Nucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III)

Published by: Espicom Healthcare Intelligence

Published: Jun. 26, 2009 - 110 Pages

Table of Contents

EXECUTIVE SUMMARY

INTRODUCTION

Overview of delivery technologies for genetic material: past, present & future

Leading technology platforms for the delivery of genetic material

Nucleic acid delivery: motivators & resistors

Nucleic acid technology motivators

Motivators

Nucleic acid technology resistors

Resistors

ADVANCED NUCLEIC ACID DELIVERY TECHNOLOGIES

Types of nucleic acid-based products under development by the pharma industry

Viral vector delivery of nucleic acids

Schematic of gene therapy utilising an AAV vector

Schematic of gene therapy utilising HVJ envelope - virosome

Bacterial vector delivery of nucleic acids

Non-viral vector delivery of nucleic acids

Chemical Technologies

Stable nucleic acid-lipid particles

Targeted nanoparticles

Physical Technologies

Schematic of Zosano Pharma’s Patch Technology

Electroporation technology - PassPort Delivery System

Advantages and disadvantages of nucleic acid platforms

Current therapeutic applications for the viral and non-viral delivery of nucleic acids

Leading nucleic acid based products in development

Nucleic acid-based approved/filed drugs

Selection of gene therapies in clinical development

Selection of RNA therapeutics in clinical development

Selection of DNA vaccines in clinical development

Future commercial applications & opportunities

STRATEGIES OF DRUG DELIVERY COMPANIES

Leading nucleic acid drug delivery companies

Leading nucleic acid drug delivery specialists

Partnerships & acquisitions

Strategic developmental & commercialisation partnerships

Mergers, acquisitions & joint ventures

Recent partnerships & acquisitions in the nucleic acid field

Intellectual Property

Nucleic acid patents

THE viral and non -viral vector Delivery MARKET

Now 2009

Approved nucleic acid product sales

Future 2018

Novel nucleic acid product sales

Global controlled release product sales

COMPETITOR ANALYSIS

Movers & Shakers: Cutting edge or losing their grip

Movers & shakers in nucleic acid drug delivery systems

COMPANY PROFILES

Alnylam Pharmaceuticals (www.alnylam.com )

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Alnylam’s product pipeline

Sales forecasts of products utilising the delivery technology

Alnylam’s sales forecasts

Competitor Ratio Analysis

AlphaVax, Inc. (www.alphavax.com)

Proprietary delivery technology

The alphavaccine platform system

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

AlphaVax’ product pipeline

Sales forecasts of products utilising the delivery technology

AlphaVax’ sales forecasts

Competitor Ratio Analysis

Altea Therapeutics, Inc (www.alteatherapeutics.com)

Proprietary delivery technology

Altea Therapeutics’ Passport Patch

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Altea Therapeutics’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

AP Pharma, Inc (www.appharma.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

AP Pharma’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

ArmaGen Technologies (www.armagen.com)

Proprietary delivery technology

ArmaGen’s BBB delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

ArmaGen Technologies’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

BioDelivery Sciences International (www.biodeliverysciences.com)

Proprietary delivery technology

Bioral Technology

Direct membrane fusion

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

BDSI’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Calando Pharmaceuticals (www.calandopharma.com)

Proprietary delivery technology

Schematic of cyclodextrin polymeric nanoparticles

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Calando’s product pipeline

Sales forecasts of products utilising the delivery technology

Calando’s sales forecasts

Competitor Ratio Analysis

Cequent Pharmaceuticals (www.cequentpharma.com)

Proprietary delivery technology

Application in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Cequent’s product pipeline

Sales forecasts of products utilising the delivery technology

Cequent’s sales forecasts

Competitor Ratio Analysis

Copernicus Therapeutics (www.cgsys.com)

Proprietary delivery technology

Uptake and trafficking of condensed nanoparticle DNA

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Copernicus’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Diatos SA (www.diatos.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Diatos’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

DOR BioPharma, Inc (www.dorbiopharma.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

DOR’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Expression Genetics, Inc (www.egencorp.com)

Proprietary delivery technology

TheraPlas Technology Platform

TheraSilence Technology Platform

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

EGEN’s product pipeline

Sales forecasts of products utilising the delivery technology

EGEN’s sales forecasts

Competitor Ratio Analysis

Inovio Biomedical Corporation (www.inovio.com)

Proprietary delivery technology

Inovio’s gene delivery platform

Inovio’s MedPulser DNA Delivery System

VGX’ Cellectra Technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Inovio’s product pipeline

Sales forecasts of products utilising the delivery technology

Inovio’s sales forecasts

Competitor Ratio Analysis

MaxCyte, Inc (www.maxcyte.com)

Proprietary delivery technology

MaxCyte’s GT exvivo cell loading system

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

MaxCyte’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Nanotherapeutics (www.nanotherapeutics.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Nanotherapeutics’ product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

NeoPharm (www.neopharm.com)

Proprietary delivery technology

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

NeoPharm’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Novagali Pharma SA (www.novagali.com)

Proprietary delivery technology

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Novagali’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Oxford Biomedica (www.oxfordbiomedica.com)

Proprietary delivery technology

Oxford Biomedica’s LentiVector system

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Oxford Biomedica’s product pipeline

Sales forecasts of products utilising the delivery technology

Oxford Biomedica’s sales forecasts

Competitor Ratio Analysis

PCI Biotech (www.pcibiotech.com)

Proprietary delivery technology

PCI enhances siRNA’s gene silencing effect and improves gene delivery

Applications in the pharma industry

Potential applications for improving the delivery of a range of drug types

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

PCI’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Silence Therapeutics plc (www.silence-therapeutics.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Silence Therapeutics’ product pipeline

Sales forecasts of products utilising the delivery technology

Silence Therapeutics’ sales forecasts

Competitor Ratio Analysis

Targeted Genetics Corporation (www.targetedgenetics.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

TGEN’s product pipeline

Sales forecasts of products utilising the delivery technology

Targeted Genetics sales forecasts

Competitor Ratio Analysis

Tekmira Pharmaceuticals Corporation (www.tekmirapharm.com)

Proprietary delivery technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Tekmira’s product pipeline

Sales forecasts of products utilising the delivery technology

Tekmira’s sales forecasts

Competitor Ratio Analysis

TissueGene, Inc (www.tissuegene.com)

Proprietary delivery technology

Manufacturing TissueGene-C cell mediated gene therapies

Applications in the pharma industry

Application of TissueGene-C cell mediated gene therapy in orthopaedics

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

TissueGene’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

Vical, Inc. (www.vical.com)

Proprietary delivery technology

Schematic of p-DNA delivery and utilisation in DNA vaccines

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Vical’s product pipeline

Sales forecasts of products utilising the delivery technology

Vical’s sales forecasts

Competitor Ratio Analysis

Zosano Pharma, Inc (www.zosanopharma.com )

Proprietary delivery technology

ZP Patch Technology

Applications in the pharma industry

Management/technical expertise

Competition within the delivery technology sector

Products in development/approved utilising the delivery technology

Zosano Pharma’s product pipeline

Sales forecasts of products utilising the delivery technology

Competitor Ratio Analysis

APPENDIX 1

Global nucleic acid approved drugs sales 2008-2018

APPENDIX 2

Global nucleic acid developmental drugs sales 2008-2018

APPENDIX 3

Competitor Ratio Analysis Criteria

Key Nucleic acid delivery companies by 2018

GLOSSARY

ACRONYMS

Endnotes

Abstract

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