Collagen and HA-Based Biomaterials

Published by: Global Industry Analysts

Published: Mar. 1, 2008 - 283 Pages

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations

Disclaimers

Data Interpretation & Reporting Level

Quantitative Techniques & Analytics

Product Definitions and Scope of Study

Product Definitions

Collagen Based Biomaterials

Urinary Incontinence

Corneal Shields

Facial Aesthetic Dermal Implants

Wound Dressings

Hyaluronic Acid (HA)

Viscosupplements

Viscoelastics

Facial Aesthetic Dermal Implants

II. EXECUTIVE SUMMARY

1. Market Dynamics

Outlook

Review of Major Segments

Collagen Based Biomaterials

Hyaluronic acid Based Biomaterials

Regional Perspective

Growth Drivers

Challenges Faced

Biomaterials Face Competition

Industry Participants

Leading Players in the Worldwide Collagen Based and HA-Based

Biomaterials Market

2. Trends and Issues

Aging Population/Baby Boomers- Play a Major Role

Injectables Market on a High Growth Curve

Skin Care Products Continue to Dominate Cosmeceuticals

Botox and Hyaluronic Acid Replacing Collagen in Facial Implants

Biomaterial Research- Develop New Applications

Potential Shortage of Biomaterials

Reasons for Shortage of Biomaterials

Inadequate Reimbursement Diminish Revenue Growth

3. Biomaterial - A Brief Overview

Definition

Types of Biomaterials for Medical Devices

Polymers

Composites

Metals & Alloys

Ceramics

Biological biomaterials

Applications of Various Forms of Biomaterials

4. Collagen & HA-Based Biomaterials

Collagen Based Biomaterials

What is Collagen?

Collagen-Based Biomaterials

Various Forms of Collagen and Applications

Soft Tissue Fillers Offer Patients More Options

Review of Collagen Dermal Implants Available

Threatened by Alternatives

Hyaluronic Acid (HA)

Table 1: HA Distribution in the Body (includes corresponding

Graph/Chart)

Properties of HA

5. Segment Overview

Collagen Based Products

Urinary Incontinence

Definition

Classification of Urinary Incontinence

Stress Incontinence

Urge Incontinence

Overflow Incontinence

Functional Incontinence

Treatment of Urinary Incontinence

Periurethral injections (Collagen Injections)

Collagen Corneal Shields

Research Proceedings

Applications of the Collagen Shields

Ocular Surface Lubrication

Ocular Surface Protection

Drug Delivery

Wound Healing

Facial Aesthetic Dermal Implants

Functions of Collagen-based Facial Implants

Aesthetic Dermal Implants-Playing a Major Role

Normal Skin Changes Associated with Aging

Collagen Injections as Facial implants

Wound Dressings

Leading Players in the Collagen Based Wound Dressing Market

The Global Woundcare Market Flaunts Steady Growth

Other Applications of Collagen

Collagen Gene Delivery Systems

Collagen as Bone Graft Substitution

Artificial Skin

Hyaluronic Acid Based Biomaterials

Viscosupplementation

Hyaluronic Acid as Viscosupplement

Viscosupplementation Treatment for Osteoarthritis

Viscosupplementation - High Rate in Japan

Major Hyaluronic Acid based Viscosupplements

Viscoelastics

Facial Aesthetic Dermal Implants

Commercially Available HA Soft Tissue Fillers

Review of Select HA based Products

Advantages of HA Based Over Collagen Products

Vesicoureteral Reflux Implants

Botox - A Competing Biomaterial

6. Technological Research & Developments

Transgenic Plant Based Recombinant Human Collagen from CollPlant

Composite Cultured Skin from Ortechs

Multi-Gene Method

FortaFlex™ Technology

7. Recent Industry Activity

Corgenix and NIDDK Sign CRADA for NASH Research

Orthovita and Allergan Sign a Raw Material Supply Agreement

Warburg Pincus Acquires Bausch & Lomb

Healtheuniverse To Develop Collagen-Based Skin Solutions

Covalon Signs an Agreement with Smith & Nephew

Ortec Seeks PMA for Orcel(R)

