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Published by: Global Industry Analysts
Published: Jul. 1, 2009 - 723 Pages
Table of Contents
- I.INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
- Study Reliability and Reporting Limitations
- Disclaimers
- Data Interpretation & Reporting Level
- Quantitative Techniques & Analytics
- Product Definition and Scope of Study
- Rheumatoid Arthritis
- Multiple Sclerosis
- Psoriasis
- Crohn's disease
- II. EXECUTIVE SUMMARY
- 1.INDUSTRY OVERVIEW & OUTLOOK
- Autoimmune Disease Therapeutics Market Continuesto Flourish
- Pharmaceutical Industry Hit by Economic Downturn
- Credit Crunch to Affect Biological Drug Pipeline
- Biotech Bankruptcies Rife in the Current EconomicDownturn
- Economic Downturn Takes Toll on R&D
- Global Market Estimates and Forecasts
- Analysis by Region
- Analysis by Segment
- 2.MARKET DYNAMICS AND TRENDS
- Biologics Continue to Gain Market Share
- New Products to Drive Market Growth
- Biogenerics to Expand Adoption of Biological Drugs
- New Indications to Fuel Market Growth
- Superior Outcomes to Enhance Adoption of Biologics
- Efficacy and Convenience - Key Factors DrivingPhysician’s Decision
- 3.DISEASE OVERVIEW
- Immunity and Immune System
- Autoimmune Diseases
- Women- Highly Susceptible to Autoimmune Diseases
- Table 1: Percentage Breakdown of Incidence ofAutoimmune Diseases in Men and Women(includes corresponding Graph/Chart)
- Complexity in Manifestations Renders Difficulty inUnderstanding the Conditions
- Etiology of Autoimmune Diseases
- Genetic Predisposition
- Environmental Factors
- Autoimmune Diseases - A Social and Health Burden
- Regulatory Glitches and High Costs Hinder Biogenerics
- Types of Autoimmune Diseases
- Incidence and Prevalence
- Diagnosis and Treatment of Autoimmune Diseases
- Overview on Select Biologic Drugs
- Remicade
- Humira
- Rituxan® (rituximab)
- Cimzia
- Cimzia to Face Stiff Competition in RheumatoidArthritis Market
- Psoriasis - A Promising Market for Cimzia
- Actemra
- Enbrel
- 4.OVERVIEW OF SELECT AUTOIMMUNEDISEASES
- Rheumatoid Arthritis
- Disease Overview
- Low Penetration to Sustain growth of Anti-TNF Drugs
- Incidence and Prevalence Higher in Urban andDeveloped Regions
- Diagnosis
- Treatment of Rheumatoid Arthritis
- BRMs Revolutionize RA Treatment
- Drugs Used in Treating Rheumatoid Arthritis
- Table 2: Leading Biologic Drugs for Rheumatoid Arthritis Worldwide (2007): Value Sales for Enbrel, Remicade, Humira, Orencia, Rituxan and Kineret (US$ Million)
- Year of Approval of Leading Biologics in RheumatoidArthritis Therapy
- Key Drugs In Late Stage Development for RheumatoidArthritis Treatment
- Competitive Landscape
- Table 3: Comparative Analysis of Leading Biologic Rheumatoid Arthritis Drugs based on ACR Scoresby End Point
- High Prices and Safety Concerns
- Multiple Sclerosis
- Etiology
- Types of Multiple Sclerosis
- Table 4: Prevalence of Different Types ofMultiple Sclerosis
- Pathology
- Prevalence of Multiple Sclerosis High in Women
- Facts About Multiple Sclerosis
- Treatment
- Interferon Drugs - High Efficacy Drugs in ExistingMS Therapies
- Beta Interferon Drugs in Multiple SclerosisTreatment
- Non-Interferon Drugs
- Non-Interferon Drugs in Multiple SclerosisTreatment
- Trends in Multiple Sclerosis Market
- High Unmet Need and Rich Pipeline to Expand MSMarket
- Interferon-based Drugs Lead Multiple SclerosisDrug Market
- Oral Drugs in Pipeline to Alter Market Dynamics inMS Therapies
