MicroRNA Research Tools, Diagnostics and Therapeutics: Global Markets

Published by: BCC Research

Published: Nov. 1, 2012 - 161 Pages

Table of Contents

CHAPTER 1 INTRODUCTION

STUDY GOALS AND OBJECTIVES

REASONS FOR DOING THIS STUDY

SCOPE AND FORMAT

METHODOLOGY AND INFORMATION SOURCES

INTENDED AUDIENCE

ANALYST CREDENTIALS

RELATED REPORTS

BCC ON-LINE SERVICES

DISCLAIMER

CHAPTER 2 SUMMARY

SUMMARY TABLE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, THROUGH 2017 ($ MILLIONS)

SUMMARY FIGURE GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, 2010–2017 ($ MILLIONS)

CHAPTER 3 INTRODUCTION TO MICRORNA RESEARCH

OVERVIEW

MICRORNA DISCOVERY

MICRORNA DEFINITION

BIOGENESIS OF MICRORNA

FIGURE 1 SCHEMATIC REPRESENTATION OF MICRORNA BIOGENESIS AND ITS EFFECT ON PROTEIN TRANSLATION

FUNCTION OF MICRORNA

MICRORNA MARKET OVERVIEW

Tools for Research of MicroRNA Molecules

TABLE 1 GLOBAL MARKET FOR REAGENTS AND TOOLS FOR DNA/RNA RESEARCH, THROUGH 2016 ($ BILLIONS)

MicroRNA as Biomarker and its Role in Bioprofiling and Diagnostics Products

Development

TABLE 2 MARKET FOR CANCER PROFILING TECHNOLOGIES, THROUGH 2015 ($ BILLIONS)

MicroRNA as Therapeutics Target in Drug Discovery

IMPORTANCE OF PATENTS IN MICRORNA RESEARCH

TABLE 3 PATENTS AND PATENT APPLICATION SEARCH IN MICRORNA RESEARCH USING SPECIFIC KEY WORDS, THROUGH 2012

miR-34 example

miR-122 Case

TABLE 4 NUMBER OF PATENTS AND PATENT APPLICATIONS IN MICRORNA RESEARCH ACCORDING TO ASSIGNEE

CHAPTER 4 RESEARCH TOOLS AND REAGENTS FOR MICRORNA RESEARCH AND PRODUCT DEVELOPMENT

OVERVIEW

TABLE 5 TYPES OF REAGENTS AND TOOLS FOR MICRORNA RESEARCH AND DRUG DISCOVERY AND THEIR RELATIVE MARKET SHARE, 2011 (%)

TABLE 6 EXAMPLES OF MICRORNA SAMPLE PREPARATION SERVICES AND THEIR PRICE RANGES ($)

ANALYSIS OF MAIN SECTORS IN THE MICRORNA RESEARCH TOOLS AND TECHNOLOGIES MARKET

qRT-PCR and Related Reagents for MicroRNA Research

RNA Extraction and Purification Products

TABLE 7 GLOBAL MARKET SHARES OF RNA ISOLATION PRODUCTS BY COMPANY (%)

ormalin Fixed Paraffin-Embedded Tissues as a Source for MicroRNA

qRT-PCR Procedure for MicroRNA Analysis

TABLE 8 GLOBAL RT–PCR MARKET SHARES BY COMPANY, 2011 (%)

TABLE 9 PLATFORMS AND VENDORS OF QRT–PCR PRODUCST FOR MICRORNA RESEARCH

TABLE 10 GLOBAL MARKET FOR QRT–PCR REAGENTS FOR MICRORNA RESEARCH, THROUGH 2017 ($ MILLIONS)

Microarrays as a Tool for Research and Product Development for microRNA

Diagnostics and Therapeutics

TABLE 11 MAIN REPRESENTATIVE MICROARRAY PRODUCTS FOR MICRORNA RESEARCH

TABLE 12 ANNUAL REVENUES OF AFFYMETRIX, 2009–2011 ($ MILLIONS)

TABLE 13 GLOBAL MARKET FOR MICROARRAY REAGENTS AND PRODUCTS FOR MICRORNA RESEARCH, THROUGH 2017 ($ MILLIONS)

MicroRNA Sequencing as a Tool for MicroRNA Research, Diagnostics and Drug

Discovery

NGS Platforms for miRNAseq

TABLE 14 GLOBAL MARKET FOR NGS SEQUENCING, THROUGH 2016 ($ BILLIONS)

TABLE 15 NGS MARKET SHARE BY COMPANY, 2011 (%)

