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Antibody Drug Target Atlas In Oncology - Where To Commercialize In A Crowded Market Place?

Published by: BioSeeker Group AB

Published: Mar. 1, 2010 - 1289 Pages


Table of Contents


1 Executive Summary

2 About Cancer Highlights

3 Methodologies

4 Table of Contents

4.1 List of Figures

4.2 List of Tables

5 Introduction

5.1 Background to the Antibody Therapeutic Market

5.2 The Scope of this Report

5.3 Definitions

5.4 Abbreviations

6 Consider the Therapeutic Target for the Highest Therapeutic Outcome and Return on Investment

6.1 Drug Repositioning in Oncology

6.2 Introduction to Antibody Therapeutic Targets in Oncology

6.2.1 Antigen Binding Targets

6.2.2 Auxiliary Transport Protein Activity Targets

6.2.3 B Cell Receptor Activity Targets

6.2.4 Carboxypeptidase Activity Targets

6.2.5 Catalytic Activity Targets

6.2.6 Cell Adhesion Molecule Activity Targets

6.2.7 Cell Adhesion Molecule Activity Targets

6.2.8 Chaperone Activity Targets

6.2.9 Chemokine Activity Targets

6.2.10 Cofactor Binding Targets

6.2.11 Complement Activity Targets

6.2.12 Cysteine-Type Peptidase Activity Targets

6.2.13 Cytokine Activity Targets

6.2.14 Defense/immunity Protein Activity Targets

6.2.15 DNA Topoisomerase Activity Targets

6.2.16 Extracellular Ligand-Gated Ion Channel Activity Targets

6.2.17 Extracellular Matrix Structural Constituent Targets

6.2.18 G-protein Coupled Receptor Activity Targets

6.2.19 Growth Factor Activity Targets

6.2.20 Hormone Activity Targets

6.2.21 Hydrolase Activity Targets

6.2.22 Intracellular Ligand-Gated Ion Channel Activity Targets

6.2.23 Isomerase Activity Targets

6.2.24 Kinase Binding Targets

6.2.25 Lipid Kinase Activity Targets

6.2.26 Metallopeptidase Activity Targets

6.2.27 MHC Class I Receptor Activity Targets

6.2.28 Molecular Function Unknown Targets

6.2.29 Oxidoreductase Activity Targets

6.2.30 Peptidase Activity Targets

6.2.31 Peptide Hormone Targets

6.2.32 Protease Inhibitor Activity Targets

6.2.33 Protease Inhibitor Activity Targets

6.2.34 Protein Binding Targets

6.2.35 Protein Serine/Threonine Kinase Activity Targets

6.2.36 Receptor Activity Targets

6.2.37 Receptor Binding Targets

6.2.38 Receptor Signaling Complex Scaffold Activity Targets

6.2.39 RNA-directed DNA Polymerase Activity Targets

6.2.40 Serine-type Peptidase Activity Targets

6.2.41 Structural Constituent of Cytoskeleton Targets

6.2.42 T cell Receptor Activity Targets

6.2.43 Transcription Factor Activity Targets

6.2.44 Transcription Regulator Activity Targets

6.2.45 Transmembrane Receptor Activity Targets

6.2.46 Transmembrane Receptor Protein Tyrosine Kinase Activity Targets

6.2.47 Transporter Activity Targets

6.2.48 Unclassified Targets

6.3 The Cancer Genome Project and Antibody Therapeutic Targets in Oncology

6.3.1 Antibody Therapeutic Targets Present in the Cancer Gene Census and in the Catalogue of Somatic Mutations in Cancer

6.4 Structure-based Drug Design in Antibody Therapeutics is Stimulated by Available Structure Data on Biological Targets

6.5 Target-Target Interactions among Identified Antibody Therapeutics Targets in Oncology

6.6 The Drug-Target Interactome

6.7 Protein Expression Levels of Identified Antibody Therapeutic Targets in Oncology

6.8 Pathway Analysis of Cancer Antibody Therapeutic Targets

7 The Rise of New Products: How Mature, Unique and Clinically Validated are the Drug Target Profiles Identified in the Cancer Antibody Therapeutic Pipeline?

