How Insulin Resistance Diagnostics Can Expand the Market for Insulin-Sensitizing Agents

Published by: Decision Resources

Published: Oct. 23, 2007 - 28 Pages

Table of Contents

Executive Summary

Strategic Considerations

Stakeholder Implications

Unmet Need in Insulin Resistance Testing

An Overview of Insulin Resistance

Link Between Insulin Resistance and Other Diseases

Epidemiology of Insulin Resistance

Current Diagnostics for Insulin Resistance

Euglycemic Hyperinsulinemic Clamp

Steady-State Plasma Glucose

Random Plasma Glucose

Fasting Plasma Glucose

Oral Glucose Tolerance Test

Frequently Sampled Intravenous Glucose Tolerance Test

Glycosylated Hemoglobin A1c

Fasting Insulin Measurements

Homeostasis Assessment Model

New Diagnostic Techniques for Insulin Resistance

KineMed

Isotechnika

Syn X

LipoScience

Entelos

Outlook

About the Authors

Appendix A. Etiology and Pathophysiology of Insulin Resistance

Etiology

Pathophysiology

Appendix B. Bibliography

Tables

1. Studies Demonstrating the Relationship Between Insulin Resistance, Diabetes, and Cardiovascular Diseases

2. Updated NCEP-ATP III Criteria for Metabolic Syndrome from the AHA and NHLBI

3. Prevalence of Insulin Resistance in Various Populations

4. Number of Total Prevalent Cases of Insulin Resistance Segmented by Type 2 Diabetic and Nondiabetic Subpopulations in the United States and Major European Markets, 2006-2016

5. Indexes Currently Used to Assess Insulin Resistance

6. Select Novel Tests and Indexes for Insulin Resistance

7. Select Companies with Diagnostics for Insulin Sensitivity/Resistance

8. Clinical Trials for the Pharmacological Prevention of Type 2 Diabetes

A-1. Risk Factors for Insulin Resistance

Figures

A-1. Clinical Progression of Insulin Resistance

Abstract

• Insulin resistance has been tied to many other conditions, including diabetes, heart attacks, and dyslipidemia. What are the benefi ts of early insulin resistance diagnosis?
• Several IR tests are used in experimental settings but not widely in clinical practice. What are the shortcomings of the current tests and what are clinicians looking for in an IR test?
• Several indexes and tests are used to measure IR, and there is no standard test used in clinical practice. What are the most common diagnostics used? Which companies are working toward creating new diagnostics?
• Diagnostic tests that enable earlier detection and therapeutic intervention for IR may help to delay or prevent the onset of type 2 diabetes and other diseases. What is the outlook for the current and novel IR diagnostics and what is their commercial potential?

• Overview and unmet needs of insulin resistance : defi nition of IR and metabolic syndrome; unmet need in IR testing; link between IR and other diseases.
• Epidemiology of insulin resistance : prevalence estimates of IR in the United States and Europe.
• Current IR diagnostics : Euglycemic hyperinsulinemic clamp, steady-state plasma glucose, fasting plasma glucose, oral glucose tolerance test, and others.
• New diagnostics and key players : KineMed’s KineMarkers, Isotechnika’s Diatest, LipoScience’s NMR LipoProfi le, Entelos’s Metabolism PhysioLab.
• Outlook and commercial potential : prospects of current and future diagnostic techniques meeting the unmet need of IR testing.

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