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Published by: BCC Research
Published: Feb. 1, 2004 - 260 Pages
Table of Contents
Introduction
Study Objectives
Reasons For Doing This Study
Contributions To The Study
Scope Of The Study
Methodology
Information Sources
About The Author
Related Bcc Reports
Bcc Online Services
Internet
Summary
Summary Table:
Sales Of Chiral Technology Products By Category In The U.S., Through 2008 ($ Millions)
Summary Figure:
Sales Of Chiral Technology Products By Category In The U.S., 2001-2008 ($ Millions)
Overview
What Is Chirality?
Isomerism
Structural Isomerism
Chain Or Nuclear Isomerism
Position Isomerism
Functional Group Isomerism
Stereoisomerism
Geometric Isomerism
Optical Isomerism
Tautomerism
Designation Of Optical Isomers
The Nature Of Chiral Isomerism
Importance Of Chirality In Pharmaceuticals
Two Aspects Of Chiral Technology: Separation And Synthesis
Two Aspects Of Chiral Technology: (Continued)
Synthesis
Partial Asymmetric Synthesis
Absolute Asymmetric Synthesis
Retrosynthesis
Functional Group Strategies
Topological Strategies
Transform-Based Strategies
Structure-Goal Strategies
Stereochemical Strategies
Types Of Reactions Involved In Chiral Synthesis
Conserved Chirality
Enzyme Catalysts In Conserved Chirality
Chirality Inversion
Asymmetric Induction
Table 1 Materials Used For Chiral Synthetic Reactions
Products For Chiral Synthesis
Chiral Intermediates
Chiral Amino Acids
Chiral Epoxides And Glycidols
Substituted Chiral Propionic Acids
Table 2 Notable Chiral Intermediates
Catalysts
Asymmetric Chemical Catalysts
Table 3 Notable Chiral Catalysts
Chiral Hydrogenation Catalysts
Sharpless And Jacobsen Epoxidation Catalysts
Sharpless And Jacobsen Epoxidation Catalysts (Continued)
Sharpless Dihydroxylation Catalyst
Regis Technologies' Doyle Catalysts
Asymmetric Hydroformylation
Diels-Alder Catalysts
Aldol Condensation Catalysts
Friedel-Crafts Catalysts
Table 4 Chiral Chemical Catalysts Vs. Enzyme Catalysts
Chiral Biocatalysts (Enzymes)
Chiral Biocatalysts (Enzymes) (Continued)
Chiral Auxiliaries
Some Chiral Auxiliary Compounds
Other Chiral Synthesis Materials
Chiral Acid And Base Catalysts
Chiral Reagents
Chiral Solvents
Catalytic Antibodies
Separation
Separation (Continued)
Physical Separation Technologies
Crystallization
Chiral Crystallization Principles
Preferential Crystallization
Diastereomeric Crystallization
Diastereomeric Crystallization (Continued)
Precipitating (Resolving) Agents
Table 5 Resolving Agents For Diastereomer Crystallization
Table 5 (Continued)
Chromatographic Methods
The Principle Of Chiral Chromatography
Types Of Preparative Chiral Chromatography
Preparative Chiral Chromatography Stationary Phases
Solvent Extraction
Enzyme-Based Kinetic Separation Technology
Enzyme-Based Kinetic Separation Technology (Continued)
How Do Enzymes Work?