- Dip in Sales Inevitable for Current Therapies
- Tough Times Ahead for Betaseron
- Competitive Landscape
- Table 5: Leading Multiple Sclerosis Drugs Worldwide(2007) by Sales: Avonex, Rebif, Copaxone, Betaseronand Tysabri (includes corresponding Graph/Chart)
- Table 6: Leading Multiple Sclerosis Drugs Worldwide(2000, 2003 and 2006): Market Shares forAvonex, Rebif, Copaxone, Betaseron and Tysabri(includes corresponding Graph/Chart)
- Multiple Sclerosis Drug Pipeline - An Overview
- Drugs Under Development for Treating MultipleSclerosis
- FTY 720 (Fingolimod)
- Mylinax
- Laquinimod
- Campath (Alemtuzumab) - Trials Marred with SideEffects
- Teriflunomide
- Fampridine-SR
- BG-12 (Oral Fumarate)
- MN-166
- Psoriasis
- Prevalence
- Available Treatment Options
- Biological Drugs Lead the Fray
- Table 7: Leading Psoriasis Drugs Worldwide (2005): Market Share by Value Sales for Biologics (Enbrel,Raptiva and Amevive), Systemic Drugs, and Topicals (includes corresponding Graph/Chart)
- Inflammatory Bowel Diseases
- Crohn's disease
- Stages of the Disease
- Prevalence
- Diagnosis
- Treatment
- Global Crohn’s Disease Therapeutics Market:Leading Biological Drugs and their Worldwide
- Year of Approval for Leading Drugs in Crohn’sDisease Treatment
- Ulcerative Colitis
- Diagnosis and Treatment
- Other Diseases
- Systemic Lupus Erythematosus (SLE)
- Prevalence and Epidemiology
- Treatment
- Sjogren's Syndrome
- Prevalence and Epidemiology
- Diagnosis and Treatment
- Type-1 Diabetes Mellitus
- Types of Diabetes Mellitus
- Type 1 or Insulin Dependent Diabetes Mellitus
- Type 2 or Non-Insulin Dependent Diabetes Mellitus
- Insulin - Vital for Blood Glucose Management
- Etiology
- Prevalence
- Diabetes in Children - A Growing Concern
- Diagnosis and Treatment
- Autoimmune Hepatitis
- Disease Categories
- Treatment
- Side Effects
- Juvenile Rheumatoid Arthritis
- Symptoms
- Diagnosis
- Scleroderma
- Prevalence
- Etiology
- Diagnosis
- Management
- Vasculitis Syndeomes
- Haematologic Autoimmune Diseases
- Ankylosing Spondylitis
- 5.PRODUCT INTRODUCTIONS/APPROVALS
- Cimzia® Receives FDA Approval for TreatingRheumatoid Arthritis
- Simponi™ Receives FDA Approval for TreatingRheumatoid Arthritis
- HUMIRA® Obtains EU Approval for PolyarticularJuvenile Idiopathic Arthritis
- Cimzia® Receives FDA Nod for Treating Crohn’s Disease
- HUMIRA® Obtains Approval from Japanese Ministryfor Rheumatoid Arthritis
- HUMIRA® Receives FDA Clerance for PolyarticularJuvenile Idiopathic Arthritis
- Abbott Receives EU Marketing Authorization for Humirain Psoriasis Treatment
- Xian-Janssen Introduces Remicade, Branded infliximabin China
- HUMIRA® Obtains EU Approval for Treating Crohn’sDisease
- HUMIRA® Obtains FDA Approval for Crohn’s Disease
- Remicade® Obtains Approval for Use in PsA andEarly RA in Australia
- Tysabri™ Receives Health Canada Approval for Usein Multiple Sclerosis
- Rituxan® Gets FDA Approval for Use in RA
- Humira® Obtains FDA Approval for Treating AS
- Betaseron® Receives FDA Approval for Use in FirstClinical Episode of MS
- Abbott Receives FDA Clearance for HUMIRA Pen
- Remicade Obtains FDA Approval for Treating PediatricCrohn`s Disease
- 6.RECENT INDUSTRY ACTIVITY
- Novo Nordisk and VLST Collaborate on TherapeuticTargets Development
- Actemra’s Approval Gets Delayed
- Apitope Raises Financing for Developing MultipleSclerosis Compound
- CalciMedica to Acquire Rights to STIM1 from TorreyPines
- Roche Acquires ARIUS Research, Inc.
