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Distribution Agreements in Biopharma

Published by: CurrentPartnering

Published: Apr. 1, 2008 - 260 Pages


Table of Contents


Executive Summary


Chapter 1 - Introduction


Chapter 2 - Trends in distribution dealmaking


2.1. Introduction

2.2. Definiton of distribution dealmaking

2.3. Trends in distribution deals since 2000

2.4. Pure deals and multi-component deals

2.5.1. Attributes of pure distribution deals

2.5.2. Attributes of distribution in multi-component deals

2.6. Aligning partners to make the distribution agreement work

2.7. The emergence of direct to pharmacy distribution in Europe

2.7.1. The role of consolidated distribution

Chapter 3 - Overview of distribution deal structure


3.1. Introduction

3.2. Pure versus multi-component distribution deals

3.3. Pure distribution agreement structure

3.3.1. Example distribution agreements

3.3.1.a. Case study 1: BioSite - Fisher Scientific - January 2006

3.3.1.b. Case study 2: Inverness Medical Innovations - Matritech - November 2006

3.4. Distribution rights as part of a wider alliance agreement

3.4.1. Example distribution clauses

3.4.1.a. Case study 3: Ipsen - Aesthetica - March 2006

3.4.1.b. Case study 4: Gilead - Bristol-Myers Squibb - September 2006

Chapter 4 - Leading distribution deals


4.1. Introduction

4.2. Top distribution deals by value

4.3. Top pure distribution deals

4.4. Top distribution deals signed by bigpharma

4.5. Most active distribution dealmakers

4.6. Bigpharma distribution deal activity

Chapter 5 - Bigpharma distribution agreements


5.1. Introduction

5.2. How to use distribution agreements

5.3. Company distribution agreement listings

Abbott

Actavis

Akzo Nobel (Organon)

Allergan

Altana

Amgen

Astellas

AstraZeneca

Baxter International

Bayer

Bayer Schering Pharma AG

Biogen Idec

Boehringer Ingelheim

Bristol-Myers Squibb

Cephalon

Chugai

CSL

Dainippon Sumitomo

Eisai

Eli Lilly

Forest Laboratories

Genentech

Genzyme

Gilead Sciences

GlaxoSmithKline

Johnson & Johnson

King

Lundbeck

Menarini

Merck & Co

Merck - Serono KGaA

Mitsubishi

Novartis AG

Novo Nordisk

Nycomed Pharma

Otsuka

Pfizer

Procter & Gamble

Roche

Sanofi-Aventis

Schering Plough

Serono

Shionogi Seiyaku

Shire

Solvay

Takeda

Tanabe Seiyaku

TAP Pharmaceuticals

Teva

UCB

Watson

Wyeth

Chapter 6 - Distribution agreement directory 2003-7


6.1. Introduction

6.2. Company A-Z

6.3. By therapy area

Accident/Hospital/Trauma

Blood/Lymphatic System

Cardiovascular

Central nervous System

Dermatology

Gastrointestinal

Genitourinary

Genetic

Autoimmune/Inflammatory

Infection

Metabolism

Musculoskeletal

Oncology

Respiratory

Sensory Organ / Oral Health

6.4. By stage of development at signing

Discovery

Preclinical

Phase I

Phase II

Phase III

Registration

Market

Appendices


Appendix 1 - Distribution references

Appendix 2 - Resources

Appendix 3 - Deal type definitions

Appendix 4 - Example distribution contract document

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Figures in report


Figure 1: Definition of distribution dealmaking

Figure 2: Trends in distribution deal announcements, 2000-2007

Figure 3: Distribution deals signed at what phase of development, 2000-2007

Figure 4: Pure versus multi-component distribution deal announcements, 2000-2007

Figure 5: Stage of development at which pure and multi-component distribution deals are announced 2000-2007

Figure 6: Issues in implementing distribution agreements

Figure 7: Recent consolidated distribution deals

Figure 8: Components of the distribution deal structure

Figure 9: Top 50 distribution deals by value since 2003

Figure 10: Top pure distribution deals by value since 2003

Figure 11: Top distribution deals signed by bigpharma value since 2003

Figure 12: Most active distribution dealmakers 2003-7

Figure 13: Characteristics of active distribution dealmakers

Figure 14: Bigpharma - top 50 - distribution deals since 2003

Figure 15: Online partnering resources

Figure 16: Deal type definitions

Figure 17: Distribution agreement between Amphastar and Andrx, May 2005

Abstract

The Distribution Agreements in Biopharma report provides comprehensive understanding and unprecedented access to the distribution partnering agreements entered into by the worlds leading biopharma companies.

The report provides a detailed understand and analysis of how and why companies enter distribution deals.

The majority of deals are multicomponent whereby the licensor offers a right to distribute the resultant product of the research collaboration. There are also numerous pure distribution deals whereby the products originator takes on a distribution partner in order to maximize a products presence in the marketplace.

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered - contract documents provide this insight where press releases and databases do not.

This report contains over 500 links to online copies of actual distribution contract documents as submitted to the Securities Exchange Commission by biopharma companies and their partners.

Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.

The initial chapters of this report provide an orientation of distribution dealmaking and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an analysis of the trends in distribution as well as a discussion on the merits of the type of deal.

Chapter 3 provides an overview of the structure of distribution deals. The chapter includes numerous case studies to enable understanding of both pure distribution deals and multicomponent deals where distribution forms a part.

Chapter 4 provides a review of the leading distribution deals since 2000. Deals are listed by headline value, signed by bigpharma, most active bigpharma, and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract.

Chapter 5 provides a comprehensive listing of the top 50 bigpharma companies with a brief summary followed by a comprehensive listing of distribution contract documents available in the public domain. Each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand.

Chapter 6 provides a comprehensive listing of all distribution agreement contracts available in the public domain. Each chapter is organized by A-Z, stage of development at signing, and therapeutic area. Each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand.

The report also includes numerous table and figures that illustrate the trends and activities in distribution dealmaking since 2000.

In conclusion, this report provides everything a prospective dealmaker needs to know about distribution as an opportunity to participate in the commercialization of either candidate compounds in development or products already on the market.

Key benefits

Distribution Agreements in Biopharma provides the reader with the following key benefits:
  • In-depth understanding of distribution deal trends since 2000
  • Analysis of the structure of distribution agreements with numerous real life case studies
  • Comprehensive access to over 500 actual distribution contracts entered into by the world’s biopharma companies
  • Detailed access to actual distribution contracts enter into by the leading fifty bigpharma companies
  • Insight into the terms included in a distribution agreement, together with real world clause examples
  • Understand the key deal terms companies have agreed in previous deals
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies


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