7.1 Terminated Drug Target Profiles of Cancer Antibody Drugs

7.2 Pre-Registration to being Marketed: New and Unique Drug Target Profiles of Antibody Therapeutics in Oncology

7.3 Phase III Clinical Development: New and Unique Drug Target Profiles of Antibody Therapeutics in Oncology

7.4 Phase II Clinical Development: New and Unique Drug Target Profiles of Antibody Therapeutics in Oncology

7.5 Phase I Clinical Development: New and Unique Drug Target Profiles of Antibody Therapeutics in Oncology

7.6 Preclinical Development: New and Unique Drug Target Profiles of Antibody Therapeutics in Oncology

7.7 Development Profiles of All Antibody Drugs in Oncology

7.8 The Competition Through Close Mechanistic Approximation of Antibody Cancer Therapeutics

8 Selecting Cancer Indications for Antibody Therapeutics

8.1 Acute Lymphocytic Leukemia

8.2 Acute Myelogenous Leukemia

8.3 Basal Cell Cancer

8.4 B-cell Lymphoma

8.5 Biliary Cancer

8.6 Bladder Cancer

8.7 Bone Cancer

8.8 Brain Cancer

8.9 Breast Cancer

8.10 Cancer (general)

8.11 Cancer Diagnosis

8.12 Cancer Fatigue

8.13 Carcinoid Tumor

8.14 Cervical Cancer

8.15 Chemotherapy-induced Anemia

8.16 Chemotherapy-induced Bone Marrow Injury (general)

8.17 Chemotherapy-induced Injury (general)

8.18 Chemotherapy-induced Thrombocytopenia

8.19 Chronic Lymphocytic Leukemia

8.20 Chronic Myelogenous Leukemia

8.21 CNS Cancer

8.22 Colorectal Cancer

8.23 Endometrial Cancer

8.24 Ewing's Sarcoma

8.25 Fallopian Tube Cancer

8.26 Gastrointestinal Cancer (general)

8.27 Gastrointestinal Stomach Cancer

8.28 Gastrointestinal Stromal Cancer

8.29 Genitourinary Cancer

8.30 Hairy Cell Leukemia

8.31 Head and Neck Cancer

8.32 Hematological Cancer (general)

8.33 Hodgkin's Lymphoma

8.34 Leiomyo Sarcoma

8.35 Leukemia (general)

8.36 Liver Cancer

8.37 Lung Cancer (general)

8.38 Lymphoma (general)

8.39 Melanoma

8.40 Merkel Cell Carcinoma

8.41 Mesothelioma

8.42 Myelodysplastic Syndrome

8.43 Myeloma

8.44 Nasopharyngeal Cancer

8.45 Neuroblastoma

8.46 Neuroectodermal Sarcoma

8.47 Neuroendocrine Cancer (general)

8.48 non-Hodgkin's Lymphoma

8.49 Non-Small Cell Lung Cancer

8.50 Oesophageal Cancer

8.51 Osteo Sarcoma

8.52 Ovarian Cancer

8.53 Pancreatic Cancer

8.54 Peritoneal Cancer

8.55 Prostate Cancer

8.56 Renal Cancer

8.57 Rhabdomyo Sarcoma

8.58 Sarcoma (general)

8.59 Skin Cancer (general)

8.60 Small Cell Lung Cancer

8.61 Soft Tissue Sarcoma

8.62 Solid Tumor

8.63 Squamous Cell Cancer

8.64 Synovial Sarcoma

8.65 T-cell Lymphoma

8.66 Testicular Cancer

8.67 Thyroid Cancer

8.68 Unspecified Cancer Indication

8.69 Vaccine Adjunct

9 Portfolio Planning: Competitive Benchmarking of Antibody Cancer Therapeutic Pipeline by Investigator

9.1 A&G Pharmaceutical

9.2 Abiogen

9.3 Ablynx

9.4 AC Immune

9.5 Access

9.6 Actinium Pharmaceuticals

9.7 Active Biotech

9.8 Adherex

9.9 Affibody

9.10 Affimed Therapeutics

9.11 Affitech

9.12 AGY Therapeutics

9.13 Aida Pharmaceuticals

9.14 Alder Biopharmaceuticals

9.15 Alethia Biotherapeutics

9.16 Alexion

9.17 Algeta

9.18 Amgen

9.19 Antisoma

9.20 Aphios

9.21 Arana Therapeutics

9.22 Arca biopharma

