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Published by: Venture Planning Group
Published: Feb. 14, 2012 - 1050 Pages
Table of Contents
- A. DNA Sequencing
- 1. Introduction
- 2. Sequencing Methods
- 3. Autoradiography
- 4. The Human Genome Project
- 5. Sequencing Automation
- 6. Image Scanners
- 7. Fluorescent Detection
- 8. Gene Profiling
- 9. Gene Expression
- 10. Polymorphism Screening
- 11. Protein Interaction Networks
- B. DNA And RNA Probe Technology
- 1. Basic Principles
- 2. Probe Preparation
- 3. The DNA Probe Test
- a. Sample Preparation
- b. Hybridization
- c. Separation
- d. Detection/Measurement
- 4. Test Formats
- a. Filter Hybridization
- b. Southern Blot
- c. Northern Blot
- d. In Situ Hybridization
- e. Others
- 5. Labeling Techniques
- 6. Amplification Methods
- O Polymerase Chain Reaction
- - Temperature Cyclers
- - PCR Variations
- * Immuno-PCR
- * QC-PCR
- * DAP-PCR
- O Strand Displacement Activation
- O TMA
- O Ligase Chain Reaction
- O Branched DNA
- - Hybridization Protection Assay
- O Nucleic-Acid Sequence-Based Amplification
- O Self-Sustained Sequence Replicase
- O Others
- - Ampliprobe
- - CAR
- - CAS
- - CPT
- - Dendritic Polymer Technology
- - ISO-CR
- - LAT
- - Probe Networks
- - RAMP
- - Repair Chain Reaction
- - Rolling Circles
- - Sequence Independent Gene Amplification
- - Sequence Initiation Reaction
- - SISPA
- C. Detection Technologies
- 1. Radioactive Methods
- a. Overview
- b. Major Isotopes
- O P-32
- O S-35
- O H-3
- O I-125
- 2. Non-Isotopic Methods
- a. Enzymatic Labels
- b. Chemical Labeling
- O Indirect Chemical Labeling
- O Direct Chemical Labeling
- c. Fluorescence
- d. Chemiluminescence
- e. Electrical Conductivity
- D. Instrumentation Review
- 1. Abbott LCx
- 2. Autogenomics Infinity
- 3. Beckman Coulter/Biomek FK
- 4. Becton Dickinson SDA
- 5. Bio-Rad GeneScope
- 6. Gen-Probe Tigris
- 7. Nanosphere Verigen Series
- 8. Roche Cobas Amplicor
- 9. Tecan LS Series
- E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
- - Liquid Transportation and Mixing
- - Separation
- - Reaction
- - Detection
- F. Pharmacogenomics
- G. Major Applications
- 1. Microbiology/Infectious Diseases
- a. Overview
- b. Major Infectious Diseases
- * AIDS
- O Structure and Composition
- O Classification
- O AIDS Origins
- O Animal Lentivirus Systems
- O Virus Receptors
- O HIV Infections in Humans
- - Pathogenesis and Pathology
- O CD4T Lymphocytes and Memory Cells
- O Monocytes and Macrophages
- O Lymphoid Organs
- O Neural Cells
- O Viral Coinfections
- - Clinical Findings
- O Plasma Viral Load
- O Pediatric AIDS
- - Neurologic Disease
- - Opportunistic Infections
- - Cancer
- O Immunity
- O Laboratory Diagnosis
- - Virus Isolation
- - Serology
- - Viral Nucleic Acid/Antigen Detection
- O Epidemiology
- - Worldwide Spread of AIDS
- - United States
- - Routes of Transmission
- O Prevention, Treatment, And Control
- - Antiviral Drugs
- - Vaccines
- O Transmission HIV in Blood Products
- O HIV Transmission in Transplant and Artificial Insemination Recipients
- O Diagnostic Tests
- - Enzyme Immunoassay Interpretation
- - Specificity, Sensitivity and Predictive Value
- O Competition Assays
- O Western Blot Technique
- O Immuno-Fluorescence Assays (IFA)
- O Radioimmunoprecipitation
- O HIV-1/HIV-2 Combination Testing
- O Methods of HIV-Antigen Detection
- O Antigen Assays and Blood Screening
- O Urine Tests
- O DNA Probes
- - Overview
