Cancer Vaccines: Drug Pipeline Update 2008 : Market Research Report

Cancer Vaccines: Drug Pipeline Update 2008

Published: Apr. 20, 2008

Please Note: Due to the brevity and/or nature of
the content posted, there is no table of contents available
for this report.

Abstract

Executive Summary

Cancer vaccines offer an attractive therapeutic addition, delivering treatment of high specificity, low toxicity and prolonged activity. However, despite years of R&D, a reproducible survival benefit has proved elusive, leaving the market wide open.

There are today more than 235 cancer vaccines, from early preclinical to marketed drugs. Cancer Vaccines Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 91 different targets. These targets are further categorized on the CD-ROM by 40 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Cancer Vaccines Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.

Find competitors, collaborations partners, M&A candidates etc.

Jump start competitive drug intelligence operations

Excellent starting point for world wide benchmarking

Compare portfolio and therapy focus with your peers

Speed up pro-active in-/out licensing strategy work

Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.

Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators Includes more than 170 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 400 names

Developmental stage This Drug Pipeline Update contains more than 235 cancer vaccine drugs in active development and more than 440 developmental projects:

9 marketed drugs
25 projects in Phase III
140 projects in Phase II
90 projects in Phase I
130 projects in Preclinical

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications Included vaccine drugs are in development for over 65 indications, where of 40+ are different cancer indications. All drugs are in development for the treatment of cancer.

Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets Identified drugs are linked to more than 138 different targets, divided into 40 classifications of molecular function:

Acid phosphatase activity
Carboxypeptidase activity
Catalytic activity
Cell adhesion molecule activity
Chaperone activity
Cofactor binding
Complement activity
Cytokine activity
DNA binding
DNA topoisomerase activity
DNA-directed DNA polymerase activity
Growth factor activity
Heat shock protein activity
Hormone activity
Hydrolase activity
Intracellular ligand-gated ion channel activity
Isomerase activity
Kinase binding
Kinase regulator activity
Metallopeptidase activity
MHC class I receptor activity
Molecular function unknown
Oxidoreductase activity
Peptidase activity
Peptide hormone
Protein binding
Protein serine/threonine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
Receptor signaling protein serine/threonine kinase activity
RNA-directed DNA polymerase activity
Serine-type peptidase activity
T cell receptor activity
Transcription factor activity
Transcription regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity

Identified targets are categorized into 22 different primary and alternate sub-cellular localizations:

Apical membrane
Cell surface
Centrosome
Clathrin-coated vesicle
Cytoplasm
Cytoskeleton
Endoplasmic reticulum
Endosome
Extracellular
Extracellular matrix
Golgi apparatus
Integral to membrane
Lysosome
Mitochondrial matrix
Mitochondrion
Nucleolus
Nucleus
Peroxisomal matrix
Plasma membrane
Sarcoplasmic reticulum
Secreted
Secretory granule

Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile Direct links are provided from inside the application to 51 protein expression profiles of 39 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.

BioCarta 121 Pathways
KEGG 64 Pathways
NetPath 17 Signaling Pathways

Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.

Mechanism In total there are more than 65 different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms
Presentation of drug name and synonyms

Principal Investigator & Partners
Presentation of principal investigator and partners

Target and Molecular Function of Target
Described target(s) is/are presented with:

Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations. Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism
Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Business & Markets

Collaborations and deals
Approvals and submissions
Analyst comments

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Licensing Information
Availability for licensing

Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs

Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
Direct links to company web pages of principal investigators

Export and sharing of information

Found information is easily shared with others over e-mail, file export (xls) or in print

System Requirements - AMD-Athlon/Pentium II PC

Windows 98/NT4/2000/ME/XP/VISTA
8x-speed CD Rom drive
SVGA 16 bit display. (32 bit recommended)
32 MB of available RAM (128 MB recommended)
Internet access (for related internet resources)

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Cancer Vaccines: Drug Pipeline Update 2008

Table of Contents

Abstract