• Cytochrome C
  
• The Bcl- Family
  
• P
  
• The Caspase Family
  
• Fas/Cd/Apo-
  
• Cards (Caspase Recruitment Domains)
  
• Mdm
  
• Iaps
  
• Trail (Apo- Ligand)
  
• Granzymes

• Annexin-V
  
• Dna Fragmentation Kits Detect The Breakup Of Dna
  
• The Future Of Apoptosis-Related Research Kits, Reagents, And Pharmaceuticals
  
  • Principal Market Forces
    
  • Selected Bibliography

FDA Regulations For Developing And Marketing New Pharmaceutical Agents

• Introduction
  
• Preclinical Testing And Submitting An Ind
  
• Clinical Trials
  
• Submitting An Nda
  
• Post-FDA Approval
  
• Conclusions

Apoptosis Markets: Apoptosis And Cancer Therapy

• Background On Cancer Therapy
  
• Background On Apoptosis-Related Cancer Therapy
  
• Aptosyn (Exisulind): Cell Pathways, Inc.
  
  • Aptosyn: Background Information
    
  • Aptosyn: Applications
    
  • Aptosyn: Forecasts
    
  • Cell Pathways: Collaborations And Alliances
    
  • Cp-: Cell Pathways, Inc.
  
  
  
  • Cp-: Background Information And Applications
    
  • Cell Pathways: Patent Portfolio
  
  
  
• Genasense: Genta, Inc.
  
  • Genasense: Background
    
  • Genasense: Applications
    
  • Genasense: Stastics And Forecasts
    
  • Genta: Patent Portfolio
  
  
  
• Ci-: Onyx Pharmaceuticals
  
  • Ci-: Background
    
  • Ci-: Applications
    
  • Onyx Pharmaceuticals: Patent Portfolio
    
  • Ci-: Forecasts
  
  
  
• Irofulven (Formerly Mgi-): Mgi Pharma
  
  • Irofulven: Background
    
  • Irofulven: Applications And Forecasts
    
  • Mgi Pharma: Collaborations And Alliances
    
  • Mgi Pharma: Patent Portfolio
  
  
  
• Sch (Rad/P): Schering-Plough
  
  • Sch : Background
    
  • Sch : Applications
    
  • Sch: Forecasts
  
  
  
• RPR/INGN : Introgen Therapeutics, Inc.
  
  • INGN : Background
    
  • Introgen: Collaborations
    
  • Introgen: Patent Position
    
  • Introgen: Forecasts
  
  
  
• Sti-: Novartis
  
  • Sti-: Background
    
  • Sti-: Forecasts
  
  
  
• Miscellaneous Agents
  
  • Onconase (Alfacell Corporation): Background
    
  • Theragyn (Antisoma, Plc): Background
    
  • Mx (Maxia Pharmaceuticals): Background
    
  • Pivanex (Titan Pharmaceuticals, Inc.): Background
    
  • Apomine (Ilex Oncology): Background
    
  • NV- (Novogen, Inc.): Background
    
  • Apomate (Theseus Imaging Corp.): Background
    
  • Rubitecan (Supergen, Inc.): Background
    
  • ME (Entremed, Inc.): Background

Apoptosis And Neurodegenerative Disorders

• Background
  
• Agents In Clinical Trials And In Preclinical Development
  
  • Dp-B (D-Pharm, Inc.): Background
    
  • Caspase Inhibitors (Idun Pharmaceuticals, Inc.): Background
    
  • Mp (Alexion Pharmaceuticals): Background
    
  • Caspase Inhibitors (Vertex Pharmaceuticals, Inc.): Background

Apoptosis And Cardiovascular Disorders

• Background
  
• Agents In Clinical Trials And In Preclinical Development
  
  • Hk- Cp-Cardiosol (Lxr Biotechnology, Inc): Background
    
  • Antrin (Pharmacyclics, Inc.): Background
    
  • Vas (Vasogen, Inc.): Background
    
  • Apomate (Theseus Imaging Corp.): Background
    
  • Cv (Cytovia, Inc.): Background
    
  • Caspase Inhibitors (Idun Pharmaceuticals, Inc.): Background

Apoptosis Markets: Research Kits And Reagents

• Background
  
• The Caspase Family
  
  • Background On Caspases
    
  • Market Trends
    
  • Research Uses Of Caspase Products
    
  • Caspase Inhibitors And Substrates
    
  • Inhibitors
    
  • Substrates
  
  
  
• Annexin-V
  
• Antibodies For Research Use
  
  • Background
    
  • Analysis
  
  
  
• Jc-
  
• Background

Apoptosis-Related Patents

• Apoptosis Patent Trends
  
• Apoptosis Technology Patents
  
• Patent Assignees

Appendix I: Pharmaceutical And Reagent Companies Engaged In Apoptosis Research

• A.G. Scientific
  
• Alexis Corporation
  
• Alfacell Corporation
  
• American Peptide Company
  
• Anaspec
  
• Ancell Corporation
  
• Antisoma Plc
  
• Apoptogen, Inc.
  
