RNA Interference Therapy in Oncology Drug Pipeline Update 2012Published by: BioSeeker Group AB Published: Feb. 21, 2012 Table of Contents
AbstractPotentially any disease-causing gene, cell type or tissue can be targeted with RNAi, including those not ’druggable’ with small molecules or protein-based therapies.There are today 43 companies plus partners developing 58 RNA interference drugs in 75 developmental projects in cancer. In addition, the accumulated number of ceased drugs over the last years amount to another 23 drugs. Rna Interference Therapy In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 44 different targets. These targets are further categorized on in the software application by 23 classifications of molecular function and with pathway referrals to BioCarta, KEGG and NetPath. How May Drug Pipeline Update Be of Use?
Drug Pipeline Update at a Glance Investigators Includes more than 43 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. Developmental stage This Drug Pipeline Update contains 58 RNA interference drugs in development, which have a total of 75 developmental projects in cancer. In addition there are ceased drugs. Pipeline Breakdown According to Number of Drugs Phase I# 7 Preclinical# 59 Suspended# 0 Ceased# 23 Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included RNA interference drugs are also in development for 26 other indications, where of 22 are different cancer indications. Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to more than 44 different targets, divided into 23 classifications of molecular function:
Target Expression Profile Direct links are provided from inside the application to 36 protein expression profiles of 25 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG and NetPath.
Mechanism In total there are different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Pathways Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma - Phase II Clinical Trial - Active Cancer, prostate - Phase III Clinical Trial - Ceased Drug Description Short introduction to drug Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of. System Requirements
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