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Opportunities in Menopausal Treatments: Will New Therapies Overtake Hormone Replacement?

Published by: Decision Resources

Published: Jun. 20, 2009 - 37 Pages


Table of Contents


Executive Summary
Strategic Considerations

Stakeholder Implications

Introduction

Overview of Menopause

Defi nition and Description

Symptoms of Menopause

Vasomotor Symptoms

Osteoporosis

Increased Cardiovascular Disease Risk

Insomnia

Depression

Other Symptoms

Current Treatments for Menopausal Symptoms

Hormone Replacement Therapy

Selective Estrogen Receptor Modulators

Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors

Gabapentin

Other Treatments

Emerging Treatments for Menopausal Symptoms

Wyeth’s Pristiq

Wyeth’s Bazedoxifene/Conjugated Estrogen Combination

Depomed’s Gabapentin

Schering-Plough’s Esmirtazapine

Outlook for the Menopausal Symptom Market

Tables

1. Common Brands of Hormone Replacement Therapy

2. Common Selective Serotonin Reuptake Inhibitors and Serotonin and Norepinephrine Reuptake Inhibitors

3. Emerging Agents for the Treatment of Menopausal Symptoms

4. Sales of Agents to Treat Menopausal Symptoms, 2008

Figures

1. Endocrine Changes Associated with Menopause

2. Worldwide Sales of Hormone Replacement Therapy, 2003-2008

Abstract

Introduction

For decades, the efficacy of hormone replacement therapy (HRT) for some of menopause’s most troublesome symptoms eliminated any incentive to develop new approaches to treatment. However, data questioning the safety of estrogen-containing therapies have galvanized researchers and drug developers to begin investigating new mechanisms to treat menopausal symptoms that can capitalize on the newly realized need for safer treatment options, although these agents will still be challenged by the efficacy of HRTs.

Questions Answered in This Report
  • Menopause is a natural process of aging that is accompanied b • y substantial hormonal changes. What are the symptoms of menopause? What are the causes of these symptoms? What are the current treatment options? What are the benefits and drawbacks of these treatments?
  • Data from the Women’s Health Initiative suggest that estrogen therapy is not suitable for all women. What are the risks associated with hormone therapy? Do emerging agents offer safer or more efficacious treatment approaches?
  • With the final wave of baby boomers reaching menopausal age, the menopause treatment patient population is on the rise. What were the sales of menopausal symptom treatments in 2008? How well will emerging agents address the remaining needs in this market? How will emerging agents fit into the treatment algorithm in the future?
Scope
  • Overview of menopause: Physiology and symptoms.
  • Current treatments: Hormone replacement therapy, selective estrogen receptor modulators, SSRIs/SNRIs, gabapentin.
  • Emerging treatments: Wyeth’s Pristiq, Wyeth’s bazedoxifene/conjugated estrogens, Depomed’s controlled-release gabapentin, Schering-Plough’s esmirtazapine.
  • Outlook: 2008 market, challenges and opportunities, the potential of emerging agents, the future of HRT.
  • Women’s Health Series: This report is part of Spectrum’s Women’s Health Series, which focuses on areas of unmet need and the best marketing strategies to ensure adoption of a new agent into the market for women’s reproductive health—a sector that exceeded $23 billion in 2007.


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