• Apoptosis Technology, Inc.
  
• Arcaris, Inc.
  
• Ariad Pharmaceuticals, Inc.
  
• Axonyx, Inc.
  
• Bionostics, Inc.
  
• Biosource International
  
• Biovision, Inc.
  
• Caltag, Inc.
  
• Canji, Inc. (Schering-Pough)
  
• Carbomed, Inc.
  
• Caspases.Com
  
• Cell Pathways, Inc.
  
• Cel-Sci Corporation
  
• Chemicon International, Inc.
  
• Clontech Laboratories, Inc.
  
• Cytovia, Inc.
  
• D-Pharm, Inc.
  
• Enzyme Systems
  
• Exalpha Biologicals
  
• Geno Technology, Inc.
  
• Genta, Inc.
  
• Hybridon
  
• Idun Pharmaceuticals, Inc.
  
• Ilex Oncology
  
• Immunex Corporation
  
• Intergen Company
  
• Introgen Therapeutics, Inc.
  
• Invivogen
  
• Kamiya Biomedical Company
  
• Kinetek Pharmaceuticals, Inc.
  
• Lab Vision Corporation
  
• Lxr Biotechnology Inc.
  
• Maxia Pharmaceuticals, Inc.
  
• Medical & Biological Laboratories Co., Ltd.
  
• Mgi Pharma, Inc.
  
• Millennium Pharmaceuticals, Inc.
  
• Molecular Probes
  
• Nexins Research
  
• Novogen, Inc.
  
• Oncogene Research Products
  
• Oncoimmunin, Inc.
  
• Onyx Pharmaceuticals, Inc.
  
• Oxford Biomedical Research
  
• Panvera Corporation
  
• Peninsula Laboratories Inc.
  
• Pentagenic Pharmaceuticals, Inc.
  
• Bd Pharmingen
  
• Promega Corporation
  
• Quality Controlled Biochemicals, Inc.
  
• R & D Systems, Inc.
  
• Research Diagnostics, Inc.
  
• Rhône-Poulenc Rorer Inc.
  
• Roche Molecular Biochemicals
  
• Santa Cruz Biotechnology, Inc.
  
• Serotec, Inc.
  
• Sigma-Aldrich Corporation
  
• Southern Biotech. Associates, Inc
  
• Stratagene, Inc
  
• Stressgen Biotechnologies Corp.
  
• Theseus Imaging Corp.
  
• Bd Transduction Laboratories
  
• Trevigen, Inc.
  
• United States Biological
  
• Upstate Biotechnology, Inc.
  
• Vertex Pharmaceuticals, Inc.
  
• Zymed Laboratories, Inc.

Appendix II Contact Information For Non-Profit Entities Mentioned In This Report

• Advanced Research And Technology Institute
  
• Alton Ochsner Medical Foundation
  
• Arch Development Corporation
  
• Baylor College Of Medicine
  
• The Burnham Institute (Formerly The La Jolla Cancer Research Foundation)
  
• Cornell Research Foundation, Inc
  
• Cold Spring Harbor Laboratory
  
• Columbia Innovation Enterprise (Cie)
  
• Dana-Farber Cancer Institute
  
• Dartmouth College
  
• Duke University
  
• Fox Chase Cancer Center
  
• Harvard University
  
• Johns Hopkins University
  
• Ludwig Inst For Cancer Research
  
• Massachusetts Institute Of Technology
  
• Memorial Sloan-Kettering Cancer Center
  
• Sir Mortimer B. Davis Jewish General Hospital
  
• National Jewish Medical And Research Center
  
• New York University
  
• Oregon Health Sciences University
  
• Osaka Bioscience Institute
  
• Princeton University
  
• Rockefeller University
  
• Rutgers University
  
• Saint Elizabeth's Medical Center Of Boston
  
• Saint Louis University Health Sciences Center
  
• The Scripps Institute
  
• Sloan-Kettering Cancer Center
  
• Stanford University
  
• Texas Heart Institute
  
• Thomas Jefferson University
  
• University Of Alabama At Birmingham
  
• University Of Arizona
  
• University Of California
  
• University Of Dundee
  
• University Of Illinois
  
• University Of Michigan
  
• University Of Ottawa
  
• University Of Pennsylvania
  
• University Of Saskatchewan
  
• University Of Texas
  
• Washington University In Saint Louis
  
• Wisconsin Alumni Research Foundation
  
• The Wistar Institute

Abstract

This report discusses pharmaceutical and technological applications of apoptosis. This field promises to bring important new treatments for cancers, neurological conditions, cardiac problems, and other diseases. The report also addresses the state of the market for apoptosis-related research kits and reagents. It also analyzes the latest research on the subject, examines investments in drug development, and forecasts worldwide sales of drugs, kits, and reagents. Market forecasts project sales to the year 2005.

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