Despite the heavy investment made into brain cancer research, primary brain cancer, with glioblastoma multiforme being the most aggressive and most common form, remains one of the most deadly diseases in the developed world. While primary brain tumors are relatively rare, the chances of survival for patients with the disease are very low, even with the best treatment options currently available.
Datamonitor predicts that there will be around 26,000 new cases of glioblastoma multiforme diagnosed in the seven major markets (US, Japan, France, Germany, Italy, Spain and UK) in 2007. In the US alone, around 14,000 people will die from brain cancer in 2007.
There are today at least 145 therapeutics targeting brain cancer in active development, from early preclinical to marketed drugs. In addition, the accumulated number of ceased drugs over the last three years amount to another 45 drugs. Brain Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 99 different targets. These targets are further categorized on the CD-ROM by 37 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Brain Cancer Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators Includes 142 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 200 names
Developmental stage This Drug Pipeline Update contains 145 drugs in active development for the treatment of brain cancer:
#9 marketed drugs
#1 registered drug
#1 drug in pre-registration
#10 drugs in Phase III
#60 drugs in Phase II
#27 drugs in Phase I
#34 drugs in Preclinical
#3 drugs in other developmental stages
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications Included brain cancer drugs are also in development for over 120 other indications.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets Identified drugs are linked to more than 99 different targets, divided into 37 classifications of molecular function:
Auxiliary transport protein activity
Catalytic activity
Cell adhesion molecule activity
Chaperone activity
Complement activity
Cysteine-type peptidase activity
Cytokine activity
DNA repair protein
DNA topoisomerase activity
DNA-directed DNA polymerase activity
Extracellular ligand-gated ion channel activity
G-protein coupled receptor activity
Growth factor activity
Ion channel activity
Kinase activity
Ligand-dependent nuclear receptor activity
Ligase activity
Lipid kinase activity
Lipid phosphatase activity
Molecular function unknown
Oxidoreductase activity
Peptidase activity
Protein serine/threonine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling protein serine/threonine kinase activity
Receptor signaling protein tyrosine phosphatase activity
Structural constituent of cytoskeleton
Sugar-phosphatase activity
Transcription factor activity
Transcription regulator activity
Transferase activity
Translation regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity
Identified targets are categorized into 12 different primary and alternate sub-cellular localizations:
Cell surface
Clathrin-coated vesicle
Cytoplasm
Cytosol
Endoplasmic reticulum
Endosome
Extracellular
Lysosome
Mitochondrion
Nucleolus
Nucleus
Plasma membrane
Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile Direct links are provided from inside the application to 109 protein expression profiles of 69 drug targets in various human tissues and cancer types, cell lines and primary cells, includin up to
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.
BioCarta 193 Pathways
KEGG 57 Pathways
NetPath 17 Signaling Pathways
Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
Mechanism In total there are 99 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms
Principal Investigator & Partners
Presentation of principal investigator and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Licensing Information
Availability for licensing
Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
Direct links to company web pages of principal investigators
Export and sharing of information
Found information is easily shared with others over e-mail, file export (xls) or in print
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