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Strategic Perspectives 2001: Dementia - Commercial Opportunities in Unfamiliar Territory

Published by: Datamonitor

Published: Jan. 3, 2002 - 171 Pages


Table of Contents


Strategic Perspectives 2001: Dementia - Commercial Opportunities in Unfamiliar



Territory















DATAMONITOR HEALTHCARE



EXECUTIVE SUMMARY



Scope



Datamonitor insight into the dementia markets



VaD is the second most common form of dementia after AD, affecting over four



million people in the seven major markets. There are no approved drugs for VaD,



although companies currently marketing AD products are likely to launch their



drugs in 2003. Further drug launches will contribute to the rapid growth of this



attractive market, which is predicted to be worth $1.9bn in 2008.



DLB is the third most prevalent dementia, although it has only recently become



recognized as a clinical entity. Consequently, DLB is associated with very low



diagnosis rates. However, physicians diagnosing DLB commonly prescribe AChEIs



off label. Novartis is in the process of gaining approval for Exelon for a 2002



launch and will initially dominate the market, which is expected to be worth



$490m in 2008.



Although antiviral combinations can prevent ADC, and sometimes reverse it, there



remains a strong unmet need for cognition enhancing drugs. The most promising



candidates thus far are NMDA antagonists and MAO inhibitors. Estimated to be



worth $119m in 2008, ADC is clearly a niche market ideal for small



pharmaceutical companies marketing antidementia drugs.



BPSD affect over 80% of dementia patients, and are widely regarded as the most



distressing symptoms for both patient and caregiver. The greatest opportunity



for pharmaceutical companies lies in the treatment of psychosis and aggression



with atypical neuroleptics. For example, sales of drugs in this class are



expected to reach $714m in 2008 for the treatment of delusions in dementia



patients.



Key metrics



TABLE OF CONTENTS



EPIDEMIOLOGY



Dementia overview



Diagnostic criteria



Etiology



Symptomology



Comorbidities



Prevalence



Sex differences



Regional differences



Epidemiological conclusion



CLINICAL PRACTICE



Introduction



Diagnosis



Diagnostic procedures



Comprehensive patient evaluation



Differential diagnosis



Treatment



Treatment aims



Treatment guidelines



Pharmacological treatment of dementia



Management of BPSD



Non-pharmacological management



Summary of treatment



Patient potential



VASCULAR DEMENTIA MARKET



Introduction



Reminyl



Aricept



Memantine



Summary of trials



Summary of clinical research



Competitive analysis



The global vascular dementia market, 2001



Key market drivers



Drug launches



Heart protection study



International Congress on VaD



The future decoded



Epidemiological forecasts to 2008



Global market forecasts



Unmet needs



DEMENTIA WITH LEWY BODIES MARKET



Introduction



Exelon



The global DLB market, 2001



Key market drivers



Drug launches



The aging population



Awareness



The future decoded



Epidemiological forecasts to 2008



Global market forecasts



Unmet needs



AIDS DEMENTIA COMPLEX MARKET



Introduction



NMDA antagonists



Platelet activating factor antagonists



Anti-inflammatory agents



MAO inhibitors



Calcium channel blockers



Nucleoside analogs



HAART



Summary of other pipeline ADC drugs



Summary of trials



The global ADC market, 2001



Key market drivers



Launch of non-antiviral drugs



Current attitudes and awareness



DTC advertising and the Internet



Patient power



The future decoded



Epidemiological forecasts to 2008



Global market forecasts



Unmet needs



THE BPSD MARKET



Introduction



Antipsychotics



Anticonvulsants



Competitive analysis



Summary of trials



The global BPSD market



Delusions



Depression



Anxiety



Hallucinations



Aggression



Summary of current BPSD drug sales



Key market drivers



The aging population



Overuse of antipsychotics



Underuse of antidepressants



Caregiver burden



The future decoded



Epidemiological forecasts to 2008



Global market forecasts



Delusions



Depression



Anxiety



Hallucinations



Aggression



Summary of BPSD forecasts



Unmet needs



APPENDIX



Summary of pipeline antidementia drugs



Datamonitor's Central Nervous System Business Unit



Contributing experts



Table of tables



Table of figures



Bibliography



References



Websites



Pricing data



Introduction



Source prices



Ex-manufacturer, wholesaler and retail prices



Data validation and margin calculation



Quality control



Exchange rates



Patent expiries



(c) Datamonitor 2002. All Rights Reserved.









Abstract

Strategic Perspectives 2001: Dementia provides comprehensive analysis of the main forms of non-Alzheimer dementias, utilizing key epidemiological and clinical data to determine where the main pharmaceutical opportunities lie across the seven major markets. The dementia types covered include vascular dementia (VaD), dementia with Lewy bodies (DLB) and AIDS dementia complex (ADC).

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