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Anti-Obesity Drugs

Published by: Global Industry Analysts

Published: Feb. 1, 2009 - 442 Pages


Table of Contents


I.INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definitions and Scope of Study

II. EXECUTIVE SUMMARY

1.Industry Overview

Current & Future Analysis

Factors Influencing the Market

Obesity - A Global Epidemic

Table 1: Global Overweight Prevalence (2006):

Overweight Population (%) of Select Countries

(includes corresponding Graph/Chart)

Table 2: Abdominal Obesity Prevalence (%) by Region

and Sex (includes corresponding Graph/Chart)

Trends and Issues

Obesity: An Unmet Medical Need

Rising Demand for Obesity Therapeutics

Barriers to Development of Effective Drugs

New Research Aids in Discovery of Novel Drugs

Growing Problem of Obesity in Asia

Particularly China

2.Competition

Roche Leads the Race

Table 3: Leading Brands in the Global Anti-obesity Drugs Market (2007): Percentage Share Breakdown of Revenues

for Xenical/orlistat, Reductil/Meridia (sibutramine),

Alli, Acomplia and Others (includes corresponding

Graph/Chart)

Competition Grows with Pipeline Drugs

Current Anti-Obesity Drugs in Pipeline: 2008

3.Obesity - An Introduction

Diagnosis of Obesity

BMI Calculation and Classification

Waist Circumference and BMI

Causes of Obesity

Unhealthy Eating Habits

Environmental and Genetic Factors

Sedentary Lifestyle

Alcohol Intake

Childhood Obesity

Psychological Factors

Pregnancy

Hormonal Disorders

Drugs

Aging

Risks Associated with Obesity

4.Obesity Treatment

Dietary Therapy

Exercise Therapy

Behavior Therapy

Pharmacotherapy

Weight Loss Surgery

Invasive Vis-à-vis Non-invasive Procedures

A Brief Review of Select Invasive Procedures

Bariatric Surgery

Laparoscopic Adjustable Gastric Banding

Vertical Banded Gastroplasty (VBG)

Roux-en-Y Gastric Bypass Procedure (RYGB)

Lap-Band Procedure

Gastric Band Procedure

Gastric Bypass Procedure

Doudenal Switch

Prescription Drugs Vis-à-vis Non-Prescription Drugs

Table 4: Obesity Treatment Options and

Corresponding Success Rate

5.Anti-Obesity Drugs- An Insight

Introduction

Mechanism of Action

Review of Available Drugs

Phentermine

Sibutramine

Orlistat

Anti-obesity Drugs, Brands and Mechanism of Action

Table 5: Global Anti-obesity Prescription Drugs Market (2006): Percentage Share Breakdown of Prescriptions by Physician Practices - Primary Care Physicians (PCP), Internal Medicine, Obsterics/Gynecology, Endocrinology/Diabetes, Psychiatry/Neurology,

Cardiology and Others (includes corresponding Graph/Chart)