Healthpoint Ltd Acquires Biospecifics Technologies Corp

Terumo and Olympus To Start Combined Biomaterial Business

SSC and CMT Inks Exclusive Distribution Agreement

Aastrom and Orthovita Inks Collaboration Agreement

Allergan Acquires Inamed

CollPlant Submits PCT Patent Application

Bioniche Pharma Signs Distribution Agreement with Grünenthal

Lifecore Extends Supply Agreement with Alcon

Inamed and Medicis Terminate Merger Agreement

Genzyme Purchases Synvisc Sales and Marketing Rights from Wyeth

Anika Terminates Partnership with OrthoNeutrogena

Anika Inks Supply Agreement with Bausch & Lomb

Advanced Medical Acquires Pfizer's Ophthalmic Surgical

Q-Med Receives Marketing Licenses

Collagen Matrix Receives NIH Grant

Genzyme Enters the Japanese Hyaluronic Acid Market

Mentor Acquires Two Subsidiaries from Vitrolife

Mentor Acquires Surgical Implants From ProSurg

8. New Launches and Product Approvals

Jarrow Formulas Rolls Out New Products Incorporating BioCell

Collagen I

Medicis’ PerlaneObtains US FDA Aprroval

NMT Medical Launches BioSTAR in Canada and Europe

Allergan Releases JUVEDERM ULTRA and JUVEDERM ULTRA PLUS

Laresse Dermal Filler Gets TGA Approval

Veritas (R) Obtains FDA Clearance

Pegasus’ DermADAPT(TM) Receives FDA Clearance

Innocoll’s CollaGUARD Obtains FDA Approval

PTMC Receives Canadian CMDCAS and European CE Mark Approval

Covalon Receives FDA Approval for Collagran and Collagran Ag

Captique Obtains FDA Approval

Q-MED Introduces RESTYLANE Touch

Genzyme’s Hylaform Plus Receives FDA Stamp of Approval

Q-Med’s RESTYLANE SubQ Gains CE Certification

Orthovisc Bags FDA Approval for Treatment of Osteoarthritis of

the Knee

IDT GmbH Receives CE Certification for Curavisc

Inamed and Genzyme Receives FDA Approval for Hylafor

Inamed Receives FDA Approval for Cosmoderm and Cosmoplast

Vitrolife Receives Approval for Ophthalin

Collagen Matrix Receives Approval for DuraMatrix™

9. Focus on Key Players

Alcon, Inc (US)

Anika Therapeutics, Inc. (US)

Bioniche Pharma USA, LLC (US)

Genzyme Biosurgery (US)

Allergan Medical (US)

Q-Med AB (Sweden)

Seikagaku Corporation (Japan)

10. Global Market Perspective

Table 2: World Recent Past, Current & Future Analysis for

Collagen and HA-Based Biomaterials by Geographic Region - US,

Canada, Japan, Europe and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2000 through 2010(includes corresponding Graph/Chart)

Table 3: World Long-term Projections for Collagen and HA-Based

Biomaterials by Geographic Region - US, Canada, Japan, Europe

and Rest of World Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2011 through

(includes corresponding Graph/Chart)

Table 4: World 10-Year Perspective for Collagen and HA-Based

Biomaterials by Geographic Region - Percentage Breakdown of

Dollar Sales for US, Canada, Japan, Europe and Rest of World

Markets for Years 2000, 2007 & 2010 (includes corresponding

Graph/Chart)

Table 5: World Recent Past, Current & Future Analysis for

Biomaterials by Product Groups - Collagen Based and Hyaluronic

Acid Based Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 6: World Long-term Projections for Biomaterials by

Product Groups - Collagen Based and Hyaluronic Acid Based

Markets Independently Analyzed with Annual Sales Figures in

US$ Million for Years 2011 through 2015 (includes

corresponding Graph/Chart)

