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Allergy Drug Pipeline and R&D 2009

Published by: Fuji-Keizai USA, Inc.

Published: Jun. 1, 2009 - 126 Pages


Table of Contents


Executive Summary

1. Overview of the Global Allergy Medications Market

1.1 Allergies as a Medical Condition

1.1.1 Types of Allergies

1.1.2 Signs and Symptoms

1.1.3 Physiological Response

Table 1-1. Gell & Coombs Classification of Allergic Reactions

1.1.4 Prevalence

Table 1-2. Global Prevalence of Allergies

1.2 Medical Treatment of Allergies

1.2.1 Prescription Medications: Current Usage & Unmet Needs

Table 1-3. Leading Prescription Allergy Medications

1.2.1.1 U.S.

Table 1-4. U.S. DTC Advertising for Leading Rx and OTC Allergy Medications 2008

1.2.1.2 Europe

1.2.1.3 Japan

1.2.1.4 ROW

1.2.2 Non-Prescription Products: Current Usage & Unmet Needs

Table 1-5. Leading OTC Allergy Medications

1.2.2.1 U.S.

1.2.2.2 Europe

1.2.2.3 Japan

1.2.2.4 ROW

2 Global Allergy Medications Market Forecast 2008 - 2013

2.1 Rx Allergy Medications Market

2.1.1 Rx Allergy Drug Market Forecast by Product

2.1.1.1 Growth Drivers

Table 2-1. Rx Allergy Drug Market Forecast 2008 - 2013 by Product in $Million

2.1.1.2 Market Restraints

Table 2-2. U.S. Patent Expirations of Leading Prescription Allergy Drugs

2.1.2 Rx Allergy Drug Market Forecast by Region

Table 2-3. Rx Allergy Drug Market Forecast, 2008 - 2013 by Region in $ Million

2.1.3 Rx Allergy Drug Market Forecast by Product Class

Table 2-4. Rx Allergy Drug Market Forecast, 2008 - 2013 by Product Class in $ Million

Table 2-5. Rx Allergy Drug Market Product Segments Share, 2008 vs. 2013

Figure 2-1. Rx Allergy Drug Market Product Segments Share, 2008

Figure 2-2. Rx Allergy Drug Market Product Segments Share, 2013

2.2 OTC Allergy Drug Market

2.2.1 OTC Allergy Drug Market Forecast by Product

Table 2-6. OTC Allergy Drug Market Forecast, 2008 - 2013 by Product in $Million

2.2.2 Growth Drivers

2.2.3 Market Restraints

2.2.4 OTC Allergy Drug Market Forecast by Region

Table 2-7. OTC Allergy Drug Market Forecast, 2008 - 2013 by Region in $ Million

2.2.5 OTC Allergy Drug Market Forecast by Product Class

Table 2-8. OTC Allergy Drug Market Forecast, 2008 - 2013 by Product Class in $ Million

2.3 Rx & OTC Allergy Drug Market

2.3.1 Rx & OTC Allergy Drug Market Forecast by Leading Manufacturers

Table 2-9. RX & OTC Allergy Drug* Sales of Leading Manufacturers, 2008 - 2013 in $Million

2.3.2 Rx & OTC Allergy Drug Market Share of Leading Drug Manufacturers

Table 2-10. Rx & OTC Market Shares of Leading Allergy Drug Manufacturers, 2008 vs. 2013

Figure 2-3. Rx & OTC Market Shares of Top Allergy Drug Manufacturers, 2008

Figure 2-4. Rx & OTC Market Shares of Top Allergy Drug Manufacturers, 2013

3. Allergy Drug Development: New Molecular Entities

Table 3-1. Key Characteristics of NMEs, Generics and Indication Expansions

3.1 All Allergy Drug Developers Position

3.1.1 Challenges in Allergy Drug Development

Table 3-2. All Allergy Drug Developers Product Position Overview

3.2 Key Products Under Development

Figure 3-1. Allergy Compounds Tested by Phase of Development

3.2.1 Antihistamines

3.2.1.1 Physiology and Mechanism of Action

3.2.1.2 Leading Antihistamine Allergy Drug Candidates

Table 3-3. Antihistamine Developers Product Position

3.2.2 Corticosteroids

3.2.2.1 Physiology and Mechanism of Action

3.2.2.2 Leading Corticosteroid Allergy Drug Candidates

Table 3-4. Corticosteroid Developers Product Position

3.2.3 Mast Cell Inhibitors

3.2.3.1 Physiology and Mechanism of Action

Figure 3-2. The Role of Mast Cells in Allergy Response

3.2.3.2 Leading Mast Cell Inhibitor Allergy Drug Candidates

Table 3-5. Mast Cell Inhibitors Developers Product Position

3.2.4 Allergy Immunotherapy

3.2.4.1 Physiology and Mechanism of Action

3.2.4.2 Leading Immunotherapy Allergy Drug Candidates

Table 3-6. Immunotherapy Developers Product Position

3.2.5 Vaccines

3.2.5.1 Physiology and Mechanism of Action

Figure 3-3. Production of TH2 Cytokines

3.2.5.2 Leading Allergy Vaccine Candidates

Table 3-7. Vaccine Developers Product Position

3.2.6 Other Types of Allergy Drugs

3.2.6.1 Physiology and Mechanism of Action

3.2.6.2 Other Leading Allergy Candidates

Table 3-8. Other Allergy Drug Developers Product Position

3.3 Global Market Forecast for New Allergy Drugs, 2008 - 2013

3.3.1 New Allergy Drug Market Forecast: Total and Segment Market

Table 3-9. Sales of New Allergy Drugs by Segment, 2008 - 2013

Figure 3-4. Market Shares of New Allergy Drugs by Segment, 2013

3.3.2 Growth Drivers

3.3.2.1 The Importance of Patents

3.3.3 Market Restraints

4. Allergy Drug Development: Indication Expansion

4.1 Indication Expansion for New Usage

Table 4-1. Selected Recent Allergy Drug Indication Expansions, U.S.