Review of Select Drugs Awaiting approval / Under Trials

6.Recent Clinical Trials

Genaera Initiates First Human Trial of Trodusquemine

Neurogen Completes First Trial of NGD-4715

Alizyme Secures USFDA Approval for Cetilistat Trials

GW Pharma to Start Human Trials of

New Anti Obesity Drug

Epix Completes Phase Ib Trial of PRX - 07034

7TM Pharma Starts Phase I/II Trial of TM30339

Arena Starts Phase III Clinical Trials of Lorcaserin

Drug Induced Serotonin Could Promote Weight Loss

Takeda Initiates Phase II Clinical Trials of ALT-962

Glenmark to Commence Phase I Trial of

New Anti-Obesity Drug

Amylin-Leptin Integrated Therapy to Treat Obesity

Vivus Completes Phase II Trial of Qnexa

VERNALIS Starts Phase I trial for Obesity

7TM Pharma Completes Phase I/ II Clinical Trials of

TM30338

Manhattan Pharmaceuticals Starts Phase I trial of

Oleoyl estrone

Arena Completes Phase2b Trials of APD356

Metabolic Accomplishes Phase 2b Trials of AOD9604

7.Product Approvals/Launches

Sanofi-Aventis Receives Swiss Approval for Acomplia

Zydus Cadila Introduces Slimona

Torrent Introduces Rimoslim

Gencor Introduces Slimaluma

Orexigen Develops Excalia

Scripps Research Institute Develops Vaccine for Obesity

Sanofi-Aventis Receives Approval to Market

Obesity Drug in EU

Sanofi-Aventis Rolls Out Acomplia

Sanofi Secures Approval for Acomplia in the UK

Novo Nordisk to Develop Anti-obesity Drug

Sanofi-Aventis Receives Approval to Market

Acomplia in Mexico

Ind-Swift Introduces Sibuslim-10

Wellnx Launches NV

Iron-Tek Introduces Appetite Suppressant

Yamanouchi and Keio University Discover Target

Molecule for Developing Anti-obesity Drug

8.Recent Industry Activity

Pfizer Halts CP-945, 598 Development

Shionogi to Acquire Sciele Pharma

Anthill Inks Agreement with Zafgen

EMEA Suspends Acomplia

GlaxoSmithKline to Sell Alli as OTC Drug

Sanofi-Aventis to Market Acomplia in UK

Orexigen Receives 4th US Patent for Contrave

BELLUS Health to Acquire Innodia

Ore Secures License to Develop Romazarit

GlaxoSmithKline Receives FDA Approval for Orlistat

Pfizer Receives Approval for Slentrol

GlaxoSmithKline Secures Licensing Rights of Orlistat

Pfizer Collaborates with Bristol-Myers Squibb

Takeda Collaborates with LG Life Sciences

Takeda to Acquire Paradigm

Sanofi-Aventis Secures Reimbursement Status

for Acomplia

AstraZeneca Inks Agreement with Palatin Technologies

Switzerland Includes Acomplia in Reimbursement List

Allergan Pockets EndoArt

Sanofi-Aventis Receives Approval for Acomplia

in Brazil

Biocon Inks MoU with Neopharma

Aurigene Partners with Forest Laboratories

Pfizer Licenses Obesity Compounds from Bayer

Pharmaceuticals

Merck Terminates Collaboration with Nastech

Sanofi-Aventis to Receive Rights for Rimonabant

UMN Pharma Inks Agreement with Crucell and

DSM Biologics

7TM Pharma Pockets CareX SA

BioLineRx Inks Licensing Agreement with Yissum

Aegis Inks Licensing Agreement with Albany

Medical College

Manhattan’s Obesity Drug Approved for Human Trials

Chugai Halts Development of Anti-Obesity Agent

HSG Acquires Polymann

Orchid Pockets Bexel

9.Focus on Select Players

Abbott Laboratories (US)

Alizyme Plc (UK)

Amylin Pharmaceuticals, Inc. (US)

AstraZeneca Plc (UK)

F. HOFFMANN-LA ROCHE LTD. (Switzerland)

GlaxoSmithKline Plc (UK)

Sanofi-Aventis SA (France)

SuperGen, Inc. (USA)

Takeda Pharmaceutical Company Limited (Japan)

VIVUS, Inc. (US)

10.Global Market Perspective

Table 6: World Recent Past, Current & Future Market Analysis for Anti-Obesity Drugs by Geographic Region - US, Europe

and Rest of World Independently Analyzed with Annual

Sales Figures in US$ million for Years 2005 through

2015 (includes corresponding Graph/Chart)

Table 7: World 10-Year Perspective for Anti-Obesity Drugs by Geographic Region - Percentage Breakdown of Dollar Sales

for US, Europe and Rest of World Markets for Years 2006,

2009 and 2015 (includes corresponding Graph/Chart)

III. MARKET

1.The United States

A. Market Analysis

Market Overview

Table 8: Leading Product Segments in the US Weight Loss Market (2008E): Percent Share Breakdown of Revenues for Diet Drinks, Health Clubs, Bariatric Surgery, Diet Foods, Artificial Sweeteners, Weight Loss Centers, Medically Supervised Programs, Meal Replacements & Appetite Suppressants, Prescription Drugs, Low Calorie Diet Programs and Others (includes corresponding Graph/Chart)

Obesity Catching Them Young

New Drugs to Rule the Market

37 States Experience Increase in Adult

Obesity Rate

Statistical Data

Table 9: US Obesity Rate (2007): Prevalence

Rate of Leading States

Table 10: US Obesity Prevalence Estimates and Forecasts (2006-2020) (includes corresponding Graph/Chart)

Table 11: US Overweight Prevalence (1998 & 2002): Breakdown of Adult population by Category -

Overweight and Obese

Table 12: US Obesity Prevalence (2005-2006): Breakdown of Population (%) by Sex and Age Group (includes corresponding Graph/Chart)

Table 13: US Anti-obesity Drugs Market (2006 &

2007): Number of Obese People Treated

in Million

Reimbursement Scenario

Regulatory Environment

Insufficient Regulatory and Enforcement Laws

Obesity and Related Ailments: Burden on Societal and

Economic Cost

Competition

Table 14: US Anti-obesity Drugs Market (2006 and 2007): Percentage Share Breakdown of Revenues by Brand - Meridia, Xenical and Others (includes corresponding Graph/Chart)

Recent Clinical Trials

Product Approval/Launches

Strategic Corporate Developments

Review of Major Players

B. Market Analytics

Table 15: US Recent Past, Current & Future Analysis for Anti-Obesity Drugs Market Independently Analyzed

with Annual Sales Figures in US$ million

for Years 2005 through 2015 (includes

corresponding Graph/Chart)

2.Europe

A. Market Analysis

Market Overview

Lack of Reimbursement: Barrier to Market

Growth

Statistical Data

Table 16: Obesity Prevalence (2007) in Select European Union Countries: Obesity Rates by Gender

