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Published by: Venture Planning Group
Published: Feb. 14, 2012 - 850 Pages
Table of Contents
- A. DNA Sequencing
- 1. Introduction
- 2. Sequencing Methods
- 3. Autoradiography
- 4. The Human Genome Project
- 5. Sequencing Automation
- 6. Image Scanners
- 7. Fluorescent Detection
- 8. Gene Profiling
- 9. Gene Expression
- 10. Polymorphism Screening
- 11. Protein Interaction Networks
- B. DNA And RNA Probe Technology
- 1. Basic Principles
- 2. Probe Preparation
- 3. The DNA Probe Test
- a. Sample Preparation
- b. Hybridization
- c. Separation
- d. Detection/Measurement
- 4. Test Formats
- a. Filter Hybridization
- b. Southern Blot
- c. Northern Blot
- d. In Situ Hybridization
- e. Others
- 5. Labeling Techniques
- 6. Amplification Methods
- O Polymerase Chain Reaction
- - Temperature Cyclers
- - PCR Variations
- * Immuno-PCR
- * QC-PCR
- * DAP-PCR
- O Strand Displacement Activation
- O TMA
- O Ligase Chain Reaction
- O Branched DNA
- - Hybridization Protection Assay
- O Nucleic-Acid Sequence-Based Amplification
- O Self-Sustained Sequence Replicase
- O Others
- - Ampliprobe
- - CAR
- - CAS
- - CPT
- - Dendritic Polymer Technology
- - ISO-CR
- - LAT
- - Probe Networks
- - RAMP
- - Repair Chain Reaction
- - Rolling Circles
- - Sequence Independent Gene Amplification
- - Sequence Initiation Reaction
- - SISPA
- - Solid Phase Amplification
- C. Detection Technologies
- 1. Radioactive Methods
- a. Overview
- b. Major Isotopes
- O P-32
- O S-35
- O H-3
- O I-125
- 2. Non-Isotopic Methods
- a. Enzymatic Labels
- b. Chemical Labeling
- O Indirect Chemical Labeling
- O Direct Chemical Labeling
- c. Fluorescence
- d. Chemiluminescence
- e. Electrical Conductivity
- D. Instrumentation Review
- 1. Abbott LCx
- 2. Beckman Coulter/Biomek FK
- 3. Becton Dickinson SDA
- 4. Bio-Rad GeneScope
- 5. Gen-Probe Tigris
- 6. Roche Cobas Amplicor
- 7. Tecan LS Series
- E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
- - Liquid Transportation and Mixing
- - Separation
- - Reaction
- - Detection
- F. Pharmacogenomics
- G. Major Applications
- 1. Microbiology/Infectious Diseases
- a. Overview
- b. Major Infectious Diseases
- * AIDS
- O Structure and Composition
- O Classification
- O AIDS Origins
- O Animal Lentivirus Systems
- O Virus Receptors
- O HIV Infections in Humans
- - Pathogenesis and Pathology
- O CD4T Lymphocytes and Memory Cells
- O Monocytes and Macrophages
- O Lymphoid Organs
- O Neural Cells
- O Viral Coinfections
- - Clinical Findings
- O Plasma Viral Load
- O Pediatric AIDS
- - Neurologic Disease
- - Opportunistic Infections
- - Cancer
- O Immunity
- - Virus Isolation
- - Serology
- - Viral Nucleic Acid/Antigen Detection
- O Epidemiology
- - Worldwide Spread of AIDS
- - United States
- - Routes of Transmission
- O DNA Probes
- - Overview
- - Quantitative PCR
- - In Situ PCR
- - Needed Improvements
- O Viral Load/Drug Resistance Testing
- O Genotype and Phenotype Testing
- O Blood Banking Considerations
- * Adenovirus
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- O Adeno-Associated Viruses (AAV)
- * Anthrax/Bacillus Anthracis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Babesiosis
- O Background
- * BEA and Other Bartonella Diseases
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Chagas Disease
- O Background
- * Campylobacter
- O Background
- O Diagnostic Tests
- - Culture Identification
- O Vaccines and Drugs
- * Chlamydia
- O Background
- - Chlamydia psittaci
- - Chlmaydia pneumoniae
- - Chlamydia trachomatis
- O Diagnostic Tests
- O Vaccines and Drugs
- * Creutzfeldt-Jakob’s Disease
- O Background
- O Blood Transmission
- O Diagnostic Tests
- O Major Commercial and Academic Players
- - Bayer
- - Disease Sciences/Bio Tec Global
- - Imperial College School of Medicine
- - Ortho-Clinical Diagnostics
- - Pall
- - ProMetic Life Sciences
- - Proteome Sciences/Idexx
- - Q-One Biotech
- - Serono
- - U.S. Agricultural Research Service
- O Drugs
- O Vaccines
- * Cytomegalovirus
- O Background
- - Chorioretinitis
- - Gastrointestinal
- - Central Nervous System Disease
- O Diagnostic Tests
- O Vaccines and Drugs
- * Ebola Virus
- O Background
- - Epidemiology
- - Clinical Syndromes
