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Flashpoint - Active Delivery Systems for OTC Drugs: Opportunity in Innovation

Published by: Kline & Company, Inc.

Published: Jan. 1, 2008 - 31 Pages


Table of Contents


Introduction

• A brief history of active delivery systems, from poultices to specially engineered patches

• The concept and definition

• A brief comment on market size

Kline Insights and Opportunity Assessment

This section summarizes Kline’s point of view on the market and the potential for the OTC side of active delivery systems.

It analyzes:

• The opportunity gaps in the global marketplace

• Lessons learned from companies that have ventured into this field

• Key factors for success

Market Overview and Dynamics

Noteworthy Actives

A description of the actives that are currently subject to/being assessed for deployment through active delivery systems. This includes detailed functional profiles (why they are needed, key industries leveraging them) and commonly “adapted” members from the specific class of actives. Actives profiled include:

• Vitamins

• Polysaccharides

• Botanicals

• Probiotics

• Proteins and peptides

• Enzymes and coenzymes

The Dynamics of Delivery

This section presents a description of the multiple factors that are relevant to the context of active delivery systems, including:

• A description of the various delivery routes that are currently available:

− Conventional routes (including skin, oral, and ocular)

− Non-conventional routes

• A description of the various delivery methods used, including sonoporation and electroporation

• A description of the various delivery devices used, including implantables, supplantables, and non-touch devices

• A description and tabular profile for various delivery technologies that are available, including the producing company, key technologies, and noteworthy products

Benefits of Active Delivery Systems

This section presents a description of benefits derived from the use of active delivery systems, such as the management of “pill burden” and “optimized delivery,” including chronotherapeutics.

Market Overview

This section presents a description of the U.S. market in terms of dollar values and reasons why Rx active delivery system companies are not too keen on exploring the OTC side of the business

Consumer Purchase Motivation

This section explains why consumers buy OTC drugs with new active delivery systems. The findings will be compiled from Kline’s primary research and assessment of some secondary sources.

Competitive Landscape

This section first gives a big-picture description of the competitive scenario with regard to the keys to success. A snapshot is then provided for about 10 key companies (both Rx and OTC) from various countries that are either generating landmark products or have made important contributions to the growth and development of the entire field, setting one or more “gold standards” for the entire industry.

Abstract

Active delivery systems, also known as targeted drug delivery systems, have introduced innovative ways to deliver actives in prescription pharmaceuticals for some time now. Now there is a wide range of novel delivery systems for many actives and the OTC market could be improved with a number of these.

The need to deliver an active agent optimally to its site of action is so important that an entire section of the drug development industry caters to meeting this end. New delivery forms and systems continue to be introduced in an effort to boost the efficacy of medications, differentiate products from their competitors, better leverage advancing technologies, and improve convenience for the consumer. A significant proportion of medications that do not currently incorporate ADS could benefit from existing or emerging technologies, as many of these drugs are poorly soluble in water, which potentially causes inadequate carriage and absorption. Such drugs could benefit with deployment through ADS that harness lipids to ensure appropriate delivery of the molecules.

The potential exists for even greater innovation in new systems delivering actives to almost every part of the human body, which can give OTC companies improved efficacy and market differentiation. Furthermore, drug delivery companies will find expanded market opportunities. This report examines the strategic implications of these market developments and covers the following topics:
  • Factors influencing the business
  • Consumer buying characteristics
  • Demand drivers
  • Barriers to entry
  • Noteworthy actives
  • Innovations and technologies in active delivery systems for OTC drugs
  • Competitive landscape
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