Organ And Tissue Transplantation

Published by: Global Industry Analysts

Published: Mar. 1, 2008 - 411 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definitions and Scope of Study

Tissue and Organ Transplantation

Bone Graft Transplantation

Product Definitions

Organ Transplantation

Heart Transplantation

Kidney Transplantation

Liver Transplantation

Pancreas Transplantation

Small Intestine Transplantation

Lungs

Tissue Transplantation

Corneal Transplantation

Blood Stem Cell Transplantation

Bone Marrow Transplantation

Heart Valves Transplantation

II. EXECUTIVE SUMMARY

1. Introduction

Introduction

2. Market Overview

Current and Future Analysis

Demand and Supply Imbalance

Cardiac Arrest Death Patients - The Untapped Potential Donors

Transplantation Expenses

3. Market Trends

Living Donor Organs on the Rise

Combined Organ Transplantation - Gaining Attention

Awareness Programs and Education to Address Organ shortage

Increasing Consent Rates - A Key Factor

Transplant Tourism - Creating Brighter Avenues

Alliances to Play a Key Role

Graying Population and Chronic Diseases Surge Need for Transplants

Fetal Tissue for Bionic Devices - Assuming Importance

4. Major Issues Impacting Transplantation Market

Organ Rejection - A Major Barrier to Transplantation

Scarcity of Donor Organs - A Stumbling Block in Organ Transplantation

Other Issues for Organ Transplantation

Ethical Concerns in Transplants

Bioethical Issues Hindering Organ Donation Process

Lack of Requisite Expertise - Hindering Implantation Process

5. Product Overview

Tissue and Organ Transplantation

Organ Transplantation

Heart Transplantation

Heart Diseases and Disorders

Post Operative Complications and Consequences of Heart Transplants

Bleeding

Infection

Arrythymia

Heart Attack

Coronary Artery Disease

Respiratory Dysfunction

Renal Dysfunction

Graft Rejection and Dysfunction

Death

Kidney Transplantation

Kidney Disorders and Diseases

Donor Evaluation

Waiting List

Surgery/Post-Operation

Post-Operative Supervision and Issues

Liver Transplantation

Liver Disorders and Diseases

Pancreas Transplantation

Post Operative Complications and Consequences of Pancreas Transplants

Small Intestine Transplantation

Intestine Disorders and Diseases

Heart-and-Lung Transplantation

Lung Transplantation

Lung Diseases and Disorders

Lung Patients Survival Statistics

Tissue Transplantation

Types of Grafts

Autograft

Allograft / Homograft

Transplant Tolerance

Isograft

Xenograft

Corneal Transplantation

Penetrating Keratoplasty

Lamellar (Non-Penetrating) Keratoplasty

Aftercare

Risks Associated with Corneal Transplants

Transplantation Outcomes

Morbidity and Mortality Rates

Alternatives

Blood Stem Cells

Peripheral Blood Stem Cell Transplant

Umbilical Cord Blood Stem Cell Transplant

Bone Marrow and Hematopoietic Stem Cells

Bone and Tissue Transplantation

Bone Marrow Transplants

Stem Cell Therapy

Human Heart Valves

Atrioventricular Valves

Mitral Valve

Tricuspid Valve

Semilunar Valves

Aortic Valve

Pulmonic Valve

Pathology of Valves

Prosthetic Heart Valves

Prosthetic Mechanical Valve

Advantages

Disadvantages

Prosthetic Biologic Valve

Advantages

Disadvantages

Fetal Cells

Fetal Tissue for Transplantation

Storage Duration Time

Storage Time Period for Organs and Tissues

Cold Ischemia Time

Transplantation Immunology

Acute Cellular Rejection

Chronic Rejection

Post Transplant Observations

Types of Donors

Alive Donors

Related Donors

Good Samaritans

Rewarded/Forced Donors

Deceased Donors

Directed / Allocated

Organs and Tissues Transplanted by Type of Donor

Organ/Tissue Donation and Eligibility Criteria

Factors Considered for Matching Recipients to Donor Organs

Testing

Blood Typing

Tissue Typing

Histocompatibility - A Major Barrier for Organ Transplantation

Transplantation - Safety Requirements

Waiting List

Active Waiting List Patients

Inactive Waiting List Patients

History

Major Milestones in Organ Transplantation

6. Artificial Organs

Artificial Organs Revolutionize Medical Technology Industry

Artificial Organs

Categorization of Artificial Organs

External Artificial Organs

Internal or Implantable Artificial Devices

Artificial Heart

Total Artificial Heart (TAH)

