Providing market research reports, industry analysis, company profiles and country reports for strategic planning, competitive intelligence, marketing and business research.
Search for Market Research Reports:    

Autoimmune Disease Therapeutics

Published by: Global Industry Analysts

Published: Jul. 1, 2009 - 723 Pages


Table of Contents


I.INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definition and Scope of Study

Rheumatoid Arthritis

Multiple Sclerosis

Psoriasis

Crohn's disease

II. EXECUTIVE SUMMARY

1.INDUSTRY OVERVIEW & OUTLOOK

Autoimmune Disease Therapeutics Market Continuesto Flourish

Pharmaceutical Industry Hit by Economic Downturn

Credit Crunch to Affect Biological Drug Pipeline

Biotech Bankruptcies Rife in the Current EconomicDownturn

Economic Downturn Takes Toll on R&D

Global Market Estimates and Forecasts

Analysis by Region

Analysis by Segment

2.MARKET DYNAMICS AND TRENDS

Biologics Continue to Gain Market Share

New Products to Drive Market Growth

Biogenerics to Expand Adoption of Biological Drugs

New Indications to Fuel Market Growth

Superior Outcomes to Enhance Adoption of Biologics

Efficacy and Convenience - Key Factors DrivingPhysician’s Decision

3.DISEASE OVERVIEW

Immunity and Immune System

Autoimmune Diseases

Women- Highly Susceptible to Autoimmune Diseases

Table 1: Percentage Breakdown of Incidence ofAutoimmune Diseases in Men and Women(includes corresponding Graph/Chart)

Complexity in Manifestations Renders Difficulty inUnderstanding the Conditions

Etiology of Autoimmune Diseases

Genetic Predisposition

Environmental Factors

Autoimmune Diseases - A Social and Health Burden

Regulatory Glitches and High Costs Hinder Biogenerics

Types of Autoimmune Diseases

Incidence and Prevalence

Diagnosis and Treatment of Autoimmune Diseases

Overview on Select Biologic Drugs

Remicade

Humira

Rituxan® (rituximab)

Cimzia

Cimzia to Face Stiff Competition in RheumatoidArthritis Market

Psoriasis - A Promising Market for Cimzia

Actemra

Enbrel

4.OVERVIEW OF SELECT AUTOIMMUNEDISEASES

Rheumatoid Arthritis

Disease Overview

Low Penetration to Sustain growth of Anti-TNF Drugs

Incidence and Prevalence Higher in Urban andDeveloped Regions

Diagnosis

Treatment of Rheumatoid Arthritis

BRMs Revolutionize RA Treatment

Drugs Used in Treating Rheumatoid Arthritis

Table 2: Leading Biologic Drugs for Rheumatoid Arthritis Worldwide (2007): Value Sales for Enbrel, Remicade, Humira, Orencia, Rituxan and Kineret (US$ Million)

Year of Approval of Leading Biologics in RheumatoidArthritis Therapy

Key Drugs In Late Stage Development for RheumatoidArthritis Treatment

Competitive Landscape

Table 3: Comparative Analysis of Leading Biologic Rheumatoid Arthritis Drugs based on ACR Scoresby End Point

High Prices and Safety Concerns

Multiple Sclerosis

Etiology

Types of Multiple Sclerosis

Table 4: Prevalence of Different Types ofMultiple Sclerosis

Pathology

Prevalence of Multiple Sclerosis High in Women

Facts About Multiple Sclerosis

Treatment

Interferon Drugs - High Efficacy Drugs in ExistingMS Therapies

Beta Interferon Drugs in Multiple SclerosisTreatment

Non-Interferon Drugs

Non-Interferon Drugs in Multiple SclerosisTreatment

Trends in Multiple Sclerosis Market

High Unmet Need and Rich Pipeline to Expand MSMarket

Interferon-based Drugs Lead Multiple SclerosisDrug Market

Oral Drugs in Pipeline to Alter Market Dynamics inMS Therapies

Dip in Sales Inevitable for Current Therapies

Tough Times Ahead for Betaseron

Competitive Landscape

Table 5: Leading Multiple Sclerosis Drugs Worldwide(2007) by Sales: Avonex, Rebif, Copaxone, Betaseronand Tysabri (includes corresponding Graph/Chart)



