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Proteomics: an Assessment of Technology & Commercial Potential

Published by: BCC Research

Published: Jan. 1, 2002 - 135 Pages


Table of Contents


Title

Introduction


Study Goals And Objectives


Reasons For Doing The Study


Audience For The Report


Scope And Format


Methodology And Information Sources


Bcc Information And Related Bcc Studies


Disclaimer

Executive Summary

Overview: Proteomics And The Current Proteomics Market Structure


What Is Proteomics?


Tools Of Proteomics


2-D Electrophoresis


Mass Spectroscopy


Bioinformatics


Other Important Proteomics Tools


Protein Chips


Capillary Hplc


Uses Of Proteomics Technologies


In Academia


Uses In Drug Discovery


Uses In Diagnostics


Industry Perceptions Of Proteomics And Its Potential


An Important Note

Government Regulations


Introduction


Drug Discovery


Preclinical Testing And Submission Of An Ind


Submission Of An Nda


Post-Fda Approval


Conclusions


Other Financial Issues Related To Pharmaceuticals


New Drug Approvals

Mass Spectroscopy


Basic Theory


Liquid Chromatography And Mass Spectroscopy Combined


Mass Spectroscopy Markets: 2000 To 2006


Time-Of-Flight Mass Spectroscopy


Maldi-Tof


Q-Tof


Lc-Ms: Quadrupole Mass Spectroscopy


Lc-Ion Trap Mass Spectroscopy


Other Developments In The Mass Spectroscopy Business

Proteomics Markets


Two-Dimensional Electrophoresis


Other Techniques For Separating Protein Mixtures


Market Outlook


Suppliers


Market Leaders In 2-D Electrophoresis


Capillary Electrophoresis (Ce)


Background


Other Ce Techniques For Analyzing Proteins


Protein Chips


Recent Advances And Future Outlook


Bioinformatics


Structure Of The Bioinformatics Industry


Bioinformatics And Proteomics: Databases


Bioinformatics And Proteomics: Software For Analysis


Concluding Remarks

Patent Trends


Mass Spectroscopy


Patents By Year Of Issuance And By Type


Patent Assignees


Capillary Electrophoresis Patent Trends


Patents By Year Of Issuance And By Type


Patent Assignees


Two-Dimensional Electrophoresis Patent Trends


Patents By Year Of Issuance And By Type


Patent Assignees

Company Profiles


Mass Spectroscopy Instrument Suppliers


Agilent Technologies, Inc.


Applera Corporation


Applied Biosystems


Bear Instruments, Inc.


Gbc Scientific Equipment, Pty. Ltd.


Hitachi Instruments, Inc.


Kratos Analytical


Micromass


Perkinelmer, Inc.


Phenomenex


Richard Scientific, Inc.


Shimadzu Scientific Instruments


Spark Holland


Thermo Electron


Thermo Separation Products (Thermoquest)


Varian, Inc.


Waters Corporation


2-D Electrophoresis Or Capillary Electrophoresis Suppliers


Amersham Pharmacia Biotech


Bio-Rad Laboratories


Compugen


Decodon, Gmbh


Dionex Corporation


Gene Logic


Geneva Proteomics


Genomic Solutions, Inc.


Invitrogen


Large Scale Biology Corporation


Micro-Tech Scientific


Nonlinear Dynamics


Proteome Systems Ltd.


Scimagix


Zaxis, Inc.


Protein Chip Companies


Applera Corporation


Biosite, Inc.


Celera Genomics


Ciphergen Biosystems, Inc.


Genomic Solutions, Inc.


Glaucus Proteomics


Hts Biosytems


Hybrigenics Sa


Illumina, Inc.


Large Scale Biology Corporation


Lumicyte, Inc.


Phylos, Inc.


Protiveris


Somalogic, Inc.


Zyomyx, Inc.


Bioinformatics Companies


Axcell Biosciences Corporation


Celera Genomics Group


Geneva Bioinformatics


Geneprot (Geneva Proteomics)


Genomic Solutions, Inc.


Hybrigenics Sa


Incyte Genomics


Inpharmatica Ltd


Integrative Proteomics


Mds Proteomics


Myriad Genetics, Inc.


Proteome Systems Ltd.