9.23 Astellas

9.24 AstraZeneca

9.25 Attenuon

9.26 AVEO

9.27 Bayer

9.28 Berkeley Lab

9.29 Biocon

9.30 Biogen Idec

9.31 BioInvent

9.32 Biolex

9.33 BioLineRx

9.34 Biosceptre

9.35 Biotecnol

9.36 Boehringer Ingelheim

9.37 Bristol-Myers Squibb

9.38 BTG

9.39 Cancer Innovations

9.40 Cancer Research Technology

9.41 Celldex Therapeutics

9.42 Celtic Pharma

9.43 Center of Molecular Immunology

9.44 CG Therapeutics

9.45 Circadian Technologies

9.46 CuraGen

9.47 CureTech

9.48 Curis

9.49 CytImmune Sciences

9.50 Daiichi Sankyo

9.51 Dendreon

9.52 Dompe

9.53 Dyax

9.54 Eisai

9.55 Elan

9.56 Eli Lilly

9.57 Epitomics

9.58 EUSA Pharma

9.59 Facet Biotech

9.60 Faron Pharmaceuticals

9.61 Favrille

9.62 FibroGen

9.63 Five Prime Therapeutics

9.64 Fusion Antibodies

9.65 Galaxy Biotech

9.66 GammaCan

9.67 Ganymed Pharmaceuticals

9.68 Gene Techno Science

9.69 Genentech

9.70 Genmab

9.71 GenPat77

9.72 Genzyme

9.73 GlaxoSmithKline

9.74 Gliknik

9.75 Glycotope

9.76 Green Cross

9.77 GTC Biotherapeutics

9.78 Hoffmann-La Roche

9.79 Human Genome Sciences

9.80 IDM Pharma

9.81 ImClone Systems

9.82 ImmunoCellular Therapeutics

9.83 ImmunoGen

9.84 Immunomedics

9.85 Innate Pharma

9.86 InNexus Biotechnology

9.87 Intracel

9.88 ISA Pharmaceuticals

9.89 ISU ABXIS

9.90 Johnson & Johnson

9.91 Kaketsuken

9.92 KaloBios

9.93 Kirin Pharma

9.94 Kissei

9.95 Kyowa Hakko Kirin

9.96 LFB Biotechnologies

9.97 MacroGenics

9.98 MAT Biopharma

9.99 Medarex

9.100 MediGene

9.101 MedImmune

9.102 Menarini

9.103 Merck & Co

9.104 Merck KGaA

9.105 Merrimack

9.106 Micromet

9.107 MorphoSys

9.108 Neovacs

9.109 Neuren

9.110 NKT Therapeutics

9.111 Non-industrial Sources

9.112 Northwest Biotherapeutics

9.113 Novartis

9.114 OncoMed

9.115 Onyvax

9.116 Oxford BioMedica

9.117 Paladin Labs

9.118 Panacea

9.119 PanGenetics

9.120 Patrys

9.121 Pepscan Therapeutics

9.122 Peregrine Pharmaceuticals

9.123 Pfizer

9.124 Philogen

9.125 Pierre Fabre

9.126 Prima Biomed

9.127 ProCell Therapeutics

9.128 Prochon Biotech

9.129 Progenics Pharmaceuticals

9.130 Protherics

9.131 Ramot

9.132 Recepta biopharma

9.133 Receptor BioLogix

9.134 Regeneron

9.135 Sanofi-Aventis

9.136 Scancell

9.137 Seattle Genetics

9.138 Sirtex Medical

9.139 Sunol Molecular

9.140 SuppreMol

9.141 Switch Pharma

9.142 Symphogen

9.143 SynerGene Therapeutics

9.144 Takeda

9.145 Targa Therapeutics

9.146 TeGenero

9.147 Teva

9.148 Therapure Biopharma

9.149 ThromboGenics

9.150 Titan Pharmaceuticals

9.151 Tolerx

9.152 Tracon Pharmaceuticals

9.153 Trillium Therapeutics

9.154 Trion Pharma

9.155 Trubion

9.156 UCB

9.157 United Therapeutics

9.158 Vaccinex

9.159 VasGene Therapeutics

9.160 Viragen

9.161 Viventia Biotech

9.162 Wilex

9.163 Xencor

9.164 Xerion

9.165 Xoma

9.166 Y's Therapeutics

10 Disclaimer

11 Drug Index

12 Company Index

4.1 List of Figures

Figure 1: Visualization of Target-Target Interactions among Antibody Drug Targets in Oncology

Figure 2: The Drug-Protein Interactome of Antibody Drugs -Large Clusters

Figure 3: The Drug-Protein Interactome of Antibody Drugs - Small Clusters