- Astellas Inks Agreement with Maxygen for MAXY-4Candidates
- Carna and Caliper Life Sciences Ink Collaborative SupplyAgreement
- Isotechnika Gets Back Worldwide Rights to TransplantDrug, Voclosporin
- Boehringer In-licenses Two Drug Targets from BioFocus
- Bionomics Enters into a Development and LicensingAgreement with Merck Serono
- Nycomed Inks Agreement with Immunomedics forVeltuzumab
- EpiVax Receives Grants from National Institutes ofHealth to Advance Epi-13
- Boehringer to Takeover Actimis
- Antisoma Acquires Xanthus Pharmaceuticals
- Merrimack Acquires Funds for Developing Cancer andAutoimmune Disease Biologics
- BioSeek and Merck Sign Collaboration Agreement forCompound Evaluation
- Questcor Amends Distribution Contract with US Distributorof Acthar
- ANP Completes Phase IIa Trial for Multiple Sclerosis Drug
- Insert and Calando Merge to Form Calando Pharmaceuticals
- Codon Inks Research & Development and LicensingDeal with Merrimack
- Debiopharm Inks licensing Deal with Airmid forDebio 0824 ShK Peptide
- Chelsea Acquires Global Rights to I-3D Range ofDHODH Inhibiting Compounds
- Cypress Bioscience Acquires Proprius
- J&J PRD Grants Milestone Payment to SunesisPharmaceuticals
- GlaxoSmithKline Acquires License to Market Vaccinex’sAntibody
- Teva to Takeover CoGenesys
- Hadasit, HMS and BWH to Co-develop Oral Therapyfor Autoimmune Diseases
- Anthera Acquires Rights to Develop and MarketAMG 623 from Amgen
- Can-Fite Enters into Two Cooperation Agreements toDevelop CF102 Drug
- Source MDx Inks an Agreement with Pfizer
- Cambridge Inks an Antibody Development Agreementwith Medarex
- Pfizer to Acquire Coley Pharma
- GSK Joins Hands with Tolerx to Develop andCommercialize otelixizumab
- Amgen Acquires Avidia
- Eli Lilly and MacroGenics Tie Up for DevelopingTeplizumab
- MorphoSys and Genesis Ink Antibody R&D Deal
- arGentis Enters into a License Agreement with UTRF
- Eden Biodesign to Investigate Novel Drug Candidatefor Autoimmune Diseases
- Nuon and Kissei Team up for Tranilast
- Organon and Dyax Team Up for DevelopingTherapeutic Antibodies
- Medarex Joins Hands with Mitsubishi for MonoclonalAntibody Development
- Merck and Archemix Collaborate
- Genzyme Takes Over Bioenvision
- Organon and Medarex Ink Drug Development Deal
- CalciMedica Secures Exclusive Rights for CBR’sAutoimmune Drug Target
- Xanthus Secures Exclusive Patent Estate Rights forFLT3 Pathway
- Eisai Corporation Acquires Morphotek
- TIRC Changes Name to Orchestra Therapeutics
- Abbott Files HUMIRA® for Psoriasis in the USand EU (USA/Europe)
- Accentia Secures Exclusive Global Rights to Revimmune
- Medarex and Compugen Ink Collaborative Agreementfor Therapeutic Antibody
- SRI and Telik Sign License Agreement for Drug Development
- China Biopharma Signs Agreement with ChineseBiopharmaceutical Firm
- Kirin and Astellas Ink Licensing Agreement forAnti-CD40 Antagonistic mAb
- QSV and Artielle Sign Contract to Produce RTL-1000
- JDRF and MacroGenics Form Partnership
- GSK and Genmad Sign Partnership Agreementfor HuMaxCD20
- Biocon Enters into Joint Venture Agreement withNeopharma
- Pipex Pharmaceuticals Acquires Remaining Stake inEffective Pharmaceuticals
- Astellas Acquires Worldwide Rights for Amevive®
- Biogen Acquires Fumapharm
- Biogen and UCB Join Hands for Oral Multiple SclerosisTherapy
- 7.FOCUS ON SELECT GLOBAL PLAYERS
- Abbott Laboratories (USA)
- Amgen Inc. (USA)
- Bayer Schering Pharma AG (Germany)
- Biogen Idec Inc. (USA)
- Bristol-Myers Squibb Company (USA)
- Elan Corporation, plc (Ireland)
- Eli Lilly And Company (USA)
- F. Hoffmann-La Roche AG (Switzerland)
- Chugai Pharmaceutical Co., Ltd. (Japan)
- Genentech, Inc. (USA)
- GlaxoSmithKline plc (UK)
- Johnson & Johnson, Inc. (USA)
- Merck Serono SA (Switzerland)
- Novartis AG (Switzerland)
- Sanofi-aventis SA (France)
- Schering-Plough Corporation (USA)
- Shire Pharmaceuticals Group plc (Ireland)
- Teva Pharmaceuticals Industries Limited (Israel)
- UCB Pharma (Belgium)
- 8.GLOBAL MARKET PERSPECTIVE
- Table 8: World Recent Past, Current & Future Analysisfor Autoimmune Disease Therapeutics by GeographicRegion - US, Japan, Europe and Rest of World MarketsIndependently Analyzed with Annual Sales in US$Billion for Years 2006 through 2015 (includescorresponding Graph/Chart)
- Table 9: World 10-year Perspective for AutoimmuneDisease Therapeutics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe andRest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)
