Botulinum Toxin

Published by: Global Industry Analysts

Published: May. 1, 2008 - 118 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Product Definitions and Scope of Study

Cosmetic Applications

Therapeutic Applications

II. EXECUTIVE SUMMARY

1. Industry Overview

‘Bright’ Outlook Forecast for Botulinum Toxin

Growth Drivers for Botulinum Toxin

Market Dynamics

Combination Therapy Supports Market Growth

Botulinum Toxin and Soft Tissue Filling Agents

Botulinum Toxin Injections and Laser Resurfacing

Botulinum Toxin and Phenol

Technological Innovations Drive Botulinum Market

Changing Consumer Belief

Under-Treated Diseases Boost Demand for Off- Label Products

Burgeoning Consumer Awareness

‘Feeling’ to Look Good - Driving Aesthetic Market

Expansion of Financing Services to Propel Growth

Adverse Effects Impedes Market Growth

High Cost - A Major Market Restraint

Concern over Long-Term Side Effects

2. Competitive Landscape

Allergan Dominates Global Botulinum Toxin Market

Table 1: Revenues of Allergan, Inc (2001-2005): Net Sales of Botox®/Neuromodulator(In US$ Million) (includes corresponding Graph/Chart)

Botox Dominance Remains Stable in the Global Market

Clinical Trails in Progress for Botox

Ipsen - Major Player in Botulinum Toxin Market

Table 2: Revenues of Ipsen Group (2004 & 2005): Net Sales of Dysport® (In € Million)

Clinical Trails in Progress for Dysport

Solstice - Only Global Manufacturer of Type B Botulinum Toxin

Table 3: Leading Players in Global Botulinum Toxin (Therapeutic) Market (2005): Percentage Breakdown by Revenues for Allergan (Botox®), Solstice (Myobloc®), Ipsen and (Dysport®) (includes corresponding Graph/Chart)

Table 4: Leading Players in Global Botulinum Toxin (Cosmetic) Market (2005): Percentage Breakdown by Revenues for Allergan (Botox®), Ipsen (Dysport®/Reloxin®), and Others (includes corresponding Graph/Chart)

Worldwide Botulinum Toxin Market (2005): Competitors Profile of the Top 2 Companies

Comparison of Allergan’s Botox® and Ipsen’s Reloxin®

Table 5: Worldwide Botulinum Toxin Market (2005 & 2006): Percentage Breakup by Key Products - Botox®, Dysport®, Myobloc®, and Others® (includes corresponding Graph/Chart)

3. Product Overview

Botulinum Toxin - An Introduction

Chemical Overview

Mechanism of Botulinum Toxin

Side Effects

Immunogenicity Effects Response to Botulinum Therapy

A Peek into the History and Development

Botulinum Toxin - A Classification

Botulinum Toxin Type A

Botox®

Historical Timeline of Botox: 1885-2002

Botox Approvals and Indications in Select Global Regions

Dysport®

Xeomin®

Botulinum Toxin Type B

Myobloc®

Key Products in Botulinum Toxin Type A, Type B

Competitive Overview of Botox® - Cosmetic Purpose (Smoothing of Facial

Wrinkles)

Other Types

Applications of Botulinum Toxin

Botulinum - Toxin or Treatment?

Therapeutic Applications of Botulinum Toxin

Botulinum Toxin for Movement Disorders

Botulinum Toxin Cures Dystonia

Botulinum is Beneficial for Cervical Dystonia

Botulinum Toxin Cures Laryngeal Dystonia

Ease from Writer’s Cramp

Botulinum - Useful To Treat Oromandibular Dystonia

Tics

Tremors

Parkinson's Disease

Botulinum Toxin Treats Hemifacial Spasm

Is Botulinum Toxin an Answer to Blepharospasm?