- - Quantitative PCR
- - In Situ PCR
- - Needed Improvements
- O Viral Load/Drug Resistance Testing
- O Genotype and Phenotype Testing
- O Blood Banking Considerations
- * Adenovirus
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- O Adeno-Associated Viruses (AAV)
- * Anthrax/Bacillus Anthracis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Babesiosis
- O Background
- * BEA and Other Bartonella Diseases
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Chagas Disease
- O Background
- * Campylobacter
- O Background
- O Diagnostic Tests
- - Culture Identification
- O Vaccines and Drugs
- * Chlamydia
- O Background
- - Chlamydia psittaci
- - Chlmaydia pneumoniae
- - Chlamydia trachomatis
- O Diagnostic Tests
- O Vaccines and Drugs
- * Creutzfeldt-Jakob’s Disease
- O Background
- O Blood Transmission
- O Diagnostic Tests
- O Major Commercial and Academic Players
- - Bayer
- - Disease Sciences/Bio Tec Global
- - Imperial College School of Medicine
- - Ortho-Clinical Diagnostics
- - Pall
- - ProMetic Life Sciences
- - Proteome Sciences/Idexx
- - Q-One Biotech
- - Serono
- - U.S. Agricultural Research Service
- O Drugs
- O Vaccines
- * Cytomegalovirus
- O Background
- - Chorioretinitis
- - Gastrointestinal
- - Central Nervous System Disease
- O Diagnostic Tests
- O Vaccines and Drugs
- * Ebola Virus
- O Background
- - Epidemiology
- - Clinical Syndromes
- O Diagnostic Tests
- O Vaccines and Drugs
- * EchoVirus
- O Background
- - Acute Aseptic Meningitisis
- - Encephalitis
- - Exanthems
- - Respiratory Disease
- - Myopericarditis
- - Neonatal Infections
- O Diagnostic Tests
- O Vaccines and Drugs
- * Encephalitis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Enteroviruses
- O Background
- O Diagnostic Tests
- - Viral Isolation and Identification
- - Antibody Tests
- O Vaccines and Drugs
- * Epstein-Barr Virus
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Gonorrhea
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Hepatitis
- O Hepatitis A
- O Hepatitis B
- - Structure and Composition
- - Replication
- O Hepatitis C
- O Hepatitis D (Delta)
- O Hepatitis E
- O Hepatitis G
- O Hepatitis Infections Pathology
- O Clinical Findings
- O Laboratory Tests
- - Hepatitis A
- - Hepatitis B
- - Hepatitis C
- - Hepatitis D
- - Hepatitis E
- O Virus-Host Immune Reactions
- O Epidemiology
- - Hepatitis A
- - Hepatitis B
- - Hepatitis C
- - Hepatitis D (Delta)
- O Vaccines and Drugs
- * Herpes Simplex Virus
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Legionella
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Lyme Disease
- O Background
- - Clinical Description
- - Clinical Case Definition
- - Laboratory Criteria for Diagnosis
- - Case Classification
- O Diagnostic Tests
- O Vaccines and Drugs
- * Malaria
- * Mycoplasma
- O Background
- - Ureaplasma Urealyticum & Mycoplasma Hominis
- O Diagnostic Tests
- O Vaccines and Drugs
- * Papillomaviruses/HPV
- O Background
- - HPV in Cancer
- - Cervical Neoplasm
- O Diagnostic Tests
- O Vaccines and Drugs
- - Prevention
- * Parvovirus B19
- O Background
- - Microbiology
- - Epidemiology
- - Clinical Syndromes
- - Erythema Infectiosum (Slapped Cheek)
- - Adult Polyarthropathy
- - Transient Aplastic Crisis
- - Transient Pancytopenia
- - Red Cell Aplasia in Immunocompromised
- - Perinatal Infections
- O Diagnostic Test
- O Vaccines and Drugs
- * Pneumonia
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Polyomaviruses