Table 6 Major Applications Of Enzymatic Kinetic Resolution
Other Separative Techniques
Magnetic Separation
Receptor-Based Resolution
Nanotechnology
Regulatory Aspects
Regulations Governing Chiral Technology
Federal Regulations
Developing A Single Stereoisomer After The Racemate Is Studied
Developing A Single Stereoisomer After The Racemate Is Studied (Continued)
Impurity Limits
Non-Federal Rules And Regulations
New Approvals
Table 7 New And Generic Approvals Of Chiral Drugs Existing As Isomers, 2001-2003
Table 7 (Continued)
Table 7 (Continued)
Table 7 (Continued)
Table 7 (Continued)
Table 7 (Continued)
Industry Structure
Market Leaders
Chiral Intermediates
Table 8 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Intermediates, 2002 (%)
Figure 1 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Intermediates, 2002 (%)
Chiral Chemical Catalysts
Table 9 Suppliers And Manufacturers Of Chiral Chemical Catalysts
Chiral Biocatalysts (Enzymes)
Table 10 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Biocatalysts, 2002 (%)
Figure 2 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Biocatalysts, 2002 (%)
Chiral Chromatography Reagents
Table 11 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Chromatography Reagents, 2002 (%)
Figure 3 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Chromatography Reagents, 2002 (%)
Chiral Kinetic Resolution
Table 12 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Kinetic Resolution Enzymes, 2002
Figure 4 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Kinetic Resolution Enzymes, 2000 (%)
Chiral Analysis
Table 13 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Analysis Instruments, 2002
Figure 5 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Analysis Instruments, 2002 (%)
Types Of Industries
Demand And Use Of Chiral Drugs
The Changing Chiral Industry
The Chiral Synthesis Market
Table 14 Sales Of Chiral Synthetic Materials In The U.S., Through 2008 ($ Millions)
Figure 6 Sales Of Chiral Synthetic Materials In The U.S., 2001-2008 ($ Millions)
Figure 7 Estimated Market Share Of Chiral Synthesis Materials, 2002 (%)
Market By Type
Chiral Intermediates
Estimating Sales Values
Chiral Intermediates Industry Leaders
Table 15 Sales Of Chiral Intermediates In The U.S., Through 2008 ($ Millions)
Chiral Chemical Catalysts
Table 16 Sales Of Chiral Chemical Catalysts In The U.S., Through 2008 ($ Millions)
Chiral Biocatalysts (Enzymes)
Chiral Biocatalysts (Enzymes) (Continued)
Table 17 Sales Of Chiral Biocatalysts In The U.S., Through 2008 ($ Thousands)
Chiral Auxiliaries
Table 18 Sales Of Chiral Auxiliaries In The U.S., Through 2008 ($ Millions)
Other Chiral Synthesis Materials
Table 19 Sales Of Other Chiral Synthesis Materials In The U.S., Through 2008 ($ Millions)
The Chiral Separation Market
Table 20 Sales Of Chiral Separation Materials In The U.S., Through 2008 ($ Millions)
Figure 8 Sales Of Chiral Separation Materials In The U.S., 2001-2008 ($ Millions)
Figure 9 Estimated Market Shares Of Chiral Separation Products, 2002 (%)
Market By Type
Crystallization
Table 21 Sales Of Chiral Crystallizing Agents In The U.S., Through 2008 ($ Millions)
Chiral Chromatography
Table 22 Sales Of Chiral Chromatography Reagents And Columns In The U.S., Through 2008 ($ Millions)
Solvent Extraction
Table 23 Sales Of Chiral Solvent Extraction Reagents And Instruments In The U.S., Through 2008 ($ Millions)
Kinetic Resolution