Tantalizing Effect in Strabismus

Childhood Strabismus

Botulinum Toxin Helps Spasticity Cure Better

Stroke

Traumatic Brain Injury

Cerebral Palsy

Multiple Sclerosis

Botulinum Toxin Soothes Pain

Botulinum Heals Hypertonic Disorders

Cosmetic Applications of Botulinum Toxin

Botulinum Toxin Irons Out Facial Wrinkles

Botulinum Lessens Facial Scarring

Botulinum Toxin (Botox) Users Becoming Addictive

Key Cosmetic Indications for Botulinum Toxin

Additional Applications

Positive Response of Rigid Spine Syndrome to Botulinum Toxin

Botulinum Toxin Effective in Bladder Dysfunctions

Botox Provides Respite from Tinnitus

Botulinum Toxin for Anal Fissure

Can Botox Prevent Baldness?

Refractory Vaginismus and Botulinum

Botulinum Toxin Helps to Cure Dysphagia

Encouraging Effects of Botox in Migraine

Botulinum Eases Severe Facial Pain

Botulinum Provides Relief from Pelvic Floor Pain

Botox Can Treat Children with Non-Neurogenic, Neurogenic Bladder

Botulinum Toxin Finds Application in Cancer Treatment

Botox Can Reduce Pain, Itching and Hand Eczema

Botulinum Reduces Plantar Fasciitis Pain

Botox Helps to Treat Carpal Tunnel Syndrome

Other Indications for Botulinum Toxin

Terrorist and Military Exploitation of Botulinum Toxin

Botulism - Infection from Botulinum

Types of Botulism

Classical or Food Borne Botulism

Home Canning - Culprit Behind Botulism

Wound Botulism

Infant Botulism

Botulism Outbreak in Animals

Safety Precautions

Medicinal Investigations

Vaccine for Botulinum Toxin

Technological Development

US Inventor Develops New Fermentation Process

4. Recent Industry Activity

Allergan and Clinique Form Strategic Collaboration

Ipsen and Medicis File BLA for Reloxin®

Medicis Plans Investment in Revance

Galderma Receives Distribution Rights for Dysport (R)

Allergan to Acquire Espirit Pharma

Allergan Launches "Project: Sweat Free"

Solstice Neurosciences Inks Commercialization Agreement

Ipsen Partners with Galderma

Allergan Rolls Out New Division with Acquisition of Inamed

FTC Mandates Allergan Divest Rights to Reloxin

Medicis Inks Agreement with Ipsen

Solstice Neurosciences Inks Licensing Agreement with DreamPharma

Botox Enters India Market

Mentor Begins Phase-I Clinical Trial on Botulinum Toxin

Allergan Inks Agreement with GlaxoSmithKline

DOR BioPharma Inks Agreement with Dowpharma

Merz Pharma Receives Approval for Botulinum Toxin Type A

Mentor Initiates Phase-I Clinical Trial

Mentor Establishes New Production Facility

DOR BioPharma and Thomas Jefferson University Teams-Up with US Army

Mentor Inks Licensing Agreement with WARF

Solstice Acquires World Rights for Myobloc

Inamed Rolls Out Reloxin Brand

5. Focus on Select Key Players

Allergan, Inc (USA)

Ipsen Group (France)

Metabiologics Inc, (USA)

Merz Pharmaceuticals GmbH (Germany)

Mentor Corporation (USA)

Solstice Neurosciences, Inc. (USA)

6. Global Market Perspective

Table 6: World Recent Past, Current & Future Analysis for Botulinum Toxin by Geographic Region - US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 7: World Long-term Projections for Botulinum Toxin by Geographic Region - US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart)

Table 8: World 10-Year Perspective for Botulinum Toxin by Geographic Region - Percentage Breakdown of Dollar Sales for US and Rest of World for the Years 2003, 2008 & 2012

Table 9: World Recent Past, Current & Future Analysis for Botulinum Toxin in Cosmetic Applications by Geographic Region - US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 10: World Long-term Projections for Botulinum Toxin in Cosmetic Applications by Geographic Region - US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart)

Table 11: World 10-Year Perspective for Botulinum Toxin in Cosmetic Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US and Rest of World for the Years 2003, 2008 & 2012

Table 12: World Recent Past, Current & Future Analysis for Botulinum Toxin in Therapeutic Applications by Geographic Region - US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 13: World Long-term Projections for Botulinum Toxin in Therapeutic Applications by Geographic Region - US and Rest of World Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart)

Table 14: World 10-Year Perspective for Botulinum Toxin in Therapeutic Applications by Geographic Region - Percentage Breakdown of Dollar Sales for US and Rest of World for the Years 2003, 2008 & 2012