Ventricle Assist Device (VAD)

Right Ventricular Assist Systems (RVAS)

Left Ventricular Assist Systems (LVAS)

Various Ventricle Assist Devices

Artificial Kidney (Dialyzer)

Limitations of Artificial Kidney

Artificial Liver

Various Liver Assist Devices

Categorization of Liver Devices

Mechanical Systems

Bio-Artificial Systems

Artificial Pancreas

Artificial Lungs (Oxygenator)

Types of Artificial Lung

Artificial Cornea

Keratoprostheses

Tissue Engineered Corneas

Artificial Skin/Skin Replacement Products

AlloDerm Regenerative Tissue Matrix

Apligraf

Cymetra Micronized AlloDerm Tissue

Dermagraft

Epicel

Integra Products

OrCel

TransCyte

Core Competitive Factors

Market Outlook for Artificial Organs

7. Preservation Solutions & Immunosuppressant Drugs

Organ Preservation Solutions

Celsior Solution

Collins Solution

Euro Collins Solution

Custodiol® HTK Solution

Hypothermosol

ViaSpan

Immunosuppressant Drugs

Antibody Products for Treatment of Organ Transplant Rejection

Antithymocyte Globulin

ATGAM

Campath/MabCampath

Thymoglobulin

Therapeutic Antibody Products

Antiproliferative Agents

Azathioprine

CellCept

Certican

Myfortic

Calcineurin Inhibitors

Cyclosporine

Gengraf

Neoral

Pulminiq

Tacrolimus

Prograf

TOR Inhibitors

Side Effects of Immunosuppression Therapy

Select Immunosuppressant Drug Players

Astellas Pharma US, Inc., (USA)

F.Hoffmann-La Roche Ltd (Switzerland)

Novartis AG (Switzerland)

Wyeth (USA)

8. Regulatory Environment

Transplant Center

Organ Procurement Organization (OPO)

Health Resources and Services Administration (HRSA)

Division of Transplantation (DoT)

United Network for Organ Sharing (UNOS)

Organ Procurement and Transplantation Network (OPTN)

University Renal Research and Education Association (URREA)

Scientific Registry of Transplant Recipients (SRTR)

Funding Sources

Patient Education and Advocacy Organizations

Legal Framework for Transplantation

Legislation Covering Organ Transplant

Organ Transplantation and Ethics

Regulations Governing Artificial Organs

9. Product Development/Innovations

Pluristem Develops New Cell Graft for Cancer Patients

CryoLife Develops Cryopreserved Orthopaedic Tissues Implants

Japanese Innovators Develop New Prognostic Scoring Model for Liver Transplants

EUREKA project E! 2674 MIDAS Develops New Test to Improve Graft Survival

10. Recent Industry Activity

St. Jude Medical’s Heart Valve Obtains US FDA Approval

Zimmer and Tutogen Expand Distribution Partnership

Leman Cardiovascular Acquires Hancock Jaffe Laboratories

Nabi Acquires Commercialization Rights of ATG-Fresenius S for North America

Cytopia and Novartis Ink Research Collaboration and Global License Agreement

ZLB Behring Inks Agreement with MedImmune

Japanese Team To Perform Liver Transplants in Hyderabad

Nabi Bags Approval for HB Intravenous in Liver Transplant Patients

Schering-Plough Announces PROTECT study Initiation

Allegheny General Hospital To Establish Adult Liver Transplantation Center in

Oakland

Global Hospitals to Setup an Organ Transplant Center in Kolkata

GCC to Establish Organ Transplant Center

Delhi-Based Hospital Offers Help in Setting Up of Liver Transplant Center in

Lahore

Kaiser To Shut Down Kidney Transplant Center

Abiomed Obtains FDA Approval for Selling Artificial Hearts

Astellas Bags FDA Approval to Use Prograf in Heart Transplant Patients

New York State Department of Health Approves Program for Kidney Transplant for Queen’s

Community

National Heart Institute Conducts First Double Lung Transplant in Malaysia

The Netherlands Obtains Orphan Drug Designations for Treatment of DGF

Papworth Transplants First Beating Human Heart in the UK

Enzon to Return ATG-Fresenius S Rights to Fresenius Biotech

Schering-Plough to Conduct ‘PROTECT’ Study

Community Tissue Services Selects NOVA 2200 Supercritical Carbon Dioxide Sterilization

Technology

CryoLife Inks Agreement with The Magdi Yacoub Institute to Enhance Xenografts in Human