TABLE 16 PLATFORMS AND VENDORS USED FOR MICRORNA SEQUENCING

Sample Preparation for microRNA Sequencing

TABLE 17 VALUE OF GLOBAL NGS SAMPLE PREP MARKET, THROUGH 2016 ($ MILLIONS)

Summary and Comparison of microRNA Profiling Techniques

TABLE 18 SUMMARY OF MICRORNA PROFILING TECHNIQUES ADVANTAGES AND DISADVANTAGES

Functional Assay for MicroRNA Research

TABLE 19 EXAMPLES OF PRODUCTS FOR FUNCTIONAL ASSAYS AND THEIR REPRESENTATIVE VENDORS

SUMMARY OF LIFE SCIENCE TOOLS AND REAGENTS MARKET FOR MICRORNA RESEARCH

TABLE 20 GLOBAL MARKET FOR RESEARCH TOOLS IN MICRORNA RESEARCH, THROUGH–2017 ($ MILLIONS)

FIGURE 2 GLOBAL MARKET FOR RESEARCH TOOLS IN MICRORNA RESEARCH, 2010–2017 ($

MILLIONS)

CHAPTER 5 MICRORNA DIAGNOSTICS AND BIOMARKER MARKET

OVERVIEW

TABLE 21 NUMBER OF PUBLICATIONS IN MICRORNA RESEARCH BASED ON DIFFERENT SEARCH CRITERIA

MICRORNA AND CANCER DIAGNOSTICS

TABLE 22 EXAMPLES OF DIFFERENTIALLY EXPRESSED MICRORNA IN DIFFERENT CANCER TYPES

IMPORTANCE OF MICRORNA SIGNATURES IN DIFFERENT DISEASES

TABLE 23 EXAMPLES OF MICRORNA EXPRESSION IN CVS CONDITIONS

TABLE 24 EXAMPLES OF MICRORNA DOWNREGULATED OR UPREGULATED IN DIFFERENT NEURODEGENERATIVE PATHOLOGIES

CURRENT STATE OF MICRORNA DIAGNOSTIC AND BIOMARKER PRODUCT

DEVELOPMENT MARKET

TABLE 25 GLOBAL BIOMARKERS MARKET, THROUGH 2015 ($ BILLIONS)

TABLE 26 CHALLENGES ASSOCIATED WITH MICRORNA MEASUREMENTS AS BIOMARKER

CURRENT DIAGNOSTIC MICRORNA PRODUCTS AND PIPELINES

TABLE 27 DIAGNOSTICS PRODUCTS BY ROSETTA GENOMICS

miRview Lung Test

miRview Meso Test

miRview Kidney Test

miRview Mets

Rosetta Genomics

TABLE 28 REVENUES FOR ROSETTA GENOMICS, 2009-2011 ($ MILLIONS)

TABLE 29 GLOBAL MICRORNA DIAGNOSTICS MARKET THROUGH 2017 ($ MILLIONS)

FIGURE 3 GLOBAL MICRORNA DIAGNOSTICS MARKET, 2010–2017 ($ MILLIONS)

Bioprofiling Services as a Positive Drive for Diagnostics Industry

TABLE 30 EXAMPLE OF EXIQON REVENUES, 2009-2012 ($ MILLIONS)

CHAPTER 6 MICRORNA THERAPEUTICS IN RNA DRUG DISCOVERY MARKET

OVERVIEW

RNA THERAPEUTICS

ANTISENSE OLIGONUCLEOTIDE APPROACH

Mechanisms of Action of Antisense Oligonucleotides

Antisense Drugs as a Proof of Concept

TABLE 31 EXAMPLE OF LIPITOR SALES AS AN ESTIMATE FOR KYNAMRO, 2008-2010 ($ BILLIONS)

TABLE 32 EXAMPLES FOR ISIS PHARMACEUTICALS REVENUES, 2009-2011 ($ MILLIONS)

RNA INTERFERENCE AS DRUG DISCOVERY PLATFORM

Mechanism of Action for RNA Interference (RNAi)

RNAi as Therapeutics Approach

TABLE 33 REVENUES OF ALNYLAM PHARMACEUTICALS AND TEKMIRA PHARMACEUTICALS, 2009–2011 ($ MILLIONS)

RIBOZYMES APPROACH FOR RNA BASED THERAPEUTICS

MARKET EVALUATION FOR ANTISENSE AND RNAI BASED DRUGS

TABLE 34 EXAMPLES OF DRUG CANDIDATES IN ANTISENSE AND RNA INTERFERENCE BASED APPROACHES

TABLE 35 GLOBAL MARKET FOR ANTISENSE DRUG DISCOVERY THROUGH 2017 ($ MILLIONS)