(includes corresponding Graph/Chart)

Table 17: Europe Obesity Prevalence (2007) by Gender and Age Category (in 000s) (includes corresponding Graph/Chart)

Overview of Novel Policies Adopted by Select European

Countries to Prevent Obesity

B. Market Analytics

Table 18: European Recent Past, Current & Future

Analysis for Anti-Obesity Drugs by Geographic Region/Country - France, Germany, Italy, UK and

Rest of Europe Markets Independently Analyzed

with Annual Sales Figures in US$ Million

for Years 2005 through 2015 (includes

corresponding Graph/Chart)

Table 19: European 10-Year Perspective for Anti-Obesity Drugs by Geographic Region/Country - Percentage Breakdown of Dollar Sales for France, Germany, Italy,

UK and Rest of Europe Markets for Years 2006, 2009

and 2015 (includes corresponding Graph/Chart)

2a.France

A. Market Analysis

Market Overview

Changing Lifestyle Alter Health Profile

Product Approval/Launches

Strategic Corporate Developments

Sanofi-Aventis SA - A Key Player

B. Market Analytics

Table 20: French Recent Past, Current & Future Analysis for Anti-Obesity Drugs Market Independently Analyzed with Annual Sales Figures in US$ Million for Years 2005

through 2015 (includes corresponding Graph/Chart)

2b.Germany

A. Market Analysis

Table 21: German Anti-obesity Drugs Market (2005 and 2006): Percentage Share Breakdown of Volume Sales by Leading Brands - Meridia and Xenical and Others

B. Market Analytics

Table 22: German Recent Past, Current & Future Analysis for Anti-Obesity Drugs Market Independently Analyzed with Annual Sales Figures in US$ Million for Years 2005

through 2015 (includes corresponding Graph/Chart)

2c.Italy

Market Analysis

Table 23: Italian Recent Past, Current & Future Analysis for Anti-Obesity Drugs Market Independently Analyzed with Annual Sales Figures in US$ Million for Years 2005

through 2015 (includes corresponding Graph/Chart)

2d.The United Kingdom

A. Market Analysis

Market Overview

Table 24: UK Childhood Prevalence (1995-2005): Percentage of Obese Children Aged 2-15 years

(includes corresponding Graph/Chart)

Recent Clinical Trials

Product Approval/Launches

Strategic Corporate Developments

Review of Major Players

B. Market Analytics

Table 25: UK Recent Past, Current & Future Analysis for Anti-Obesity Drugs Market Independently Analyzed with Annual Sales Figures in US$ Million for Years 2005

through 2015 (includes corresponding Graph/Chart)

2e.Rest of Europe

A. Market Analysis

Recent Clinical Trials

Product Approval/Launches

Strategic Corporate Developments

F. HOFFMANN-LA ROCHE LTD. - A Key Player

B. Market Analytics

Table 26: Rest of Europe Recent Past, Current & Future Analysis for Anti-Obesity Drugs Market Independently Analyzed with Annual Sales Figures in US$ Million for Years 2005 through 2015 (includes

corresponding Graph/Chart)

3.Rest of World

A. Market Analysis

Brief Review of Select Regions

Canada

Table 27: Canadian Obesity Prevalence

(1979 & 2004): Obesity Rate by Age Group

(includes corresponding Graph/Chart)

Table 28: Canadian Adult Overweight and Obesity Prevalence (2004): Breakdown of Population

(in 000s) by Sex

Asia-Pacific

Australia

Table 29: Prevalence Rate (%) of overweight/obese Students in Australia (includes corresponding Graph/Chart)

China

India

Drugs Under Development by Indian

Companies

Japan

Takeda Pharmaceutical Company Limited -

A Key Player

Korea

Use of Diet Pills Lack Proper Monitoring

New Zealand

Recent Clinical Trials

Product Approval/Launches

Strategic Corporate Developments

B. Market Analytics

Table 30: Rest of World Recent Past, Current & Future Analysis for Anti-Obesity Drugs Market Independently Analyzed with Annual Sales Figures in US$ Million for Years 2005 through 2015 (includes

corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE


Abstract

This report analyzes the worldwide markets for Anti-Obesity Drugs in Millions of US$. The report provides separate comprehensive analytics for the US, Europe, and Rest of World. Annual forecasts are provided for each region for the period of 2005 through 2015. The report profiles 85 companies including many key and niche players worldwide such as Abbott Laboratories, Alizyme Plc, Amylin Pharmaceuticals, Inc., AstraZeneca Plc., F.HOFFMANN-LA ROCHE LTD., GlaxoSmithKline Plc, Sanofi-Aventis SA, SuperGen, Inc., Takeda Pharmaceutical Company Limited, and VIVUS, Inc. Market data and analytics are derived from primary and secondary research. Company profiles are mostly extracted from URL research and reported select online sources.

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