Botanical and Plant-Derived Drugs: Global Markets

Published by: BCC Research

Published: Feb. 1, 2009

Table of Contents

CHAPTER 1: INTRODUCTION

STUDY BACKGROUND

STUDY GOAL AND OBJECTIVES

INTENDED AUDIENCE

SCOPE OF REPORT

METHODOLOGY AND INFORMATION SOURCES

COMMERCIAL DRUGS

DEVELOPMENTAL DRUGS

TABLE 1 FDA APPROVAL PROCESS FOR NEW DRUGS

ANALYST CREDENTIALS

RELATED BCC PUBLICATIONS

BCC ONLINE SERVICES

DISCLAIMER

CHAPTER 2: SUMMARY

SUMMARY TABLE GLOBAL FORECAST FOR BOTANICAL* AND PLANT-DERIVED DRUGS, THROUGH 2013 ($ BILLIONS)

SUMMARY FIGURE GLOBAL FORECAST FOR BOTANICAL* AND PLANT-DERIVED DRUGS, THROUGH 2013 ($ BILLIONS)

CHAPTER 3: OVERVIEW

BRIEF HISTORY OF PLANT-DERIVED MEDICINES

BRIEF HISTORY OF PLANT-… (CONTINUED)

TABLE 2 KEY DATES IN BOTANICAL MEDICINE

TABLE 3 WELL KNOWN PLANT-DERIVED DRUGS

OPPORTUNITY LIES BEYOND WHAT’S KNOWN

FIGURE 1 COMPOSITION OF FDA-APPROVED NATURAL-DERIVED COMPOUNDS IN U.S. (2000-2005)* (%)

KEY DRIVERS

KEY CHALLENGES

SIGNS OF INDUSTRY INVESTMENT

TABLE 4 SWOT ANALYSIS ON BOTANICAL DRUG DEVELOPMENT

TABLE 5 KEY SIGNS OF INVESTMENT IN BOTANICAL AND OTHER PLANT-DERIVED DRUGS

BOTANICAL DRUGS DEFINED

UNDERSTANDING THE REGULATORY PROCESS

TABLE 6 DISTINCTIONS AMONG PRODUCTS THAT USE PLANTS MEDICINALLY

THE FIRST APPROVED BOTANICAL

A GROWING PIPELINE

FIGURE 2 INDS IN THE FDA BY THERAPEUTIC AREA (NUMBER)

OVERALL PHARMA LANDSCAPE

TABLE 7 TOP PHARMA COMPANIES BY REVENUE, 2007 ($ BILLIONS)

MAJOR CLASSES OF PLANT DRUGS

Terpenes and Steroids

Terpenes

Steroids

Alkaloids and Glycosides

Alkaloids

Ergot Alkaloids

Morphine Alkaloids

Vinca Alkaloids

Glycosides

Cardiac Glycosides

Anthraglycosides

Phenols

E. Cava Algae

Flavonoids

Resveratrol

Coumarin

Catechins

Proanthocyanidins

INTELLECTUAL PROPERTY

PRODUCTION

MOVING PRODUCTION FORWARD

ARTEMISININ: A CASE STUDY

SUPPLY AND LEGAL ISSUES

TABLE 8 MAJOR PRODUCERS OF RAW MATERIALS FOR PLANT-BASED MEDICINALS

DRUG DEVELOPMENT AND MANUFACTURE

TABLE 9 KEY COMPANIES WITH NATURAL PRODUCT LIBRARIES

CHAPTER 4: MARKET SEGMENTATION

GEOGRAPHIC SEGMENTATION

SALES OF PLANT-DERIVED DRUGS BY REGION

TABLE 10 PLANT-DERIVED DRUG SALES FORECAST BY REGION, THROUGH 2013 (% TOTAL SALES)

FIGURE 3 GEOGRAPHIC SEGMENTATION FOR PLANT-DERIVED DRUGS, 2008 AND 2013 (%)

THERAPEUTIC AREA SEGMENTATION

NUMBER OF PLANT-DERIVED DRUGS BY THERAPEUTIC AREA

TABLE 11 FDA APPROVED BOTANICAL DRUGS FORECAST THROUGH 2013 (UNITS)

FIGURE 4 COMPOSITION OF FDA APPROVED BOTANICAL INDICATION FORECAST BY THERAPEUTIC AREA, 2008 AND 2013 (%)*

Value of Plant-Derived Drugs by Therapeutic Area

TABLE 12 RELATIVE VALUES OF FDA APPROVED BOTANICAL DRUGS FORECAST BY THERAPUETIC AREA, THROUGH 2013 ($ MILLIONS)

FIGURE 5 RELATIVE VALUES OF FDA APPROVED BOTANICAL DRUGS FORECAST BY THERAPEUTIC AREA, 2008 AND 2013 (%)

