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Successful Pharmabiotech Alliance Strategies: Driving Synergies, Avoiding Failure and Managing Relationships

Published by: Business Insights

Published: Sep. 1, 2008 - 143 Pages


Table of Contents



Successful Pharma-Biotech Alliance Strategies

Executive summary

Pharma and biotech company synergies

Overview of pharma-biotech alliances

Why pharma-biotech alliances fail

Strategies to manage pharma-biotech alliances

The future of pharma-biotech alliance management

Chapter 1 Pharma and biotech company synergies

Summary

Background

The pharmaceutical industry

The research and development process

Resources

Constraints and pressures

The biotechnology industry

The research and development process

Resources

Constraints and presures

Drug development today

More sophisticated science

More complicated disease targets

Rapidly escalating costs

Declining R&D productivity

Conclusions

Chapter 2 Overview of pharma- biotech alliances

Summary

Introduction

Evolution of major alliances

Genentech

ImClone

MedImmune

Current deal trends

Types of relationships currently undertaken

Licensing

Significant recent pharma-biotech licensing deals

Joint ventures

Significant recent pharma-biotech joint ventures

Acquisitions

Significant recent pharma-biotech acquisitions

Hostile takeovers

Offshore alliances

Japan

China

India

Canada

Number and value of alliances

Key therapeutic areas for pharma-biotech alliances

Conclusions

Chapter 3 Why pharma-biotech alliances fail

Summary

High failure rates

Symptoms of alliance failure

Factors that do not affect alliance success

Main causes of alliance failure

Management changes

Culture

Project organization and expectations

Alliance goals

Incentives

Roles and responsibilities

Sharing of business processes

Decision support infrastructure

Project and alliance leadership

Harmonization of information technology

Timelines and budgets

Alliance expectations

Other preventable problems

Technology failure

The drug approval process

Drug development success rates

Case study: Alza and Scios

Vulnerability by alliance type

Licensing deals

Joint ventures

Acquisitions

Conclusions

Chapter 4 Strategies to manage pharmabiotech alliances

Summary

Determining alliance success

Performance measurement

Alliance goals versus company goals

Why effective alliance management is crucial

Key alliance management strategies

Deal structure

Case study : Wyeth

Case study : Novartis

Relationship managing and monitoring

Case study : Eli Lilly

Case study : GlaxoSmithKline

Exploiting synergies across alliances

Biologics consolidation

Case study: AstraZeneca

Case study: Novartis

Case study: Pfizer

Addressing corporate culture

Case study: WuXi PharmaTech

Leadership continuity

Renegotiation

Third party services

Conclusions

Chapter 5 The future of pharma-biotech alliance management

Summary

Increasing reliance on biotech by Big Pharma

Positions of the leading pharmaceutical companies

AstraZeneca

Bayer

Eli Lilly

GlaxoSmithKline

Johnson & Johnson

Merck

Novartis

Pfizer

Sanofi-Aventis

Weyth

Deal trends

Number and value

Therapeutic areas

Types of relationships

Offshore relationships

Relationship management trends

Conclusions

Index

List of Figures

Figure 1.1: U.S. NME approvals vs. R&D spend, 1980 - 2007

Figure 1.2: U.S. R&D spend per NME approval by year, 1990 - 2007

Figure 2.1: Comparison of key types of pharma-biotech alliances

Figure 2.2: Volume and value of biolicensing deals, 1997 - 2007

Figure 3.1: Compounds tested by phase of development, 2008

Figure 3.2: Pharma-biotech alliance failure trends by alliance type

Figure 4.1: Pharma, biotech and alliance goals

Figure 4.2: Roles and responsibilities for alliance personnel

Figure 4.3: Biologics consolidation vs. alliance consolidation

Figure 5.1: Volume and value of biolicensing deals, 2005 - 2015 (est.)

List of Tables

Table 1.1: Characteristics of pharmaceutical companies and biotechs, 2008

Table 1.2: Pharma and biotech views of alliances, 2008

Table 1.3: R&D expenditure within the U.S. and abroad by PhRMA members

Table 1.4: U.S. R&D spend per NME approved, 1990 - 2007

Table 2.5: Significant recent pharma-biotech licensing deals

Table 2.6: Significant recent pharma-biotech licensing deals (continued)

Table 2.7: Significant recent pharma-biotech licensing deals (continued)

Table 2.8: Significant recent pharma-biotech licensing deals (continued)

Table 2.9: Significant recent pharma-biotech licensing deals (continued)

Table 2.10: Significant recent pharma-biotech acquisitions

Table 2.11: Significant recent pharma-biotech acquisitions (continued)

Table 2.12: Significant recent pharma-biotech acquisitions (continued)

Table 3.13: Cultural characteristics of pharmaceutical companies and biotechs

Table 4.14: Selected GlaxoSmithKline biotech alliances, 2008

Table 4.15: Capabilities of selected alliance management specialists

Table 5.16: Current and future biotech positions of top 10 pharmaceutical companies, 2008

Abstract

Successful Pharma-Biotech Alliance Strategies Driving synergies, avoiding failure and managing relationships "The average value of pharma-biotech deals will almost treble by 2015 as pharma companies focus on gaining exclusive access to high potential technologies via large equity investments..."

In recent years, alliances between pharma and biotech companies have become increasingly common.The potential synergistic benefits to both parties have resulted in over 30% of drugs in clinical trials now being a direct product of such alliances. However, poor deal structure and implemenation continue to contribute to the failure of almost half of these relationships.

‘Successful Pharma-Biotech Alliance Strategies’ is a new report published by Business Insights that provides a detailed examination of the current alliance landscape and analyses the underlying factors that can determine their success or failure. Recent major joint ventures, acquistions and licensing deals are evaluated and the latest trends and developments affecting alliance management are assessed. This report also examines 9 case studies that profile varying approaches to deal structuring and relationship management, and charts the current and future alliance activities of the top ten pharmaceutical companies. Volume and value forecasts for pharma-biotech deals to 2015 are also provided.

Explore the landscape for pharma-biotech alliances and identify the most successful approaches to deal structuring and relationship management...

Use this new report to...
  • Benchmark 9 case studies of key alliance management strategies to help you optimize your drug development alliances by identifying successful and unsuccessful approaches across the areas of deal structure, relationship management and monitoring and deal renegotiation.
  • Identify the factors that are pivotal to the success or failure of alliances by measuring the influence of a host of variables including management structure, therapeutic area focus, partner locations, drug development stage and manner of partner introduction.
  • Assess the competitive positions of potential pharma/biotech partners with this report’s analysis of current and future biotech positions of the top ten pharmaceutical companies and a detailed evaluation of recent major joint ventures, acquistions and licensing deals.
  • Understand the future landscape for pharma-biotech alliances with this report’s analysis of the latest trends and developments influencing relationship management in addition to deal trends that include volume and value forecasts for pharma-biotech deals to 2015.


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