Transplantation

ReGen Inks Exclusive Marketing Deals with Polymedic and Xmedica

University of California-Irvine Announces Closure of Liver-Transplantation

Program

Swedish Health Services Bags Approval for Liver Transplant Program

New Organ Transplant Research Center in South Korea

Child Lung Transplant Unit to be opened in Melbourne Hospital

Narayana Hrudayalaya Health City Establishes Exclusive Organ Transplant

Hospital

Liver Transplant Facility in Delhi Region

First Liver Transplant Research Institute in China

PIMS to establish Liver Transplant Unit

Liver Transplant Programme in Pakistan

Isotechnika Gains FDA Approval

FDA Offers Approval for Brain Stem Cell Transplant Trial

Methodist Specialty and Transplant Hospital Gains Approval to Execute Liver

Transplants

Cubist Pharmaceuticals Enters into Licensing Agreement with XTL

Biopharmaceuticals

Jackson Memorial Receives Approval from the U.S. Centers for Medicare and Medicaid

Services

Royal Perth Hospital to Open Lung Transplant Unit in Perth

Mater Hospital Opens Lung Transplant Unit in Dublin

Genzyme Makes a Synergistic Purchase of Ilex Oncology

NIAID Sets Up Clinical Consortium to Enhance Organ Transplants Success

Chiron files NDA for Pulminiq Inhalation Solution

Roche Acquires IL-15 Antagonist

Genzyme Completes Acquisition of SangStat

11. Focus on Select Global Players

Abiomed Inc (USA)

Arbios Systems, Inc. (USA)

CryoLife, Inc.(USA)

Exactech, Inc. (USA)

Fresenius Medical Care AG & Co. KGaA (Germany)

Forticell Bioscience, Inc. (USA)

Gambro AB (Sweden)

Genzyme Corporation (USA)

Jarvik Heart, Inc. (USA)

LifeCell Corporation (USA)

Medtronic, Inc. (USA)

MicroMed Cardiovascular, Inc. (USA)

Organogenesis, Inc. (USA)

SynCardia Systems (USA)

Terumo Corporation (Japan)

Thoratec Corporation (USA)

Ventracor Limited (Australia)

WorldHeart Corporation (USA)

12. Global Market Perspective

Table 1: World Recent Past, Current & Future Market Analysis for Organ Transplantation by Geographic Region - US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 2: World 10-Year Perspective for Organ Transplantation by Geographic Region - Percentage Breakdown of Number of Procedures for US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 3: World Recent Past, Current & Future Market Analysis for Heart Transplantation by Geographic Region - US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 4: World 10-Year Perspective for Heart Transplantation by Geographic Region - Percentage Breakdown of Number of Procedures for US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 5: World Recent Past, Current & Future Market Analysis for Kidney Transplantation by Geographic Region - US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 6: World 10-Year Perspective for Kidney Transplantation by Geographic Region - Percentage Breakdown of Number of Procedures for US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 7: World Recent Past, Current & Future Market Analysis for Liver Transplantation by Geographic Region - US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 8: World 10-Year Perspective for Liver Transplantation by Geographic Region - Percentage Breakdown of Number of Procedures for US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 9: World Recent Past, Current & Future Market Analysis for Pancreas Transplantation by Geographic Region - US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 10: World 10-Year Perspective for PancreasTransplantation by Geographic Region - Percentage Breakdown of Number of Procedures for US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 11: World Recent Past, Current & Future Market Analysis for Lung Transplantation by Geographic Region - US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 12: World 10-Year Perspective for Lung Transplantation by Geographic Region - Percentage Breakdown of Number of Procedures for US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 13: World Recent Past, Current & Future Market Analysis for Corneal Transplantation by Geographic Region - US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 14: World 10-Year Perspective for Corneal Transplantation by Geographic Region - Percentage Breakdown of Number of Procedures for US, Canada, Europe, Asia (including Japan), Latin America and Rest of World Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

