Proteomics

Published by: Global Industry Analysts

Published: May. 1, 2008 - 681 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definitions and Scope of Study

Expression Proteomics

Functional Proteomics

Structural Proteomics

II. EXECUTIVE SUMMARY

1. Global Market Overview

Current Spotlight

Genesis of Proteomics

Tales From Times Gone By

Proteomics: A Critical Drug Discovery Tool

Factors Influencing the Market

Market Drivers

Factors Limiting Market Growth

Major Challenges

Proteomics Sample Preparation Market

Protein Chemistry and its Complexities

Integration of Data & Equipment

Data Validation - A Burning Issue

Standardization & Consistency- A Prime Concern

2. Industry Competition

Industry Participants

Proteomics Market Worldwide: Competitive Landscape

Proteomics Supplier Market

Challenges Ahead

Designing a Novel Business Model

3. Product and Technology Overview

Proteins, Proteome and Proteomics !!!- What are They?

Proteomics - An Introduction

Components of Proteomics

Expression Proteomics

Functional Proteomics

Cell-map Proteomics

Structural Proteomics

Technologies and Proteomics

Proteomics and Genomics

Proteomics and Genomics: A Comparison

Protein Production Pathway: From Gene Expression to Functional Protein with Controls

From Genomics to Proteomics

Functional Genomics and Proteomics

Push From Genomic Information

Standard Proteomics Approach

Sample Preparation- Step I

Protein Separation-Step II

Protein Visualization

Protein Expression Analysis-Step III

Protein Identification -Step IV

Data Storage and Processing-Step V

4. Overview of Proteomics Technologies

A Snapshot of Various Proteomics Tools

An Insight into Various Proteomics Technologies and their Application Areas

Protein Separation

Table 1: Worldwide Protein Separation Market (2003-2008P): Market Share of Leading Players- Applied Biosystems, Waters Corp., Amersham Biosciences, Agilent Technologies Inc., Bio-Rad/ Micromass, Thermo Electron, and Others (Includes corresponding Graph/Chart)

2-Dimensional Gel Electrophoresis (2DGE)

Protein Characterization

Analysis of Protein Through Mass Spectrometry

MS and Proteins

Y2H, Yeast 2-Hybrid System

Protein Microarrays

Chip Technology

Microfluidic Applications

Role of Bioinformatics in Proteomics

Bioinformatics Applications and Tools in Proteomics

Emerging Proteomics Technologies

MudPIT

ICAT

Phage Display Technique

Advanced Proteomics Technologies: Structural Analysis Tools

X-ray Crystallography

Nuclear Magnetic Resonance (NMR)

In silico Modelling

Physicochemical Factors Constraining Metabolic Functions

5. End-Use Application Areas

End-Use Application Areas

Proteomics in Drug and Diagnostic Discovery

Proteomics and Drug Discovery

Proteomic Approaches Gaining Prominence in Cancer Drug Discovery

Leading Companies in Proteomics-Based Drug Discovery

Future of Proteomics in Drug Discovery

6. New Product Solutions/Developments

Bruker Daltonics Introduces Advanced ETD II Module

Applied Biosystems Expands its iTRAQ® Line of Labeling Reagents

PerkinElmer Expands Its Imaging Technologies and Protein Analysis Product Portfolio

