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Disease INFOPACK: Clostridium difficile

Published by: VacZine Analytics

Published: Aug. 1, 2008 - 53 Pages


Table of Contents



Executive Summary

The pathogen

Transmission

Pathogenesis

Host response

Risk factors

Diagnosis

Relative sensitivity of C.diff diagnostic tests

Disease outcome and classification

Expert viewpoints: disease classification

Expert viewpoints: WBC classification

Pathology

Treatment

Treatment outcomes

Expert viewpoints: first-line treatment

Expert viewpoints: multiple disease recurrences

Expert viewpoints: oral vancomycin usage to increase?

Morbidity/mortality

Epidemiology: surveillance (North America)

Epidemiology: surveillance (Europe)

Expert viewpoints: disease surveillance

Epidemiology: Overall incidence

Epidemiology: Community CDI

Expert viewpoints: community CDI

Expert viewpoints: is CDI a global problem?

Economic impact

Disease trends and dynamics

Increasing CDI incidence (US)

Increasing CDI incidence (UK)

Reasons for increasing CDI Incidence

Increasing severity

Reasons for increased severity

C.diff ribotype 027

C.diff 027 in the US

C.diff 027 in the EU (June 2008)

C.diff 027 focus on the UK

Key issues and challenges

Opportunity for new treatments

Appendix I - Back-up

Appendix II - Bibliography

Appendix III - About VacZine Analytics


Abstract

Clostridium difficile (C.diff) is a Gram-positive bacterium, which causes gastrointestinal infections in vulnerable hospitalized patients. Outcomes range from mild uncomplicated diarrhea to severe-complicated disease with fever, tachycardia and psuedomembranous colitis. Mortality rates can reach 6-30%. This DiseaseINFOPACK report is an expert review of the current literature (August 2008) providing the reader with a full easy-to-read overview of the pathogen, its epidemiology, through to its clinical impact and current management. The report also includes discussion with global opinion leaders regarding their viewpoints on current disease trends and future dynamics.

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