III. MARKET

1. The United States

A. Market Analysis

Current and Future Analysis

Analysis by Value Sales

Liver Transplantation Sustains Dominance

Skin Grafts Take the Largest Chunk

Analysis by Number of Procedures

Intestine - Fastest Growing Segment

Skin Grafts - Largest and Fastest Growing Tissue Segment

Bone Graft Procedure Volume by Graft Type and Application

US Organ Transplant Facts and Figures

Number of Organ Transplants Witnesses Phenomenal Surge-2004

Increasing Organ Donations in New Jersey

Innovative Means of Organ Procurement to Increase Organ Donations

A New Technique to Enhance and Extend Kidney Transplants

California Stands Up Against Insurance on HIV Patients’ Transplantation

Awareness Programs to Address Shortage of Minority Donors

Organs and Tissues on A Recovery Spree

Unexamined Human Tissue Transplants - A Major Threat

Defective Medical Implants - A Health Hazard

Eye Infections from Usage of MoistureLoc Leads to Corneal Transplants

Sources of Donor Organs

Table 15: US Kidney Donations by Donor Type - Cadaveric and Living for Years 2000 through 2005 (includes corresponding Graph/Chart)

Table 16: US Liver Donations by Donor Type - Cadaveric and Living for Years 2000 through 2005 (includes corresponding Graph/Chart)

Table 17: US Heart Donations by Cadaveric Donor Type for Years 2000 through 2005 (includes corresponding Graph/Chart)

Table 18: US Lung Donations by Donor Type - Cadaveric and Living for Years 2000 through 2005 (includes corresponding Graph/Chart)

Table 19: US Pancreas Donations by Donor Type - Cadaveric and Living for Years 2000 through 2005 (includes corresponding Graph/Chart)

Table 20: US Intestine Donations by Donor Type - Cadaveric and Living for Years 2000 through 2005 (includes corresponding Graph/Chart)

Lung Transplantation

Lung Transplant Death Rates

Heart-Lung Transplantation

Incidence of Organ Transplants

Table 21: Incidence of Organ Transplant Type for Kidney, Liver, Heart, Lung, Pancreas, Intestine, and Heart-Lung Transplants per 1 Million Population in the US for the Year 2000 through 2005 (includes corresponding Graph/Chart)

Table 22: Incidence of Organ Transplants (Kidney, Liver, Heart, Lung, Pancreas, Intestine, and Heart-Lung) per 1 Million Population in the US by Recipient Race (White, African American, Asian, Hispanic, and Other) for 2005 (includes corresponding Graph/Chart)

Table 23: Incidence of Organ Transplants (Kidney, Liver, Heart, Lung, Pancreas, Intestine, and Heart-Lung) per 1 Million Population in the US by Recipient Gender (Male, and Female) for 2005 (includes corresponding Graph/Chart)

Table 24: Incidence of Organ Transplants (Kidney, Liver, Heart, Lung, Pancreas, Intestine, and Heart-Lung) per 1 Million Population in the US by Recipient Age (65+ Years, 50-64 Years, 35-49 Years, 18-34 Years, 11-17 Years, 6-10 Years, 1-5 Years, <1 Year) for 2005 (includes corresponding Graph/Chart)

Waiting List

Table 25: Waiting List of Patients As of July 2007 (includes corresponding Graph/Chart)

Table 26: Waiting List of Active and Inactive Patients for Years 2004 & 2005 (includes corresponding Graph/Chart)

Waiting List for Heart Transplants

Table 27: Waiting List of Active Patients for Heart for Years 2000 to 2005 (includes corresponding Graph/Chart)

Categorized by Diseases

Categorized by Age

Categorized by Race

Death Rates on Waiting List

Kidney Transplantation Waiting List

Categorized by Age

Categorized by Race

Waiting List for Liver Transplants

Categorized by Age

Categorized by Race

Categorized by Gender

Categorized by Diseases

Categorized by Re-Transplant Necessity

Death Rates on Waiting List

Pancreas Transplant Waiting List

Simultaneous Pancreas Kidney Transplantation Waiting List

Pancreas After Kidney and Pancreas Transplant Alone Transplant Waiting

List

Waiting List for Lung Transplants

Categorized by Age

Categorized by Primary Diagnoses

Categorized by Gender and Ethnic Makeup

Waiting Time for Lung Transplant

Annual Death Rates

Waiting List for Intestine Transplants

Death Rates on Waiting List

Patient Survival Rate

Table 28: Patient Survival Percent by Organ Type for 1-Year and 5-Years (includes corresponding Graph/Chart)

Annual Death Rate of Kidney Recipients

Pancreas Patient Survival Rate

Pancreas Graft Survival Rate

Immunosuppression Therapy

Immunosuppression Therapy for Heart Transplant Recipients

Table 29: Usage Rates of Major Immunosuppressants in 2004 (includes corresponding Graph/Chart)