Table 6: Leading Multiple Sclerosis Drugs Worldwide(2000, 2003 and 2006): Market Shares forAvonex, Rebif, Copaxone, Betaseron and Tysabri(includes corresponding Graph/Chart)

Multiple Sclerosis Drug Pipeline - An Overview

Drugs Under Development for Treating MultipleSclerosis

FTY 720 (Fingolimod)

Mylinax

Laquinimod

Campath (Alemtuzumab) - Trials Marred with SideEffects

Teriflunomide

Fampridine-SR

BG-12 (Oral Fumarate)

MN-166

Psoriasis

Prevalence

Available Treatment Options

Biological Drugs Lead the Fray

Table 7: Leading Psoriasis Drugs Worldwide (2005): Market Share by Value Sales for Biologics (Enbrel,Raptiva and Amevive), Systemic Drugs, and Topicals (includes corresponding Graph/Chart)

Inflammatory Bowel Diseases

Crohn's disease

Stages of the Disease

Prevalence

Diagnosis

Treatment

Global Crohn’s Disease Therapeutics Market:Leading Biological Drugs and their Worldwide

Year of Approval for Leading Drugs in Crohn’sDisease Treatment

Ulcerative Colitis

Diagnosis and Treatment

Other Diseases

Systemic Lupus Erythematosus (SLE)

Prevalence and Epidemiology

Treatment

Sjogren's Syndrome

Prevalence and Epidemiology

Diagnosis and Treatment

Type-1 Diabetes Mellitus

Types of Diabetes Mellitus

Type 1 or Insulin Dependent Diabetes Mellitus

Type 2 or Non-Insulin Dependent Diabetes Mellitus

Insulin - Vital for Blood Glucose Management

Etiology

Prevalence

Diabetes in Children - A Growing Concern

Diagnosis and Treatment

Autoimmune Hepatitis

Disease Categories

Treatment

Side Effects

Juvenile Rheumatoid Arthritis

Symptoms

Diagnosis

Scleroderma

Prevalence

Etiology

Diagnosis

Management

Vasculitis Syndeomes

Haematologic Autoimmune Diseases

Ankylosing Spondylitis

5.PRODUCT INTRODUCTIONS/APPROVALS

Cimzia® Receives FDA Approval for TreatingRheumatoid Arthritis

Simponi™ Receives FDA Approval for TreatingRheumatoid Arthritis

HUMIRA® Obtains EU Approval for PolyarticularJuvenile Idiopathic Arthritis

Cimzia® Receives FDA Nod for Treating Crohn’s Disease

HUMIRA® Obtains Approval from Japanese Ministryfor Rheumatoid Arthritis

HUMIRA® Receives FDA Clerance for PolyarticularJuvenile Idiopathic Arthritis

Abbott Receives EU Marketing Authorization for Humirain Psoriasis Treatment

Xian-Janssen Introduces Remicade, Branded infliximabin China

HUMIRA® Obtains EU Approval for Treating Crohn’sDisease

HUMIRA® Obtains FDA Approval for Crohn’s Disease

Remicade® Obtains Approval for Use in PsA andEarly RA in Australia

Tysabri™ Receives Health Canada Approval for Usein Multiple Sclerosis

Rituxan® Gets FDA Approval for Use in RA

Humira® Obtains FDA Approval for Treating AS

Betaseron® Receives FDA Approval for Use in FirstClinical Episode of MS

Abbott Receives FDA Clearance for HUMIRA Pen

Remicade Obtains FDA Approval for Treating PediatricCrohn`s Disease

6.RECENT INDUSTRY ACTIVITY

Novo Nordisk and VLST Collaborate on TherapeuticTargets Development

Actemra’s Approval Gets Delayed

Apitope Raises Financing for Developing MultipleSclerosis Compound

CalciMedica to Acquire Rights to STIM1 from TorreyPines

Roche Acquires ARIUS Research, Inc.