Figure 4: Head-to-Head Targeting Interactome of Antibody Drugs - Large Clusters

Figure 5: Head-to-Head Targeting Interactome of Antibody Drugs - Small Clusters

4.2 List of Tables

Table 1: Head to Head Competition among Apoptopic Drugs in Oncology

Table 2: Overall Breakdown of the Included Antibody Pipeline by Cancer Indication and Stage of Development31

Table 3: Overview of Drug Target Profile Themes

Table 4: Terminally Ceased Therapeutic Antibody Targets in Oncology

Table 5: Drug Targets of Antibody Drugs in Oncology Present in the Catalogue of Somatic Mutations in Cancer and in the Cancer Gene Census

Table 6: Identity of Antibody Drug Targets with Available Biological Structures

Table 7: Number of Target-Target Interactions among Antibody Drug Targets in Oncology

Table 8: Antibody Drug Targets with Available Protein Expression Profiles

Table 9: Pathway Summary

Table 10: Drug Targets without any Identified Assigned Pathways

Table 11: Pathway Profiles According to BioCarta of Antibody Drug Targets in Oncology

Table 12: Pathway Profiles According to KEGG of Antibody Drug Targets in Oncology

Table 13: Pathway Profiles According to NetPath of Antibody Drug Targets in Oncology

Table 14: Number of Drug Target Profiles by their Highest Developmental Stage and Uniqueness

Table 15: Top Competitive Antibody Target Profiles in Oncology

Table 16: Terminated Drug Target Strategies of Antibody Drugs in Oncology

Table 17 New and Unique Antibody Target Strategies in Cancer Currently in Pre-Registration to Marketed

Table 18: The Competition Through Close Mechanistic Approximation Between Pre-registration to Marketed Antibody Drugs in Oncology

Table 19: New and Unique Antibody Target Strategies in Cancer Currently in Phase III Clinical Development . 332

Table 20: The Competition Through Close Mechanistic Approximation Between Phase III Antibody Drugs in Oncology

Table 21: New and Unique Antibody Target Strategies in Cancer Currently in Phase II Clinical Development

Table 22: The Competition Through Close Mechanistic Approximation Between Phase II Antibody Drugs in Oncology

Table 23 New and Unique Antibody Target Strategies in Cancer Currently in Phase I Clinical Development

Table 24: The Competition Through Close Mechanistic Approximation Between Phase I Antibody Drugs in Oncology

Table 25: New and Unique Antibody Target Strategies in Oncology Currently in Preclinical Development

Table 26: The Competition Through Close Mechanistic Approximation Between Preclinical Antibody Drugs in Oncology

Table 27: The Progression, Maturity and Competitive Comparison of Antibody Drug Target Profiles in Cancer Drug Development

Table 28: The Competition Through Close Mechanistic Approximation Among All Antibody Drugs in Oncology

Table 29: Competitive Summary of Antibody Drugs by Cancer Indication

Table 30: Drug Target Profiles of Antibody Drugs for the Treatment of Acute Lymphocytic Leukemia

Table 31: The Competition through Close Mechanistic Approximation between Acute Lymphocytic Leukemia Drugs

Table 32: Drug Target Profiles of Antibody Drugs for the Treatment of Acute Myelogenous Leukemia