Sigma-Aldrich Introduces new Proteomics Dynamic Range Standard

Thermo Fisher Scientific Expands Mass Spectrometry Portfolio

Bruker Daltonics Launches New Versions of Compass™ and ProteinScape™ Softwares

Applied Biosystems and Sciex Roll Out New Proteomic Tools

Bruker Daltonics Rolls Out New Compass™ 1.2 Software

Bruker Daltonics Unveils New Mass Spectrometer, apex®-ultra FTMS

Thermo Fisher Unveils the Latest LTQ XL mass spectrometer

Genedata Introduces Genedata Expressionist® Pro 3.0

Biozentrum to Employ GeneBio’s Phenyx as Primary Search Engine

Shimadzu Biotech Unveils AXIMA-TOF2

Waters Corporation Unveils Latest Columns for Peptide Analysis and Isolation

Applied Biosystems and MDS Sciex Unveil QSTAR® Elite LC/MS/MS System

Waters Corporation to Roll out Updated ProteinLynx Global SERVER™ Version

Syngene Unveils the Latest Integrated Proteomics Products

Sigma Unveils the Latest ProteoPrep 20 Plasma Immunodepletion Kit

Sigma-Aldrich Introduces First Commercial Proteomics Standard

Bruker Daltonics and Serva Electrophoresis Unveil ICPL Triplex kit

Agilent Unveils 3100 OFFGEL Fractionator

Agilent Technologies Unveils Multiple Affinity Removal System 7

Bio-Rad Unveils Proteon XPR36 Protein Interaction Array System

Sigma-Aldrich Adds Panorama Human Kinase v1 Array to Extend Panorama Protein Array Line

PerkinElmer Expands Proteomic Research Tools Offering

Waters Launches Advanced Version of Proteomics Research Software

Lumera to Develop New Protein Biochip in Collaboration with HMS

Agilent Launches Ion Trap Mass Spectrometer, LC/MSD Trap XCT Ultra

Bruker Launches Novel Mass Spectrometer System, HCTultra

Bruker Launches Novel Post-Translational Protein Technique

Kinexus Launches New Functional Proteomic Database

Applied Biosystems Launches Series of Liquid Chromatography Systems

Pall Introduces Three Novel Protein Purification Kits

Ciphergen Launches Nex-Gen ProteinChip System, Series 4000

Ciphergen Introduces Protein Software in Collaboration with Salford

Bruker Launches New Proteomics RIMS

Invitrogen Launches High-Density Protein Microarray

Amersham Biosciences Introduces Improved 2-D Software

Proteome Introduces Latest Version of Proteomic Software Solutions

Proteome Systems Introduces Intelligent Electrophoresis Solutions

Applied Biosystems Develops 4700 System

Biacore Launches Functional Proteomics System

Biacore Launches Software and Sensor Chips

Biacore Launches Procel™

Agilent Introduces Dual Loop Autosampler for HPLC Purification

Agilent Introduces New Methods for RNAi

Agilent Introduces Human 1B Oligo Microarray Kit

Agilent Introduces New Seperation System

Agilent Introduces Nano-flow LC System

Ciphergen Launches IDM Platform

Dionex Releases Monolithic Capillary Columns

Beckman Enhances the Product Line of ProteomeLab

7. Recent Industry Activity

Sigma-Aldrich Enters an Exclusive Alliance with Atlas Antibodies to Distribute New Prestige Antibodies™

Nonlinear Dynamics Inks Distribution Agreement with UVP, LLC

Plexera Enters into an Access Agreement with Auguron for NAPPA

NextGen and Paragon Bioservices Enter into a Commercial Partnership Agreement

Digilab Acquires Genomic Solutions and MAIA Scientific from Harvard Bioscience

Power3 Ropes in FAH to Distribute its BC-SeraPro™ in the Middle East

Thallion Sells Majority Stake to US-based Private Equity Firm, Great Point Partners

Ecopia and Caprion Merge to Form Thallion Pharmaceuticals

BG Medicine and Applied Biosystems Collaborate for Biomarker Discovery and Development

Bio-Rad Acquires Ciphergen’s Proteomics Instrument Business

BioMachines Establishes New Proteomics Services Unit

GE Acquires Biacore

Fuji Film Acquires Minority Stake in Perseus

Cenix BioScience, Applied Biosystems, and Biotec of the Technische Universität Dresden Collaborate

