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Treating COPD Comorbidities: A Market Opportunity for Systemic Anti-Inflammatory Agents?

Published by: Decision Resources

Published: Mar. 18, 2008 - 42 Pages


Table of Contents


Executive Summary


Strategic Considerations


Stakeholder Implications


Introduction


Understanding the Mechanisms of COPD


Risk Factors for COPD


Pathophysiology of COPD


Small Airway Disease


Emphysema


Role of Systemic Infl ammation in COPD


Comorbidities Associated with COPD Caused by Systemic Infl ammation


Cardiovascular Complications: Atherosclerosis and Pulmonary Arterial Hypertension


Atherosclerosis


Pulmonary Arterial Hypertension


Osteoporosis


Type 2 Diabetes


Cachexia


Drug Classes with Possible Use in Treating the Systemic and Localized Infl ammation of COPD


TNF-á Inhibitors


PPAR-Gamma Agonists


Statins


PDE Inhibitors


Assessing the Unanswered Questions About Treating Systemic Infl ammation in COPD


Appendix:Current Treatments for Localized COPD


Short-Acting Beta2 Agonists


Long-Acting Beta2 Agonists


Muscarinic Antagonists


Inhaled Corticosteroids


Beta2 Agonist/Muscarinic Antagonist Combinations


Long-Acting Beta2 Agonist/Inhaled Corticosteroid Combinations


Methylxanthines






Tables:


1. Sales of Leading Agents to Treat COPD, 2006


2. Risk Factors Linked to COPD


3. Infl ammatory Molecules Involved in COPD


4. Existing and Emerging TNF-á Inhibitors, 2008


5. Existing and Emerging PPAR-Gamma Agonists, 2008


6. Approved Statins, 2008


7. Approved and Emerging PDE 4 and 5 Inhibitors, 2008






Figures:


1. Prevalent Cases of COPD in the United States, Europe, and Japan, 2006 and 2011


2. Comorbidities Associated with COPD




Abstract

Research data on COPD increasingly point to systemic infl ammation as the cause of many of the severe comorbidities associated with the disease. However, agents under study for COPD continue to focus only on the local infl ammation caused by the disease. Significant opportunity exists for agents that can reduce the infl ammation both in the lungs and throughout the system. Given that inhaler drugs will not be displaced as the primary treatment for the disease, is there a drug on the market for another indication that will address the systemic comorbidities associated with COPD? Should any existing therapies be able to show clear clinical benefit on systemic infl ammation, such an agent would gain a useful competitive edge in the COPD market.

Get the Answers You Need to Shape Your Strategy
  • COPD is a progressive infl ammatory disease affecting the respiratory tract and the lungs. What comorbidities are associated with COPD? What roles do local and systemic infl ammation play in this disease? What is the status of research on the connection between systemic infl ammation and pulmonary function?
  • Researchers are beginning to investigate the potential of systemic agents in the treatment of COPD. What are some of the most promising drug classes being studied? Will these agents have an effect on the localized symptoms and the severe comorbidities?
  • See the appendix in this report for a discussion on the current treatments for localized COPD. What are the most effective treatments? What new therapies need to be considered?
Scope
  • The role of infl ammation in the comorbidities in COPD: therapies are needed to address the multiple facets of the disease; established agent for another indication may be aimed at COPD.
  • Risk factors: cigarette smoking; particulate dust; impaired lung development; age; nutritional and socioeconomic factors.
  • Comorbidities: chronic cardiovascular diseases; osteoporosis; type 2 diabetes; cachexia.
  • Treatments most likely to address systemic infl ammation: TNF-á inhibitors; PPAR-gamma agonists; statins; PDE-5 inhibitors


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