Table 24 Sales In Chiral Kinetic Resolution In The U.S., Through 2008 ($ Millions)
Chiral Analysis Market
Table 25 Sales Of Chiral Analysis Materials In The U.S., Through 2008 ($ Millions)
Figure 10 Sales Of Chiral Analysis Materials In The U.S., 2001-2008 ($ Millions)
Figure 11 Estimated Market Shares For Suppliers And Manufacturers Of Chiral Analysis, 2002 (%)
Market By Type
Market By Type (Continued)
Chiral Analytical Chromatography
Chiral Liquid Chromatography
Chiral Liquid Chromatography (Continued)
Chiral Gas Chromatography
Table 26 Agents Used To Form Chiral Derivatives For Gc Analysis
Table 27 Advantages Of Chiral Liquid Chromatography Vs. Chiral Gas Chromatography
Capillary Electrophoresis
Chiral Supercritical Fluid Chromatography
Chiral Supercritical Fluid Chromatography (Continued)
Table 28 Sales In Chiral Analytical Chromatography In The U.S., Through 2008 ($ Millions)
Chiral Polarimetry
Polarimetry Principles
Table 29 Sales Of Reagents In Chiral Polarimetry In The U.S., Through 2008 ($ Millions)
Nuclear Magnetic Resonance
Table 30 Sales In Chiral Nmr-Shift Reagents In The U.S., Through 2008 ($ Millions)
Other Chiral Analytical Techniques
Calorimetry
Enzymatic Assay
Immunoassay
Isotope Dilution
X-Ray Crystallography
X-Ray Crystallography (Continued)
Technology
Developments
Significant Patents
Patents By Technology
Table 31 Patents By Technology, 1998-2003
Table 31 (Continued)
Figure 12 Number Of Patents By Technology, Per Year, 1998-2003
Figure 13 Total Number Of Patents, Synthesis Vs. Separation, 1998-2003 (%)
Table 32 Significant Patents, Synthesis In Chiral Technology, 1998-2003
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 32 (Continued)
Table 33 Significant Patents In Chiral Technology, By Separation Technique, 1998-2003
Table 33 (Continued)
Table 33 (Continued)
Table 33 (Continued)
Patents By Applications
Table 34 Significant Patents In Chiral Technology, By Disease Sector, 1998-2003
Table 34 (Continued)
Patents By Company
Table 35 Patents By Abbott Laboratories In Chiral Technology, 1998-2003
Table 36 Patents By Beckman Coulter In Chiral Technology, 1998-2003
Table 37 Patents By Bend Research In Chiral Technology, 1998-2003
Table 38 Patents By Biocatalytics, Inc. In Chiral Technology, 1998-2003
Table 39 Patents By Bristol-Meyers Squibb, Inc. In Chiral Technology, 1998-2003
Table 40 Patents By Boulder Scientific In Chiral Technology, 1998-2003
Table 41 Patents By Celegen In Chiral Technology, 1998-2003
Table 42 Patents By Chirotech Technology In Chiral Technology, 1998-2003
Table 43 Patents By Daicel Chemical Industries In Chiral Technology, 1998-2003
Table 44 Patents By Dsm Fine Chemicals In Chiral Technology, 1998-2003
Table 45 Patents By Eastman Chemical Co. In Chiral Technology, 1998-2003
Table 46 Patents By Genzyme In Chiral Technology, 1998-2003
Table 47 Patents By Great Lakes Chemical Corp. In Chiral Technology, 1998-2003
Table 48 Patents By Lonza Group In Chiral Technology, 1998-2003
Table 49 Patents By Macherey-Nagel & Co. In Chiral Technology, 1998-2003
Table 50 Patents By Merck & Co. In Chiral Technology, 1998-2003
Table 51 Patents By Novasep In Chiral Technology, 1998-2003
Table 52 Patents By Pfizer In Chiral Technology, 1998-2003
Table 53 Patents By Pharm-Eco In Chiral Technology, 1998-2003
Table 54 Patents By Rhodia In Chiral Technology, 1998-2003
Patents By Country
Table 55 U.S. Patents By Country, 1998-2003
Figure 14 U.S. Patents By Country, 1998-2003
Patents By Assignee