CHAPTER 5: THERAPEUTIC AREAS IN DETAIL FOR PLANT-DERIVED AND BOTANICAL DRUGS, THROUGH 2013

HORMONE THERAPY AND METABOLISM APPLICATIONS

TABLE 13 PLANT-DERIVED HORMONE THERAPY AND METABOLISM DRUGS IN LATE STAGE DEVELOPMENT

INFECTIOUS DISEASE APPLICATIONS

TABLE 14 PLANT-DERIVED INFECTIOUS DISEASE DRUGS IN LATE STAGE DEVELOPMENT

PAIN AND CENTRAL NERVOUS SYSTEM DISEASE APPLICATIONS

TABLE 15 BRAIN DISORDERS THAT ARE REFRACTORY TO SMALL MOLECULE DRUGS

TABLE 16 PLANT-DERIVED PAIN AND CNS DRUGS IN LATE STAGE DEVELOPMENT

CARDIOVASCULAR AND METABOLIC DISEASE

TABLE 17 PLANT-DERIVED CARDIOVASCULAR AND METABOLIC DRUGS IN LATE STAGE DEVELOPMENT

RESPIRATORY, INFLAMMATION, AND AUTOIMMUNE

TABLE 18 PLANT-DERIVED RESPIRATORY, INFLAMMATION, AND AUTOIMMUNE DRUGS IN LATE STAGE DEVELOPMENT

DERMATOLOGY APPLICATIONS

TABLE 19 PLANT-DERIVED DERMATOLOGY/WOUND CARE DRUGS IN LATE STAGE DEVELOPMENT

GASTROINTESTINAL APPLICATIONS

TABLE 20 PLANT-DERIVED GASTROINTESTINAL DRUGS IN LATE STAGE* DEVELOPMENT )

ONCOLOGY APPLICATIONS

TABLE 21 ESTIMATED U.S. CANCER CASES, 2007

TABLE 22 PLANT-DERIVED ONCOLOGY DRUGS IN LATE STAGE DEVELOPMENT

TABLE 23 BOTANICAL DRUGS IN LATE STAGE DEVELOPMENT WITH EXPECTED FDA-APPROVED COMMERCIALIZATION, THROUGH 2013*

CHAPTER 6: COMPANY PROFILES

ADVANCED LIFE SCIENCES

ARTECEF B.V.

AMERICAN ORIENTAL BIOENGINEERING

ANALYTICON DISCOVERY GMBH

AVESTHAGEN, LTD.

BAYER SCHERING

BIONUMERIK PHARMACEUTICALS, INC.

BIONOVO, INC.

BOEHRINGER INGELHEIM

PHARMATON SA

BRISTOL MYERS SQUIBB

CARDAX PHARMACEUTICALS

CHONG KUN DANG PHARMACEUTICAL CORPORATION

CUBIST PHARMACEUTICALS, INC.

CURAPHARM, INC.

EISAI, INC.

EKOMED, LLC

ELI LILLY

FYTOKEM PRODUCTS, INC.

GALAPAGOS NV

GLAXOSMITHKLINE

GLOBAL PHARMATECH, INC.

GW PHARMACEUTICALS, PLC

HETEROGENEITY, LLC

INDENA

JOHNSON & JOHNSON

LIFEPHARMS, INC

LEO PHARMA

LUPIN, LTD.

LUPIN PHARMACEUTICALS, INC.

MADAUS GMBH

MERA PHARMACEUTICALS, INC.

MERIDIAN MEDICAL TECHNOLOGIES, INC.

KING PHARMACEUTICALS, INC. (PARENT COMPANY)

MERLION PHARMACEUTICALS

MEDIGENE

MEDIGENE, INC.

TABLE 24 MEDIGENE BOTANICAL PIPELINE

MERCK & CO., INC.

MICROBIO

NAPO PHARMACEUTICALS, INC.

NEUROGESX, INC.

NOVARTIS INTERNATIONAL AG

PANACOS

PHYTOMEDICAL TECHNOLOGIES

PHYTOMEDICS, INC.

PFIZER

POLYPHENON PHARMA

PHYNOVA

TABLE 25 PHYNOVA PIPELINE

PHYTOCEUTICA, INC.

PHYTOMYCO RESEARCH CORP.

PHYTOPHARM, PLC

PIRAMAL ENTERPRISES, LTD.

PUNISYN PHARMACEUTICALS, LTD.

RANBAXY LABORATORIES, LTD.

SANOFI-AVENTIS

SCHWABE PHARMACEUTICALS

SEQUOIA SCIENCES, INC.

SIRTRIS

SOLVAY PHARMACEUTICALS

SUNTEN PHYTOTECH CO., LTD.

TABLE 26 SUNTECH PHYTOTECH PIPELINE

TASLY PHARMACEUTICALS, INC.

TCM BIOTECH INTERNATIONAL CORP

VEDIC LIFESCIENCES PVT., LTD.

YAUPON THERAPEUTICS

WYETH PHARMACEUTICALS

ZHEJIANG KANGLAITE GROUP CO, LTD.

APPENDIX

TABLE 27 PLANT-DERIVED DRUGS: THEIR ORIGIN AND ACTIONS

TABLE 28 USEFUL RESOURCES FOR THE BOTANICAL DRUG INDUSTRY

Abstract

This report:

• Identifies and classifies the plant-derived drugs that have been commercialized to date
• Contains forecasts for the global volume and value of plant-derived drug shipments and their markets through 2013
• Analyzes the historical and current volume and value of shipments of each of these drugs in specified geographical markets
• Identifies and evaluates the impact of factors that will drive future demand for plant-derived drugs
• Describes plant-derived drugs that are currently in the clinical testing or approvals stage and assesses the probability that they will be commercialized successfully in the next 5 years
• Profiles the leading manufacturers of plant-derived drugs and the firms that may become important players in the next 5 years.

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