Table 7: World 10-Year Perspective for Biomaterials by Product

Groups - Percentage Breakdown of Dollar Sales for Collagen

Based and Hyaluronic Acid Based Markets for Years 2000, 2007 &

2010

Table 8: World Recent Past, Current & Future Analysis for

Collagen Based Biomaterials by Geographic Region - US, Canada,

Japan, Europe and Rest of World Markets Independently Analyzed

with Annual Sales Figures in US$ Million for Years

through 2010 (includes corresponding Graph/Chart)

Table 9: World Long-term Projections for Collagen Based

Biomaterials by Geographic Region - US, Canada, Japan, Europe

and Rest of World Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2011 through

(includes corresponding Graph/Chart)

Table 10: World Recent Past, Current & Future Analysis for

Collagen Based Biomaterials by Product Segments - Urinary

Incontinence, Corneal Shields, Facial Aesthetic Dermal

Implants and Wound Dressings Markets Independently Analyzed

with Annual Sales Figures in US$ Million for Years

through 2010 (includes corresponding Graph/Chart)

Table 11: World Long-term Projections for Collagen Based

Biomaterials by Product Segments - Urinary Incontinence

Products, Corneal Shields, Facial Aesthetic Dermal Implants

and Wound Dressings Markets Independently Analyzed with Annual

Sales Figures in US$ Million for Years 2011 through

(includes corresponding Graph/Chart)

Table 12: World 10-Year Perspective for Collagen Based

Biomaterials by Geographic Region - Percentage Breakdown of

Dollar Sales for US, Canada, Japan, Europe and Rest of World

Markets for Years 2000, 2007 & 2010 (includes corresponding

Graph/Chart)

Table 13: World 10-Year Perspective for Collagen Based

Biomaterials by Product Segment - Percentage Breakdown of

Dollar Sales for Urinary Incontinence, Corneal Shields, Facial

Aesthetic Dermal Implants and Wound Dressings Markets for

Years 2000, 2007 & 2010 (includes corresponding Graph/Chart)

Table 14: World Recent Past, Current & Future Analysis for

Collagen Based Urinary Incontinence by Geographic Region - US,

Canada, Japan, Europe and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2000 through 2010 (includes corresponding Graph/Chart)

Table 15: World Long-term Projections for Collagen Based

Urinary Incontinence Products by Geographic Region -

Percentage Breakdown of Dollar Sales for US, Canada, Japan,

Europe and Rest of World Markets for Years 2011 through

(includes corresponding Graph/Chart)

Table 16: World 10-Year Perspective for Collagen Based Urinary

Incontinence by Geographic Region - Percentage Breakdown of

Dollar Sales for US, Canada, Japan, Europe and Rest of World

Markets for Years 2000, 2007 & 2010 (includes corresponding

Graph/Chart)

Table 17: World Recent Past, Current & Future Analysis for

Collagen Based Corneal Shields by Geographic Region - US,

Canada, Japan, Europe and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2000 through 2010 (includes corresponding Graph/Chart)

Table 18: World Long-term Projections for Collagen Based

Corneal Shields by Geographic Region - US, Canada, Japan,

Europe and Rest of World Markets Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2011 through

2015 (includes corresponding Graph/Chart)

Table 19: World 10-Year Perspective for Collagen Based Corneal

Shields by Geographic Region - Percentage Breakdown of Dollar

Sales for US, Canada, Japan, Europe and Rest of World Markets

for Years 2000, 2007 & 2010 (includes corresponding

Graph/Chart)

Table 20: World Recent Past, Current & Future Analysis for

Collagen Based Facial Aesthetic Dermal Implants by Geographic

Region - US, Canada, Japan, Europe and Rest of World Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2000 through 2010 (includes corresponding

Graph/Chart)

Table 21: World Long-term Projections for Collagen Based

Facial Aesthetic Dermal Implants by Geographic Region - US,

Canada, Japan, Europe and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2011 through 2015 (includes corresponding Graph/Chart)

