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Published by: BioSeeker Group AB
Published: Apr. 20, 2008
Table of Contents
Please Note: Due to the brevity and/or nature of
the content posted, there is no table of contents available
for this report. AbstractExecutive Summary
Lymphoma is a broad term encompassing a variety of cancers of the lymphatic system. There are today more than 180 therapeutics targeting lymphoma, from early preclinical to marketed drugs. Lymphoma Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 103 different targets. These targets are further categorized on the CD-ROM by 39 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Lymphoma Drug Pipeline Update is organized.
How May Drug Pipeline Update Be of Use?
- Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operations
- Excellent starting point for world wide benchmarking
- Compare portfolio and therapy focus with your peers
- Speed up pro-active in-/out licensing strategy work
- Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators Includes more than 140 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.
Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 300 names
Developmental stage This Drug Pipeline Update contains more than 180 drugs in active development for the treatment of lymphoma (including: B-cell, T-cell, Hodgkin`s, and non-Hodgkin`s):
27 marketed drugs
20 projects in Phase III
90 projects in Phase II
55 projects in Phase I
35 projects in Preclinical
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications Included lymphoma drugs are also in development for over 100 other listed indications
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.
Targets Identified drugs are linked to more than 103 different targets, divided into 39 classifications of molecular function:
Carboxy-lyase activity
Catalytic activity
Cell adhesion molecule activity
Cysteine-type peptidase activity
Cytokine activity
DNA binding
DNA repair protein
DNA topoisomerase activity
DNA-directed DNA polymerase activity
G-protein coupled receptor activity
Glutathione transferase activity
Hormone activity
Hydrolase activity
Kinase activity
Kinase regulator activity
Ligand-dependent nuclear receptor activity
Lipid phosphatase activity
MHC class I receptor activity
Molecular function unknown
Motor activity
Oxidoreductase activity
Phosphorylase activity
Protein binding
Protein serine/threonine kinase activity
Protein tyrosine phosphatase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
RNA binding
Serine-type peptidase activity
Structural constituent of cytoskeleton
Superoxide dismutase activity
T cell receptor activity
Transcription factor activity
Transcription regulator activity
Translation regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Identified targets are categorized into 19 different primary and alternate sub-cellular localizations:
Centrosome
Clathrin-coated vesicle
Cytoplasm
Cytoskeleton
Cytosol
Endoplasmic reticulum
Endosome
Extracellular
Golgi apparatus
Integral to membrane
Lysosome
Microtubule
Mitochondrial membrane
Mitochondrion
Nucleolus
Nucleus
Perinuclear region
Peroxisome
Plasma membrane
Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.
Target Expression Profile Direct links are provided from inside the application to 65 protein expression profiles of 58 drug targets in various human tissues and cancer types, cell lines and primary cells, includin u to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.
BioCarta 186 Pathways
KEGG 62 Pathways
NetPath 20 Signaling Pathways
Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.
Mechanism In total there are more than 130 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.
Compound Identified drug compounds are described by:
- Compound type, Chemical name, CAS Number and molecular weight
Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms
Principal Investigator & Partners
Presentation of principal investigator and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weight
Patent Data
Available patent information related to the drug is presented here.
Business & Markets
- Collaborations and deals
- Approvals and submissions
- Analyst comments
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Licensing Information
Availability for licensing
Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs
Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
- Direct links to company web pages of principal investigators
Export and sharing of information
- Found information is easily shared with others over e-mail, file export (xls) or in print
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System Requirements - AMD-Athlon/Pentium II PC
- Windows 98/NT4/2000/ME/XP/VISTA
- 8x-speed CD Rom drive
- SVGA 16 bit display. (32 bit recommended)
- 32 MB of available RAM (128 MB recommended)
- Internet access (for related internet resources)
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