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Published by: BioInformatics, LLC
Published: Oct. 1, 2002 - 140 Pages Special discount! Hard copy regularly $3200, now just $1000!
Table of Contents
Section 1. Executive Overview and Introduction
- Among the Study’s Key Findings
- The Human Genome Project Continues to Drive Technological Change and Innovation
- Promised Pay-Offs of Pharmacogenomics
- Beyond Pharmacogenomics: Other Exciting Genotyping Applications
- A SNP By Any Other Name
- How SNP Genotyping is Performed
- Overview of Molecular Techniques Used in SNP Genotyping
- Cost Considerations
- Workflow Analysis in SNP Laboratories
- Relationship Between Weekly Throughput and Perceived Customer Needs
- Conclusion
- Niche Market Entry Strategies
Section 2. Study Methodology and Demographics
- Objectives
- Comments
- Assumptions
- Definition of Terms
- Market Segment
- Job Position
- Geographic Region
- Area(s) of Research
- Questionnaire
Section 3. Significant Findings
- Genotyping and SNP Genotyping
- Outsourcing SNP Genotyping
- Performing SNP Genotyping In-House
- Throughput
Section 4. Presentation of Survey Data
SNP Genotyping (Respondents = 543)
- SNP genotyping currently performed either in-house or by outsourcing
- Approaches currently performed either in-house or by outsourcing
- Type of laboratory
- Objectives of SNP genotyping research
- Organisms in which SNP genotyping is performed
- Stages of SNP genotyping performed or outsourced
- Location where most SNP genotyping is performed
Outsourcing SNP Genotyping (Respondents = 166 of 543)
- Principle reason for outsourcing SNP genotyping
- Factors that contribute to decision to outsource to a particular service provider
- “Top-of-mind” company/supplier for SNP genotyping
In-house SNP Genotyping (Respondents = 377 of 543)
- Use of database resources to select validated SNPs for further study
- Analysis of more than one SNP in a reaction
- Automation of any step(s) of SNP genotyping
- Methods currently used to perform SNP genotyping
- Use of modified oligonucleotides when performing SNP genotyping
- Most influential features in decision to genotype SNPs using one method over another
- Most influential factors in decision to purchase one SNP genotyping kit or SNP microarray over another
- Most valuable improvement to SNP genotyping
- Most significant limitations or problems experienced when genotyping SNPs
- Purchase of SNP genotyping kits
- Purchase of microarrays for SNP genotyping
- Average cost to analyze a single SNP
- Importance of the features of the manufacturer’s genotyping or allele-calling software package in decision to purchase a SNP genotyping kit or SNP microarray
- Primary supplier of the genotyping or allele-calling software package used most frequently
- Most commonly employed detection method when performing SNP genotyping
- Primary supplier of instrumentation used for SNP genotyping
- “Top-of-mind” company/supplier for SNP genotyping
Throughput (Respondents = 543)
- Number of DNA samples that are SNP genotyped per week
- Average number of SNPs analyzed per sample
- Average number of SNP reactions performed per week
- Future level of SNP genotyping
Section 5. Appendices
- Insights & Perspectives
- Cross-Tabulations of Survey Data
- Other Recent Publications
- About BioInformatics
- Our Valued Clients
AbstractUnderstanding the role of genetic variation is expected to profoundly change our understanding of human disease and the practice of medicine in the years to come. Genotyping is the assignment of different variants in an otherwise conserved DNA region, and is used for the identification of susceptibility genes in case/control populations. SNP is the most common variation that occurs in DNA. Because of their ubiquity, SNPs provide a powerful approach to understanding the connection between genetic variation and its physical manifestation. As such, they are the focus of much attention in the pharmacogenomic arena.
Life science suppliers are positioning themselves to support SNP genotyping—especially in the pharmaceutical segment—with a broad spectrum of products and services. Conventional wisdom rightly assumes that new technologies providing high-throughput and cost effectiveness are the paramount needs of researchers seeking a practical means of mutation detection. However, SNP genotyping methods vary depending on the scale and the scientific question a project is trying to answer. When contemplating the landscape of these SNP genotyping methods, one can become easily overwhelmed by the options available. Researchers face alternatives at every step of the process, from the selection of which molecular technique to use, to a myriad of choices for labeling, detection and scoring. This report, based on a detailed 32-question survey of over 540 life scientists engaged in SNP genotyping, clearly highlights the complexity of the market for both scientists and suppliers. Looking at the entire market potential, this report not only reflects the experience and opinions of 166 respondents who primarily outsource their SNP genotyping but 377 respondents who currently perform SNP genotyping in their own lab/group.
The tremendous attention and money directed towards pharmacogenomics is likely to overshadow other applications of SNP genotyping and attract both new customers and suppliers to the field. In this expanding market, successful competitors are likely to be those who practice careful positioning and appeal to the extremely diverse needs of their customers.
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