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Apoptosis in Oncology: Drug Pipeline Update 2009Published by: BioSeeker Group AB Published: Jan. 20, 2009 Table of Contents
the content posted, there is no table of contents available for this report. AbstractExecutive SummaryCancer cells frequently and possibly invariably possess apoptotic defects. In this context, apoptotic pathways provide exciting molecular targets for new therapeutic agents to specifically promote apoptosis of cancer cells. There are today more than 300 apoptopic drugs in active development for the treatment of cancer, from early preclinical to marketed drugs. In addition, the accumulated number of ceased drugs over the last three years amount to another 81 drugs. Apoptosis in Oncology: Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 188 different targets. These targets are further categorized on the CD-ROM by 52 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Apoptosis in Oncology: Drug Pipeline Update is organized. How May Drug Pipeline Update Be of Use? Show investors/board/management that you are right on top of drug development progress in your therapeutic area. Find competitors, collaborations partners, M&A candidates etc. Jump start competitive drug intelligence operations Excellent starting point for world wide benchmarking Compare portfolio and therapy focus with your peers Speed up pro-active in-/out licensing strategy work Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below. Drug Pipeline Update at a Glance Investigators Includes 246 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators. Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator. Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 450 names Developmental stage This Drug Pipeline Update contains 301 apoptopic cancer drugs in active development and 793 developmental projects: #37 projects have reached market approval #2 projects have been registered #7 projects in pre-registration #34 projects in Phase III #299 projects in Phase II #233 projects in Phase I #167 projects in Preclinical #14 projects in other developmental stages Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application. Indications Included apoptopic drugs are in development for 145 indications, where of 72 are different cancer indications. All drugs are in development for the treatment of cancer. Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application. Targets Identified drugs are linked to more than 188 different targets, divided into 52 classifications of molecular function:
Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application. Target Expression Profile Direct links are provided from inside the application to 191 protein expression profiles of 129 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to: Mechanism In total there are 221 different drug mechanism of action represented in this Drug Pipeline Update. Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application. Compound Identified drug compounds are described by: Compound type, Chemical name, CAS Number and molecular weight Note: You are able to sort and find drugs according to compound type from drop-down menu in the application. Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information: Drug Name & Synonyms Presentation of drug name and synonyms Principal Investigator & Partners Presentation of principal investigator and partners Target and Molecular Function of Target Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function Target Localization Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to: 48 different normal tissue types 20 different types of cancer 47 cell lines 12 samples of primary blood cells Targeted Pathways Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath. Mechanism Drug mechanism of action Developmental Projects Summary field of developmental projects for the drug, including indication, developmental stage and status. Example: Cancer, myeloma - Phase II Clinical Trial - Active Cancer, prostate - Phase III Clinical Trial - Ceased Drug Description Short introduction to drug Compound Data Compound type, Chemical name, CAS Number and molecular weight Patent Data Available patent information related to the drug is presented here. Business & Markets Collaborations and deals Approvals and submissions Analyst comments Phase III Data Available Phase III development data, developmental history and scientific data. Phase II Data Available Phase II development data, developmental history and scientific data. Phase I Data Available Phase I development data, developmental history and scientific data. Preclinical Data Available preclinical development data, developmental history and scientific data. Licensing Information Availability for licensing Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
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