Astellas Inks Agreement with Maxygen for MAXY-4Candidates

Carna and Caliper Life Sciences Ink Collaborative SupplyAgreement

Isotechnika Gets Back Worldwide Rights to TransplantDrug, Voclosporin

Boehringer In-licenses Two Drug Targets from BioFocus

Bionomics Enters into a Development and LicensingAgreement with Merck Serono

Nycomed Inks Agreement with Immunomedics forVeltuzumab

EpiVax Receives Grants from National Institutes ofHealth to Advance Epi-13

Boehringer to Takeover Actimis

Antisoma Acquires Xanthus Pharmaceuticals

Merrimack Acquires Funds for Developing Cancer andAutoimmune Disease Biologics

BioSeek and Merck Sign Collaboration Agreement forCompound Evaluation

Questcor Amends Distribution Contract with US Distributorof Acthar

ANP Completes Phase IIa Trial for Multiple Sclerosis Drug

Insert and Calando Merge to Form Calando Pharmaceuticals

Codon Inks Research & Development and LicensingDeal with Merrimack

Debiopharm Inks licensing Deal with Airmid forDebio 0824 ShK Peptide

Chelsea Acquires Global Rights to I-3D Range ofDHODH Inhibiting Compounds

Cypress Bioscience Acquires Proprius

J&J PRD Grants Milestone Payment to SunesisPharmaceuticals

GlaxoSmithKline Acquires License to Market Vaccinex’sAntibody

Teva to Takeover CoGenesys

Hadasit, HMS and BWH to Co-develop Oral Therapyfor Autoimmune Diseases

Anthera Acquires Rights to Develop and MarketAMG 623 from Amgen

Can-Fite Enters into Two Cooperation Agreements toDevelop CF102 Drug

Source MDx Inks an Agreement with Pfizer

Cambridge Inks an Antibody Development Agreementwith Medarex

Pfizer to Acquire Coley Pharma

GSK Joins Hands with Tolerx to Develop andCommercialize otelixizumab

Amgen Acquires Avidia

Eli Lilly and MacroGenics Tie Up for DevelopingTeplizumab

MorphoSys and Genesis Ink Antibody R&D Deal

arGentis Enters into a License Agreement with UTRF

Eden Biodesign to Investigate Novel Drug Candidatefor Autoimmune Diseases

Nuon and Kissei Team up for Tranilast

Organon and Dyax Team Up for DevelopingTherapeutic Antibodies

Medarex Joins Hands with Mitsubishi for MonoclonalAntibody Development

Merck and Archemix Collaborate

Genzyme Takes Over Bioenvision

Organon and Medarex Ink Drug Development Deal

CalciMedica Secures Exclusive Rights for CBR’sAutoimmune Drug Target

Xanthus Secures Exclusive Patent Estate Rights forFLT3 Pathway

Eisai Corporation Acquires Morphotek

TIRC Changes Name to Orchestra Therapeutics

Abbott Files HUMIRA® for Psoriasis in the USand EU (USA/Europe)

Accentia Secures Exclusive Global Rights to Revimmune

Medarex and Compugen Ink Collaborative Agreementfor Therapeutic Antibody

SRI and Telik Sign License Agreement for Drug Development

China Biopharma Signs Agreement with ChineseBiopharmaceutical Firm

Kirin and Astellas Ink Licensing Agreement forAnti-CD40 Antagonistic mAb

QSV and Artielle Sign Contract to Produce RTL-1000

JDRF and MacroGenics Form Partnership

GSK and Genmad Sign Partnership Agreementfor HuMaxCD20

Biocon Enters into Joint Venture Agreement withNeopharma

Pipex Pharmaceuticals Acquires Remaining Stake inEffective Pharmaceuticals

Astellas Acquires Worldwide Rights for Amevive®

Biogen Acquires Fumapharm

Biogen and UCB Join Hands for Oral Multiple SclerosisTherapy

7.FOCUS ON SELECT GLOBAL PLAYERS

Abbott Laboratories (USA)