Structural Bioinformatics


List Of Tables



Summary Table: Revenues For Selected Proteomics-Related Products,* Worldwide Forecast, Through 2006


1 Publications Conerning Proteomics


2 A Sample Of 2-D Electrophoresis Suppliers


3 A Sample Of Mass Spectroscopy Suppliers


4 A Sample Of Companies Involved In Proteomics-Bioinformatics


5 A Sample Of Protein Chip Companies


6 Important Capillary Hplc Companies


7 R&D Spending In The Pharmaceutical Industry, 1980 To 2001


8 Distribution Of Drug Research Costs


9 Drugs Approved By The Fda, 1993 To 2000


10 Mass Spectroscopy Expenditures, Through 2006


11 Market-Specific Mass Spectroscopy Expenditures, Through 2006


12 Overall Market Shares For Mass Spectroscopy, 2000


13 Selected Maldi-Tof Models


14 Q-Tof Models


15 Selected Quadrupole Mass Spectrometers


16 Selected Ion Trap Mass Spectrometer Models


17 2-D Gel Electrophoresis Expenditures, Through 2006


18 Selected Units For 2-D Electrophoresis Units*


19 Selected Software Packages For Analyzing 2-D Electrophoresis Experiments


20 The Capillary Hplc Market, Through 2006


21 Selected Models Of Automated Capillary Hplc Equipment


22 Selected Models Of Automated Capillary Electrophoresis Equipment


23 Projections For Protein Chip Revenues, Through 2006


24 Suppliers Of Protein Chips


25 Projections For Bioinformatics Expenditures, Through 2006


26 Selected Commerical Proteomics Databases


27 Selected Software Packages For Analyzing 2-D Electrophoresis Experiments


28 Mass Spectroscopy Patents By Year Of Issuance: 1996 To July 2001


29 Patents By Technology Type, 1996 To July 2001


30 Patents Relating To Protein Sequencing By Mass Spectroscopy, 1996 To July 2001


31 Patents By Assignee Classification


32 Patents By Institution, 1996 To July 2001*


33 Capillary Electrophoresis/Mass Spectroscopy Patents


34 Maldi-Tof Patents


35 Proteomics-Related Methods/Mass Spectroscopy Patents


36 Capillary Electrophoresis Patents By Year Of Issuance, 1996 To July 2001


37 Capillary Electrophoresis: Apparatus And Reagents Patents, 1996 To July 2001


38 Capillary Electrophoresis: Methods Patents, 1996 To July 2001


39 Capillary Electrophoresis Patents By Technology Type, 1996 To July 2001


40 Capillary Electrophoresis Patents By Assignee Classification


41 All Electrophoresis Patents By Institution, 1996 To July 2001*


42 Two Dimensional Electrophoresis Patents By Year Of Issuance, 1986 To July 2001


43 Two Dimensional Electrophoresis: Apparatus And Reagents Patents, 1986 To July 2001


44 Two Dimensional Electrophoresis: Methods Patents, 1989 To July 2001


45 Patents By Technology Type, 1996 To July 2001


46 All Electrophoresis Patents By Institution, 1996 To July 2001*


List Of Figures



Summary Figure: Revenues For Selected Proteomics-Related Products,* Worldwide Forecast, 2000, 2001 And 2006


1 Drugs Approved By The Fda, 1993 To 2000


2 Mass Spectroscopy Expenditures, 2000, 2001 And 2006


3 Overall Market Shares For Mass Spectroscopy, 2000


4 Protein Separation Using 2-D Electrophoresis


























































































































































































































































































Abstract

Proteomics is an emerging field that has developed in the wake of genomics. Its goal is to understand protein expression at the cellular level, and apply this information to scientific and medical problems. For example, compared to healthy cells, how does influenza virus infection affect the total protein output? Are any of the proteins expressed only in the infected cells suitable targets for new antiviral drugs? This approach also applies to cancerous cells, and cells from patients with degenerative diseases and many other conditions. New technologies like protein chips and capillary electrophoresis are emerging to serve proteomic studies, and more mature technologies like 2-D electrophoresis, mass spectroscopy, and nuclear magnetic resonance spectroscopy are being adapted for protein studies, and in some cases, for high throughput uses. Bioinformatics applications are constantly being developed to analyze the data produced by all of these technologies. This BCC study examines how proteomics technologies have affected basic research and pharmaceutical research, and how they are likely to affect research in the near future. It also analyzes how proteomics technologies are developing, and examines new companies that are likely to make substantial contributions to the field. An important part of the report analyzes instruments that are vital to proteomics studies. Sales and spending projections through 2006 are included.

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