Immunosuppression Therapy for Kidney Transplant Recipients

Immunosuppression Therapy for Pancreas Transplants

Immunosuppression Therapy for Lung Transplant Recipients

Table 30: Usage Rates of Induction Therapies in 2005 (includes corresponding Graph/Chart)

Immunosuppression Therapy Following Bone Marrow Transplantation

Table 31: US Recent Past, Current & Future Market Analysis for Immunosuppressive Drug Therapy Following Bone Marrow Transplantation by Category - For GVHD and Maintenance Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2012 (includes corresponding Graph/Chart)

Immunosuppression Therapy Following Blood Stem Cell Transplantation

Table 32: US Recent Past, Current & Future Market Analysis for Immunosuppressive Drug Therapy Following Blood Stem Cell Transplantation by Category - For GVHD and Maintenance Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2012 (includes corresponding Graph/Chart)

United Network for Organ Sharing

The American Association of Tissue Banks (AATB)

Accredited Banks from Select US States

Eye Banks from Select US States

Number of Transplant Center Programs

Table 33: Number of Transplant Center Programs for the Years 1990, 1997 and 2000 (includes corresponding Graph/Chart)

Table 34: Average Number of Transplants Per Program for the Years 1990, 1997 and 2000 (includes corresponding Graph/Chart)

Strategic Developments

Select Players

Abiomed Inc

Arbios Systems Inc

Arrow International, Inc

CryoLife, Inc

Exactech, Inc

Genzyme Corporation

Jarvik Heart Inc

LifeCell Corporation

Medtronic Inc

MicroMed Cardiovascular, Inc

Organogenesis Inc

Forticell Bioscience, Inc

SynCardia Systems

Thoratec Corporation

WorldHeart Corporation

B. Market Analytics

Table 35: US Recent Past, Current & Future Market Analysis for Organ Transplantation by Organ Type - Heart, Kidney, Liver, Pancreas, Lung and Intestine Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 36: US 10-Year Perspective for Organ Transplantation by Organ Type - Percentage Breakdown of Dollar Sales for Heart, Kidney, Liver, Pancreas, Lung and Intestine Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 37: US Recent Past, Current & Future Market Analysis for Tissue Transplantation by Tissue Type - Cornea, Heart Valves and Skin Grafts Independently Analyzed with Annual Sales Figures in US$ Million for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 38: US 10-Year Perspective for Tissue Transplantation by Tissue Type - Percentage Breakdown of Dollar Sales for Cornea, Heart Valves and Skin Grafts Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 39: US Recent Past, Current & Future Market Analysis for Organ Transplantation by Organ Type - Heart, Kidney, Liver, Pancreas, Lung and Intestine Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 40: US 10-Year Perspective for Organ Transplantation by Organ Type - Percentage Breakdown of Number of Procedures for Heart, Kidney, Liver, Pancreas, Lung and Intestine Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 41: US Recent Past, Current & Future Market Analysis for Tissue Transplantation by Tissue Type - Cornea, Heart Valves, Skin Grafts, Vascular Grafts, Bone Marrow and Bone Grafts Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 42: US 10-Year Perspective for Tissue Transplantation by Tissue Type - Percentage Breakdown of Number of Procedures for Cornea, Heart Valves, Skin Grafts, Vascular Grafts, Bone Marrow and Bone Grafts Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

Table 43: US Recent Past, Current & Future Market Analysis for Bone Graft Transplantation by Graft Type - Autologous Graft, Allograft and Other Materials Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 44: US 10-Year Perspective for Bone Graft Transplantation by Graft Type - Percentage Breakdown of Number of Procedures for Autologous Graft, Allograft and Other Materials Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart) (includes corresponding Graph/Chart)

Table 45: US Recent Past, Current & Future Market Analysis for Bone Graft Transplantation by Application - General Orthopedics, Spinal Fusions and Cranio/Maxillofacial Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 46: US 10-Year Perspective for Bone Graft Transplantation by Application - Percentage Breakdown of Number of Procedures for General Orthopedics, Spinal Fusions and Cranio/Maxillofacial Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

2. Canada

A. Market Analysis

Current and Future Analysis

Canadians More Receptive to Organ Transplants

Waiting List

Table 47: Canadian Patients (Active and Inactive) on Waiting List by Organ Type for 2005 & 2006 (includes corresponding Graph/Chart)

Organ Donation

Success Rate of Organ Transplants

Table 48: Success Rate of Organ Transplants After 1-Year (includes corresponding Graph/Chart)

