIMENSIONAL NEXT-GENERATION OUTLOOK
OVERVIEW
CANCER
CO-CULTURE
METASTASES
TUMOR RECURRENCE
PATIENT-DERIVED CELLS
LIVER
LIKELY SUBSEGMENTS
INTEGRATION WITH -OMICS
Transcriptomics
Proteomics
Metabolomics
Metallomics
REGENERATIVE MEDICINE AND CELL THERAPY
BIOLOGICS DEVELOPMENT
CHARACTERIZATION OF NEW CELL LINES
FUTURE CHALLENGES
CHAPTER 13 COMPANY PROFILES
3D BIOMATRIX INC.
3D BIOTEK LLC
3D CELL TECHNOLOGIES LLC
ACEA BIOSCIENCES INC.
AKRON BIOTECHNOLOGY LLC
AMSBIO LLC
APPLIKON BIOTECHNOLOGY
BIOGELX LTD.
CELLULAR DYNAMICS INTERNATIONAL INC.
CORNING LIFE SCIENCES
CYTOO INC.
GE HEALTHCARE LIFE SCIENCES
GREINER BIO-ONE BVBA
HEPREGEN CORP.
HÂμREL CORP.
INSPHERO AG
KIYATEC INC.
MEDICYTE GMBH
METABOLON INC.
MOLECULAR DEVICES LLC
NANO3D BIOSCIENCES INC.
ORGANOVO HOLDINGS INC.
REINNERVATE LTD
STRATATECH CORP.
SYNVIVO INC.
TAP BIOSYSTEMS
THERMO FISHER SCIENTIFIC
VISTAGEN THERAPEUTICS INC.
WYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD
UNIVERSITY
ZEN-BIO INC.
CHAPTER 14 INTELLECTUAL PROPERTY ANALYSIS
TABLE 28 PATENTS AND APPLICATIONS, 2006-2012

Download our eBook: How to Succeed Using Market Research

Learn how to effectively navigate the market research process to help guide your organization on the journey to success.

Download eBook

Share this report