Table 33: The Competition through Close Mechanistic Approximation between Acute Myelogenous Leukemia Drugs

Table 34: Drug Target Profiles of Antibody Drugs for the Treatment of Basal Cell Cancer

Table 35: Drug Target Profiles of Antibody Drugs for the Treatment of B-cell Lymphoma

Table 36: The Competition through Close Mechanistic Approximation between B-cell Lymphoma Drugs

Table 37: Drug Target Profiles of Antibody Drugs for the Treatment of Biliary Cancer

Table 38: The Competition through Close Mechanistic Approximation between Biliary Cancer Drugs

Table 39: Drug Target Profiles of Antibody Drugs for the Treatment of Bladder Cancer

Table 40: The Competition through Close Mechanistic Approximation between Bladder Cancer Drugs

Table 41: Drug Target Profiles of Antibody Drugs for the Treatment of Bone Cancer

Table 42: Drug Target Profiles of Antibody Drugs for the Treatment of Brain Cancer

Table 43: The Competition through Close Mechanistic Approximation between Brain Cancer Drugs

Table 44: Drug Target Profiles of Antibody Drugs for the Treatment of Breast Cancer

Table 45: The Competition through Close Mechanistic Approximation between Breast Cancer Drugs

Table 46: Drug Target Profiles of Antibody Drugs for the Treatment of Cancer (general)

Table 47: The Competition through Close Mechanistic Approximation between Cancer (general)

Table 48: Drug Target Profiles of Antibody Drugs for Cancer Diagnosis

Table 49: The Competition through Close Mechanistic Approximation between Cancer Diagnosis Drugs

Table 50: Drug Target Profiles of Antibody Drugs for the Treatment of Cancer Fatigue

Table 51: Drug Target Profiles of Antibody Drugs for the Treatment of Carcinoid Tumor

Table 52: Drug Target Profiles of Antibody Drugs for the Treatment of Cervical Cancer

Table 53: The Competition through Close Mechanistic Approximation between Cervical Cancer Drugs

Table 54: Drug Target Profiles of Antibody Drugs for the Treatment of Chemotherapy-induced Anemia

Table 55: Drug Target Profiles of Antibody Drugs for the Treatment of Chemotherapy-induced Bone Marrow Injury (general)

Table 56: Drug Target Profiles of Antibody Drugs for the Treatment of Chemotherapy-induced Injury (general)

Table 57: Drug Target Profiles of Antibody Drugs for the Treatment of Chemotherapy-induced Thrombocytopenia

Table 58: Drug Target Profiles of Antibody Drugs for the Treatment of Chronic Lymphocytic Leukemia

Table 59: The Competition through Close Mechanistic Approximation between Chronic Lymphocytic Leukemia Drugs

Table 60: Drug Target Profiles of Antibody Drugs for the Treatment of Chronic Myelogenous Leukemia

Table 61: The Competition through Close Mechanistic Approximation between Chronic Myelogenous Leukemia

Table 62: Drug Target Profiles of Antibody Drugs for the Treatment of CNS Cancer

Table 63: Drug Target Profiles of Antibody Drugs for the Treatment of Colorectal Cancer

Table 64: The Competition through Close Mechanistic Approximation between Colorectal Cancer Drugs

Table 65: Drug Target Profiles of Antibody Drugs for the Treatment of Endometrial Cancer

Table 66: Drug Target Profiles of Antibody Drugs for the Treatment of Ewing's Sarcoma

Table 67: The Competition through Close Mechanistic Approximation between Ewing's Sarcoma Drugs

Table 68: Drug Target Profiles of Antibody Drugs for the Treatment of Fallopian Tube Cancer

Table 69: Drug Target Profiles of Antibody Drugs for the Treatment of Gastrointestinal Cancer (general)

Table 70: The Competition through Close Mechanistic Approximation between Gastrointestinal Cancer (general) Drugs

Table 71: Drug Target Profiles of Antibody Drugs for the Treatment of Gastrointestinal Stomach Cancer

Table 72: The Competition through Close Mechanistic Approximation between Gastrointestinal Stomach Cancer Drugs

Table 73: Drug Target Profiles of Antibody Drugs for the Treatment of Gastrointestinal Stromal Cancer