GeneBio and Goodlett Enter into Collaboration

Genetix Group to Acquire Applied Imaging

Massively Parallel Technologies Signs a Deal with University of Colorado

Genospectra Plans Merger with Panomics

PerkinElmer Announces Acquisition of Proteomics Labeling Technology

ActivX Biosciences Extends Alliance with Pfizer

Invitrogen Acquires Zymed

FALCO Signs a Collaborative Agreement with PPD

Invitrogen Acquires BioSource International

Agilix and Protana Enters into a Licensing Agreement

Invitrogen Pacts Marketing Agreement with Applied Biosystems

Waters Corp. Pacts a Technical Collaboration with Matrix

Kyorin Acquires ActivX Biosciences

Bruker Signs Marketing Agreement with Serva Electrophoresis

PerkinElmer Enters into a Marketing Agreement with NLD

Pepscan Collaborates with Cytos Biotechnology

BD Acquires Protein Separation Technology of FFE Weber

Invitrogen Acquires Caltag Laboratories

Qiagen Acquires Major Assets of LumiCyte

LifeSpan BioSciences Inks Long-Term Agreement with Pfizer

Dana-Farber Cancer Institute To Establish Proteomics Research Center

Bruker, University of Goettingen and PANATecs Signs an Development Agreement

NextGen Sciences Partners with Protagen

GeneBio Collaborates with Genedata

Sage-N Research to Establish R&D Center in China

Sage-N Research Integrates Sorcerer™ Systems with TPP analysis Platform of ISB

Agilent Introduces Whole Human Genome Microarray

Invitrogen Acquires Protometrix

Nanogen Acquires SXP

BioCrossroads Establishes INCAPS, Protein Center of Excellence

Ciphergen Acquires Remaining Stake in Ciphergen Biosystems K.K

Shimadzu Inks OEM Agreement with Nonlinear Dynamics

Whatman Acquires Schleicher & Schuell

GE Healthcare Acquires Amersham Plc

GeneProt Extends Collaborative Agreement with Novartis

GeneProt Collaborates with Lundbeck to Conduct CNS Proteomics Study

8. Focus on Select Key Players

Agilent Technologies, Inc. (USA)

Applied Biosystems (USA)

Bio-Rad Laboratories, Inc

Dionex Corporation (USA)

GE Healthcare (United Kingdom)

Biacore Life Sciences

Invitrogen Corporation (USA)

PerkinElmer, Inc. (USA)

Proteome Systems Ltd. (Australia)

Shimadzu Biotech (Japan)

Thermo Fisher Scientific (USA)

9. Global Market Perspective

Table 2: World Recent Past, Current & Future Analysis for Proteomics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 3: World Long-term Projections for Proteomics by Geographic Region - US, Canada, Japan, Europe and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

Table 4: World 10-Year Perspective for Proteomics by Geographic Region/Country - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe and Rest of World Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart)

Table 5: World Recent Past, Current & Future Analysis for Proteomics by Product Segment - Expression Proteomics, Functional Proteomics and Structural Proteomics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 6: World Long-term Projections for Proteomics by Product Segment - Expression Proteomics, Functional Proteomics and Structural Proteomics Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

Table 7: World 10-Year Perspective for Proteomics by Product Segment - Percentage Breakdown of Dollar Sales for Expression Proteomics, Functional Proteomics and Structural Proteomics Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart)

10. Glossary of Terms

1-D, 2-D, 3-D

Atmospheric Pressure Ionisation

Electrophoresis

Functional Genomics

High-Throughput

Liquid Chromatography (LC)

Mass Spectrometry (MS)

Matrix-Assisted Laser Desorption Ionisation (MALDI)

Nuclear Magnetic Resonance

X-ray Diffraction

Yeast Two-Hybrid System

2D-PAGE (Two-dimensional PolyAcrylamide Gel Electrophoresis)

TOF (Time of Flight)

Quadrupole

Q-TOF (Quadrupole Time of Flight)

ESI (Electrospray Ionisation)