TABLE 36 EXAMPLES OF DEALS AND COLLABORATION IN RNAI THERAPEUTICS, 2009-2012

TABLE 37 GLOBAL MARKET FOR RNAI THERAPEUTIC APPROACH, THROUGH 2017 ($ MILLIONS)

MICRORNA APPROACH IN DRUG DISCOVERY

TABLE 38 EXAMPLES OF MICRORNA DIFFERENTIAL EXPRESSION IN DIFFERENT CELLULAR PROCESSES

STABILITY ASPECTS AND CHEMICAL MODIFICATION

"DECOY" TRANSCRIPTS: COMPETITION FOR ENDOGENOUS MICRORNAS

MICRORNA REPLACEMENT THERAPY AS THERAPEUTIC APPROACH

MICRORNA REGULATION AS A TOOL FOR TRADITIONAL GENE THERAPY APPROACH

TABLE 39 DIFFERENT APPROACHES FOR DEVELOPMENT OF MICRORNA BASED THERAPEUTICS

Delivery Aspects of microRNA and RNA Based Therapeutics

TABLE 40 GLOBAL MARKET FOR RNA DRUG DELIVERY, THROUGH 2017 ($ BILLIONS)

TABLE 41 MAIN APPROACHES AND TECHNIQUES IN NONVIRAL RNA DRUG DELIVERY

TABLE 42 RNA DRUG DELIVERY SYSTEMS BY COMPANY

TABLE 43 SUMMARY OF MAIN DRUG DEVELOPMENT PLATFORMS FOR MICRORNA THERAPEUTICS: LIMITATIONS AND ADVANTAGES

EVALUATION OF MICRORNA DRUG DISCOVERY MARKET AND ITS PARTICIPANTS

TABLE 44 MAIN MARKET PARTICIPANTS IN MICRORNA DRUG DISCOVERY AND EXAMPLES OF THEIR DRUG CANDIDATES

Santaris Pharma

TABLE 45 SALES OF INCIVEK AND VICTRELIS, 2011 AND 2012 ($ MILLIONS)

miRagen

Regulus Therapeutics

Drug Development for Fibrosis Treatment

Anti-Hepatitis C Virus Drug Development

Immune System Related Diseases

Metabolic Diseases Drug Development

Development of MicroRNA Therapeutics for Oncology Market

Rosetta Genomics

Mirna Therapeutics

InteRNA Technologies

Additional Drug Discovery Companies

TABLE 46 REVENUES FOR SANTARIS PHARMA AND REGULUS THERAPEUTICS, 2008-2011 ($ MILLIONS)

TABLE 47 RECENT COLLABORATIONS, DEALS AND AGREEMENTS IN THE MICRORNA DRUG DISCOVERY MARKET, 2008-2012

TABLE 48 GLOBAL MARKET FOR MICRORNA DRUG DISCOVERY THROUGH 2017 ($ MILLIONS)

FIGURE 4 GLOBAL MARKET FOR MICRORNA DRUG DISCOVERY 2010-2017 ($ MILLIONS)

DEVELOPMENT OF ADDITIONAL SUB MARKETS IN MICRORNA DRUG DISCOVERY

MARKET

Sistemic

Cenix BioScience CRO

Pyxant Labs

Polyplus Transfection

Accelero Bioanalytics

SUMMARY OF GENERAL RNA THERAPEUTICS DRUG DISCOVERY MARKET

TABLE 49 GLOBAL MARKET FOR RNA–BASED THERAPEUTICS, THROUGH 2017 ($ MILLIONS)

FIGURE 5 GLOBAL MARKET FOR RNA BASED THERAPEUTICS, 2010-2017 ($ MILLIONS)

TABLE 50 GEOGRAPHICAL DISTRIBUTION OF RNA-BASED DRUG DISCOVERY COMPANIES (%)

CHAPTER 7 IMPORTANCE OF BIOINFORMATICS TOOLS AND RECOURSES FOR MICRORNA RESEARCH AND PRODUCT DEVELOPMENT

OVERVIEW

TABLE 51 GLOBAL BIOINFORMATICS MARKET, THROUGH 2016 ($ BILLIONS)