Strategic Development

B. Market Analytics

Table 49: Canadian Recent Past, Current & Future Market Analysis for Organ Transplantation by Organ Type - Heart, Kidney, Liver, Pancreas and Lung Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 50: Canadian 10-Year Perspective for Organ Transplantation by Organ Type - Percentage Breakdown of Number of Procedures for Heart, Kidney, Liver, Pancreas and Lung Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

3. Europe

A. Market Analysis

Current and Future Analysis

Italy

Surge in Organ Transplants

The United Kingdom

Organ and Tissue Transplantation in the UK

Table 51: UK Organ Transplantations for the Years 2003 and 2004 (includes corresponding Graph/Chart)

Table 52: Waiting List (Active and Inactive) by Organ Type in the UK for the Years 2003 and 2004 (includes corresponding Graph/Chart)

Kidney Transplantation

Waiting List

Categorized by Race

Categorized by Age and Sex

Donors and Transplantation Recipients

Categorized by Race

Categorized by Age and Gender

Pancreas Transplantation

Waiting List

Categorized by Race

Categorized by Age and Gender

Donors and Transplantations

Categorized by Race

Categorized by Age and Gender

Lung Transplant Record Numbers Boasts of Lung Power

Bladder Transplantation A Roaring Success

Russia

Organ Transplantations Show a Downward Trend in Russia

Turkey

Akdeniz University - A World-Renowned Transplantation Center

Strategic Developments

Select Players

Fresenius Medical Care AG & Co. KGaA (Germany)

Gambro AB (Sweden)

B. Market Analytics

Table 53: European Recent Past, Current & Future Market Analysis for Organ Transplantation by Organ Type - Heart, Kidney, Liver, Pancreas and Lung Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 54: European 10-Year Perspective for Organ Transplantation by Organ Type - Percentage Breakdown of Number of Procedures for Heart, Kidney, Liver, Pancreas and Lung Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

4. Asia

A. Market Analysis

Current & Future Analysis

Australia

Australia Registers Highest Success Rate in Transplantation

Kidney Transplantation Snapshots

Organ Donor Register

China

Organ Transplantations in China

Transplantation Tourism in China

Low Transplant Success Rate Due to Unskilled Professionals

Cost Effective Transplant Procedures Lure Foreign Patients

Illegal Activities for Harvesting Organs in China

Regulations on Organ Transplantation

Regulations on Brain Death

India

Overview of Renal Transplantation

Transplantation Expenses in India

Indian Government to amend Organ Transplantation Rules

Singapore

Awareness Programs to Increase Living Kidney Donations in Singapore

Taiwan

Taiwan Competes with the US in Kidney and Liver Transplant Survival Rates

Strategic Developments

Select Players

Terumo Corporation (Japan)

Ventracor Limited (Australia)

B. Market Analytics

Table 55: Asia Recent Past, Current & Future Market Analysis for Organ Transplantation by Organ Type - Heart, Kidney, Liver, Pancreas and Lung Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 56: Asia 10-Year Perspective for Organ Transplantation by Organ Type - Percentage Breakdown of Number of Procedures for Heart, Kidney, Liver, Pancreas and Lung Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

5. Latin America

A. Market Analysis

Current & Future Analysis

Brazil - A Major Transplant Market

B. Market Analytics

Table 57: Latin America Recent Past, Current & Future Market Analysis for Organ Transplantation by Organ Type - Heart, Kidney, Liver, Pancreas and Lung Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 58: Latin America 10-Year Perspective for Organ Transplantation by Organ Type - Percentage Breakdown of Number of Procedures for Heart, Kidney, Liver, Pancreas and Lung Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

6. Rest of World

A. Market Analysis

Current & Future Analysis

Kuwait - A Rapidly Emerging ‘Third World’ Country in Organ Transplants

Strategic Development

B. Market Analytics

Table 59: Rest of World Recent Past, Current & Future Market Analysis for Organ Transplantation by Organ Type - Heart, Kidney, Liver, Pancreas and Lung Independently Analyzed by Number of Procedures for Years 2003 through 2012 (includes corresponding Graph/Chart)

Table 60: Rest of World 10-Year Perspective for Organ Transplantation by Organ Type - Percentage Breakdown of Number of Procedures for Heart, Kidney, Liver, Pancreas and Lung Markets for Years 2003, 2007 & 2012 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 77 (including Divisions/Subsidiaries - 91 )

Region/Country Players

The United States 61

Canada 2

Japan 10

Europe 16

France 1

Germany 6

The United Kingdom 2

Italy 3

Rest of Europe 4

Asia-Pacific (Excluding Japan) 1

Middle East 1

Abstract

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