- Table 10: World Recent Past, Current & Future Analysisfor Rheumatoid Arthritis Therapeutics by Geographic Region - US, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)
- Table 11: World 10-year Perspective for RheumatoidArthritis Therapeutics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe andRest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)
- Table 12: World Recent Past, Current & Future Analysisfor Multiple Sclerosis Therapeutics by Geographic Region -US, Japan, Europe and Rest of World- MarketsIndependently Analyzed with Annual Sales in US$Billion for Years 2006 through 2015 (includescorresponding Graph/Chart)
- Table 13: World 10-year Perspective for MultipleSclerosis Therapeutics by Geographic Region -Percentage Breakdown of Dollar Sales for US, Japan,Europe and Rest of World Markets for Years 2006, 2009 &2015 (includes corresponding Graph/Chart)
- Table 14: World Recent Past, Current & Future Analysis for Psoriasis Therapeutics by Geographic Region - US, Japan, Europe and Rest of World- Markets Independently Analyzedwith Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)
- Table 15: World 10-year Perspective for PsoriasisTherapeutics by Geographic Region - Percentage Breakdownof Dollar Sales for US, Japan, Europe and Rest of WorldMarkets for Years 2006, 2009 & 2015 (includescorresponding Graph/Chart)
- Table 16: World Recent Past, Current & Future Analysis for Crohn’s Disease Therapeutics (Biologics) by Geographic Region - US, Japan, Europe and Rest of World- Markets Independently Analyzed with Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)
- Table 17: World 10-year Perspective for Crohn’s Disease Therapeutics (Biologics) by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe andRest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)
- Table 18: World Recent Past, Current & Future Analysis for Other Autoimmune Disease Therapeutics by GeographicRegion - US, Japan, Europe and Rest of World- Markets Independently Analyzed with Annual Sales in US$Billion for Years 2006 through 2015 (includescorresponding Graph/Chart)
- Table 19: World 10-year Perspective for Other Autoimmune Disease Therapeutics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europeand Rest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)
- III. MARKET
- 1.THE UNITED STATES
- A. Market Analysis
- Current and Future Analysis
- Autoimmune Diseases Fact Sheet
- Table 20: Prevalence of Key AutoimmuneDiseases in the US for 2006 (in Millions)(includes corresponding Graph/Chart)
- Market Trends
- Biologic Drugs Lead the Fray
- Biologics To Add Further Impetus to the Market
- Rheumatoid Arthritis Drugs Lead the Market
- Enbrel and Humira Continue to Gain Share in theAnti-TNF Market
- Increased Incidence and Rise in Drug Prices toDrive Growth in MS Market
- Table 21: US Multiple Sclerosis Drug Market (2006): Percentage Breakdown of Number of Dispensed Prescriptions for Avonex, Copaxone, Rebif,Betaseron and Tysabri (includes corresponding Graph/Chart)
- Incidence of Type 1 Diabetes Mellitus Endemicin White Youth
- Lialda’s Share Gaining Momentum in UlcerativeColitis Drugs Market
- Key Ulcerative Colitis Drugs Market in theUS (2006)
- Table 22: US Ulcerative Colitis Drugs Market(2007 & 2008): Percentage Breakdown ofPrescriptions Dispensed Ranked by LeadingDrugs for Asacol, Pentasa, Lialda, Canasa, Sulphasalazine, Colazal, Other Drugs andGenerics (includes corresponding Graph/Chart)
- Product Launches/ Approvals
- Strategic Corporate Developments
- Key Players
- B. Market Analytics
- Table 23: US Recent Past, Current & FutureAnalysis for Autoimmune DiseaseTherapeutics by Disease Segment - RheumatoidArthritis, Multiple Sclerosis, Psoriasis, Crohn’sDisease (Biologics) and Other Autoimmune DiseasesIndependently Analyzed with Annual Salesin US$ Billion for Years 2006 through 2015(includes corresponding Graph/Chart)
- Table 24: US 10-year Perspective forAutoimmune Disease Therapeutics by DiseaseSegment - Percentage Breakdown of DollarSales for Rheumatoid Arthritis, Multiple Sclerosis,Psoriasis, Crohn’s Disease (Biologics) and Other Autoimmune Diseases for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)
- 2.JAPAN
- A. Market Analysis
- Current and Future Analysis
- Product Launches/Approvals
- Key Players
- B. Market Analytics
