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Phosphatases: Emerging Role in Signal Transduction, Human Therapeutics, & As Drug TargetsPublished by: Drug and Market Development Publishing Published: Feb. 18, 2004 - 80 Pages Table of ContentsChapter 1: Executive Summary Chapter 2: Introduction and Background on Phosphatases PTP Super-family Chapter 3: Phosphatases in Signal Transduction Classification of Phosphatases Serine and ThreonineSpecific Phosphatases PP1 and PP2A PP2B PP2C Protein Tyrosine Phosphatases (PTP) PTPs in Signaling PTP-1B Phosphatases in Insulin Receptor Signaling LAR RPTPs Other Phosphatases RPTPa SH2 Phosphatases: SHP-1, SHP-2 RPTPe TCPTP HePTP Chapter 4: Phosphatases Associated with Disease Protein Tyrosine Phosphatase (PTP) in the Immune System PTP in Infectious Diseases PTP in Vascular Leakage PTP in Osteoporosis Phosphatases in Apoptosis BCL-2 Family Proteins Phosphatases in Cancer PTEN MAPK Phosphatases in Diabetes and Obesity PRL-3 CDC25 MKP-1 PP2A PTP1B in Diabetes and Obesity Phosphatases in Alzheimer’s Disease Small Molecule Inhibitors of Serine/Threonine Protein Phosphatases Cantharidin Biological Effects Modifications Anhydride Multiple Modifications Involvement of PTPs in Control of Receptor Tyrosine Kinase Signaling Chapter 5: Commercial Opportunity and Legal Aspects of Commercialization Structural Challenges in Developing Anti-PTP Molecules Chapter 6: Literature and Latest News on Phosphatases Literature Bibliography Latest News in Phosphatases Area Sunesis Identifies New Small Molecules to Target PTP-1B ISIS Pharmaceuticals Chapter 7: Intellectual Property Landscape for Phosphatases and Their Inhibitors Chapter 8: Companies Providing Reagents and Assays for Phosphatase Space Commercial Opportunities Chapter 9: Interviews with Industry Experts Dr. Rob Hooft, Principal Scientist / Project Leader, Serono Research Institute Paul G. Abrams, MD, JD, President & Chief Executive Officer, CEPTYR 9-3 James Wells, Ph.D., President, Chief Officer and Founder, Sunesis Scientific Pharmaceuticals Inc Christopher Lipinski, Ph.D., Adjunct Senior Research Fellow, PFIZER Global R&D, Groton Labs Chapter 10: Company Profiles Ceptyr Isis Pharmaceuticals, Inc Serono Pharmaceuticals Sunesis Pharmaceuticals, Inc. Vertex Pharmaceutical Inc TABLE OF E XHIBITS Exhibit 1.1 Number of Publications on Phosphatases in the Last Five Decades Exhibit 1.2 Overview of PTPs that are Potential Therapeutic Targets, Grouped by Disease Area Exhibit 1.3 Companies Developing Therapeutic Molecules Targeting Phosphatases Exhibit 2.1 The Reversible Events in Phosphorylation and Dephosphorylation by Kinase and Phosphatase Exhibit 2.2 Classification of Exhibit 2.3 Structural Classification of Phosphatases Exhibit 3.1 Role of Phosphatases in Insulin Signaling Exhibit 3.2 Insulin Mediated Signal Transduction Exhibit 3.3 Number of PTP Family Genes Predicted from Celera and Human Genome Sequences, Based on Carious PTP Subclasses Exhibit 4.1 Phosphorylation and Dephosphorylation Events of Proteins Related to Apoptosis Exhibit 4.2 Inhibition of Serine/Threonine Protein Phosphatases 1 and 2A by Various Natural Toxins (IC50 nM) Exhibit 5.1 Protein Target Depicted from Human Genome Sequencing Exhibit 5.2 Schematic of Segmentation of Number of Human Drug Targets Depicted from Human Genome Sequencing Exhibit 5.3 Schematic of Signal Transduction Pathway Showing the Involvement of Phosphate Addition and Removal (Potential Role of Kinase and Phosphatase) Exhibit 5.4 Human Protein Substrates and Associated Phosphatases Exhibit Identified Related to Phosphatases 5.5 Number and Classes of Structures Exhibit 5.6 Companies Involved in Protein Tyrosine Phosphatase-1B Inhibitor Discovery Exhibit 5.7 Development of Small Molecules to Target Phosphatases Proteins AbstractThis Report provides an in-depth analysis of the emerging market for phosphatases. What phosphatases are is clearly defined, including their classification, role in diseases, role in signal transduction, and as potential targets for developing therapeutics. The intellectual property landscape is reviewed, companies invested in phosphatase development are profiled, and key industry players are interviewed.Get Full Details About This Report >> |
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