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Salmonellosis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Shigellosis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Streptococci
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- - Group A Streptococci
- - Group B Streptococci
- * Toxoplasmosis
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- * Tuberculosis
- O Background
- O Diagnostic Tests
- - Microscopic Characteristics
- - Cultural Characteristics
- - Skin Tests
- - MDRTB
- O Vaccines and Drugs
- * West Nile Virus
- O Background
- - Clinical Syndromes
- O Diagnostic Tests
- O Vaccines and Drugs
- * Yersinia
- O Background
- O Diagnostic Tests
- O Vaccines and Drugs
- c. Antibiotic Susceptibility
- 2. Cancer Testing
- a. Overview
- b. Major Cancer Types
- * Prostate
- * Lung
- * Colon and Rectum
- * Breast
- * Skin
- * Uterine
- * Leukemia
- * Oral
- c. Oncogenes
- O Abl/abl-bcr
- O AIB1
- O BRCA1
- O CD44
- O C-fos
- O C-myb
- O C-myc
- O CYP17
- O Erb-B
- O HPC1
- O N-myc
- O P40
- O P51
- O P53
- O PIK3CA
- O PTI-1
- O Ras
- O Reg
- O Sis
- O Src
- 3. Genetic Diseases
- a. Overview
- b. Nucleic Acid Amplification
- c. Chromosome Imaging
- d. Genomics Technologies
- e. Proteomics Technologies
- f. Current Pharmacogenomic Tests
- g. Future Pharmacogenomic Testing
- h. Major Diseases
- * Achondroplasia
- * Autosomal Dominant Polycystic Kidney Disease
- * Cancer
- * Cosmetogenomics
- * Cystic Fibrosis
- * Down's Syndrome
- * Duchenne and Becker Muscular Dystrophy
- * Factor V (Leiden)
- * Factor IX Deficiency
- * Fragile X Syndrome
- * Heart Disease
- * Hemochomatosis
- * Hemophilia
- * Huntington's Disease
- * Maternal-Fetal Incompatibility
- * Multiple Endocrine Neoplasia
- * Phenylketonuria (PKU)
- * Polycystic Kidney Disease (PKD)
- * Prenatal Screening
- * Retinitis Pigmentosa
- * Retinoblastoma
- * Sickle Cell Anemia
- * Spinal Muscular Atrophy
- * Vitamin B12 Metabolism
- i. Social Issues and Concerns
- 4. Forensic Testing
- a. Overview
- b. Multilocus and Single Locus Probes
- * Multilocus Probes
- * Single Locus Probes
- * PCR and RFLP
- c. The FBI
- d. DNA Profile Data Banks
- * U.S.A.
- * U.K.
- e. Judicial Implementation
- f. Major Crime Categories
- g. Factors Contributing to the DNA Probe Market Expansion
- * Technology Availability
- * Use of Hair as Evidence
- h. Wildlife Forensics
- 5. Paternity Testing/HLA Typing
- 6. Other Applications
- a. Disease Susceptibility Testing
- b. Cardiovascular Diseases
- c. Diabetes
- d. Alzheimer's Disease
- e. Plasma Purification
- f. Organ Transplantation
- g. Water Contamination
- h. Others
- G. Cost Analysis
- 1. Equipment
- 2. Consumables
- H. Competing/complementing Technologies
- 1. Monoclonal Antibodies/Immunoassays
- 2. RNA Probes
- 3. Two-Dimensional Electrophoresis
- 4. Flow Cytometry
- I. Reimbursement Issues
- J. Worldwide Market Overview
- 1. Business Environment
- 2. Market Structure
- 3. Market Size and Growth
- France
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
- Germany
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
- Italy
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
- Japan
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
- Spain
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
- U.K.
- A. Executive Summary
- B. Business Environment
- C. Market Structure
- D. Market Size, Growth And Major Suppliers’ Sales And Market Shares
- U.S.A.