- Table 25: Japanese Recent Past, Current & FutureAnalysis for Autoimmune Disease Therapeutics byDisease Segment - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics) and Other Autoimmune Diseases Independently Analyzed with Annual Sales in US$ Billion for Years 2006 through 2015 (includes corresponding Graph/Chart)
- Table 26: Japanese 10-year Perspective for Autoimmune Disease Therapeutics by Disease Segment - Percentage Breakdown of Dollar Sales for Rheumatoid Arthritis,Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics)and Other Autoimmune Diseases for Years 2006, 2009 &2015 (includes corresponding Graph/Chart)
- 3.EUROPE
- A. Market Analysis
- Current and Future Analysis
- Europe - A Burgeoning Market for AutoimmuneDisease Therapeutics
- Increasing Awareness to Drive Market Growth
- Low Penetration to Fuel Growth in EuropeanMS DMDs Market
- Table 27: Prevalence of Key AutoimmuneDiseases in Europe for 2006 in Millions(includes corresponding Graph/Chart)
- Lower Treatment Rate Bodes Huge Potential forthe UK MS Drug Market
- Drugs Hindering Disease Progression to GainProminence
- Product Launches/Approvals
- Strategic Corporate Developments
- Key Players
- B. Market Analytics
- Table 28: European Recent Past, Current & FutureAnalysis for Autoimmune Disease Therapeutics by Disease Segment - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics) and Other Autoimmune Diseases Independently Analyzed withAnnual Sales in US$ Billion for Years 2006 through2015 (includes corresponding Graph/Chart)
- Table 29: European 10-year Perspective forAutoimmune Disease Therapeutics byDisease Segment - Percentage Breakdown ofDollar Sales for Rheumatoid Arthritis, MultipleSclerosis, Psoriasis, Crohn’s Disease (Biologics) andOther Autoimmune Diseases for Years 2006, 2009 &2015 (includes corresponding Graph/Chart)
- 4.REST OF WORLD
- A. Market Analysis
- Current and Future Analysis
- Canada
- Canada - Highest Prevalence Rates for MultipleSclerosis
- Sales of Biologics on the Rise in CanadianRheumatoid Arthritis Drugs Market
- Asia-Pacific
- Autoimmune Diseases Market in Asia-Pacific -An Overview
- Incidence of Multiple Sclerosis in India on the Rise
- Overview of Rheumatoid Arthritis in Australia
- Table 30: Percentage Breakdown of Prevalence of Rheumatoid Arthritis in Australia by Age Group (includes corresponding Graph/Chart)
- Table 31: Percentage Breakdown ofPrevalence of Rheumatoid Arthritis inAustralia by Sex (includes corresponding Graph/Chart)
- Overview of Irritable Bowel Diseases in Australia
- Product Launches/Approvals
- Strategic Corporate Developments
- B. Market Analytics
- Table 32: Rest of World Recent Past, Current & Future Analysis for Autoimmune Disease Therapeuticsby Disease Segment - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics) andOther Autoimmune Diseases Independently Analyzedwith Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)
- Table 33: Rest of World 10-year Perspective forAutoimmune Disease Therapeutics by DiseaseSegment - Percentage Breakdown of Dollar Sales for Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis,Crohn’s Disease (Biologics) and Other AutoimmuneDiseases for Years 2006, 2009 & 2015 (includescorresponding Graph/Chart)
- IV. COMPETITIVE LANDSCAPE
- Total Companies Profiled: 115 (including Divisions/Subsidiaries - 122)
- Region/Country Players
- The United States
- Canada
- Japan
- Europe
- France
- Germany
- The United Kingdom
- Rest of Europe
- Asia-Pacific (Excluding Japan)
AbstractThis report analyzes the worldwide markets for Autoimmune Disease Therapeutics in US$ Billion by the following therapeutic class - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn's Disease (Biologics only), and Others. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual forecasts are provided for each region for the period 2006 through 2015. The report profiles 115 companies including many key and niche players worldwide such as Abbott Laboratories, Amgen Inc., Bayer Schering Pharma AG, Biogen Idec Inc., Bristol-Myers Squibb Company, Elan Corporation, plc, Eli Lilly And Company, F. Hoffmann-La Roche AG, Chugai Pharmaceutical Co., Ltd., Genentech, Inc., GlaxoSmithKline plc, Johnson & Johnson, Inc., Merck Serono SA, Novartis AG, Sanofi-aventis SA , Schering-Plough Corporation, Shire Pharmaceuticals Group plc, Teva Pharmaceuticals Industries Limited, and UCB Pharma. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.
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