III. MARKET

1. The United States

A. Market Analysis

Proteomics Sample Preparation Market

Table 8: US Proteomics Market (2004): Market Share of Leading Players in Proteomics Sample Preparation Markets -GE Healthcare, Agilent Technologies,, Millipore Corporation, Bio-Rad Laboratories, Inc., Invitrogen Corp., Sigma-Aldrich Co and Others (Ranked by Breakdown of Revenues) (Includes corresponding Graph/Chart)

Proteomics Arrays Markets

Table 9: US Proteomics Market (2005): Market Share of Leading Players in Proteomics Array Segment- Bio-Rad Laboratories, Invitrogen Corporation, and Others (Includes corresponding Graph/Chart)

Product Launches/Developments

Strategic Corporate Developments

Focus on Select Players

ActivX Biosciences, Inc

Adnexus

Agilent Technologies Inc

Applied Biosystems

Bio-Rad Laboratories, Inc

Bruker Daltonics, Inc

Caliper Life Sciences

Digilab Genomic Solutions, Inc

Dionex Corporation

Human Genome Sciences, Inc

Invitrogen Corporation

Millipore Corp

PerkinElmer, Inc

Thermo Fisher Scientific

Waters Corp

Xencor,Inc

Zyomyx, Inc

B. Market Analytics

Table 10: US Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 11: US Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

2. Canada

A. Market Analysis

Research Funding

Product Launches

Strategic Corporate Developments

Key Player

Caprion Proteomics, Inc

B. Market Analytics

Table 12: Canadian Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 13: Canadian Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

3. Japan

A. Market Analysis

Strategic Corporate Developments

Shimadzu Biotech - A Key Player

B. Market Analytics

Table 14: Japanese Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 15: JapaneseLong-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4. Europe

A. Market Analysis

Europe on the Fast Track

Table 16: European Proteomics Market (2007): Percentage Breakdown of Deployment of Proteomics Technologies in End-Use Segment- Research and Academia Institutions, Pharmaceutical Companies and Clinical Laboratories (Includes corresponding Graph/Chart)

B. Market Analytics

Table 17: European Recent Past, Current & Future Analysis for Proteomics by Geographic Region/Country- France, Germany, UK and Rest of Europe Markets Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 18: European Long-term Projections for Proteomics by Geographic Region/Country- France, Germany, UK and Rest of Europe Markets Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

Table 19: European 10-Year Perspective for Proteomics by Geographic Region/Country - Percentage Breakdown of Dollar Sales for France, Germany, UK and Rest of Europe Markets for Years 2003, 2008 and 2012 (Includes corresponding Graph/Chart)

4a. France

A. Market Analysis

Key Player Review

Hybrigenics SA

B. Market Analytics

Table 20: French Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 21: French Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4b. Germany

A. Market Analysis

Outlook

Strategic Corporate Developments

B. Market Analytics

Table 22: German Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million fo Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 23: German Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4c. The United Kingdom

A. Market Analysis

Current Trends in the UK Market for Proteomics

Highlights

Product Launches

Strategic Corporate Developments

B. Market Analytics

Table 24: United Kingdom Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million fo Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 25: United Kingdom Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

4d. Rest of Europe

A. Market Analysis

Switzerland

Portugal

Strategic Corporate Developments

Key Players

Biacore Life Sciences

Geneva Bioinformatics S.A. (Switzerland)

B. Market Analytics

Table 26: Rest of Europe Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 27: Rest of Europe Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

5. Rest of World

A. Market Analysis

Outlook

Australia

India

Indian Scientific Research towards Functional Genomics and Proteomics

Strategic Corporate Developments

Key Player

Proteome Systems Ltd. (Australia)

B. Market Analytics

Table 28: Rest of World Recent Past, Current & Future Analysis for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2003 through 2010 (Includes corresponding Graph/Chart)

Table 29: Rest of World Long-term Projections for Proteomics Market Independently Analyzed with Annual Sales in US$ Million for Years 2011 through 2015 (Includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Abstract

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