Amgen Inc. (USA)

Bayer Schering Pharma AG (Germany)

Biogen Idec Inc. (USA)

Bristol-Myers Squibb Company (USA)

Elan Corporation, plc (Ireland)

Eli Lilly And Company (USA)

F. Hoffmann-La Roche AG (Switzerland)

Chugai Pharmaceutical Co., Ltd. (Japan)

Genentech, Inc. (USA)

GlaxoSmithKline plc (UK)

Johnson & Johnson, Inc. (USA)

Merck Serono SA (Switzerland)

Novartis AG (Switzerland)

Sanofi-aventis SA (France)

Schering-Plough Corporation (USA)

Shire Pharmaceuticals Group plc (Ireland)

Teva Pharmaceuticals Industries Limited (Israel)

UCB Pharma (Belgium)

8.GLOBAL MARKET PERSPECTIVE

Table 8: World Recent Past, Current & Future Analysisfor Autoimmune Disease Therapeutics by GeographicRegion - US, Japan, Europe and Rest of World MarketsIndependently Analyzed with Annual Sales in US$Billion for Years 2006 through 2015 (includescorresponding Graph/Chart)



Table 9: World 10-year Perspective for AutoimmuneDisease Therapeutics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe andRest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)



Table 10: World Recent Past, Current & Future Analysisfor Rheumatoid Arthritis Therapeutics by Geographic Region - US, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)



Table 11: World 10-year Perspective for RheumatoidArthritis Therapeutics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe andRest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)



Table 12: World Recent Past, Current & Future Analysisfor Multiple Sclerosis Therapeutics by Geographic Region -US, Japan, Europe and Rest of World- MarketsIndependently Analyzed with Annual Sales in US$Billion for Years 2006 through 2015 (includescorresponding Graph/Chart)



Table 13: World 10-year Perspective for MultipleSclerosis Therapeutics by Geographic Region -Percentage Breakdown of Dollar Sales for US, Japan,Europe and Rest of World Markets for Years 2006, 2009 &2015 (includes corresponding Graph/Chart)



Table 14: World Recent Past, Current & Future Analysis for Psoriasis Therapeutics by Geographic Region - US, Japan, Europe and Rest of World- Markets Independently Analyzedwith Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)



Table 15: World 10-year Perspective for PsoriasisTherapeutics by Geographic Region - Percentage Breakdownof Dollar Sales for US, Japan, Europe and Rest of WorldMarkets for Years 2006, 2009 & 2015 (includescorresponding Graph/Chart)



Table 16: World Recent Past, Current & Future Analysis for Crohn’s Disease Therapeutics (Biologics) by Geographic Region - US, Japan, Europe and Rest of World- Markets Independently Analyzed with Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)



Table 17: World 10-year Perspective for Crohn’s Disease Therapeutics (Biologics) by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe andRest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)



Table 18: World Recent Past, Current & Future Analysis for Other Autoimmune Disease Therapeutics by GeographicRegion - US, Japan, Europe and Rest of World- Markets Independently Analyzed with Annual Sales in US$Billion for Years 2006 through 2015 (includescorresponding Graph/Chart)



Table 19: World 10-year Perspective for Other Autoimmune Disease Therapeutics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europeand Rest of World Markets for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)

III. MARKET

1.THE UNITED STATES

A. Market Analysis

Current and Future Analysis

Autoimmune Diseases Fact Sheet

Table 20: Prevalence of Key AutoimmuneDiseases in the US for 2006 (in Millions)(includes corresponding Graph/Chart)

