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Published by: Decision Resources
Published: Jan. 26, 2009 - 21 Pages
Table of Contents
- Executive Summary
- Strategic Considerations
- Stakeholder Implications
- Introduction
- Overview of Generalized Anxiety Disorder
- Disease Defi nition
- Diagnosis
- Pathophysiology of Generalized Anxiety Disorder
- Serotonin
- Norepinephrine
- Gamma-Aminobutyric Acid
- Glutamate
- Corticotropin-Releasing Factor
- Substance P
- Prevalence of Generalized Anxiety Disorder
- Current Therapies for Generalized Anxiety Disorder
- Selective Serotonin Reuptake Inhibitors
- Serotonin and Norepinephrine Reuptake Inhibitors
- Benzodiazepines
- Emerging Therapies for Generalized Anxiety Disorder
- Sanofi -Aventis’s Saredutant
- Takeda/Lundbeck’s Lu AA21004
- Pfizer’s Lyrica and PD-332334
- Synosia Therapeutics’ Rufi namide
- Sepracor’s SEP-225441
- Generalized Anxiety Disorder Market: 2007 Statistics and Future Outlook
- Tables
- 1. Common Symptoms of Generalized Anxiety Disorder
- 2. Common Risk Factors for Generalized Anxiety Disorder
- 3. Therapies Commonly Used to Treat Generalized Anxiety Disorder
- 4. Agents in Development to Treat Generalized Anxiety Disorder
- 5. Sales of Agents to Treat Generalized Anxiety Disorder, 2007
- Figures
- 1. Structures of the Brain Implicated in Anxiety Disorders
- 2. Prevalent Cases of Generalized Anxiety Disorder in the Major Pharmaceutical Markets,
2007 and 2012
AbstractIntroduction
Generalized anxiety disorder (GAD) is a prevalent psychiatric disorder in the major pharmaceutical
markets, and drug therapy is considered the most effective treatment. The therapy market for GAD
is crowded and includes many generic players, creating a diffi cult environment for launching new
agents. Nonetheless, several emerging agents are set to challenge current market leaders.
Get the Answers You Need to Shape Your Strategy
- GAD can be very debilitating, causing those affected to significantly limit their activities.
How many people in the major pharmaceutical markets we cover (United States, France,
Germany, Italy, Spain, United Kingdom, and Japan) have GAD? What brain structures and
neurotransmitters have been implicated in its development? How is the disease diagnosed?
- A variety of drug classes are used to treat GAD. What are the most popular therapies for GAD?
What are their benefi ts and drawbacks?
- Several new agents for GAD should launch in the next few years. What agents are in the pipeline
for GAD, and are they likely to replace any existing agents? What changes can be expected in
the GAD market over the next five years?
Scope
- Overview of GAD: disease description, diagnosis, and pathophysiology.
- Epidemiology: total prevalent cases, diagnosed and drug-treated populations.
- Current therapies: selective serotonin reuptake inhibitors, serotonin and norepinephrine
reuptake inhibitors, and benzodiazepines.
- Emerging therapies: Sanofi -Aventis’s Saredutant, Pfi zer’s Lyrica, Pfi zer’s PD-332334,
Takeda/Lundbeck’s Lu AA21004, Synosia Therapeutics’ Rufi namide, Sepracor’s SEP-
225441 and AstraZeneca’s AZD-7325.
- GAD market: 2007 statistics, outlook for emerging agents.
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