III. MARKET

1. The United States

A. Market Analysis

Botulinum Toxin Market to Grow at a Healthy Rate

Botox Leads the US Botulinum Toxin Market

Botox Growth - Largely Supported by FDA Approval for Cosmetic Use

Botox Approvals and Indications in the US

Market Dynamics

Booming Non-Surgical Treatments

Aging Baby Boomers Drive Aesthetic Business

Increasing Physician Base Impels Botulinum Market

Direct-to-Consumer Advertising Drive Cosmetic Botulinum Toxin

Increasing Off-label Use of Botulinum Toxin

Medical Spas - Growing in Number

Heightened Competition Limits Growth

Arduous Regulations Deter Product Progress

Botulism Poisoning - A Major Concern

Botox Injection - Popular Non-Invasive Cosmetic Procedure

Table 15: Number of Botox Injections (2000-2005) (includes corresponding Graph/Chart)

Table 16: Botox Injections by Gender (2004)

Table 17: Botox Injections by Age Group (2004) (includes corresponding Graph/Chart)

Botox Attracts American Men

Table 18: Non-Invasive Cosmetic Procedures in the US (2005): Percentage of Patients Treated by All US-Based AACS Members Practices (includes corresponding Graph/Chart)

Table 19: Cosmetic Procedures (Surgical/Non-Surgical) in the US (2005): Percentage of Patients Treated by All US-Based AACS Members Practices

Factors to be Considered Prior to Cosmetic Botox Treatment

Botox for Spasticity - Improved Quality of Life

Coding and Reimbursement

US Cosmetic Market - Statistical Data

Table 20: Cosmetic Market in the US (2004 & 2005): Leading Surgical Procedures (includes corresponding Graph/Chart)

Table 21: Cosmetic Market in the US (2004 & 2005): Leading Non-Surgical Procedures (includes corresponding Graph/Chart)

Table 22: Number of Cosmetic Procedures in the US (2005): Percentage Breakdown by Gender

Table 23: Number of Cosmetic Procedures in the US (2005): Percentage Breakdown by Age Group (includes corresponding Graph/Chart)

Table 24: Number of Cosmetic Procedures in the US (2005): Percentage Breakdown by Facility (includes corresponding Graph/Chart)

Table 25: Cosmetic Market in the US (2004): Percentage Breakdown by Procedure Type

Technological Development

Strategic Corporate Developments

Key Players

B. Market Analytics

Table 26: US Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 27: US Long-term Projections for Botulinum Toxin by Application - Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart)

Table 28: US 10-Year Perspective for Botulinum Toxin - Percentage Breakdown of Dollar Sales for Cosmetic Applications and Therapeutic Applications for the Years 2003, 2008 & 2012

2. Rest of World

A. Market Analysis

Current and Future Analysis

Europe

Botox Demand Increases with Zeal For Beauty

Botox Approvals and Indications in Select European Countries

Botox to Support Radiation Treatments

Asia

India - An Emerging Market for Botox

Korea - Fast Catching Up the Trend

Australia - A Well Supported Market

Botox Approvals and Indications in Select Asian Countries

Botox Approvals and Indications in Select Latin American Regions

Botox Approvals and Indications in Other Select Global Regions

Strategic Corporate Developments

Key Players

B. Market Analytics

Table 29: Rest of World Recent Past, Current & Future Analysis for Botulinum Toxin by Application - Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2000 through 2010 (includes corresponding Graph/Chart)

Table 30: Rest of World Long-term Projections for Botulinum Toxin by Application - Cosmetic Applications and Therapeutic Applications Independently Analyzed by Annual Sales in US$ Million for the Years 2011 through 2015 (includes corresponding Graph/Chart)

Table 31: Rest of World 10-Year Perspective for Botulinum Toxin - Percentage Breakdown of Dollar Sales for Cosmetic Applications and Therapeutic Applications for the Years 2003, 2008 & 2012

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 15 (including Divisions/Subsidiaries - 17)

Region/Country Players

The United States 7

Japan 1

Europe 4

France 1

Germany 2

The United Kingdom 1

Asia-Pacific (Excluding Japan) 5

Abstract

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