Providing market research reports, industry analysis, company profiles and country reports for strategic planning, competitive intelligence, marketing and business research.
Search for Market Research Reports:    

Rheumatoid Arthritis Drug Discoveries: What the Future Holds

Published by: Espicom Healthcare Intelligence

Published: Mar. 18, 2008 - 250 Pages


Table of Contents


INTRODUCTION

WHAT.IS.RHEUMATOID.ARTHRITIS?

Pathogenesis.Of.Rheumatoid.Arthritis

Classification.Of.Rheumatoid.Arthritis

Assessment.Of.Disease.Activity.And.Response.To.Treatment

CURRENT.TREATMENT.OPTIONS

Diagnosis.of.Rheumatoid.Arthritis

Pharmacological.Therapy

Treatment.Strategies

PATIENT.STATISTICS

Incidence.and.Prevalence

The.Future

THE.RHEUMATOID.ARTHRITIS.MARKET

PLAYERS AND PRODUCTS

Players.And.Products.In.2007

Players.And.Products.In.2015

DRUG GROWTH DRIVERS AND DAMPENERS

ANALYSIS.OF.CURRENT.LEADING.PRODUCTS

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Celebrex

Arcoxia

Mobic

GLUCOCORTICOIDS

TRADITIONAL DISEASE-MODIFYING ANTI-RHEUMATIC DRUGS

BIOLOGICAL AGENTS

TNF.Inhibitors

Remicade

Humira

Enbrel

Interleukin-1.Receptor.Inhibitor

Kineret

B-Cell.Targeted.Therapy

Rituxan/MabThera

T-Cell.Co-Stimulation.Modulator

Orencia

RESEARCH.AND.DEVELOPMENT.OF.RHEUMATOID.ARTHRITIS.DRUGS

LATE-PHASE PROJECTS

TNF.Inhibitors

Cimzia

Golimumab

Interleukin-6.Receptor.Inhibitor

Actemra

Interleukin-1.Receptor.Inhibitor

Canakinumab

B-Cell.Targeted.Therapy

Ocrelizumab

Ofatumumab

Non-Steroidal.Anti-Inflammatory.Drugs

Iguratimod

PN-400

Glucocorticoid

Lodotra

PHASE II PROJECTS

Oral Therapies

Adenosine.Receptor.Antagonist

CF101

Cathepsin-S.Inhibitor

RWJ-445380

Chemokine.Receptor.Antagonists

Selzentry

DHODH.Inhibitor

SC12267

Interleukin.Inhibitors

Apilimod

Kinase.Inhibitors

681323

856553

BMS-582949

CP-195543

CP-690550

INCB18424

PH-797804

SCIO-469

Tamatinib

VX-702

T-Cell.Co-Stimulation.Modulator

RhuDex

Other.Oral.Therapies

274150

CH-1504

CRx-102

K-832

PMI-001

R7277

Injectable Therapies

B-Cell.Targeted.Therapy

Atacicept

LymphoStat-B

TRU-015

Interleukin.Inhibitors

AMG 108

Lymphotoxin.Beta.and.LIGHT.Pathway.Inhibitor

Baminercept

RANK.Ligand.Inhibitor

Denosumab

TNF.Inhibitor

tgAAC94

Other.Injectable.Therapies

MM-093

PHASE I PROJECTS

Kinase.Inhibitors

ARRY-438162

ARRY-797

MLN0415

Anti-TNF

ART621

Others

PRTX-100

VAP-1

APPENDIX.1:.COMPETITOR.RATIO.ANALYSIS

APPENDIX.2:.COMPANY.PROFILES

4SC

Abbott

Amgen

Arana Therapeutics

AstraZeneca

Biogen Idec

Bristol-Myers Squibb

Can-Fite Biopharma

Chelsea Therapeutics

Chugai

CombinatoRx

Dainippon Sumitomo Pharma

Eisai

Eli Lilly

Genmab

GlaxoSmithKline

Human Genome Sciences

Johnson & Johnson

Kowa Pharmaceutical

Medarex

Medigene

Merck KGaA

Merrimack Pharmaceuticals

Millennium Pharmaceuticals

Mitsubishi Tanabe Pharma

Novartis

Phytomedics

Pozen

Pfizer

Rigel Pharmaceuticals

Roche

sanofi-aventis

Schering-Plough

Synta Pharmaceuticals

Takeda

Targeted Genetics

Toyama Chemical

Trubion

Wyeth

Vertex Pharmaceuticals

APPENDIX.3:.GLOSSARY

APPENDIX.4:.SOURCES

APPENDIX.5:.PRODUCT.INDEX

Index of tables

Traditional DMARDs used in the treatment of RA

ACR responses

Products In Development For The Treatment Of Rheumatoid Arthritis

Competitor Ratio Analysis Scores

Six- and 12-month ACR responses for RAPID 1

Six and 12 month mean mTSS changes from baseline for RAPID 1

Competitor Ratio Analysis Scores

Competitor Ratio Analysis Summary

Index of Charts

Synovitis And Joint Destruction In Rheumatoid Arthritis

Bone Erosion In Untreated Rheumatoid Arthritis

Current Views On The Pathogenesis Of Rheumatoid Arthritis

Guidelines For The Management Of Rheumatoid Arthritis

Global Rheumatoid Arthritis Drug Sales (2007E)