- A. Executive Summary
- B. Business Environment
- 1. Health Care Expenditures
- 2. Cost Consciousness
- 3. Reimbursement
- 4. Industry Consolidation
- 5. Managed Care
- a. HMO
- b. PPO
- 6. Hospitals
- 7. Admissions
- 8. Length of Stay
- 9. Industry Diversification
- 10. Physician Demographics
- 11. Population Aging
- a. Chronic Illness
- b. Disease Incidence
- c. Susceptibility to Iatrogenesis
- d. Multiple Illness Cases
- 12. Laboratory Regulations
- 13. FDA Reform
- C. Market Structure
- 1. Hospitals
- 2. Commercial/Private Laboratories
- 3. Blood Banks
- D. Market Size, Growth and Major Suppliers’
- Sales and Market Shares
- Major Product Development Opportunities
- A. Instrumentation
- B. Reagent Kits and Test Systems/panels
- C. Computers, Software and Automation
- D. Auxiliary Products
- Design Criteria For Decentralized Testing Products
- Alternative Market Penetration Strategies
- A. Internal Development
- B. Collaborative Arrangements
- C. University Contracts
- D. Distribution Strategies For Decentralized Testing Markets
- 1. Marketing Approaches
- 2. Product Complexity
- 3. Customer Preference
- 4. Established Suppliers
- 5. Emerging Suppliers
- 6. Major Types Of Distributors
- 7. Market Segmentation
- Potential Market Entry Barriers And Risks
- A. Market Maturity
- B. Cost Containment
- C. Competition
- D. Technological Edge And Limitations
- E. Patent Protection
- F. Regulatory Constraints
- G. Decentralized Testing Market Challenges
- Competitive Profiles
- - Abbott
- - Aclara
- - Affymetrix
- - Agilent
- - Ambion
- - Applera
- - Applied Gene Technologies
- - Beckman Coulter
- - Becton Dickinson
- - Biokit
- - BioMerieux
- - Biotest
- - Boston Biomedica
- - Caliper
- - Cepheid
- - Chiron
- - Decode
- - Diadexus
- - Digene
- - Eiken
- - Enzo
- - Exact Sciences
- - Fujirebio
- - Gen-Probe
- - Gene Tec
- - Illumina
- - Innogenetics
- - Kreatech
- - Li-Cor
- - Molecular Diagnostics
- - Myriad Genetics
- - Nanogen
- - Nuvelo
- - Orchid Biosciences
- - Qiagen
- - Roche
- - Sangtec
- - Sequenom
- - Scienion
- - Sierra Diagnostics
- - Shimadzu
- - Takara Bio
- - Tepnel Life Sciences
- - Tecan Group
- - Third Wave
- Appendixes
- Appendix I: Major Companies Developing or Marketing NAT Reagents and Test Kits
- Appendix II: Major Universities and Research Centers Developing NAT Technologies
- Appendix III: Glossary of Terms
- Appendix IV: Currency Exchange Rates
- List of Tables
- Major Companies Developing or Marketing Thermocyclers
- Major Companies Developing or Marketing AIDS NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Adenovirus NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Campylobacter NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Chlamydia NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing CMV NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing EBV NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Gonorrhea NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Hepatitis NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Herpes NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Legionella NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Lyme Disease NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Mycoplasma NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Papilloma Virus NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Pneumonia NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Salmonella NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Shigella NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Streptococci NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Toxoplasmosis NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Tuberculosis NAT And Other Direct Identification Tests
- Major Companies Developing or Marketing Cancer NAT Tests
- Major Companies Developing or Marketing NAT Assays For Genetic Diseases
- Worldwide, Laboratories Performing DNA Sequencing By Country
- Worldwide, NAT Market, Potential Laboratory Universe by Country
- Worldwide, NAT Volume Forecast by Country
- Worldwide, NAT Market Forecast by Country Summary Table France, NAT Volume And Sales Forecast by Major Application
- France, Laboratories Performing DNA Sequencing By Market Segment
- France, NAT Market Potential Laboratory Universe by Market Segment
- France, NAT Volume Forecast By Major Application
- France, Major Infectious Disease NAT Volume Forecast
- France, Infectious Disease Screening NAT Volume Forecast
- France, NAT Market Forecast By Major Application
