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Drugs of Tomorrow 2000: Prostate Cancer - Hormonals and Beyond

Published by: Datamonitor

Published: Mar. 1, 2001 - 222 Pages


Table of Contents


Introduction to Datamonitor

TABLE OF CONTENTS

EXECUTIVE SUMMARY

Report summary

Introduction

Patient potential in prostate cancer

Unmet needs in prostate cancer

Investors in prostate cancer

Class focus

Future market leaders

R&D opportunities in Prostate cancer

DISEASE OVERVIEW AND DEFINITIONS

Definition of disease

Classification of disease

Staging

Hormone refractory prostate cancer

Second-line patient treatment

Risk factors

Classification of pipeline products

Hormonals

Angiogenesis inhibitors

Immunotherapies

Cytotoxics

Gene therapies

Clinical endpoints in disease

Disease progress

PSA reduction

Quality-of-life

Multiple endpoints

Unmet needs in disease

Improved efficacy

Hormone refractory prostate cancer

Side effects

Compliance

PIPELINE ANALYSIS

Pipeline analysis by development strategy

Key drug discovery strategies in prostate cancer

Key R&D protocol strategies in disease

Key drug delivery strategies in disease

Key licensing strategies in disease

Pipeline analysis by class

Pipeline analysis by region

Pipeline analysis by company type

Pipeline analysis by individual company

DRUG ANALYSIS

Overview of drug analysis

Cytotoxics currently in late-stage development for prostate cancer

Vinorelbine

Suramin

Apra

CEP-701

Irofulven

Rubitecan

DX-8951f

SR 48692

Immunotherapies currently in late-stage development for prostate cancer

Provenge

MDX210

Prostvac

SGN-15

GVAX

Prolog

Mobista

Onyvax

Angiogenesis inhibitors currently in late stage development for prostate cancer

Iressa

Thalomid

Prinomastat

ABT627

Hormonals currently in late-stage development for prostate cancer

Abarelix

SPD 424

Cetrotide

Promaxx 100

Gene therapies

ISIS 3521

ISIS 5132

Leuvectin

Genasense

Other therapies

Aptosyn

Atragen

Incel

Perillyl alcohol

Promising agents in phase I development

Gonadimmune

Neovastat

Metastat

SnET2

Recently discontinued projects

SU101

Anti-VEGF Humanized Monoclonal Antibody

BMS 182751

COMPARATIVE ANALYSIS

Comparison by class

Efficacy

Side effects

Hormone-refractory prostate cancer

Comparative analysis of cytotoxics

Comparison of satisfaction of unmet needs within the cytotoxic class

Comparative analysis of immunotherapies

Comparison of satisfaction of unmet needs within the immunotherapy class

Comparative analysis of anti-angiogenesis agents

Comparison of satisfaction of unmet needs within the anti-angiogenesis class

Comparative analysis of hormonals

Comparison of satisfaction of unmet needs within the hormonals class

Comparative analysis of gene therapies

Comparison of satisfaction of unmet needs within the gene therapy class

Comparative analysis of 'others'

FUTURE FOCUS

Market drivers in prostate cancer

Patent expiries

New hormonal therapy launches

New drug classes: angiogenesis inhibitors and gene therapies

Price cuts in Japan

Reformation of Medicare

Factors affecting individual classes, 2000-2007

Future trends in the prevalence of prostate cancer

Prospective drug launches in Prostate cancer

Launch forecast methodology

Forecast launches in Prostate cancer from 2000 to 2007

Prostate cancer market forecasts

Forecast methodology

Key R&D product forecasts

Cytotoxic product forecasts

Immunotherapy product forecasts

Hormonal product forecasts

Anti-angiogenesis product forecasts

Gene therapy product forecasts

Long term potential of phase I and pre-clinical compounds

APPENDICES

Research program methodology

SPRINT databases

SPRINT R&D;

Primary Research

Quantification of Data Reliability

Strategic Issues and Opinion Surveys

References

LIST OF TABLES

LIST OF FIGURES

(c) Datamonitor 2000. All Rights Reserved.

Abstract

The prostate cancer R&D pipeline is showing a swing toward innovative therapies and away from the current standard of hormonal treatments where there is limited scope for increases in efficacy. If these new therapies are able to penetrate the market, it could soon be one of the most active areas of cancer therapy research. Drugs of Tomorrow 2000: Prostate Cancer - Hormonals and Beyond provides an in-depth analysis of the prostate cancer pipeline, and a competitive analysis of the most promising classes and drugs in development. The report enables you to competitively position your products, strengthen your marketing strategy and market penetration, expose potential threats to your business and target R&D resources more effectively.

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