Market Trends

Biologic Drugs Lead the Fray

Biologics To Add Further Impetus to the Market

Rheumatoid Arthritis Drugs Lead the Market

Enbrel and Humira Continue to Gain Share in theAnti-TNF Market

Increased Incidence and Rise in Drug Prices toDrive Growth in MS Market

Table 21: US Multiple Sclerosis Drug Market (2006): Percentage Breakdown of Number of Dispensed Prescriptions for Avonex, Copaxone, Rebif,Betaseron and Tysabri (includes corresponding Graph/Chart)

Incidence of Type 1 Diabetes Mellitus Endemicin White Youth

Lialda’s Share Gaining Momentum in UlcerativeColitis Drugs Market

Key Ulcerative Colitis Drugs Market in theUS (2006)

Table 22: US Ulcerative Colitis Drugs Market(2007 & 2008): Percentage Breakdown ofPrescriptions Dispensed Ranked by LeadingDrugs for Asacol, Pentasa, Lialda, Canasa, Sulphasalazine, Colazal, Other Drugs andGenerics (includes corresponding Graph/Chart)

Product Launches/ Approvals

Strategic Corporate Developments

Key Players

B. Market Analytics

Table 23: US Recent Past, Current & FutureAnalysis for Autoimmune DiseaseTherapeutics by Disease Segment - RheumatoidArthritis, Multiple Sclerosis, Psoriasis, Crohn’sDisease (Biologics) and Other Autoimmune DiseasesIndependently Analyzed with Annual Salesin US$ Billion for Years 2006 through 2015(includes corresponding Graph/Chart)



Table 24: US 10-year Perspective forAutoimmune Disease Therapeutics by DiseaseSegment - Percentage Breakdown of DollarSales for Rheumatoid Arthritis, Multiple Sclerosis,Psoriasis, Crohn’s Disease (Biologics) and Other Autoimmune Diseases for Years 2006, 2009 & 2015(includes corresponding Graph/Chart)

2.JAPAN

A. Market Analysis

Current and Future Analysis

Product Launches/Approvals

Key Players

B. Market Analytics

Table 25: Japanese Recent Past, Current & FutureAnalysis for Autoimmune Disease Therapeutics byDisease Segment - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics) and Other Autoimmune Diseases Independently Analyzed with Annual Sales in US$ Billion for Years 2006 through 2015 (includes corresponding Graph/Chart)



Table 26: Japanese 10-year Perspective for Autoimmune Disease Therapeutics by Disease Segment - Percentage Breakdown of Dollar Sales for Rheumatoid Arthritis,Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics)and Other Autoimmune Diseases for Years 2006, 2009 &2015 (includes corresponding Graph/Chart)

3.EUROPE

A. Market Analysis

Current and Future Analysis

Europe - A Burgeoning Market for AutoimmuneDisease Therapeutics

Increasing Awareness to Drive Market Growth

Low Penetration to Fuel Growth in EuropeanMS DMDs Market

Table 27: Prevalence of Key AutoimmuneDiseases in Europe for 2006 in Millions(includes corresponding Graph/Chart)

Lower Treatment Rate Bodes Huge Potential forthe UK MS Drug Market

Drugs Hindering Disease Progression to GainProminence

Product Launches/Approvals

Strategic Corporate Developments

Key Players

B. Market Analytics

Table 28: European Recent Past, Current & FutureAnalysis for Autoimmune Disease Therapeutics by Disease Segment - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics) and Other Autoimmune Diseases Independently Analyzed withAnnual Sales in US$ Billion for Years 2006 through2015 (includes corresponding Graph/Chart)



Table 29: European 10-year Perspective forAutoimmune Disease Therapeutics byDisease Segment - Percentage Breakdown ofDollar Sales for Rheumatoid Arthritis, MultipleSclerosis, Psoriasis, Crohn’s Disease (Biologics) andOther Autoimmune Diseases for Years 2006, 2009 &2015 (includes corresponding Graph/Chart)

