Antibodies in Oncology: Drug Pipeline Update 2008 : Market Research Report

Antibodies in Oncology: Drug Pipeline Update 2008

Published: Apr. 20, 2008

Please Note: Due to the brevity and/or nature of
the content posted, there is no table of contents available
for this report.

Abstract

Executive Summary
The commercial and therapeutic success of antibodies like Rituxan, Avastin, and Erbitux will force the industry to look into the next generation of therapeutic antibodies, preparing themselves for the second wave in the lucrative field of therapeutic antibodies. Today, there are more than 190 companies plus partners developing more than 430 antibody based oncology drugs in more than 770 developmental projects. In all targeting around 50 different cancer indications. The number of antibody targets has increased to over 170 described molecular targets in just a few years. These targets are further categorized on the CD-ROM by 37 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Antibody in Oncology: Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.

Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance
Investigators Includes more than 190 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.

Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 700 names

Developmental stage This Drug Pipeline Update contains more than 430 antibody drugs in active development and more than 770 developmental projects:

13 marketed drugs
45 projects in Phase III
170 projects in Phase II
150 projects in Phase I
370 projects in Preclinical

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications Included antibody drugs are in development for over 95 indications, where of 50+ are different cancer indications. All antibodies are in development for the treatment of cancer.

Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets Identified drugs are linked to more than 170 different targets, divided into 37 classifications of molecular function:

Auxiliary transport protein activity
Carboxypeptidase activity
Catalytic activity
Cell adhesion molecule activity
Chaperone activity
Chemokine activity
Cofactor binding
Complement activity
Cytokine activity
DNA topoisomerase activity
Extracellular matrix structural constituent
G-protein coupled receptor activity
Growth factor activity
Hormone activity
Hydrolase activity
Intracellular ligand-gated ion channel activity
Metallopeptidase activity
MHC class I receptor activity
Molecular function unknown
Oxidoreductase activity
Peptidase activity
Peptide hormone
Protease inhibitor activity
Protein binding
Protein serine/threonine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
Receptor signaling protein tyrosine phosphatase activity
RNA-directed DNA polymerase activity
Serine-type peptidase activity
T cell receptor activity
Translation regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity
Unclassified

Identified targets are categorized into 18 different primary and alternate sub-cellular localizations:

Centrosome
Clathrin-coated vesicle
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Endoplasmic reticulum
Endosome
Extracellular
Extracellular matrix
Golgi apparatus
Integral to membrane
Lysosome
Mitochondrion
Nucleolus
Nucleus
Perinuclear vesicle
Plasma membrane
Secretory granule

Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile Direct links are provided from inside the application to 90 protein expression profiles of 75 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.

BioCarta 128 Pathways
KEGG 46 Pathways
NetPath 13 Signaling Pathways

Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.

Mechanism In total there are at least 180 different drug mechanism of action represented in this Drug Pipeline Update.

Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound All antibody based
Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms
Presentation of drug name and synonyms

Principal Investigator & Partners
Presentation of principal investigator and partners

Target and Molecular Function of Target
Described target(s) is/are presented with:

Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism
Drug mechanism of action

Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.Example:

Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Business & Markets

Collaborations and deals
Approvals and submissions
Analyst comments

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Licensing Information
Availability for licensing

Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs

Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
Direct links to company web pages of principal investigators

Export and sharing of information

Found information is easily shared with others over e-mail, file export (xls) or in print

System Requirements - AMD-Athlon/Pentium II PC

Windows 98/NT4/2000/ME/XP/VISTA
8x-speed CD Rom drive
SVGA 16 bit display. (32 bit recommended)
32 MB of available RAM (128 MB recommended)
Internet access (for related internet resources)

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Antibodies in Oncology: Drug Pipeline Update 2008

Table of Contents

Abstract