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What Strategies Will Yield Novel Treatments for Autoimmune Disease?

Published by: Decision Resources

Published: Mar. 14, 2008 - 26 Pages


Table of Contents


Executive Summary

Strategic Considerations

Introduction

Overview of Autoimmune Diseases

Pathophysiology and Etiology

Epidemiology

Novel Targets and New Approaches to Treating Autoimmune Disease

Novel Targets

Sphingosine-1-Phosphate Receptor Modulators

Janus Kinases

Matrix Metalloproteinases

Tolerance Induction

PDE Inhibitors

Novel Treatment Methods

Antisense

Hematopoietic Stem Cell Transplant

Cell Therapy for the Treatment of Type 1 Diabetes

New Approaches to Drug-Target and Biomarker Discovery for Autoimmune Diseases

Genetic Analysis

Proteomics: Mass Spectrometry, Protein and Antibody Arrays

Mass Spectrometry

Microarrays

Flow Cytometry

Lipidomics

Imaging

Company Profiles

Alba Therapeutic

Bayhill Therapeutics

BioSeek

MultiCell Technologies

Novocell

Osiris Therapeutics

Osprey Pharmaceuticals

Outlook

Ongoing Unmet Need Creates Opportunity

Potential Curative Therapies on the Horizon

Other Future Yields of Today’s Autoimmune R&D

Tables:

1. Overview of Select Autoimmune Diseases

2. Select Drug Classes Used to Treat Autoimmune Diseases

3. Select Novel Targets for the Treatment of Autoimmune Disease

4. Select Novel Approaches to Autoimmune Therapy

5. Select Companies Investigating Autoimmune Disease, 2008

Figures:

1. Prevalent Cases of Select Autoimmune Diseases in the United States, 2007

2. Sites of Action of Current and Experimental Immunosuppressive Agents

Abstract

More than 80 autoimmune disorders have been identified, all involving aberrant immune responses to self-antigens. The emergence of biologic agents, such as the interferons and the TNF-á inhibitors, has greatly improved the treatment outlook for some of the more common autoimmune diseases. These agents have significant drawbacks, however, including side effects and high costs. Pharmaceutical companies large and small have already begun to focus their efforts on the molecular events that trigger autoimmunity, a discovery process that, it is hoped, will reveal new drug targets that suppress undesired autoimmune infl ammatory responses in some of the most common diseases.

Get the Answers You Need to Shape Your Strategy
  • Understanding the etiology of the different autoimmune diseases will allow more successful diagno- sis and treatment options. How will the identification of genetic markers help to create new diagnostic tools? Will these tools offer a greater chance for successful treatment, or even a cure?
  • Biologic agents have greatly improved the treatment of many autoimmune diseases, but these agents are expensive and carry the risk of significant side effects. What new methods are being studied as both treatments and curatives?
  • Earlier identification of autoimmune diseases could greatly improve the quality of life for patients. What’s in store for the future of autoimmune R&D? What companies already have trials under way?
Scope
  • Pathophysiology and etiology: autoimmune disease is caused by antibodies that attack normal tissue; the diseases can be organ-specific or systemic; most autoimmune diseases are caused by genetic and/or environmental factors.
  • Epidemiology: 2-8% of the U.S. population has some type of autoimmune disease, and the prevalence of these diseases is increasing.
  • Novel approaches to treatment: targeted biologics, new cell technologies, and novel treatment methods are the focus of current drug discovery programs.
  • Unmet need creates opportunity for new therapies: interferon-beta (for MS) and the TNF-alpha inhibitors offer significant benefit over more traditional corticosteroid and DMARD treatments.
  • Potential curative therapies on the horizon: cell therapies like stem cell replacement and tolerization vaccines represent potential for cures.


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