Table 74: Drug Target Profiles of Antibody Drugs for the Treatment of Genitourinary Cancer

Table 75: The Competition through Close Mechanistic Approximation between Genitourinary Cancer Drugs . 429

Table 76: Drug Target Profiles of Antibody Drugs for the Treatment of Hairy Cell Leukemia

Table 77: Drug Target Profiles of Antibody Drugs for the Treatment of Head and Neck Cancer

Table 78: The Competition through Close Mechanistic Approximation between Head and Neck Cancer Drugs 432

Table 79: Drug Target Profiles of Antibody Drugs for the Treatment of Hematological Cancer (general)

Table 80: Drug Target Profiles of Antibody Drugs for the Treatment of Hodgkin's Lymphoma

Table 81: The Competition through Close Mechanistic Approximation between Hodgkin's Lymphoma Drugs . 435

Table 82: Drug Target Profiles of Antibody Drugs for the Treatment of Leiomyo Sarcoma

Table 83: Drug Target Profiles of Antibody Drugs for the Treatment of Leukemia (general)

Table 84: Drug Target Profiles of Antibody Drugs for the Treatment of Liver Cancer

Table 85: The Competition through Close Mechanistic Approximation between Liver Cancer Drugs

Table 86: Drug Target Profiles of Antibody Drugs for the Treatment of Lung Cancer (general)

Table 87: The Competition through Close Mechanistic Approximation between Lung Cancer (general)Drugs . 441

Table 88: Drug Target Profiles of Antibody Drugs for the Treatment of Lymphoma (general)

Table 89: Drug Target Profiles of Antibody Drugs for the Treatment of Melanoma

Table 90: The Competition through Close Mechanistic Approximation between Melanoma Drugs

Table 91: Drug Target Profiles of Antibody Drugs for the Treatment of Merkel Cell Carcinoma

Table 92: Drug Target Profiles of Antibody Drugs for the Treatment of Mesothelioma

Table 93: The Competition through Close Mechanistic Approximation between Mesothelioma Drugs

Table 94: Drug Target Profiles of Antibody Drugs for the Treatment of Myelodysplastic Syndrome

Table 95: Drug Target Profiles of Antibody Drugs for the Treatment of Myeloma

Table 96: The Competition through Close Mechanistic Approximation between Myeloma Drugs

Table 97: Drug Target Profiles of Antibody Drugs for the Treatment of Nasopharyngeal Cancer

Table 98: Drug Target Profiles of Antibody Drugs for the Treatment of Neuroblastoma

Table 99: Drug Target Profiles of Antibody Drugs for the Treatment of Neuroectodermal Sarcoma

Table 100: Drug Target Profiles of Antibody Drugs for the Treatment of Neuroendocrine Cancer (general)

Table 101: Drug Target Profiles of Antibody Drugs for the Treatment of non-Hodgkin's Lymphoma

Table 102: The Competition through Close Mechanistic Approximation between non-Hodgkin's Lymphoma Drugs

Table 103: Drug Target Profiles of Antibody Drugs for the Treatment of Non-Small Cell Lung Cancer

Table 104: The Competition through Close Mechanistic Approximation between Non-Small Cell Lung Cancer Drugs

Table 105: Drug Target Profiles of Antibody Drugs for the Treatment of Oesophageal Cancer

Table 106: The Competition through Close Mechanistic Approximation between Oesophageal Cancer

Table 107: Drug Target Profiles of Antibody Drugs for the Treatment of Osteo Sarcoma

Table 108: The Competition through Close Mechanistic Approximation between Osteo Sarcoma Drugs

Table 109: Drug Target Profiles of Antibody Drugs for the Treatment of Ovarian Cancer

Table 110: The Competition through Close Mechanistic Approximation between Ovarian Cancer Drugs

Table 111: Drug Target Profiles of Antibody Drugs for the Treatment of Pancreatic Cancer

Table 112: The Competition through Close Mechanistic Approximation between Pancreatic Cancer Drugs

Table 113: Drug Target Profiles of Antibody Drugs for the Treatment of Peritoneal Cancer

