Cardiovascular Biomarkers: Players, products and prospects (Volume III)

Published by: Espicom Healthcare Intelligence

Published: Aug. 28, 2008 - 120 Pages

Table of Contents

EXECUTIVE SUMMARY

Figure 1: Growth in biomarker market 2007-2015

What are biomarkers?

Why are they important?

Figure 2: Potential impact of biomarkers on disease pathways

What technologies are involved?

What impact will biomarkers have on R&D?

Figure 3: Potential impact of biomarkers on R&D

Who are the major biomarker players and in what research area?

Cancer biomarker companies

Cardiovascular biomarker companies

CNS biomarkers companies

Company Analysis Criteria

Biomarker technology & platforms

Association/clinical studies

Management strategy

Application & potential

CARDIOVASCULAR MARKET & REVENUES

Market revenues - global

Figure 1: Global cardiovascular disease drug sales 2007

Market revenues - leading brands

Figure 2: Leading Cardiovascular brands (2007)

Market revenues - leading players

Figure 3: Top 10 cardiovascular players (2007 revenues)

CARDIOVASCULAR EPIDEMIOLOGY, DIAGNOSIS, SCREENING & TREATMENT

Epidemiology

Figure 4: Breakdown of deaths from cardiovascular diseases in the US (2004)

Diagnosis

Screening

Table 1: Screening for cardiovascular disease

Current treatments

Table 2: Cardiovascular therapeutic drug categories and their indications

Future treatments

Figure 5: Drugs in clinical development for heart disease

CARDIOVASCULAR BIOMARKERS

Cardiovascular biomarker R&D

Figure 6: Impact of biomarkers on the drug R&D process

Table 3: Types of biomarker

Known cardiovascular biomarkers

Table 4: Commercially available cardiovascular diagnostics

Probable and possible valid cardiovascular biomarkers

Table 5: Probable cardiovascular biomarkers

Table 6: Possible cardiovascular biomarkers

CARDIOVASCULAR BIOMARKER OPPORTUNITIES & CHALLENGES

Opportunities

Figure 7: Cardiovascular biomarker opportunities

Challenges

Figure 8: Cardiovascular biomarker challenges

BIOMARKER MARKET

Biomarker market revenues - global

Figure 9: Global biomarker sales in 2007

Cardiovascular biomarker market revenues - global

Figure 10: Global cardiovascular biomarker sales in 2007

Future biomarker market revenues - global

Figure 11: Global biomarker sales in 2015

Future cardiovascular biomarker market revenues - global

Figure 12: Global cardiovascular biomarker sales in 2015

CARDIOVASCULAR BIOMARKER TRENDS

Table 7: Recent deals in cardiovascular biomarkers

Pharma and specialty pharma deals

Collaborations with service providers

Collaborations with academics and consortia

BIOMARKER ANALYSIS

Assays for circulating biomarkers

DNA and RNA biomarkers

Proteomic, metabolomic biomarkers

Systems biology for biomarker discovery

Imaging biomarkers

KEY BIOMARKER COMPANIES ANALYSED

KEY BIOMARKER EVALUATION CRITERIA

CARDIOVASCULAR BIOMARKERS - COMPANY ANALYSIS

Abbott Diagnostics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Atherotech

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Affymetrix

Biomarker novelty & technology platform

Figure 13: Affymetrix’ approach to biomarker discovery, validation and clinical utility applications

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Beckman Coulter

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Berkeley HeartLab

Biomarker novelty & technology platform

Figure 14: Markers of cardiovascular disease measured at Berkeley HeartLab

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

BG Medicine

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Figure 15: BG Medicine’s Biomarker Programme

Application & market potential

Biomarker analysis

CardioDx

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Competitor Ratio Analysis Score = 9/40

Celera

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

CIS Biotech

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Clinical Data

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Compugen

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Critical Diagnostics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

deCODE Genetics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Figure 16: deCODE’s approach to target discovery and development

Application & market potential

Biomarker analysis

diaDexus

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Entelos

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

FoxHollow Technologies

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

GE Healthcare

Biomarker novelty & technology platform

Figure 17: Cardiology focus at GE Healthcare

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Genomas

Biomarker novelty & technology platform

Figure 18: PhysioGenomics Technology from Genomas

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Inverness Medical Innovations

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Jurilab

Biomarker novelty & technology platform

Figure 19: Jurilab’s Genetic Discovery Method

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Competitor Ratio Analysis Score = 12/40

Laboratory Corporation of America

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Lipomics Technologies

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

LipoScience

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Competitor Ratio Analysis Score = 15/40

Nanosphere Inc.

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Osmetech Molecular Diagnostics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Competitor Ratio Analysis Score = 12/40

PrognostiX

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Quest Diagnostics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Competitor Ratio Analysis Score = 27/40

Roche Diagnostics

Biomarker novelty & technology platform

Figure 20: Roche’s technologies for biomarker discovery and development

Association studies/clinical data

Figure 21: Roche’s clinical trial programme for cardiac biomarker NT-proBNP

Management strategy

Application & market potential

Biomarker analysis

Siemens Medical Solutions

Biomarker novelty & technology platform

Figure 22: Siemens Integrated in vivo & in vitro diagnostic suites

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Singulex

Biomarker novelty & technology platform

Figure 23: Sensitivity of Singulex’s Erenna system compared to ELISA and bead-based fluorescence readout systems

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

SuperArray Bioscience Corporation

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Vermillion

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Zora Biosciences OY

Biomarker novelty & technology platform

Table 8: Zora metabolite profiling platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

CARDIOVASCULAR BIOMARKER APPENDIX 1

Table 9: Global biomarker sales 2007-20015E

CARDIOVASCULAR BIOMARKER APPENDIX 2

Table 10: Global cardiovascular biomarker sales 2007-20015E

CARDIOVASCULAR BIOMARKER APPENDIX 3

Company Analysis Criteria

Biomarker technology & platforms

Association studies

Management strategy

Application & potential

Table 9: Key cardiovascular biomarker companies

Figure 26: Leading Cardiovascular Biomarker Companies - Service providers, Technology Providers, Biomarker Discovery & Diagnostic Developers

GLOSSARY

ACRONYMS

BIBLIOGRAPHY & ENDNOTES

Abstract

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