Table 22: World 10-Year Perspective for Collagen Based Facial

Aesthetic Dermal Implants by Geographic Region - Percentage

Breakdown of Dollar Sales for US, Canada, Japan, Europe and

Rest of World Markets for Years 2000, 2007 & 2010 (includes

corresponding Graph/Chart)

Table 23: World Recent Past, Current & Future Analysis for

Collagen Based Wound Dressings by Geographic Region - US,

Canada, Japan, Europe and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2000 through 2010 (includes corresponding Graph/Chart)

Table 24: World Long-term Projections for Collagen Based Wound

Dressings by Geographic Region - US, Canada, Japan, Europe and

Rest of World Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2011 through 2015 (includes

corresponding Graph/Chart)

Table 25: World 10-Year Perspective for Collagen Based Wound

Dressings by Geographic Region - Percentage Breakdown of

Dollar Sales for US, Canada, Japan, Europe and Rest of World

Markets for Years 2000, 2007 & 2010 (includes corresponding

Graph/Chart)

Table 26: World Recent Past, Current & Future Analysis for

Hyaluronic Acid Based Biomaterials by Geographic Region - US,

Canada, Japan, Europe and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2000 through 2010 (includes corresponding Graph/Chart)

Table 27: World Long-term Projections for Hyaluronic Acid

Based Biomaterials by Geographic Region - US, Canada, Japan,

Europe and Rest of World Markets Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2011 through

2015 (includes corresponding Graph/Chart)

Table 28: World 10-Year Perspective for Hyaluronic Acid Based

Biomaterials by Geographic Region - Percentage Breakdown of

Dollar Sales for US, Canada, Japan, Europe and Rest of World

Markets for Years 2000, 2007 & 2010 (includes corresponding

Graph/Chart)

Table 29: World Recent Past, Current & Future Analysis for

Hyaluronic Acid Based Biomaterials by Product Segments-

Viscosupplements, Viscoelastics and Facial Aesthetic Dermal

Implants Independently Analyzed with Annual Sales Figures in

US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 30: World Long-term Projections for Hyaluronic Acid

Based Biomaterials by Product Segments - Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 31: World 10-Year Perspective for Hyaluronic Acid Based

Biomaterials by Product Segments - Percentage Breakdown of

Dollar Sales for Viscosupplements, Viscoelastics and Facial

Aesthetic Dermal Implants Markets for Years 2000, 2007 &

(includes corresponding Graph/Chart)

Table 32: World Recent Past, Current & Future Analysis for

Hyaluronic Acid Based Viscosupplements by Geographic Region -

US, Canada, Japan, Europe and Rest of World Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2000 through 2010 (includes corresponding

Graph/Chart)

Table 33: World Long-term Projections for Hyaluronic Acid

Based Viscosupplements by Geographic Region - US, Canada,

Japan, Europe and Rest of World Markets Independently Analyzed

with Annual Sales Figures in US$ Million for Years

through 2015 (includes corresponding Graph/Chart)

Table 34: World 10-Year Perspective for Hyaluronic Acid Based

Viscosupplements by Geographic Region - Percentage Breakdown

of Dollar Sales for US, Canada, Japan, Europe and Rest of

World Markets for Years 2000, 2007 & 2010 (includes

corresponding Graph/Chart)

Table 35: World Recent Past, Current & Future Analysis for

Hyaluronic Acid Based Viscoelastics by Geographic Region - US,

Canada, Japan, Europe and Rest of World Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2000 through 2010 (includes corresponding Graph/Chart)

Table 36: World Long-term Projections for Hyaluronic Acid

Based Viscoelastics by Geographic Region - US, Canada, Japan,

Europe and Rest of World Markets Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2011 through

2015 (includes corresponding Graph/Chart)

Table 37: World 10-Year Perspective for Hyaluronic Acid Based

Viscoelastics by Geographic Region - Percentage Breakdown of

Dollar Sales for US, Canada, Japan, Europe and Rest of World

Markets for Years 2000, 2007 & 2010 (includes corresponding

Graph/Chart)