Table 114: The Competition through Close Mechanistic Approximation between Peritoneal Cancer Drugs

Table 115: Drug Target Profiles of Antibody Drugs for the Treatment of Prostate Cancer

Table 116: The Competition through Close Mechanistic Approximation between Prostate Cancer Drugs

Table 117: Drug Target Profiles of Antibody Drugs for the Treatment of Renal Cancer

Table 118: The Competition through Close Mechanistic Approximation between Renal Cancer Drugs

Table 119: Drug Target Profiles of Antibody Drugs for the Treatment of Rhabdomyo Sarcoma

Table 120: The Competition through Close Mechanistic Approximation between rhabdomyo sarcoma Drugs 478

Table 121: Drug Target Profiles of Antibody Drugs for the Treatment of Sarcoma (general)

Table 122: The Competition through Close Mechanistic Approximation between Sarcoma (general) Drugs

Table 123: Drug Target Profiles of Antibody Drugs for the Treatment of Skin Cancer (general)

Table 124: Drug Target Profiles of Antibody Drugs for the Treatment of Small Cell Lung Cancer

Table 125: The Competition through Close Mechanistic Approximation between Small Cell Lung Cancer Drugs

Table 126: Drug Target Profiles of Antibody Drugs for the Treatment of Soft Tissue Sarcoma

Table 127: Drug Target Profiles of Antibody Drugs for the Treatment of Solid Tumor

Table 128: Drug Target Profiles of Antibody Drugs for the Treatment of Squamous Cell Cancer

Table 129: Drug Target Profiles of Antibody Drugs for the Treatment of Synovial Sarcoma

Table 130: Drug Target Profiles of Antibody Drugs for the Treatment of T-cell Lymphoma

Table 131: Drug Target Profiles of Antibody Drugs for the Treatment of Testicular Cancer

Table 132: Drug Target Profiles of Antibody Drugs for the Treatment of Thyroid Cancer

Table 133: The Competition through Close Mechanistic Approximation between Thyroid Cancer Drugs

Table 134: Drug Target Profiles of Antibody Drugs for the Treatment of Unspecified Cancer Indication

Table 135: The Competition through Close Mechanistic Approximation between Unspecified Cancer Indication Drugs

Table 136: Drug Target Profiles of Antibody Drugs as Vaccine Adjunct

Table 137: A&G Pharmaceutical's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 138: Abiogen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 139: Ablynx's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 140: AC Immune's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 141: Access’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 142: Actinium Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 143: Active Biotech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 144: Adherex's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 145: Affibody's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 146: Affimed Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 147: Affitech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 148: AGY Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 149: Aida Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 150: Alder Biopharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out549

Table 151: Alethia Biotherapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 152: Alexion's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 153: Algeta's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 154: Amgen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 155: Antisoma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 156: Aphios’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 157: Arana Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 158: Arca biopharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 159: Astellas’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 160: AstraZeneca's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 161: Attenuon's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 162: AVEO's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 163: Bayer's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 164: Berkeley Lab's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 165: Biocon's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 166: Biogen Idec's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 167: BioInvent's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 168: Biolex's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 169: BioLineRx's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 170: Biosceptre's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 171: Biotecnol's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 172: Boehringer Ingelheim's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 173: Bristol-Myers Squibb's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 174: BTG's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 175: Cancer Innovations’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 176: Cancer Research Technology's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 177: Celldex Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 178: Celtic Pharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 179: Center of Molecular Immunology's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 180: CG Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 181: Circadian Technologies’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 182: CuraGen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 183: CureTech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 184: Curis’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 185: CytImmune Sciences’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 186: Daiichi Sankyo's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 187: Dendreon's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 188: Dompe's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 189: Dyax's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 190: Eisai's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 191: Elan's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 192: Eli Lilly's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 193: Epitomics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 194: EUSA Pharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 195: Facet Biotech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 196: Faron Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 197: Favrille's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 198: FibroGen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 199: Five Prime Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 200: Fusion Antibodies’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 201: Galaxy Biotech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 202: GammaCan's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 203: Ganymed Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 204: Gene Techno Science's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 205: Genentech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 206: Genmab's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 207: GenPat77's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 208: Genzyme's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 209: GlaxoSmithKline's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 210: Gliknik's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 211: Glycotope's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 212: Green Cross’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 213: GTC Biotherapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 214: Hoffmann-La Roche's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 215: Human Genome Sciences’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out 878

