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Cancer Biomarkers: Players, products and prospects (Volume I)

Published by: Espicom Healthcare Intelligence

Published: Aug. 28, 2008 - 138 Pages


Table of Contents


EXECUTIVE SUMMARY

Figure1: Growth in biomarker market 2007-2015

What are biomarkers?

Why are they important?

Figure 2: Potential impact of biomarkers on disease pathways

What technologies are involved?

What impact will biomarkers have on R&D?

Figure 3: Potential impact of biomarkers on R&D

Who are the major biomarker players and in what research area?

Cancer biomarker companies

Cardiovascular biomarker companies

CNS biomarkers companies

Company Analysis Criteria

Biomarker technology & platforms

Association/clinical studies

Management strategy

Application & potential

CANCER MARKET & REVENUES

Market revenues - global

Figure 1: Global cancer drugs sales (2007)

Market revenues - leading brands

Figure 2: Leading cancer brands (2007)

Market revenues - leading players

Figure 3: Top 10 oncology players (2007 revenues)

CANCER EPIDEMIOLOGY, DIAGNOSIS, SCREENING & TREATMENT

Epidemiology

Table 1: Cancer Statistics for four most common cancers, 2008

Diagnosis

Screening

Table 2: Cancer screening

Current & future treatment

Future treatment

Figure 4: Anticancer drugs in clinical development

CANCER BIOMARKERS

Cancer biomarker R&D

Table 3: Types of biomarker

Known cancer biomarkers

Table 4: Commercially available known cancer biomarker diagnostics

Probable and possible valid cancer biomarkers

Table 5: Probable cancer biomarkers diagnostics

Table 6: Possible cancer biomarkers diagnostics

CANCER BIOMARKER OPPORTUNITIES & CHALLENGES

Opportunities

Challenges

BIOMARKER MARKET

Biomarker market revenues - global

Figure 8: Global biomarker sales in 2007

Cancer biomarker market revenues - global

Figure 9: Global cancer biomarker sales in 2007

Future biomarker market revenues - global

Figure 10: Global biomarker sales in 2015

Future cancer biomarker market revenues - global

Figure 11: Global cancer biomarker sales in 2015

CANCER BIOMARKER TRENDS

Table 7: Recent deals in oncology biomarkers

Pharma and specialty pharma deals

Collaborations with service providers

Collaborations with academics and consortia

BIOMARKER ANALYSIS

DNA biomarkers

RNA and microRNA biomarkers

Proteomic biomarkers

KEY BIOMARKER COMPANIES ANALYSED

KEY BIOMARKER EVALUATION CRITERIA

CANCER BIOMARKER- COMPANY ANALYSIS

Abbott Diagnostics

Biomarker novelty & technology platform

Figure 12: Abbott’s UroVysion bladder cancer test

Association studies/clinical data

Pivotal Trial

Table 7: Comparison of UroVysion vs Cystoscopy/Histology for Detection of Bladder Cancer Recurrence by Stage and Grade*

Management strategy

Application & market potential

Biomarker analysis

Affymetrix

Biomarker novelty & technology platform

Figure 13: Affymetrix’ approach to biomarker discovery, validation and clinical utility applications

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Agendia BV

Biomarker novelty & technology platform

Association studies/clinical data

Figure 14: MammaPrint Profile vs NIH Consensus Criteria

Management strategy

Application & market potential

Biomarker analysis

AltheaDx

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

AVEO Pharmaceuticals

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

BG Medicine

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Figure 15: BG Medicines Biomarker Programme

Application & market potential

Biomarker analysis

Beckman Coulter

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

BioCurex

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Biomedical Diagnostics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Biomerica

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Bruker Daltonics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Caprion Proteomics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Clinical Data

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Celera

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Dako Denmark A/S

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

DxS Ltd

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Epigenomics AG

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Epistem Plc

Biomarker novelty & technology platform

Figure 16: Epistem’s Biomarker Drug Development Programme

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

GeneNews

Biomarker novelty & technology platform

Figure 17: GeneNews’ Sentinel Principle

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Fujirebio Diagnostics, Inc

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Genomic Health

Biomarker novelty & technology platform

Figure 18: Oncotype Dx test for invasive breast cancer

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Gen-Probe

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Genzyme Genetics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

InterGenetics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Ipsogen Therapeutics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Figure 19: Oncotype Dx test for invasive breast cancer

Application & market potential

Biomarker analysis

Laboratory Corporation of America

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Matritech

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Monogram Biosciences

Biomarker novelty & technology platform

Figure 20: VeraTag Assay

Association studies/clinical data

Figure 21: VeraTag Clinical Data: Bordet Cohort

Management strategy

Application & market potential

Biomarker analysis

Orion Genomics

Biomarker novelty & technology platform

Figure 22: Orion’s MethylScope

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Oxford Genome Biosciences (UK) Ltd

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Power3 Medical Products

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Figure 23: Powder3’s business strategy

Application & market potential

Biomarker analysis

Predictive Biosciences

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Provista Life Sciences

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Quest Diagnostics

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Roche Diagnostics

Biomarker novelty & technology platform

Figure 24: Diagnostic marker candidate to a product

Association studies/clinical data

Figure 25: Biomarkers distinguish Leukaemia subclasses

Management strategy

Application & market potential

Biomarker analysis

SuperArray Bioscience Corporation

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Third Wave Technologies

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Upstream Biosciences

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Veridex, LLC

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

Vermillion

Biomarker novelty & technology platform

Association studies/clinical data

Management strategy

Application & market potential

Biomarker analysis

CANCER BIOMARKER APPENDIX 1

Table 8: Global biomarker sales 2007-20015E

CANCER BIOMARKER APPENDIX 2

Table 8: Global cancer biomarker sales 2007-20015E

CANCER BIOMARKER APPENDIX 3

Company Analysis Criteria

Biomarker technology & platforms

Association studies

Management strategy

Application & potential

Table 9: Key cancer biomarker companies

Figure 26: Leading Cancer Biomarker Companies - Service providers, Technology Providers, Biomarker Discovery & Diagnostic Developers

GLOSSARY

ACRONYMS

BIBLIOGRAPHY & ENDNOTES

Abstract

Part of Espicom's new 3-volume report on Cancer, CNS and Cardiovascular Biomarkers, this volume provides a comprehensive analysis of the cancer biomarker sector, along with a critical assessment of the companies involved.

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