Gene Amplification Technologies: End Users, Marketers, and Markets

Published by: Kalorama Information

Published: Aug. 1, 2002 - 156 Pages

Table of Contents

Target vs. Signal Amplification


• Target Amplification Technology Glossary
  
• Signal Amplification Technology Glossary
  
• Other Amplification Technology Glossary


Isothermal vs. Cycling Temperature



• Isothermal DNA Amplification Technologies
  
• Cycling Temperature DNA Amplification Technologies
  
• Isothermal Signal Amplification Technologies
  
• Cycling Temperature Signal Gene Amplification Technologies
  
• Isothermal Other Gene Amplification Technologies
  
• Cycling Other Gene Amplification Technologies


Exponential vs. Linear DNA Amplification Techniques



• Exponential Gene Amplification
  
• Linear Gene Amplification


Trends in Gene Amplification Technologies Development



• Additional Properties: Sensitivity, Range, Specificity


Amplification Technology Market Players

Chapter Three: The Markets

Amplification Technology Revenue


Amplification Technology Market Share



• Market Share by Competitor
  
• Target vs Signal Gene Amplification Technology
  
• Cycling vs Isothermal Gene Amplification Technology Revenue
  
• Exponential vs Linear Gene Amplification Technology Revenue

Chapter Four: The Applications

Introduction


Medical Applications



• FDA-Regulated Molecular Diagnostic Tests
  
• FDA-Approved Clinical Molecular Diagnostic Tests by Disease


Forensics, Paternity, Identity


Food Safety, Agri-Diagnostics


Veterinary

Chapter Five: The Reign Of PCR—The PCR Patent Fort

Chapter Six: DNA Amplification Technologies End-User Survey

• Summary of Results
  
• Conclusions

Chapter Seven: Next Generation: DNA Amplification On A Chip

Chapter Eight: Conclusions And Strategic Implications

• First Conclusion
  
• Second Conclusion
  
• Third Conclusion
  
• Fourth Conclusion

Chapter Nine: Company Profiles

• Abbott Laboratories
  
• Agilent Technologies
  
• Ambion, Inc.
  
• Amersham Biosciences, Inc.
  
• Axcell Biosciences
  
• Bayer Corporation
  
• Becton, Dickinson, and Co.
  
• Biogenex
  
• Biotecon Diagnostics
  
• Bio Merieux
  
• Caliper Technology Corporation
  
• Cepheid
  
• Chugai Biopharmaceuticals, Inc.
  
• Cytocell, Ltd.
  
• Cytogen Corporation
  
• Digene Corporation
  
• Eragen Biosciences, Inc.
  
• Exiqon, Inc.
  
• Genisphere 3DNA
  
• Gen-Probe
  
• Hamilton Thorne Biosciences
  
• Hibergen Limited
  
• ID Biomedical Corporation
  
• ImClone Systems, Inc.
  
• Linco Research, Inc.
  
• Molecular Sensing, PLC
  
• Molecular Staging, Inc.
  
• Nanogen, Inc.
  
• Orchid Biosciences, Inc.
  
• PerkinElmer Life Sciences
  
• Phylogenetix Laboratories, Inc.
  
• Qbiogene
  
• Rubicon Genomics
  
• SignalGene, Inc.
  
• Takara Shuzo Co., Ltd.
  
• Third Wave Technologies
  
• Tm Bioscience Corporation
  
• U.S. Genomics
  
• Xtrana, Inc.

Appendix A: DNA Amplification Techniques End-User Questionnaire

Appendix B: Company Directory

List of Exhibits

Table 2-1: Gene Amplification Technology Summary

Table 2-2: Comparison of RCAT with PCR by Feature

Table 2-3: Summary of Isothermal & Cycling Gene Amplification Technologies

Table 2-4: Advantages/Disadvantages of Isothermal and Cycling DNA Amplification Techniques

Table 2-5: Advantages & Disadvantages: Exponential versus Linear DNA Amplification Techniques

Table 2-6: Gene Amplification Technologies Physical Characteristic and Development Date Summary

Table 2-7: Range, Sensitivity & Specificity Gene Amplification Properties

Table 2-8: Amplification Technology Research-Only Companies

Table 2-9: Amplification Technology Application-Only Companies

Table 2-10: Amplification Technology Research & Application Companies

Table 3-1: Gene Amplification Technology Sales

Table 3-2: Gene Amplification Technology Market Share by Competitor

Table 3-3: Target vs. Signal Gene Amplification Technology Revenue

Table 3-4: Cycling vs Isothermal Gene Amplification Technology Revenue

Table 3-5: Exponential vs Linear Gene Amplification Technology Revenue

Table 4-1: Technology Used in FDA Approved Molecular Diagnostic Tests

Table 4-2: FDA-Approved Clinical Molecular Diagnostic Test by Technology and Company

Table 4-3: PCR FDA-Approved Molecular Diagnostic Tests and Companies

Table 4-4: TMA FDA-Approved Molecular Diagnostic Tests and Companies

Table 4-5: Hybrid Capture FDA-Approved Molecular Diagnostic Tests and
Companies

Table 4-6: NASBA FDA-Approved Molecular Diagnostic Tests and Companies

Table 4-7: FDA-Approved Clinical Molecular Diagnostic Tests by Disease

Table 4-8: FDA-Approved Chlamydia Tests

Table 4-9: FDA-Approved Gonorrhea Tests

Table 4-10: FDA-Approved HIV & HCV Tests




Figure 2-1: Kinetic Classification of Gene Amplification Technologies

Figure 2-2: Number of Competitors by DNA Amplification Technology Use

Figure 3-1: Gene Amplification Technology, Competitive Market Share, 2002

Figure 3-2: Gene Amplification Technology, Competitive Market Share, 2007

Figure 4-1: Percentage of Laboratories Using a Direct Detection Amplification Procedure for M. tuberculosis, 1997, 1999, 2001


Survey Results Figures

Abstract

The market for amplification technology is currently in the hundreds of millions of dollars, but as the need for information about genes in genomics and other research progresses, and as clinical diagnostic tools develop, the market for amplification technology will continue to grow. Although PCR is currently the dominant amplification technology, other technologies are emerging to challenge PCR in many areas. Patents, costs, and ease of use of a technique are forces that drive the development of amplification technology and will shape this dynamic market.

This study reviews the landscape in this emerging sector, discussing technologies, applications, competitors, and regulation. In addition, Kalorama has conducted the first ever end-user survey, to determine the preferences of actual researchers using various amplification technologies in various settings and for various applications.

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