Table 38: World Recent Past, Current & Future Analysis for

Hyaluronic Acid Based Facial Aesthetic Dermal Implants by

Geographic Region - US, Canada, Japan, Europe and Rest of

World Markets Independently Analyzed with Annual Sales Figures

in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 39: World Long-term Projections for Hyaluronic Acid

Based Facial Aesthetic Dermal Implants by Geographic Region -

US, Canada, Japan, Europe and Rest of World Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 40: World 10-Year Perspective for Hyaluronic Acid Based

Facial Aesthetic Dermal Implants by Geographic Region -

Percentage Breakdown of Dollar Sales for US, Canada, Japan,

Europe and Rest of World Markets for Years 2000, 2007 &

(includes corresponding Graph/Chart)

III. MARKET

1. The United States

A.Market Analysis

The Largest Market

Market Outlook by Segment

Urinary Incontinence Products

Leading Players

Table 41: Leading Players in the US Collagen- Based

Urinary Incontinence Implants Market (2004-2006):

Percentage Sales Breakdown for Allergan Medical /C.R.

Bard, and Others (includes corresponding Graph/Chart)

Corneal Shields

Facial Aesthetic Dermal Implants Highly Competitive

Wound Dressings Market

Viscosupplements Spur Industry Growth

Hyaluronic Acid Knee Procedures on the Rise

Medicare for Viscosupplements

Leading Players

Table 42: Leading Players in the US Viscosupplementation

Market (HA based) (2005 &2006): Percentage Share

Breakdown by Value Sales for Genzyme, Sanofi, and Others

(includes corresponding Graph/Chart)

Viscoelastics

Table 43: Leading Players in the US Viscoelastics # Market

(HA based) (2005-2006): Percentage Share Breakdown by

Value Sales for Alcon, Advanced Medical Optics, Bausch &

Lomb, and Others (includes corresponding Graph/Chart)

Dermal Implants -The Fastest Growing Biomaterial

Trends

US Biomaterials Market Elicits Rosy Future

US - A promising Facial Aesthetic Dermal Implants Market

Enhanced Cosmetic Surgery Procedures to Boost Sales

US Facial Aesthetics Implants- Open Doors for New Players

Table 44: Leading Players in the US Collagen Based Facial

Aesthetics Implants Market (2005-2006)

Baby Boomers Trigger Growth

Non-Surgical Cosmetic Procedures in US

Strategic Corporate Developments

Product Launches

Focus on Key Players

Alcon, Inc

Anika Therapeutics, Inc.

Bioniche Pharma USA, LLC (USA)

Datascope Corporation

FibroGen, Inc

Genzyme Biosurgery

Allergan Medical

Isolagen Inc.

Lifecore Biomedical Inc.

B.Market Analytics

Table 45: US Recent Past, Current & Future Analysis for

Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 46: US Long-term Projections for Collagen and HA-based

Biomaterials by Product Segment - Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets Independently Analyzed

with Annual Sales Figures in US$ Million for Years

through 2015 (includes corresponding Graph/Chart)

Table 47: US 10-Year Perspective for Collagen and HA-based

Biomaterials by Product Groups - Percentage Breakdown of

Dollar Sales for Collagen Based (Urinary Incontinence

Products, Corneal Shields, Facial Aesthetic Dermal Implants

and Wound Dressings) and Hyaluronic Acid Based

(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal

Implants) Biomaterial Markets for Years 2000, 2007 &

2010(includes corresponding Graph/Chart)

2. Canada

A.Market Analysis

Strategic Corporate Developments

Product Launches

B.Market Analytics

Table 48: Canadian Recent Past, Current & Future Analysis

for Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 49: Canadian Long-term Projections for Collagen and

HA-based Biomaterials by Product Segment - Collagen Based

(Urinary Incontinence Products, Corneal Shields, Facial

Aesthetic Dermal Implants and Wound Dressings) and

Hyaluronic Acid Based (Viscosupplements, Viscoelastics and

Facial Aesthetic Dermal Implants) Biomaterial Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 50: Canadian 10-Year Perspective for Collagen and

HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

3. Japan

A.Market Analysis

Competitors

Strategic Corporate Developments

Focus on Key Players

Seikagaku Corporation

B.Market Analytics

Table 51: Japanese Recent Past, Current & Future Analysis

for Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 52: Japanese Long-term Projections for Collagen and

HA-based Biomaterials by Product Segment - Collagen Based

(Urinary Incontinence Products, Corneal Shields, Facial

Aesthetic Dermal Implants and Wound Dressings) and

Hyaluronic Acid Based (Viscosupplements, Viscoelastics and

Facial Aesthetic Dermal Implants) Biomaterial Markets

Independently Analyzed with annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 53: Japanese 10-Year Perspective for Collagen and

HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

4. Europe

A.Market Analysis

Regional Analysis

Hyaluronic Acid Biomaterials Market in Europe

Table 54: Leading Manufacturers of Viscosupplemen-tation

Products in Europe (2006) : Percentage Breakdown by Value

Sales for Fidia, Genzyme/Wyeth, Curasan, Seikagaku/Smith &

Nephew, and Others (includes corresponding Graph/Chart)

Strategic Corporate Developments

Product Launches

B.Market Analytics

Table 55: European Recent Past, Current & Future Analysis

for Collagen and HA-Based Biomaterials by Geographic Region

- France, Germany, Italy, UK & Rest of Europe Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2000 through 2010 (includes corresponding

Graph/Chart)

Table 56: European Long-term Projections for Collagen and

HA-Based Biomaterials by Geographic Region - France,

Germany, Italy, UK & Rest of Europe Markets Independently

Analyzed with Annual Sales Figures in US$ Million for Years

2011 through 2015 (includes corresponding Graph/Chart)

Table 57: European 11- Year Perspective for Collagen and

HA-Based Biomaterials by Geographic Region - Percentage

Breakdown of Dollar Sales for France, Germany, Italy, UK &

Rest of Europe Markets for Years 2000, 2007 & 2010 (includes

corresponding Graph/Chart)

Table 58: European Recent Past, Current & Future Analysis

for Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 59: European Long-term Projections for Collagen and

HA-based Biomaterials by Product Segment - Collagen Based

(Urinary Incontinence Products, Corneal Shields, Facial

Aesthetic Dermal Implants and Wound Dressings) and

Hyaluronic Acid Based (Viscosupplements, Viscoelastics and

Facial Aesthetic Dermal Implants) Biomaterial Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 60: European 10-Year Perspective for Collagen and

HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

4a. France

Market Analysis

Table 61: French Recent Past, Current & Future Analysis for

Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal

Implants)Biomaterial Markets Independently Analyzed with

Annual Sales Figures in US$ Million for Years 2000 through

2010 (includes corresponding Graph/Chart)

Table 62: French Long-term Projections for Collagen and

HA-based Biomaterials by Product Segment - Collagen Based

(Urinary Incontinence Products, Corneal Shields, Facial

Aesthetic Dermal Implants and Wound Dressings) and

Hyaluronic Acid Based (Viscosupplements, Viscoelastics and

Facial Aesthetic Dermal Implants) Biomaterial Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 63: French 10-Year Perspective for Collagen and

HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

4b. Germany

A.Market Analysis

Key Player

Curasan AG

B.Market Analytics

Table 64: German Recent Past, Current & Future Analysis for

Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 65: German Long-term Projections for Collagen and

HA-based Biomaterials by Product Segment - Collagen Based

(Urinary Incontinence Products, Corneal Shields, Facial

Aesthetic Dermal Implants and Wound Dressings) and

Hyaluronic Acid Based (Viscosupplements, Viscoelastics and

Facial Aesthetic Dermal Implants) Biomaterial Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 66: German 10-Year Perspective for Collagen and

HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

4c. Italy

Market Analysis

Table 67: Italian Recent Past, Current & Future Analysis for

Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 68: Italian Long-term Projections for Collagen and

HA-based Biomaterials by Product Segment - Collagen Based

(Urinary Incontinence Products, Corneal Shields, Facial

Aesthetic Dermal Implants and Wound Dressings) and

Hyaluronic Acid Based (Viscosupplements, Viscoelastics and

Facial Aesthetic Dermal Implants) Biomaterial Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 69: Italian 10-Year Perspective for Collagen and

HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

4d. United Kingdom

Market Analysis

Table 70: UK Recent Past, Current & Future Analysis for

Collagen and HA-based Biomaterials by Product Groups-

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 71: UK Long-term Projections for Collagen and HA-based

Biomaterials by Product Segment - Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implant) Biomaterial Markets Independently Analyzed

with Annual Sales Figures in US$ Million for Years

through 2015 (includes corresponding Graph/Chart)

Table 72: UK 10-Year Perspective for Collagen and HA-based

Biomaterials by Product Groups - Percentage Breakdown of

Dollar Sales for Collagen Based (Urinary Incontinence

Products, Corneal Shields, Facial Aesthetic Dermal Implants

and Wound Dressings) and Hyaluronic Acid Based

(Viscosupplements, Viscoelastics and Facial Aesthetic Dermal

Implants) Biomaterial Markets for Years 2000, 2007 &

(includes corresponding Graph/Chart)

4e. Rest of Europe

A.Market Analysis

Strategic Corporate Developments

Focus on Key Players

FibroGen Europe Corporation (Finland)

Q-Med AB (Sweden)

B.Market Analytics

Table 73: Rest of Europe Recent Past, Current & Future

Analysis for Collagen and HA-based Biomaterials by Product

Groups- Collagen Based (Urinary Incontinence Products,

Corneal Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 74: Rest of Europe Long-term Projections for Collagen

and HA-based Biomaterials by Product Segment - Collagen

Based (Urinary Incontinence Products, Corneal Shields,

Facial Aesthetic Dermal Implants and Wound Dressings) and

Hyaluronic Acid Based (Viscosupplements, Viscoelastics and

Facial Aesthetic Dermal Implants) Biomaterial Markets

Independently Analyzed with Annual Sales Figures in US$

Million for Years 2011 through 2015 (includes corresponding

Graph/Chart)

Table 75: Rest of Europe 10-Year Perspective for Collagen

and HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

5. Rest of World

A.Market Analysis

Focus on Key Player

ColBar LifeScience Ltd (Israel)

Recent Industry Activity

B.Market Analytics

Table 76: Rest of World Recent Past, Current & Future

Analysis for Collagen and HA-based Biomaterials by Product

Groups- Collagen Based (Urinary Incontinence Products,

Corneal Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2000 through 2010 (includes

corresponding Graph/Chart)

Table 77: Rest of World Recent Long-term Projections for

Collagen and HA-based Biomaterials by Product Segment -

Collagen Based (Urinary Incontinence Products, Corneal

Shields, Facial Aesthetic Dermal Implants and Wound

Dressings) and Hyaluronic Acid Based (Viscosupplements,

Viscoelastics and Facial Aesthetic Dermal Implants)

Biomaterial Markets Independently Analyzed with Annual Sales

Figures in US$ Million for Years 2011 through 2015 (includes

corresponding Graph/Chart)

Table 78: Rest of World 10-Year Perspective for Collagen and

HA-based Biomaterials by Product Groups - Percentage

Breakdown of Dollar Sales for Collagen Based (Urinary

Incontinence Products, Corneal Shields, Facial Aesthetic

Dermal Implants and Wound Dressings) and Hyaluronic Acid

Based (Viscosupplements, Viscoelastics and Facial Aesthetic

Dermal Implants) Biomaterial Markets for Years 2000, 2007 &

2010 (includes corresponding Graph/Chart)

IV. COMPETITIVE LANDSCAPE

Abstract

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