Breast Cancer Drug Pipeline Update 2008 : Market Research Report

Breast Cancer Drug Pipeline Update 2008

Published: Apr. 20, 2008

Please Note: Due to the brevity and/or nature of
the content posted, there is no table of contents available
for this report.

Abstract

Executive Summary
Breast cancer is the leading cause of cancer-related mortality among women worldwide. High unmet needs still persist for this tumor type. Despite recent drug approvals in the adjuvant and metastatic setting, the overall survival remains below five years.

There are today more than 340 therapeutics targeting breast cancer, from early preclinical to marketed drugs. Breast Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 165 different targets. These targets are further categorized on the CD-ROM by 49 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Breast Cancer Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.

Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance
Investigators Includes more than 245 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 500 names

Developmental stage This Drug Pipeline Update contains more than 340 drugs in active development for the treatment of breast cancer:

50 marketed drugs
10 projects in Phase III
110 projects in Phase II
65 projects in Phase I
85 projects in Preclinical

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications Included breast cancer drugs are also in development for over 120 other listed indications

Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets Identified drugs are linked to more than 165 different targets, divided into 49 classifications of molecular function:

Catalytic activity
Cell adhesion molecule activity
Chaperone activity
Chemokine activity
Complement activity
Cysteine-type peptidase activity
Cytokine activity
DNA binding
DNA repair protein
DNA topoisomerase activity
DNA-directed DNA polymerase activity
Extracellular matrix structural constituent
G-protein coupled receptor activity
Glutathione transferase activity
Growth factor activity
Hormone activity
Isomerase activity
Kinase activity
Kinase binding
Kinase regulator activity
Ligand-dependent nuclear receptor activity
Ligase activity
Lipid kinase activity
Lipid phosphatase activity
Metallopeptidase activity
Molecular function unknown
Motor activity
Oxidoreductase activity
Phosphoric diester hydrolase activity
Protein binding
Protein serine/threonine kinase activity
Protein threonine/tyrosine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
Receptor signaling protein serine/threonine kinase activity
Serine-type peptidase activity
Structural constituent of cytoskeleton
Structural molecule activity
Superoxide dismutase activity
T cell receptor activity
Transcription factor activity
Transcription regulator activity
Transferase activity
Translation regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity

Identified targets are categorized into 22 different primary and alternate sub-cellular localizations:

Centrosome
Clathrin-coated vesicle
Cytoplasm
Cytoskeleton
Cytosol
Endoplasmic reticulum
Endosome
Extracellular
Golgi apparatus
Integral to membrane
Lysosome
Mitochondrial membrane
Mitochondrion
Nuclear membrane
Nucleolus
Nucleus
Perinuclear region
Peroxisome
Plasma membrane
Secreted
Secretory granule
Secretory vesicle

Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile Direct links are provided from inside the application to 107 protein expression profiles of 89 drug targets in various human tissues and cancer types, cell lines and primary cells, includin u to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.

BioCarta 233 Pathways
KEGG 81 Pathways
NetPath 20 Signaling Pathways

Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.

Mechanism In total there are more than 190 different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms
Presentation of drug name and synonyms

Principal Investigator & Partners
Presentation of principal investigator and partners

Target and Molecular Function of Target
Described target(s) is/are presented with: Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism
Drug mechanism of action

Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status. Example:

Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Business & Markets

Collaborations and deals
Approvals and submissions
Analyst comments

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Licensing Information
Availability for licensing

Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs

Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
Direct links to company web pages of principal investigators

Export and sharing of information

Found information is easily shared with others over e-mail, file export (xls) or in print

System Requirements - AMD-Athlon/Pentium II PC

Windows 98/NT4/2000/ME/XP/VISTA
8x-speed CD Rom drive
SVGA 16 bit display. (32 bit recommended)
32 MB of available RAM (128 MB recommended)
Internet access (for related internet resources)

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Breast Cancer Drug Pipeline Update 2008

Table of Contents

Abstract