Rheumatoid Arthritis Market (2007E-2015E)

Global Market Share of Major Biologic RA Products (2007E)

Global Market Share Of RA Biologics And Oral Therapies By Sales (2015E)

Celebrex RA Sales (2008E-2015E)

Remicade RA Sales (2008E-2015E)

Humira RA Sales (2008E-2015E)

Enbrel RA Sales (2008E-2015E)

Kineret RA Sales (2008E-2015E)

Rituxan/MabThera RA Sales (2008E-2015E)

Orencia RA Sales (2008E-2015E)

Launch Of Biologics In Late-Phase Development To Treat Rheumatoid Arthritis

Cimzia RA Sales (2008E-2015E)

Golimumab RA Sales (2009E-2015E)

The Role Of IL-6 In Inflammation

Actemra RA Sales (2008E-2015E)

Ocrelizumab RA sales (2011E-2015E)

Ofatumumab RA Sales (2010E-2015E)

CF101 RA Sales (2012E-2015E)

SC12267 RA Sales (2011E-2015E)

CP-195543 RA Sales (2012E-2015E)

CP-690550 RA Sales (2011E-2015E)

Scio-469 RA Sales (2012E-2015E)

R788 RA Sales (2011E-2015E)

RhuDex RA Sales (2012E-2015E)

Atacicept RA Sales (2011E-2015E)

LymphoStat-B RA sales (2011E-2015E)

TRU-015 RA Sales (2011E-2015E)

AMG 108 RA Sales (2011E-2015E)

Baminercept RA Sales (2010E-2015E)

Denosumab RA Sales (2009E-2015E)

Abstract

Over 200 pages of product analysis, forecasts and data.

Providing…
Detailed assessment and 5-year forecasts for current leading products by value
A detailed review and assessment of up and coming products
Unique product assessment and scoring

Major approaches
Adenosine receptor antagonist
B-cell targeted therapy
Cathepsin-S inhibitors
Chemokine receptor antagonists
DHODH inhibitors
Glucocorticoids
Interleukin inhibitors
Kinase inhibitors
Lymphotoxin beta and light pathway inhibitor
Non-steroidal anti-inflammatory drugs
RANK ligand inhibitor
T-cell co-stimulation modulator
TNF inhibitors
Traditional disease-modifying anti-rheumatic drugs
The rheumatoid arthritis sector is set for substantial growth. With significant unmet clinical need and the progressive introduction of higher value and effective biopharmaceuticals, the market is expected to more than double in value to US$27 billion by 2015.

The value of the rheumatoid arthritis (RA) market currently stands at approximately US$11.6 billion and is continuing to grow, driven mainly by the biologic DMARDs. It is dominated by five major pharma companies: Abbott, Amgen, Johnson & Johnson, Schering-Plough and Wyeth, which between them market three of the most successful biologics, the tumour necrosis factor inhibitors Enbrel (etanercept), Remicade (infliximab) and Humira (adalimumab).

Research into new treatments is intense, driven by the need for safer and even more effective medications with more convenient dosing schedules. GlaxoSmithKline, Johnson & Johnson, Roche, Schering-Plough and UCB all have biologics in the late phases of development, while Pfizer is pinning its hopes on its oral kinase inhibitors, which are currently in Phase II development. As these new therapies come on board and the market becomes more competitive, the prospects for RA patients can only improve.

This report provides a complete assessment of the market’s potential
This new management report provides a complete examination of the RA market and its prospects in the medium term. Packed with analysis and forecasts, anyone needing to understand the drivers of this fast growing sector need look no further.

Despite falling prevalence levels in the future in developed markets, there still remains significant unmet need, with many patients both undiagnosed and untreated.

Get Full Details About This Report >>
US: 800.298.5699
Int'l: +1.240.747.3093
Buy this Report
Price and Delivery Options

Search Inside Report


 

About MarketResearch.com
MarketResearch.com is an online aggregator selling over 160,000 market research reports, company profiles and country profiles from over 600 research firms. Our reports will provide you with the critical business and competitive intelligence you need for strategic planning and marketing research. Coverage includes the US, UK, Europe, Asia and global markets.

 

© MarketResearch.com 2008