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The Tools & Techniques of Drug Discovery: DNA Sequencing

Published by: BioInformatics, LLC

Published: Jun. 1, 2002 - 121 Pages


Table of Contents


Section 1. Executive Overview & Introduction

  • Among the Study’s Key Findings



Section 2. Study Methodology & Demographics

  • Objectives
  • Comments
  • Definition of Terms
  • Market Segment
  • Organization Size
  • Laboratory Size
  • Region
  • Job Position
  • Area(s) of Research Expertise
  • Questionnaire Used to Conduct the Study



Section 3. Significant Findings

  • Product Use & Application
  • Product Expectations
  • Technology & Suppliers



Section 4. Presentation of Survey Data


DNA Sequencing Technology


  • Current use of DNA sequencing
  • Location of automated DNA sequencing experiments
  • Principle reason why automated DNA sequencing experiments are not performed within own lab/group
  • Sequencing method(s) currently used
  • DNA sequencing strategies currently used
  • Average number of DNA sequencing reactions performed per week
  • Size of typical DNA sequencing output per week
  • Sequencing techniques currently used



Automated DNA Sequencers

  • Application(s) for which automated sequencer(s) are used
  • Number of automated DNA sequencers currently located in lab/group or centralized on-site facility
  • Number of automated DNA sequencers dedicated only to sequencing applications
  • Future use of automated DNA sequencers
  • Most influential factor in decision to purchase one automated DNA sequencer over another
  • Most significant performance limitation/operational problem experienced when using automated DNA sequencing equipment
  • Most valuable improvement to automated DNA sequencers
  • Importance of the features of the manufacturer’s sequencing software package in purchasing decision
  • “Top-of-mind” company/supplier for automated DNA sequencers
  • Primary supplier of automated DNA sequencing equipment
  • “Top-of-mind” company/supplier for sequencing software
  • Manufacturer of the most frequently used sequencing software



DNA Sequencing Kits

  • Number of DNA sequencing kits used per week
  • Most influential features in decision to use one DNA sequencing kit over another
  • Most influential factor in decision to purchase one automated DNA sequencing kit over another
  • Most significant performance limitation/operational problem experienced when using DNA sequencing kits
  • Most valuable improvement to DNA sequencing kits
  • “Top-of-mind” company/supplier for DNA sequencing kits
  • Primary supplier of automated DNA sequencing kits



Trends & Comments

  • Estimated percentage of current total annual budget for products/services dedicated to automated DNA sequencers, sequencing kits and sequencing software
  • Estimated percentage of future total annual budget for products/services dedicated to automated DNA sequencers, sequencing kits and sequencing software
  • Additional comments as to where suppliers should focus their efforts to better meet needs in the area of automated DNA sequencers, sequencing kits or software



Section 5. Cross Tabulations of Survey Data

  • Questions and answer choices tabulated against Market Segment, Region, Area of Research(s) or other relevant questions.



Section 6. Appendix

  • Other Published Reports
  • About BioInformatics
  • Our Valued Clients


Abstract

Rather than providing a broad overlook of the drug discovery market, BioInformatics’ series, The Tools & Techniques of Drug Discovery, looks in-depth at six different market segments though the eyes of a worldwide panel of research scientists. Based on a 31-question survey, DNA Sequencing is the first of six titles in the series and specifically examines the applications of automated DNA sequencers and DNA sequencing kits.

DNA sequence information is critical to understanding genetic variations, which can influence disease, and genetic interactions, which can influence drug efficacy. As such, automated sequencers play a vital role in the drug discovery process. The use of sequencers in drug discovery has expanded beyond simply decoding genomes to understanding cellular messages in the hopes of developing novel drug compounds. Therefore, the objective of this report is to provide a detailed analysis of how drug discovery researcher’s needs are evolving as they relate to automated DNA sequencers and related technologies.

As researchers look to make sense of the copious amounts of information unlocked by the Human Genome Project (HGP), obtaining sequence information will continue to be important in drug discovery. Researchers are now using automated DNA sequencers to study more targeted avenues of gene expression and function in an effort to facilitate the drug discovery process. Automated sequencing applications have moved from traditional genome sequencing projects to more refined genotyping and fragment analysis experiments.

A number of companies participate in developing novel products for the sequencing market and an equal number of companies target the drug discovery and pharmaceutical/biotech segment. As this market continues to grow, the organizations that develop products and services that address the needs of this dynamic workplace will evolve not only as thought leaders but also as market leaders. The investigation of these needs in DNA Sequencing can be leveraged across several areas with the end goals of developing better products and expanding market position in this coveted segment.

Objectives
The major objectives of this report are as follows:

  • Examine the use and applications of DNA sequencing technology in drug discovery research.
  • Determine which features are influential in purchasing decisions for automated DNA sequencers and DNA sequencing kits and software.
  • Identify the preferred suppliers of DNA sequencing products.
  • Establish the parameters for quality for DNA sequencing and its technologies.
  • Understand—from the user’s perspective—the level of satisfaction with current products and any unmet needs in the area of DNA sequencing.



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