4.REST OF WORLD

A. Market Analysis

Current and Future Analysis

Canada

Canada - Highest Prevalence Rates for MultipleSclerosis

Sales of Biologics on the Rise in CanadianRheumatoid Arthritis Drugs Market

Asia-Pacific

Autoimmune Diseases Market in Asia-Pacific -An Overview

Incidence of Multiple Sclerosis in India on the Rise

Overview of Rheumatoid Arthritis in Australia

Table 30: Percentage Breakdown of Prevalence of Rheumatoid Arthritis in Australia by Age Group (includes corresponding Graph/Chart)



Table 31: Percentage Breakdown ofPrevalence of Rheumatoid Arthritis inAustralia by Sex (includes corresponding Graph/Chart)

Overview of Irritable Bowel Diseases in Australia

Product Launches/Approvals

Strategic Corporate Developments

B. Market Analytics

Table 32: Rest of World Recent Past, Current & Future Analysis for Autoimmune Disease Therapeuticsby Disease Segment - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn’s Disease (Biologics) andOther Autoimmune Diseases Independently Analyzedwith Annual Sales in US$ Billion for Years 2006through 2015 (includes corresponding Graph/Chart)



Table 33: Rest of World 10-year Perspective forAutoimmune Disease Therapeutics by DiseaseSegment - Percentage Breakdown of Dollar Sales for Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis,Crohn’s Disease (Biologics) and Other AutoimmuneDiseases for Years 2006, 2009 & 2015 (includescorresponding Graph/Chart)


IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 115 (including Divisions/Subsidiaries - 122)

Region/Country Players

The United States

Canada

Japan

Europe

France

Germany

The United Kingdom

Rest of Europe

Asia-Pacific (Excluding Japan)

Abstract

This report analyzes the worldwide markets for Autoimmune Disease Therapeutics in US$ Billion by the following therapeutic class - Rheumatoid Arthritis, Multiple Sclerosis, Psoriasis, Crohn's Disease (Biologics only), and Others. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual forecasts are provided for each region for the period 2006 through 2015. The report profiles 115 companies including many key and niche players worldwide such as Abbott Laboratories, Amgen Inc., Bayer Schering Pharma AG, Biogen Idec Inc., Bristol-Myers Squibb Company, Elan Corporation, plc, Eli Lilly And Company, F. Hoffmann-La Roche AG, Chugai Pharmaceutical Co., Ltd., Genentech, Inc., GlaxoSmithKline plc, Johnson & Johnson, Inc., Merck Serono SA, Novartis AG, Sanofi-aventis SA , Schering-Plough Corporation, Shire Pharmaceuticals Group plc, Teva Pharmaceuticals Industries Limited, and UCB Pharma. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

Please note: Reports are sold as single-site single-user licenses. The delivery time for hard copies is between 3-5 business days, as each hard copy is custom printed for the organization ordering it. Electronic versions require 24-48 hours as each copy is customized to the client with digital controls and custom watermarks. The Publisher uses digital controls protecting against copying and printing is restricted to one full copy to be used at the same location.

Adobe Acrobat Reader 7.0 is required to view the report. Upon ordering an electronic version, the Publisher will provide a link to download the purchased report.

Titles available via "online download" are not affected by this and are still delivered to your reading room immediately.

Prior to fulfillment of an order, the client will be required to sign a document detailing the purchase terms for a publication from this publisher.

Get Full Details About This Report >>
US: 800.298.5699
Int'l: +1.240.747.3093
Buy this Report

Price and Delivery Options

See related reports or call the number above for help from a research specialist.


 

About MarketResearch.com
MarketResearch.com is an online aggregator selling over 250,000 market research reports, company profiles and country profiles from over 650 research firms. Our reports will provide you with the critical business and competitive intelligence you need for strategic planning and marketing research. Coverage includes the US, UK, Europe, Asia and global markets.

 

© MarketResearch.com 2009