Cancer immunotherapy offers an attractive therapeutic addition, delivering treatment of high specificity, low toxicity and prolonged activity. In this Drug Pipeline Update BioSeeker brings together the fields of antibodies, vaccines, and immunostimulators in oncology drug development into one source.
There are today more than 290 immunotherapy drugs in active development for the treatment of cancer, from early preclinical to marketed drugs. In addition, the accumulated number of ceased drugs over the last three years amount to another 159 drugs. Immunotherapy in Oncology: Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 84 different targets. These targets are further categorized on the CD-ROM by 37 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Immunotherapy in Oncology: Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators Includes more than 226 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 300 names
Developmental stage This Drug Pipeline Update contains 293 immunotherapy drugs in active development and 447 developmental projects:
#28 projects have reached market approval
#2 projects have been registered
#2 projects in pre-registration
#15 projects in Phase III
#98 projects in Phase II
#88 projects in Phase I
#203 projects in Preclinical
#11 projects in other developmental stages
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications Included immunotherapy drugs are in development for 84 indications, where of 56 are different cancer indications. All drugs are in development for the treatment of cancer.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets Identified drugs are linked to more than 84 different targets, divided into 37 classifications of molecular function:
Acid phosphatase activity
Carboxypeptidase activity
Catalytic activity
Cell adhesion molecule activity
Cofactor binding
Complement activity
Cytokine activity
DNA binding
DNA topoisomerase activity
DNA-directed DNA polymerase activity
Extracellular ligand-gated ion channel activity
Extracellular matrix structural constituent
Heat shock protein activity
Hormone activity
Intracellular ligand-gated ion channel activity
Isomerase activity
Kinase binding
Metallopeptidase activity
MHC class I receptor activity
Molecular function unknown
Oxidoreductase activity
Peptide hormone
Protein binding
Protein serine/threonine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
Receptor signaling protein serine/threonine kinase activity
RNA-directed DNA polymerase activity
Serine-type peptidase activity
Transcription factor activity
Transcription regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity
Unclassified
Identified targets are categorized into 20 different primary and alternate sub-cellular localizations:
Apical membrane
Centrosome
Clathrin-coated vesicle
Cytoplasm
Cytoskeleton
Endoplasmic reticulum
Endosome
Extracellular
Extracellular matrix
Golgi apparatus
Integral to membrane
Lysosome
Mitochondrial matrix
Mitochondrion
Nuclear membrane
Nucleolus
Nucleus
Peroxisomal matrix
Plasma membrane
Secretory granule
Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile Direct links are provided from inside the application to 78 protein expression profiles of 50 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.
BioCarta 91 Pathways
KEGG 76 Pathways
NetPath 16 Signaling Pathways
Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
Mechanism In total there are 34 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms
Principal Investigator & Partners
Presentation of principal investigator and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol Official Gene Name [Species/Homo Sapiens] Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma Phase II Clinical Trial Active
Cancer, prostate Phase III Clinical Trial Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Licensing Information
Availability for licensing
Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
Direct links to company web pages of principal investigators
Export and sharing of information
Found information is easily shared with others over e-mail, file export (xls) or in print
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