- France, Infectious Disease Screening NAT Reagent Market Forecast by Test
- France, NAT Market By Major Supplier
- France, HIV/Hepatitis NAT Market By Major Supplier Summary Table Germany, NAT Volume And Sales Forecast by Major Application
- Germany, Laboratories Performing DNA Sequencing by Market Segment
- Germany, NAT Market Potential Laboratory Universe By Market Segment
- Germany, NAT Volume Forecast By Major Application
- Germany, Major Infectious Disease NAT Volume Forecast
- Germany, Infectious Disease Screening NAT Volume Forecast
- Germany, NAT Market Forecast By Major Application
- Germany, Infectious Disease Screening NAT Reagent Market Forecast by Test
- Germany, NAT Market by Major Supplier
- Germany, HIV/Hepatitis NAT Market by Major Supplier Summary Table Italy, NAT Volume And Sales Forecast by Major Application
- Italy, Laboratories Performing DNA Sequencing by Market Segment
- Italy, NAT Market Potential Laboratory Universe by Market Segment
- Italy, NAT Volume Forecast By Major Application
- Italy, Major Infectious Disease NAT Volume Forecast
- Italy, Infectious Disease Screening NAT Volume Forecast
- Italy, NAT Market Forecast By Major Application
- Italy, Infectious Disease Screening NAT Reagent Market Forecast by Test
- Italy, NAT Market By Major Supplier
- Italy, HIV/Hepatitis NAT Market By Major Supplier Summary Table Japan, NAT Volume And Sales Forecast by Major Application
- Japan, Laboratories Performing DNA Sequencing by Market Segment
- Japan, NAT Market Potential Laboratory Universe by Market Segment
- Japan, NAT Volume Forecast By Major Application
- Japan, Major Infectious Disease NAT Volume Forecast
- Japan, Infectious Disease Screening NAT Volume Forecast
- Japan, NAT Market Forecast By Major Application
- Japan, Infectious Disease Screening NAT Market Forecast by Test
- Japan, NAT Market By Major Supplier
- Japan, HIV/Hepatitis NAT Market by Major Supplier Summary Table Spain, NAT Volume And Sales Forecast by Major Application
- Spain, Laboratories Performing DNA Sequencing by Market Segment
- Spain, NAT Market, Potential Laboratory Universe by Market Segment
- Spain, NAT Volume Forecast by Major Application
- Spain, Major Infectious Disease NAT Volume Forecast
- Spain, Infectious Disease Screening NAT Volume Forecast
- Spain, NAT Market Forecast By Major Application
- Spain, Infectious Disease Screening NAT Reagent Market Forecast by Test
- Spain, NAT Market By Major Supplier
- Spain, HIV/Hepatitis NAT Market by Major Supplier Summary Table U.K., NAT Volume And Sales Forecast by Major Application
- U.K., Laboratories Performing DNA Sequencing by Market Segment
- U.K., NAT Market Potential Laboratory Universe by Market Segment
- U.K., NAT Volume Forecast By Major Application
- U.K., Major Infectious Disease NAT Volume Forecast
- U.K., Infectious Disease Screening NAT Volume Forecast
- U.K., NAT Market Forecast By Major Application
- U.K., Infectious Disease Screening NAT Reagent Market Forecast by Test
- U.K., NAT Market by Major Supplier Summary Table U.S.A., NAT Volume And Sales Forecast by Major Application
- U.S.A., Laboratories Performing DNA Sequencing by Market Segment
- U.S.A., NAT Market, Potential Laboratory Universe by Market Segment
- U.S.A., NAT Volume Forecast By Major Application
- U.S.A., Major Infectious Disease NAT Volume Forecast
- U.S.A., Infectious Disease Screening NAT Volume by Test Forecast
- U.S.A., NAT Market Forecast By Major Application
- U.S.A., Infectious Disease Screening NAT Reagent Market Forecast by Test
- U.S.A., NAT Market by Major Supplier
- U.S.A., HIV/Hepatitis C NAT Market By Major Supplier
- U.S.A., West Nile Virus NAT Market By Major Supplier
AbstractThis comprehensive seven-country, 1,050-page report is designed to help current suppliers and potential market entrants identify and evaluate major business opportunities emerging in the NAT market during this decade.
Highlights- Business and technological trends in seven major markets
- Five- and ten-year test volume and sales forecasts
- Market shares of leading competitors
- Feature comparison of major analyzers
- Profiles of market players and start-up firms developing innovative technologies and products
- Specific product and business opportunities for instrument and consumable suppliers.
Please note: The delivery time for the electronic version of this report is between 1-3 business days to allow the preparation of an updated version prior to dispatch.
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