Obesity Drug Markets in the US and EU: Analysis of product pipelines and the competitive environment

Published by: Business Insights

Published: Jul. 1, 2008 - 148 Pages

Table of Contents

Obesity Drug Markets in the US and EU

Executive Summary

The large and growing obesity problem

Current approaches to obesity management

Pharmaceutical options for the treatment of obesity

The obesity drug pipeline

Market forecasts

Chapter 1 The large and growing obesity problem

Summary

A potentially life threatening medical condition

Levels of obesity

Overweight

Obesity

Morbid obesity

Super obesity

Co-morbidities and mortality

Arthritis

Asthma

Cancer

Cardiovascular disease and hypertension

Dementia

Depression

Diabetes

Kidney disease

Rising prevalence of obesity

Trends by sub-population

United States

Europe

Obesity in children and adolescents

Heavy social and economic impact

Cost burden

Social effects

Societal and other effects

Medical overview of obesity

Pathogenesis of obesity

Physiological factors

Genetic factors

Environmental factors

Lifestyle factors

Psychological factors

Societal trends

Obesity as a component of metabolic syndrome

Conclusion

Chapter 2 Current approaches to obesity management

Summary

Background

Diet and exercise programs

Dieting

Types of programs

Patient volumes

Exercise

Types of programs

Patient volumes

OTC weight loss supplements

Types of products

Patient volumes

Pharmaceutical options

Types of medications

Patient volumes

Surgical intervention

Types of procedures

Patient volumes

Comparison of options

Safety

Efficacy

Cost

Insurance reimbursement

Unmet needs

Conclusion

Chapter 3 Pharmaceutical options for treatment of obesity

Summary

Leading prescription medications

Meridia

Xenical

Acomplia

Others

OTC medicines

Alli

Comparison of pharmaceutical options

Safety

Efficacy

Cost

Insurance reimbursement

Conclusion

Chapter 4 The obesity drug pipeline

Summary

Introduction

Pre-clinical testing

Phase I testing

Phase II testing

Phase III testing

Leading obesity drug candidates

Lorcaserin hydrochloride

Lepislim

Taranabant

Contrave

CP-945,598

Qnexa

Discontinued obesity drug candidates

Conclusion

Chapter 5 Market forecasts

Summary

Introduction

Current sales levels

United States

Europe

Five year forecasts

United States

Europe

Conclusion

Index

List of Figures

Figure 1.1: Rates of obesity and overweight in the US, 1980-2006

Figure 1.2: Rates of obesity and overweight in Europe, 1980-2006

Figure 2.3: Comparison of safety, efficacy and cost of obesity management approaches

Figure 3.4: Comparison of safety, efficacy and cost of pharmaceutical options for obesity management

Figure 4.5: Comparison of leading obesity drug candidates, 2008

Figure 5.6: Obesity medication sales in the US and EU, 2006 and 2007

Figure 5.7: Obesity medication sales by region, 2007

Figure 5.8: Obesity medication sales in the US and EU, 2008-2013

Figure 5.9: Total obesity medication sales by region, 2008-2013

List of Tables

Table 1.1: Proportion of cancers related to obesity

Table 1.2: Prevalence of adult overweight and obesity by country, 2003

Table 2.3: US and EU patient caseloads for leading obesity management approaches, 2007-12 (millions of persons)

Table 2.4: Safety risks associated with obesity management approaches

Table 2.5: Comparative efficacy of obesity management approaches

Table 3.6: Safety risks associated with leading obesity medications

Table 3.7: Safety risks associated with leading obesity management approaches

Table 3.8: US cost comparison for leading obesity medications, 2008

Table 4.9: Pharmaceutical pipeline for obesity medications

Table 4.10: Discontinuations of obesity drug programs

Table 5.11: US sales of obesity medications, 2006 and 2007

Table 5.12: European sales of obesity medications, 2006 and 2007

Table 5.13: US sales of obesity medications in $m, 2008-2012

Table 5.14: European sales of obesity medications in $m, 2008-2012

Abstract

• An estimated 17% (85m people) of the EU population are obese and a further 32% (160m people) are overweight. The average rate of obesity in the US is forecast to reach 40% by 2010.
• US sales of obesity drugs more than tripled in 2007 to reach $421m following the introduction of Alli, which accounted for 71% of total revenue. Strong support from GlaxoSmithKline will stimulate further expansion for Alli in both the US and EU.
• The majority of weight loss products currently marketed have proven to be ineffective, with only a small proportion of consumers having been able to achieve and maintain weight loss.
• The US and European obesity drug markets will expand at a combined CAGR of 23.3% between 2008-2012. This growth will be driven by the launch of several products currently in late stage development, and increase revenues to an estimated $3.1b by 2012.
• A large number of novel obesity medications are currently under development, many of which represent novel approaches to the treatment of obesity and new drug classes such as CB1 antagonists and serotonin receptor agonists.

• Examine the major issues surrounding obesity in the US and EU with this report’s detailed analysis of co-morbidities, prevalence rates by sub-population, socioeconomic impacts, regulatory trends and the latest medical intelligence from this rapidly evolving treatment area.
• Evaluate the relative safety, efficacy and cost of currently marketed obesity drugs with this report’s comparative analysis of Rx and OTC medications including Alli, Meridia, Xenical and Accomplia.
• Explore emerging obesity treatments with details and descriptions of 146 drugs at various stages of pipeline development and assess the safety, efficacy and cross-indication potential of leading obesity drug candidates such as Lorcaserin hydrochloride, Lepislim, Taranabant, Contrave, CP-945,598 and Qnexa.
• Forecast sales for obesity medications in the US and EU through to 2013, measure the performances of currently marketed drugs in each region and discover how competitive dynamics will change in the future.
• Identify the strategies that offer the greatest success potential within the expanding market for obesity treatments and understand the challenges currently facing companies within this therapeutic area.

• Full pipelines reflect demand. Increasing proportions of both US andEU populations are becoming overweight, obese, morbidly obese orsuper obese, creating a growing need for treatments in this field. Alarge number of pharma companies are currently developing suchtreatments, most of which are in the early stages of development.
• Consumer dissatisfaction. Consumers are largely dissatisfied withcurrent obesity products, as most require significant lifestyle changes(ie. diet and exercise) that can often prove difficult to accomodate.
• Rising regulatory scrutiny. Heightened scrutiny, particularly at theFDA, is causing approval delays and denials for all drug candidates.Sanofi-Aventis’s new obesity drug, Acomplia, is widely availableoutside the US but was rejected by the FDA on safety concerns.
• Non-prescription availability. Alli’s switch from Rx to OTC usage in2007 reinvigorated the US market for obesity treatments.GlaxoSmithKline is currently pursuing a similar switch in Europe withapproval expected during 2009 at the latest.

• How can the rising trend of obesity in the US and EU be countered effectively?
• Which approaches to obesity management will experience the most growth through to 2012?
• Why was Alli able to achieve significantly more OTC sales than Xenical?
• Why are there relatively few advanced-stage drug candidates for obesity?
• How will the competitive dynamics of leading obesity medications change in the US and EU over the 2008-2012 period?
• Why is the approval late-stage obesity drugs under threat?
• Which newly identified condition is obesity related to?

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