Table 56 Number And Share Of U.S. Patents By Assignee, 1998-2003
Figure 15 Number Of U.S. Patents By Assignee, 1998-2003
Figure 16 Shares Of U.S Patents By Assignee, 1998-2003 (%)
Market By Applications
Overall Sales Forecast
Table 57 Sales Of Chiral Technology-Enabling Products By Major Application, Through 2008 ($ Millions)
Figure 17 Sales Of Chiral Technology-Enabling Products By Major Applications, 2001-2008 ($ Millions)
Table 58 Sales Of Chiral Technology-Enabling Products By Product Type, Through 2008 ($ Millions)
Table 59 Percent (%) Of Chiral Technology-Enabling Products By Product Type, 2002
Specific Applications
Pharmaceuticals
Table 60 Sales Of Chiral Technology-Enabling Products By Pharmaceutical Application, Through 2008 ($ Millions)
Table 61 U.S. Sales Of Pharmaceuticals, 1998-2002 ($ Millions)
Table 62 U.S. Expenditures In R&D In The Pharmaceutical Industry, 1998-2002 ($ Millions)
Table 63 U.S. Sales Of Synthetic Chiral Drugs By Major Applications, Through 2008 ($ Billions)
Retrospective And Prospective Chiral Drug Activities
Retrospective Applications
Prospective Applications
Analgesics
Analgesics (Continued)
Ibuprofen And Other Profens
Naproxen
Table 64 Chiral Analgesics
Anesthetics
Table 65 Chiral Anesthetics
Table 65 (Continued)
Anti-Infective Products
Semisynthetic Antibiotics With Chiral Components
Table 66 Chiral Adducts Used To Produce Semisynthetic Antibiotics
Synthetic Chiral Anti-Infectives
Antiviral Compounds
Table 67 Synthetic Chiral Anti-Infective Drugs
Cardiovascular System Products
Ace Inhibitors
Table 68 Chiral Ace Inhibitors
Angiotensin Ii Receptor Antagonists
Beta-Blockers
Table 69 Chiral Beta-Blockers
Table 69 (Continued)
Calcium Channel Blockers
Calcium Channel Blockers (Continued)
Table 70 Chiral Calcium Channel Blockers
Cholesterol-Lowering Agents
Table 71 Chiral Hmg-Coa Reductase Inhibitors
Dedicated Antiarrhythmic Drugs
Table 72 Chiral Dedicated Antiarrhythmia Drugs
Diuretics
Table 73 Chiral Diuretics
Vasodilators
Table 74 Chiral Vasodilators
Other Antihypertensive Drugs
Central Nervous System Agents
Anticonvulsant Drugs
Table 75 Chiral Anticonvulsant Drugs
Add/Adhd Drugs
Parkinson's Disease Agents
Table 76 Chiral Parkinson's Disease Agents
Sedatives And Tranquilizers
Table 77 Chiral Sedatives And Tranquilizers
Stimulants And Antidepressants
Table 78 Chiral Stimulants And Antidepressants
Endocrine System Disorder Products
Antidiabetic Agents
Table 79 Chiral Antidiabetes Drugs
Gastrointestinal Products
Table 80 Chiral Gastrointestinal Drugs
Hematology Products
Table 81 Chiral Hematology Drugs
Oncogenic (Cancer-Treatment) Products
Table 82 Chiral Oncogenic Drugs
Paclitaxel And Docetaxel
Other New Anticancer Agents
Respiratory System Products
Cough And Cold Remedies
Table 83 Popular Chiral Cough And Cold Remedies
Products For More Serious Respiratory Problems
Table 84 Chiral Drugs For Asthma And Other Chronic Respiratory Diseases
Biochemical Products
Table 85 Sales Of Chiral Technology-Enabling Products For Biomedical Applications, Through 2008 ($ Millions)
Amino Acids
Amino Acids (Continued)
Table 86 Commercial Methods For Manufacturing Natural Amino Acids
Amino Acids In Chiral Drug Development
Hydroxy Acids
Oligonucleotides
Peptides
Sugars And Other Oligosaccharides
Vitamins
Table 87 Chiral Vitamins And Their Manufacturing Methods
Table 87 (Continued)
Pesticides
Table 88 Sales Of Chiral Technology-Enabling Products For Pesticide Applications, Through 2008 ($ Millions)