TABLE 52 DATABASES FOR MICRORNA RESEARCH

TABLE 53 EXAMPLES OF COMPUTATIONAL TOOLS FOR MICRORNA PREDICTION AND TARGET IDENTIFICATION

EFFECT OF NGS TREND ON MICRORNA RESEARCH AND BIOINFORMATICS TOOL

DEVELOPMENT

CHAPTER 8 NEW TECHNOLOGIES, APPLICATIONS AND MARKETS IN MICRORNA RESEARCH AND PRODUCT DEVELOPMENT

NEW TECHNOLOGIES AND DRUG DISCOVERY APPROACHES

TABLE 54 PROTEIN TARGETS FOR DRUG DISCOVERY RESEARCH IN MICRORNA

NEW APPLICATIONS AND TARGET MARKETS IN MICRORNA RESEARCH

AGRICULTURAL MARKET FOR MICRORNA

BIOFUEL MARKET FOR MICRORNA

TABLE 55 GLOBAL MARKET FOR BIOFUELS, THROUGH 2017 ($ BILLIONS)

LIVESTOCK MARKET FOR MICRORNA

FORENSICS AS A TARGET MARKET IN MICRORNA RESEARCH AND DEVELOPMENT

CHAPTER 9 MARKET SUMMARY FOR MICRORNA RESEARCH AND PRODUCT DEVELOPMENT

TABLE 56 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, THROUGH 2017 ($ MILLIONS)

FIGURE 6 GLOBAL MARKET FOR MICRORNA RESEARCH TOOLS, DIAGNOSTIC AND THERAPEUTIC PRODUCTS, 2010-2017 ($ MILLIONS)

TABLE 57 MAIN MARKET PARTICIPANTS IN MICRORNA RESEARCH MARKET

CHAPTER 10 PROFILES OF SELECT COMPANIES

ALNYLAM PHARMACEUTICALS

ASURAGEN, INC.

EXIQON A/S

ISIS PHARMACEUTICALS

MIRNA THERAPEUTICS

REGULUS THERAPEUTICS

ROSETTA GENOMICS

SANTARIS PHARMA A/S

CHAPTER 11 LIST OF COMPANIES MENTIONED IN REPORT

ACCESS PHARMACEUTICALS

AEGERA THERAPEUTICS

AFFYMETRIX

AGILENT TECHNOLOGIES

ALNYLAM PHARMACEUTICALS

ANTISENSE PHARMA GMBH

APARNA BIOSCIENCES CORP.

APPLIED BIOLOGICAL MATERIALS INC.

ASTRAZENECA PHARMACEUTICALS LP

ASURAGEN INC.

AVI BIOPHARMA/SAREPTA THERAPEUTICS

BENITEC BIOPHARMA

BIOCANCELL THERAPEUTICS INC.

BIOGEN IDEC

CALANDO PHARMACEUTICALS INC.

CBC COMPREHENSIVE BIOMARKER CENTER GMBH

CENIX BIOSCIENCE GMBH

CLONTECH LABORATORIES

COVANCE INC.

DICERNA PHARMACEUTICALS INC.

EGEN INC.

ELI LILLY AND CO.

EMD4BIOSCIENCES

ENZO BIOCHEM

ENZON PHARMACEUTICALS INC.

EXIQON A/S

F. HOFFMAN-LA ROCHE AG

FLUIDIGM

GENECOPOEIA INC.

GENOSENSOR CORP.

GENSIGNIA INC.

GENTA INC.

GROOVE BIOPHARMA

GSK U.S.

HTG MOLECULAR DIAGNOSTICS INC.

ICO THERAPEUTICS INC.

IDERA PHARMACEUTICALS

ILLUMINA INC.

INOVIO

INTERNA TECHNOLOGIES B.V.

ISIS PHARMACEUTICALS

LC SCIENCES

LIFE TECHNOLOGIES CORP.

LORUS THERAPEUTICS INC.

MARINA BIOTECH

MERCK

MIRAGEN THERAPEUTICS

MIRNA THERAPEUTICS

NANOSTRING TECHNOLOGIES

NORGEN BIOTEK

NOVARTIS INTERNATIONAL AG

OPKO HEALTH INC.

PFIZER

PHALANX BIOTECH GROUP

PHASERX

PROLIAS TECHNOLOGIES

QIAGEN

QUARK PHARMACEUTICALS INC.

REGULUS THERAPEUTICS

ROSETTA GENOMICS

RXI PHARMACEUTICALS CORP.

SANOFI U.S.

SANTARIS PHARMA A/S

SENESCO TECHNOLOGIES INC.

SIGMA-ALDRICH

SILENCE THERAPEUTICS

SIRNAOMICS INC.

SIRNASENSE

SYLENTIS

TACERE THERAPEUTICS INC.

TEKMIRA PHARMACEUTICALS CORP.

THERADIAG

THERMO FISHER SCIENTIFIC INC.

TRAVERSA THERAPEUTICS INC.

WAFERGEN BIOSYSTEMS INC.

Abstract

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