Drug Delivery Technologies - Controlled Release

Published by: Espicom Healthcare Intelligence

Published: Jun. 26, 2009 - 126 Pages

Table of Contents

EXECUTIVE SUMMARY

INTRODUCTION

Overview of controlled-release delivery: past, present & future

Leading controlled-release technology platforms & characteristics

Controlled delivery profiles

Drug release profiles

Controlled-release delivery: motivators & resistors

Motivators

Controlled-Release technology motivators

Resistors

Controlled-Release technology resistors

Controlled-release delivery: impact on product lifecycles

Impact of reformulation on product life-cycle

CONTROLLED-RELEASE DELIVERY

Types of controlled-release delivery used by pharma industry

Activated controlled-release delivery

Activated controlled-release delivery - ALZA’s OROS systems

Degradation controlled-release delivery

Degradation controlled-release delivery - SkyePharma’s GEOMATRIX

Diffusion controlled-release delivery

Monolithic diffusion controlled-release delivery - LaboPharm’s Contramid

Reservoir diffusion controlled-release delivery - Impax’ CMDS

Combined controlled-release delivery - Flamel’s Micropump

Advantages and disadvantages of controlled-release platforms

Current therapeutic application of controlled-release in drug delivery

Leading brands that utilise controlled-release delivery

Leading controlled-release approved drugs

Future commercial applications & opportunities

STRATEGIES OF DRUG DELIVERY COMPANIES

Leading controlled-release drug delivery companies

Leading controlled-release drug delivery companies

Partnerships & acquisitions

Strategic developmental & commercialisation partnerships

Merger & acquisitions

Recent partnerships & acquisitions in the controlled-release field

Intellectual Property

Controlled-Release patents

THE CONTROL LED -RELEASE MARKET

Now 2009

Approved controlled-release product sales

Future 2018

Global controlled-release product sales

Novel controlled-release product sales

COMPETITOR ANALYSIS

Movers & Shakers: Cutting edge or losing their grip

Movers & shakers in controlled-release drug delivery systems

COMPANY PROFILES

AlphaRx Corporation (www.alpharx.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

AlphaRx’ product pipeline

Sales forecasts of products utilising the delivery technology

AlphaRx’ drug delivery sales

Competitor Ratio Analysis

ALZA Corporation (www.alza.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

ALZA’s product pipeline

Sales forecasts of products utilising the delivery technology

ALZA’s drug delivery sales

Competitor Ratio Analysis

Antares Pharma, Inc. (www.antarespharma.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Antares’ product pipeline

Sales forecasts of products utilising the delivery technology

Antares’ drug delivery sales

Competitor Ratio Analysis

Biovail Corporation (www.Biovail.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Biovail’s product pipeline

Sales forecasts of products utilising the delivery technology

Biovail’s drug delivery sales

Competitor Ratio Analysis

Camurus AB (www.camurus.se)

Proprietary delivery technology

Camurus’ FluidCrystal CR technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Camurus AB’s product pipeline

Sales forecasts of products utilising the delivery technology

Camurus AB’s drug delivery sales

Competitor Ratio Analysis

Cerulean Pharma Inc (www.ceruleanrx.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Cerulean’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Cipher Pharmaceuticals, Inc. (www.cipherpharma.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Cipher’s product pipeline

Sales forecasts of products utilising the delivery technology

Cipher’s drug delivery sales

Competitor Ratio Analysis

Debiopharm Group (www.debio.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Debiopharm’s product pipeline

Sales forecasts of products utilising the delivery technology

DebioPharm’s drug delivery sales

Competitor Ratio Analysis

DelSite Biotechnologies, Inc. (www.delsite.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

DelSite’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Depomed, Inc. (www.depomedinc.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Depomed’s product pipeline

Sales forecasts of products utilising the delivery technology

Depomed’s product sales

Competitor Ratio Analysis

Durect Corporation (www.Durect.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Durect’s product pipeline

Sales forecasts of products utilising the delivery technology

Durect’s product sales

Competitor Ratio Analysis

Elan Corporation (www.elan.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Elan’s product pipeline

Sales forecasts of products utilising the delivery technology

Elan’s drug delivery sales

Competitor Ratio Analysis

Elite Pharmaceuticals, Inc. (www.elitepharma.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Elite’s product pipeline

Sales forecasts of products utilising the delivery technology

Elite’s product sales

Competitor Ratio Analysis

Endo Pharmaceuticals, Inc. (www.endo.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Endo’s product pipeline

Sales forecasts of products utilising the delivery technology

Endo’s product sales

Competitor Ratio Analysis

Ethypharm SA (www.ethypharm.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Ethypharm’s product pipeline

Sales forecasts of products utilising the delivery technology

Ethypharm’s product sales

Competitor Ratio Analysis

Eurand (www.eurand.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Eurand’s product pipeline

Sales forecasts of products utilising the delivery technology

Eurand’s product sales

Competitor Ratio Analysis

Flamel Technologies, Inc. (www.flamel.com)

Proprietary delivery technology

Flamel’s Medusa technology

Flamel’s Micropump technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Flamel’s product pipeline

Sales forecasts of products utilising the delivery technology

Flamel’s product sales

Competitor Ratio Analysis

Glycologic, Ltd (www.glycologic.co.uk)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Glycologic’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

KV Pharmaceuticals, Inc (www.kvpharmaceutical.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

KV’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Labopharm, Inc. (www.labopharm.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Labopharm’s product pipeline

Sales forecasts of products utilising the delivery technology

Labopharm’s product sales

Competitor Ratio Analysis

Lavipharm SA (www.lavipharm.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Lavipharm’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Nano Interface Technology (www.nanointerfacetech.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

NITI’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

OctoPlus N.V. (www.octoplus.nl)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

OctoPlus’ product pipeline

Sales forecasts of products utilising the delivery technology

OctoPlus’ product sales

Competitor Ratio Analysis

Penwest Pharmaceuticals (www.penw.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Penwest’s product pipeline

Sales forecasts of products utilising the delivery technology

Penwest’s product sales

Competitor Ratio Analysis

SCOLR Pharma, Inc. (www.scolr.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

SCOLR’s product pipeline

Sales forecasts of products utilising the delivery technology

SCOLR’s drug delivery sales

Competitor Ratio Analysis

Shire, Plc (www.shire.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Shire’s product pipeline

Sales forecasts of products utilising the delivery technology

Shire’s leading drug delivery product sales

Competitor Ratio Analysis

Skinvisible, Inc. (www.skinvisible.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Skinvisible’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

SkyePharma (www.skyepharma.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

SkyePharma’s product pipeline

Sales forecasts of products utilising the delivery technology

SkyePharma’s product sales

Competitor Ratio Analysis

Spherics (www.spherics.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Spheric’s product pipeline

Sales forecasts of products utilising the delivery technology

Spheric’s product sales

Competitor Ratio Analysis

Watson Pharmaceuticals (www.watson.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Watson’s product pipeline

Sales forecasts of products utilising the delivery technology

Watson’ drug delivery sales

Competitor Ratio Analysis

APPENDIX 1

Global controlled-release approved drugs sales 2008-2018 (US$million)

APPENDIX 2

Global controlled-release developmental drugs sales 2008-2018 (US$million)

APPENDIX 3

Competitor Ratio Analysis Criteria

Key Controlled-release delivery companies by 2015

BIBLIOGRAPHY

GLOSSARY

ACRONYMS

Endnotes

Abstract

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