- O Diagnostic Tests
- O Vaccines and Drugs
- * EchoVirus
- O Background
- - Acute Aseptic Meningitisis
- - Encephalitis
- - Exanthems
- - Respiratory Disease
- - Myopericarditis
- - Neonatal Infections
- O Diagnostic Tests
- O Vaccines and Drugs
- * Encephalitis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Enteroviruses
- O Background
- O Diagnostic Tests
- - Viral Isolation and Identification
- - Antibody Tests
- O Vaccines and Drugs
- * Epstein-Barr Virus
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Gonorrhea
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Hepatitis
- O Hepatitis A
- O Hepatitis B
- - Structure and Composition
- - Replication
- O Hepatitis C
- O Hepatitis D (Delta)
- O Hepatitis E
- O Hepatitis G
- O Hepatitis Infections Pathology
- O Clinical Findings
- O Laboratory Tests
- - Hepatitis A
- - Hepatitis B
- - Hepatitis C
- - Hepatitis D
- - Hepatitis E
- O Virus-Host Immune Reactions
- O Epidemiology
- - Hepatitis A
- - Hepatitis B
- - Hepatitis C
- - Hepatitis D (Delta)
- O Vaccines and Drugs
- * Herpes Simplex Virus
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Legionella
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Lyme Disease
- O Background
- - Clinical Description
- - Clinical Case Definition
- - Laboratory Criteria for Diagnosis
- - Case Classification
- O Diagnostic Tests
- O Vaccines and Drugs
- * Malaria
- * Mycoplasma
- O Background
- - Ureaplasma Urealyticum & Mycoplasma Hominis
- O Diagnostic Tests
- O Vaccines and Drugs
- * Papillomaviruses/HPV
- O Background
- - HPV in Cancer
- - Cervical Neoplasm
- O Diagnostic Tests
- O Vaccines and Drugs
- - Prevention
- * Parvovirus B19
- O Background
- - Microbiology
- - Epidemiology
- - Clinical Syndromes
- - Erythema Infectiosum (Slapped Cheek)
- - Adult Polyarthropathy
- - Transient Aplastic Crisis
- - Transient Pancytopenia
- - Red Cell Aplasia in Immunocompromised
- - Perinatal Infections
- O Diagnostic Test
- O Vaccines and Drugs
- * Pneumonia
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Polyomaviruses
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Salmonellosis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Shigellosis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Streptococci
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- - Group A Streptococci
- - Group B Streptococci
- * Toxoplasmosis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Tuberculosis
- O Background
- O Diagnostic Tests
- - Microscopic Characteristics
- - Cultural Characteristics
- - Skin Tests
- - MDRTB
- O Vaccines and Drugs
- * West Nile Virus
- O Background
- - Clinical Syndromes
- O Diagnostic Tests
- O Vaccines and Drugs
- * Yersinia
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- c. Antibiotic Susceptibility
- 2. Cancer Testing
- a. Overview
- b. Major Cancer Types
- * Prostate
- * Lung
- * Colon and Rectum
- * Breast
- * Skin
- * Uterine
- * Leukemia
- * Oral
- c. Oncogenes
- O Abl/abl-bcr
- O AIB1
- O BCL-2
- O BRCA1
- O CD44
- O C-fos
- O C-myb
- O C-myc
- O CYP17
- O Erb-B
- O HPC1
- O N-myc
- O P40
- O P51
- O P53
- O PIK3CA
- O PTI-1
- O Ras
- O Reg
- O Sis
- O Src
- 3. Genetic Diseases
- a. Overview
- b. Nucleic Acid Amplification
- c. Chromosome Imaging
- d. Genomics Technologies
- e. Proteomics Technologies
- f. Current Pharmacogenomic Tests
- g. Future Pharmacogenomic Testing
- h. Major Diseases
- * Achondroplasia
- * Autosomal Dominant Polycystic Kidney Disease
- * Cancer
- * Cosmetogenomics
- * Cystic Fibrosis
- * Down's Syndrome
- * Duchenne and Becker Muscular Dystrophy
- * Factor V (Leiden)
- * Factor IX Deficiency
- * Fragile X Syndrome
- * Heart Disease
- * Hemochomatosis
- * Hemophilia
- * Huntington's Disease
- * Maternal-Fetal Incompatibility
- * Multiple Endocrine Neoplasia
- * Phenylketonuria (PKU)
- * Polycystic Kidney Disease (PKD)
- * Prenatal Screening
- * Retinitis Pigmentosa
- * Retinoblastoma
- * Sickle Cell Anemia
- * Spinal Muscular Atrophy
- * Vitamin B12 Metabolism
- i. Social Issues and Concerns
- 4. Forensic Testing
- a. Overview
- b. Multilocus and Single Locus Probes
- * Multilocus Probes
- * Single Locus Probes
- * PCR and RFLP
- c. The FBI
- d. DNA Profile Data Banks
- * U.S.A.