Chiral Pesticide Overview
Table 89 U.S. Pesticide Consumption, 1999 (Million Pounds)
Chiral Pesticide Overview (Continued)
Pesticide Chirality
Table 90 Chemical Pesticide Chirality
Table 90 (Continued)
Table 90 (Continued)
Table 91 Number Of Chiral Vs. Non-Chiral Pesticide Products
Figure 18 Share Of Chiral Products In Pesticides (%)
Herbicides
Fungicides
Insecticides
Insecticides (Continued)
Other Products
Table 92 Sales Of Other Chiral Technology-Enabling Products, Through 2008 ($ Millions)
Aroma And Flavor Chemicals
Chiral Aroma/Flavor Compounds
Table 93 Notable Chiral Aroma And Flavor Compounds
Assistives
Dyes And Pigments
Liquid Crystals
Nonlinear Optical Materials
Polymers
International Aspects
International Aspects
Table 94 Worldwide Sales Of Chiral Technology-Enabling Products: Geographic Breakdown, Through 2008 ($ Millions)
Figure 19 Worldwide Sales Of Chiral Technology-Enabling Products: Geographic Breakdown, 2001-2008 ($ Millions)
Figure 20 Worldwide Sales Of Chiral Technology-Enabling Products: Geographic Breakdown, 2002 (% Of Total)
Figure 20 (Continued)
Table 95 Worldwide Sales Of Synthetic Chiral Drugs, Through 2008 ($ Billions)
Figure 21 Worldwide Sales Of Synthetic Chiral Drugs, 2001-2008 ($ Billions)
Company Profiles
Abbott Laboratories
Altus Biologics, Inc.
Avecia, Inc.
Basf Corp.
Beckman Coulter
Bend Research, Inc.
Biocatalytics, Inc.
Boulder Scientific
Cambrex Corp.
Cambrex Corp. (Continued)
Celgene Corp.
Diversa Corp.
Diversa Corp. (Continued)
Digital Specialty Chemicals
Dsm Fine Chemicals
Daicel Chemical Industries
Chiral Technologies
Davos Chemical Corp.
Dowpharma
Eastman Chemical Co.
Fisher Scientific, Intl.
Genencor International, Inc.
Genzyme Corp.
Great Lakes Chemical Co.
Jasco, Inc.
Johnson Matthey Plc
Johnson Matthey Catalysts
J.T.Baker, Inc.
Lonza Group, Ltd.
Lonza, Inc.
Macherey-Nagel, Inc.
Maxygen
Merck Kgaa
Emd Biosciences Inc.
Emd Chemicals, Inc.
Emd Chemicals, Inc.
Emd Lexigen Research Center Corp.
Emd Pharmaceuticals, Inc.
Vwr International, Inc.
Dey, Inc.
Nitragin, Inc.
Novasep, Inc.
Pharm-Eco
Pfizer
Pdr-Chiral, Inc.
Perkin Elmer, Inc.
Phenomenex, Inc.
Ppg-Sipsy
Rhodia, Inc.
Roche Diagnostics Corp.
Rudolph Instruments
Regis Technologies, Inc.
Sedere, Inc.
Sigma-Aldrich
Sepracor, Inc.
Sk Energy & Chemical
Strem Chemicals, Inc.
Synthetech, Inc.
Synthon Chiragenics Corp.
Thermogen, Inc.
Universal Pharma Technologies, Llc
AbstractThe report "Opportunities in Chiral Technology" provides an in-depth analysis of the U.S. market for chiral technology, including synthesis, separation and applications. The report is the 4th in the series and is an updated edition to the one published in 2000. The report deals with topics like what is chiral technology, what are the current and potential applications of chiral technology, what is the U.S./worldwide market value of chiral technology-enabling products and what is the market value of products emerging from chiral technology applications. The increasing market for chiral compounds in the pharmaceutical industry is one of the key objectives of the report. The report reviews the markets for synthesis as well as separation techniques and gives the present and future (2008) trends in chiral technology. The Market leaders, regulatory requirements and restrictions and a discussion about patents are also included in the report.
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