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Lung Cancer Drug Pipeline Update 2009Published by: BioSeeker Group AB Published: Jan. 20, 2009 Table of ContentsPlease Note: Due to the brevity and/or nature of the content posted, there is no table of contents available for this report. AbstractExecutive SummaryNon-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) comprises over 95% of all lung cancers. High unmet needs still persist for this tumor type and despite two decades of extensive R&D and chemotherapy use, the median overall survival of NSCLC patient’s remains below 12 months. More than 80,000 new SCLC cases are expected to be diagnosed in 2007 in the seven major markets, although it is set to decrease due to changing smoking habits. Mesothelioma is rarer, although incidence is expected to increase in the coming years in Europe and Japan given the heavy use of asbestos in the 1970s and long latency period of the disease. There are today more than 350 therapeutics targeting lung cancer in active development, from early preclinical to marketed drugs. In addition, the accumulated number of ceased drugs over the last three years amount to another 117 drugs. Lung Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 181 different targets. These targets are further categorized on the CD-ROM by 55 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Lung Cancer Drug Pipeline Update is organized. How May Drug Pipeline Update Be of Use? Show investors/board/management that you are right on top of drug development progress in your therapeutic area. Find competitors, collaborations partners, M&A candidates etc. Jump start competitive drug intelligence operations Excellent starting point for world wide benchmarking Compare portfolio and therapy focus with your peers Speed up pro-active in-/out licensing strategy work Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below. Drug Pipeline Update at a Glance Investigators Includes more than 265 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 500 names Developmental stage This Drug Pipeline Update contains 352 drugs in active development for the treatment of lung cancer: #37 marketed drugs #1 drug registered #3 drugs pre-registered #22 drugs in Phase III #140 drugs in Phase II #76 drugs in Phase I #63 drugs in Preclinical #10 drugs in other developmental stages Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included lung cancer drugs are also in development for over 120 other listed indications Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to more than 181 different targets, divided into 55 classifications of molecular function: Target Expression Profile Direct links are provided from inside the application to 193 protein expression profiles of 135 drug targets in various human tissues and cancer types, cell lines and primary cells, includin u to:
Mechanism In total there are 217 different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Pathways Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma - Phase II Clinical Trial - Active Cancer, prostate - Phase III Clinical Trial - Ceased Drug Description Short introduction to drug Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
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