- * U.K.
- e. Judicial Implementation
- f. Major Crime Categories
- g. Factors Contributing to the DNA Probe Market Expansion
- * Technology Availability
- * Use of Hair as Evidence
- h. Wildlife Forensics
- 5. Paternity Testing/HLA Typing
- 6. Other Applications
- a. Disease Susceptibility Testing
- b. Cardiovascular Diseases
- c. Diabetes
- d. Alzheimer's Disease
- e. Periodontal Disease
- f. Plasma Purification
- g. Organ Transplantation
- h. Water Contamination
- i. Other
- H. Competing/complementing Technologies
- 1. Monoclonal Antibodies/Immunoassays
- 2. RNA Probes
- 3. Two-Dimensional Electrophoresis
- 4. Flow Cytometry
- I. Worldwide Market Overview
- 1. Business Environment
- 2. Market Structure
- 3. Market Size and Growth
- France
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
- Major Product Development Opportunities
- A. Instrumentation
- B. Reagent Kits and Test Systems/panels
- C. Computers, Software and Automation
- D. Auxiliary Products
- Design Criteria For Decentralized Testing Products
- Alternative Market Penetration Strategies
- A. Internal Development
- B. Collaborative Arrangements
- C. University Contracts
- D. Distribution Strategies For Decentralized Testing Markets
- 1. Marketing Approaches
- 2. Product Complexity
- 3. Customer Preference
- 4. Established Suppliers
- 5. Emerging Suppliers
- 6. Major Types Of Distributors
- 7. Market Segmentation
- Potential Market Entry Barriers And Risks
- A. Market Maturity
- B. Cost Containment
- C. Competition
- D. Technological Edge And Limitations
- E. Patent Protection
- F. Regulatory Constraints
- G. Decentralized Testing Market Challenges
- Competitive Profiles
- - Abbott
- - Affymetrix
- - Agilent
- - Applied Gene Technologies
- - Arca
- - Beckman Coulter/Danaher
- - Becton Dickinson
- - Biokit
- - BioMerieux
- - Bio-Rad
- - Biotest
- - Caliper
- - Cepheid
- - Decode
- - Diadexus
- - Eiken
- - Enzo
- - Exact Sciences
- - Fujirebio
- - Gen-Probe
- - Hologic
- - Illumina
- - Innogenetics/Solvay
- - Kreatech
- - Li-Cor Biosciences
- - Life Technologies
- - Monogram Biosciences
- - Myriad Genetics
- - Nanogen/Elitech
- - Novartis
- - Orchid CellMark
- - Ortho-Clinical Diagnostics
- - Proteome Sciences
- - Qiagen
- - Roche
- - Scienion
- - Sequenom
- - Shimadzu
- - Siemens
- - Sierra Molecular
- - Takara Bio
- - Tecan Group
- Appendixes
- Appendix I: Major Universities and Research Centers Developing NAT Technology
- Appendix II: Glossary of Terms
- Appendix III: Currency Exchange Rates
- List of Tables
- Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
- Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
- Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests Oncogenes Potential Application in Cancer Diagnosis
- Major Companies Developing or Marketing Cancer NAT Tests List of Tables (continued)
- Major Companies Developing or Marketing NAT Assays For Genetic Diseases
- Summary Table France, NAT Test Volume And Sales Forecast by Major Application
- France, Laboratories Performing DNA Sequencing By Market Segment
- France, NAT Market Potential Laboratory Universe by Market Segment
- France, NAT Test Volume Forecast By Major Application
- France, Major Infectious Disease Molecular Diagnostics Test Volume Forecast
- France, Infectious Disease Screening NAT Volume Forecast
- France, NAT Market Forecast By Major Application
- France, Infectious Disease Screening NAT Reagent Market Forecast by Test
- France, NAT Market By Major Supplier
- France, HIV/Hepatitis NAT Market Reagent Sales By Major Supplier
AbstractHighlights- Comprehensive 850-page market segmentation analysis of the French NAT market.
- Major issues pertaining to the French NAT laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
- An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
- Ten-year test volume and reagent sales forecasts for the following categories:
- Infectious Diseases
- Cancer
- Forensic Testing
- Genetic Diseases
- Paternity Testing/HLA Typing- Review of testing methodologies and instrumentation technologies.
- Feature comparison of automated and semiautomated analyzers.
- Sales and market shares of leading suppliers.
- Over 60 specific opportunities for NAT instruments, test systems, IT and auxiliary products.
- Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
- Alternative market penetration strategies.
- Potential market entry barriers and risks.
- Business planning issues and concerns.
Contains 850 pages and 36 tables
Please note: The delivery time for the electronic version of this report is between 1-3 business days to allow the preparation of an updated version prior to dispatch.
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