Table 216: IDM Pharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 217: ImClone Systems’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 218: ImmunoCellular Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 219: ImmunoGen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 220: Immunomedics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 221: Innate Pharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 222: InNexus Biotechnology's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 223: Intracel's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 224: ISA Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 225: ISU ABXIS's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 226: Johnson & Johnson's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 227: Kaketsuken's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 228: KaloBios’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 229: Kirin Pharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 230: Kissei's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 231: Kyowa Hakko Kirin's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 232: LFB Biotechnologies’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 233: MacroGenics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 234: MAT Biopharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 235: Medarex's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 236: MediGene's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 237: MedImmune's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 238: Menarini's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 239: Merck & Co's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 240: Merck KGaA's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 241: Merrimack's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 242: Micromet's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 243: MorphoSys’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 244: Neovacs’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 245: Neuren's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 246: NKT Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 247: Non-industrial source's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 248: Northwest Biotherapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 249: Novartis’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 250: OncoMed's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 251: Onyvax's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 252: Oxford BioMedica's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 253: Paladin Labs’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 254: Panacea's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 255: PanGenetics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 256: Patrys’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 257: Pepscan Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 258: Peregrine Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 259: Pfizer's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 260: Philogen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 261: Pierre Fabre's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 262: Prima Biomed's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 263: ProCell Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 264: Prochon Biotech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 265: Progenics Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 266: Protherics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 267: Ramot's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 268: Recepta biopharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 269: Receptor BioLogix's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 270: Regeneron's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 271: Sanofi-Aventis’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 272: Scancell's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 273: Seattle Genetics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 274: Sirtex Medical's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 275: Sunol Molecular's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 276: SuppreMol's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 277: Switch Pharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 278: Symphogen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 279: SynerGene Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out 1176

Table 280: Takeda's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 281: Targa Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 282: TeGenero's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 283: Teva's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 284: Therapure Biopharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out . 1193

Table 285: ThromboGenics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 286: Titan Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 287: Tolerx's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 288: Tracon Pharmaceuticals’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out 1207

Table 289: Trillium Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 290: Trion Pharma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 291: Trubion's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 292: UCB's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 293: United Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 294: Vaccinex's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 295: VasGene Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 296: Viragen's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 297: Viventia Biotech's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 298: Wilex's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 299: Xencor's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 300: Xerion's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 301: Xoma's Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Table 302: Y's Therapeutics’ Included Antibody Drug Pipeline in Oncology and Competitive Fall-Out

Abstract

The antibody market represents the fastest-growing segment within the pharmaceutical industry. As such it has become a complex and crowded market place. This is particularly true for the cancer market. When navigating in the competitive landscape of antibody therapeutics in oncology one has to consider available options for your own drug pipeline as well as the position of others.

This report comprises defined and up to date development strategies for 441 antibody drugs (993 projects) within the portfolio of 168 investigators, from Ceased to Marketed. The report extensively analyses 225 identified targets of antibody drugs, organized into 234 drug target profiles, and assesses them in 69 different cancer indications.

The report is written for you to understand and assess the impact of competitor entry and corresponding changes to development strategies for your own portfolio products. It serves as an external commercial advocate for pharmaceutical companies’ portfolio planning and new product planning by:
  • Providing you with competitive input to the R&D organization to guide development of early product ideas and ensure efforts are aligned with business objectives
  • Assisting you to make informed decisions in selecting cancer indications that are known to be appropriate for your drug's properties
  • Analyzing, correlating and integrating valuable data sources in order to provide accurate data for valuation of pipeline, in-licensing and new business opportunities
  • Providing you with commercial analytic support for due diligence on in-licensing and acquisition opportunities
  • Integrating knowledge for you to consider the therapeutic target for the highest therapeutic outcome and return on investment
This report will also be an important part of creating and implementing a market development plan for any antibody drug in oncology to ensure that the optimal market conditions exist by the time the product is commercialized.

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