4.1.1 The Economic Benefits of Indication Expansion

Table 4-2. U.S. R&D Expenditure for New Medicines by the Pharma-Industry

4.1.2 Challenges in Allergy Drug Indication Expansion

Figure 4-1. Cost and Time Savings of Indication Expansions

4.2 Key Products Under Development

4.2.1 Database of Allergy Indication Expansion Initiatives by Company

Table 4-3. Selected Allergy Drug Indication Expansion Trials

4.2.2 Leading Areas of R&D Activity

4.2.2.1 Clarinex

4.2.2.2 Nasonex

4.2.2.3 Patanase

4.2.2.4 Singulair

4.2.2.5 Veramyst

4.2.2.6 Xolair

4.2.2.7 Xyzal

4.3 Global Market Forecast for Allergy Drug Indication Expansions

Table 4-4. Sales of Allergy Drug Indication Expansions, 2008 - 2013 in $ Million

Table 4-5. Product Market Share of Allergy Drug Indication Expansions, 2009 vs. 2013

Figure 4-2. Product Market Share of Allergy Drug Indication Expansions, 2009

Figure 4-3. Product Market Share of Allergy Drug Indication Expansions, 2013

4.3.1 Growth Drivers

4.3.2 Market Restraints

5. Allergy Drug Development: Basic Research

5.1 Basic Research Group & Activity

Table 5-1. Leading Organizations & Details for Basic Allergy Research

5.1.1 Challenges in Basic Allergy Research

Figure 5-1. National Institutes of Health Research Budget by Disease Area, Fiscal 2008

5.2 Key Areas of Investigation

Table 5-2. Recent Basic Research in the Field of Allergies

5.3 Unanswered Questions

6. Strategic Alliances for Allergy Drug Development

6.1 Types of Strategic Alliances

Figure 6-1. Comparison of Selected Deal Types

6.2 Current Strategic Alliances for Allergy Drug Development

Table 6-1. Ongoing Strategic Alliances for Allergy Drug Development

7. Activities of the Leading Allergy Drug Developers

Common Research Item:

1) Table: Product Profile:

2) R&D Strength and Capabilities

3) Marketed Allergy Drugs

4) Allergy Drug Pipeline

5) Table: Profile

7.1 Alcon Research

7.2 Allergy Therapeutics

7.3 AstraZeneca

7.4 GlaxoSmithKline

7.5 Johnson & Johnson

7.6 Meda AB

7.7 Merck

7.8 Novartis

7.9 Sanofi-Aventis

7.10 Schering-Plough

7.11 Sepracor

7.12 UCB Pharma

8. Total Allergy Drug Market: Forecasts & Directions

Table 8-1. Total Allergy Drug Sales by Segment, 2008 - 2013 in $Million

Figure 8-1. Total Allergy Drug Sales Growth by Segment, 2008 - 2013

Figure 8-2. Allergy Drug Market Share by Segment, 2008

Figure 8-3. Allergy Drug Market Share by Segment, 2013

9. Other Top Companies with Allergy Projects

Table 9-1. Other Top Companies with Late Stage Allergy Projects

Table 9-2. Other Top Companies with Early Stage Allergy Projects

10. Database of Allergy Drug Developers

Abstract

This report describes current global research initiatives in the field of allergies. It focuses on the most common allergies, which affect more than 300 million persons worldwide: seasonal and perennial allergic rhinitis and food allergies.

Sales estimates from 2008 to 2013 are provided for the leading prescription allergy drugs and vaccines, as well as over-the-counter (OTC) allergy medicines in the U.S., European Union, Japan and rest of world area (defined as South America and the Caribbean, Middle East, Africa, and Asia except Japan). Forecasts include an analysis of the market forces affecting sales in each region, as well as a discussion of patent expirations of leading medications and the effects of generic competition on existing allergy drug sales.

Allergy medications and vaccines under development are discussed, with a comprehensive analysis of technology, stage of development and commercialization potential. This includes new molecular entities and indication expansions of medicines currently approved for other uses. For leading allergy drug candidates, sales estimates from 2009 to 2013 are provided.

Profiles of the 12 leading allergy drug developers offer details of these companies’ capabilities, particularly focusing on R&D strength, pipeline products, strategic alliances and partnerships, and the effects of any recent merger or acquisition activity. A directory of more than five dozen leading players worldwide allows readers to access companies’ own web sites for further review.

Information for this report was gathered from a wide variety of published sources; interviews with company representatives were then conducted to assess trends, and form the basis of the forecasting and competitive analysis.

This report is designed for business development and other senior executives, marketers, R&D managers, investors, VCs, consultants, entrepreneurs and others who require an in-depth understanding of the current status of the allergy therapeutics market and potential new products. More than 50 detailed tables or figures provide key data about items such as strategic alliances, M&As, market size, segments and the like.

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